检索结果-南通市图书馆

Genes & Diseases 2024年第3期11卷 98-101页

作者： Zishuai Wang Yilong Yao Xinhua Hou Danyang Fan Yanwen liu Adeyinka Abiola Adetula Yalan Yang kui li Zhonglin Tang Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong518000China Kunpeng Institute of Modern Agriculiture at Foshan Chinese Academy of Agricultural SciencesFoshanGuangdong528226China GuangXi Engineering Centre for Resource Development of Bama Xiang Pig BamaGuangxi 547500China Institute of Animal Science Chinese Academy of Agricultural SciencesBeijing100193China

Aerobic exercise training alters gene expression in skeletal muscle,and miRNAs significantly contribute to motion response.However,the molecular mechanisms by which miRNAs regulate the response to exercise training are not well understood.Here,we found that the abundance of miR-378a-3p in skeletal muscle significantly decreased after exercise training.miR-378a-3p knockout mice showed increased insulin sensitivity,insulin-mediated glucose uptake.

关键词： skeletal miR uptake

Risk factors and predictive model of cerebral edema after road traffic accidents-related traumatic brain injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2024年第3期27卷 153-162页

作者： Di-You Chen Peng-Fei Wu Xi-Yan Zhu Wen-Bing Zhao Shi-Feng Shao Jing-Ru Xie Dan-Feng Yuan liang Zhang kui li Shu-Nan Wang Hui Zhao Institute for Traffc Medicine aping HospitalArmy Medical UniverstyChongqing400042China Department of Radiology Daping HospitalArmy Medical UniversityChongqing400042China Chongqing Key Laboratory of Traffic Injury and Vehicle Ergonomics Chongqing400042China Wound Trauma Medical Center State Key Laboratory of TraumnaBurns and Combined lnjuryInstitute of Surgery ResearchDaping HospialArmy Medical UniversityChongqing.400042China

Purpose:Cerebral edema(CE)is the main secondary injury following traumatic brain injury(TBI)caused by road traffic accidents(RTAs).It is challenging to be predicted timely.In this study,we aimed to develop a prediction model for CE by identifying its risk factors and comparing the timing of edema occurrence in TBI patients with varying levels of injuries.Methods:This case-control study included 218 patients with TBI caused by RTAs.The cohort was divided into CE and non-CE groups,according to CT results within 7 days.Demographic data,imaging data,and clinical data were collected and analyzed.Quantitative variables that follow normal distribution were presented as mean±standard deviation,those that do not follow normal distribution were presented as median(Q1,Q3).Categorical variables were expressed as percentages.The Chi-square test and logistic regression analysis were used to identify risk factors for CE.Logistic curve fitting was performed to predict the time to secondary CE in TBI patients with different levels of injuries.The efficacy of the model was evaluated using the receiver operator characteristic curve.Results:According to the study,almost half(47.3%)of the patients were found to have CE.The risk factors associated with CE were bilateral frontal lobe contusion,unilateral frontal lobe contusion,cerebral contusion,subarachnoid hemorrhage,and abbreviated injury scale(AIS).The odds ratio values for these factors were 7.27(95%confidence interval(CI):2.08-25.42,p=0.002),2.85(95%CI:1.11-7.31,p=0.030),2.62(95%CI:1.12-6.13,p=0.027),2.44(95%CI:1.25-4.76,p=0.009),and 1.5(95%CI:1.10-2.04,p=0.009),respectively.We also observed that patients with mild/moderate TBI(AIS≤3)had a 50%probability of developing CE 19.7 h after injury(χ^(2)=13.82,adjusted R2=0.51),while patients with severe TBI(AIS>3)developed CE after 12.5 h(χ^(2)=18.48,adjusted R2=0.54).Finally,we conducted a receiver operator characteristic curve analysis of CE time,which showed an area under the curve of 0.744 and 0.672 for severe and mild/moderate TBI,

