Glycan targeting nanoparticle for photodynamic immunotherapy of melanoma

作     者：Yonghyun Choi Wooic Son Youngpin Han Jayoung Chae Chul-Su Yang Jonghoon Choi Yonghyun Choi;Wooic Son;Youngpin Han;Jayoung Chae;Chul-Su Yang;Jonghoon Choi

作者机构：School of Integrative EngineeringChung-Ang UniversitySeoul 06974Republic of Korea Department of Molecular&Life ScienceHanyang UniversityAnsan 15588Republic of Korea Center for Bionano Intelligence Education and ResearchHanyang UniversityAnsan 15588Republic of Korea 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第5期

页      面：1903-1918页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：a National Research Foundation of Korea(NRF)grant the Korean government(MSIT)(Nos.2020R1A5A1018052 2017M3A7B8061942 2019R1A2C1006018 2021R1A4A5032463 and 2021M3H4A4079629 Republic of Korea) 

主　　题：Immunotherapy Macrophages Phagocytosis Lectin Melanoma cancer Photothermal nanoparticles Immune checkpoint Glycan 

摘      要：Interaction between tumour cells and macrophages enables cancer cells to evade immune detection and clearance by interfering with macrophage *** anti-phagocytic signals regulated by anti-phagocytic proteins are termeddon t eat mesignals;these signals include sialic acidbinding immunoglobulin-type lectin-10(Siglec-10)and the recently revealed CD24 immune checkpoint(ICP).In this study,we demonstrate that targeting a specific glycan on CD24 exhibits the potential to inhibit *** nigra agglutinin(SNA),a sialic acid-binding lectin,was employed to block CD24 and to enhance phagocytosis in melanoma *** addition,we prepared SNA-conjugated hollow gold-iron oxide nanoparticles for photothermal therapy of *** findings show that the combination treatment of SNA-conjugated photothermal nanoparticles and near-infrared exposure successfully augments tumour cell phagocytosis both in vitro and in vivo models.