关键词： Road traffic accident Traumatic brain injury Cerebral edema Risk factors Time window

Highly efficient and aberration-free off-plane grating spectrometer and monochromator for EUV—soft X-ray applications

在线全文

学校读者我要写书评

暂无评论

light(Science & Applications) 2024年第1期13卷 68-79页

作者： Jie li kui li Xiaoshi Zhang Dimitar Popmintchev Hao Xu Yutong Wang Ruixuan li Guangyin Zhang Jiyue Tang Jin Niu Yongjun Ma Runyu Meng Changjun Ke Jisi Qiu Yunfeng Ma Tenio Popmintchev Zhongwei Fan Aerospace Information Research Institute Chinese Academy of SciencesBeijing100094China School of Optoelectronics University of the Chinese Academy of SciencesBeijing100049China Yunnan University KunmingYunnan650500China Photonics Institute TU WienViennaA-1040Austria Yunnan Observatories Chinese Academy of SciencesKunmingYunnan650011China University of California Physics DepartmentSan DiegoLa JollaCA92093USA

We demonstrate a novel flat-field,dual-optic imaging EUV—soft X-ray spectrometer and monochromator that attains an unprecedented throughput efficiency exceeding 60%by design,along with a superb spectral resolution ofλ/Δλ>200 accomplished without employing variable line spacing gratings.Exploiting the benefits of the conical diffraction geometry,the optical system is globally optimized in multidimensional parameter space to guarantee optimal imaging performance over a broad spectral range while maintaining circular and elliptical polarization states at the first,second,and third diffraction orders.Moreover,our analysis indicates minimal temporal dispersion,with pulse broadening confined within 80 fs tail-to-tail and an FWHM value of 29 fs,which enables ultrafast spectroscopic and pump-probe studies with femtosecond accuracy.Furthermore,the spectrometer can be effortlessly transformed into a monochromator spanning the EUV—soft X-ray spectral region using a single grating with an aberration-free spatial profile.Such capability allows coherent diffractive imaging applications to be conducted with highly monochromatic light in a broad spectral range and extended to the soft X-ray region with minimal photon loss,thus facilitating state-of-the-art imaging of intricate nano-and bio-systems,with a significantly enhanced spatiotemporal resolution,down to the nanometer–femtosecond level.

关键词： chromato Highly exceeding

Highly selective electrosynthesis of 3,4-dihydroisoquinoline accompanied with hydrogen production over three-dimensional hollow CoNi-based microarray electrocatalysts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 2509-2519页

作者： Yu Xin liyu Chen Yingwei li kui Shen Guangdong Provincial Key Lab for Green Chemical Product Technology School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China State Key Laboratory of Pulp and Paper Engineering School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China

Electrocatalytic oxidation reaction of biomass-based derivatives is an excellent candidate to replace water oxidation for obtaining both value-added products and hydrogen(H_(2)),but the exploration of competent electrocatalysts is still highly challenging.Herein,two new types of three-dimensional self-supported hollow microarrays containing CoNi layered double hydroxide(CoNi-LDH)and N-doped carbon nanosheets decorated with CoNi alloyed nanoparticles(CoNi-NC)on carbon cloth(CC)are prepared,which are further used as efficient electrocatalysts for tetrahydroisoquinoline(THIQ)electrooxidation and hydrogen evolution reaction(HER),respectively.We demonstrate that the Co-modulated electronic environment for Ni(II)/Ni(Ⅲ)redox-looping in CoNi-LDH is the main factor to boost the selectivity of 3,4-dihydroisoquinoline(DHIQ)for the indirect electrooxidation process of THIQ.Density functional theory(DFT)calculations reveal that the Ni(Ⅲ)/Co(Ⅲ)dual sites of CoNi-LDH exhibit enhanced adsorption for THIQ but poorer adsorption for DHIQ compared to pure Co(Ⅲ)or Ni(Ⅲ).Therefore,the Ni(Ⅲ)/Co(Ⅲ)dual sites can effectively inhibit the peroxidation of DHIQ to isoquinoline(IQ)over CoNi-LDH,thus improving the selectivity of DHIQ to nearly 100%,much higher than that of its pure Ni counterpart.Moreover,CC@CoNi-NC can deliver high HER activity with low overpotential(40 mV@10 mA·cm^(-2))and high exchange current density(3.08 mA·cm^(-2)).Impressively,the assembled flow-cell device with CC@CoNi-LDH anode and CC@CoNi-NC cathode only requires low cell voltage and electricity consumption of 1.6 V and 3.50 kWh per cubic meter of H_(2)(@25 mA·cm^(-2)).

关键词： highly selective electrosynthesis dihydroisoquinolines hydrogen evolution reaction metal-organic frameworks hollow microarrays

Secure resource allocation against colluding eavesdropping in a user-centric cell-free massive multiple-input multiple-output system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Information Technology & Electronic Engineering 2024年第4期25卷 500-512页

作者： Na li Yuanyuan GAO kui XU Xiaochen XIA Huazhi HU Yang li Yueyue ZHANG College of Communication Engineering Army Engineering University of PLANanjing 210007China

We investigate the resource allocation problem of a cell-free massive multiple-input multiple-output system under the condition of colluding eavesdropping by multiple passive eavesdroppers.To address the problem of limited pilot resources,a scheme is proposed to allocate the pilot with the minimum pollution to users based on access point selection and optimize the pilot transmission power to improve the accuracy of channel estimation.Aiming at the secure transmission problem under a colluding eavesdropping environment by multiple passive eavesdroppers,based on the local partial zero-forcing precoding scheme,a transmission power optimization scheme is formulated to maximize the system’s minimum security spectral efficiency.Simulation results show that the proposed scheme can effectively reduce channel estimation error and improve system security.

关键词： Cell-free Colluding eavesdropping limited pilot resources Access point selection Security rate

Structural and functional connectivity of the whole brain and subnetworks in individuals with mild traumatic brain injury:predictors of patient prognosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第7期19卷 1553-1558页

作者： Sihong Huang Jungong Han Hairong Zheng Mengjun li Chuxin Huang Xiaoyan kui Jun liu Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Computer Science Aberystwyth UniversityAberystwythCeredigionUK Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhenGuangdong ProvinceChina School of Computer Science and Engineering Central South UniversityChangshaHunan ProvinceChina Department of Radiology Quality Control Center of Hunan ProvinceChangshaHunan ProvinceChina Clinical Research Center for Medical Imaging of Hunan Province ChangshaHunan ProvinceChina

Patients with mild traumatic brain injury have a diverse clinical presentation,and the underlying pathophysiology remains poorly understood.Magnetic resonance imaging is a non-invasive technique that has been widely utilized to investigate neuro biological markers after mild traumatic brain injury.This approach has emerged as a promising tool for investigating the pathogenesis of mild traumatic brain injury.G raph theory is a quantitative method of analyzing complex networks that has been widely used to study changes in brain structure and function.However,most previous mild traumatic brain injury studies using graph theory have focused on specific populations,with limited exploration of simultaneous abnormalities in structural and functional connectivity.Given that mild traumatic brain injury is the most common type of traumatic brain injury encounte red in clinical practice,further investigation of the patient characteristics and evolution of structural and functional connectivity is critical.In the present study,we explored whether abnormal structural and functional connectivity in the acute phase could serve as indicators of longitudinal changes in imaging data and cognitive function in patients with mild traumatic brain injury.In this longitudinal study,we enrolled 46 patients with mild traumatic brain injury who were assessed within 2 wee ks of injury,as well as 36 healthy controls.Resting-state functional magnetic resonance imaging and diffusion-weighted imaging data were acquired for graph theoretical network analysis.In the acute phase,patients with mild traumatic brain injury demonstrated reduced structural connectivity in the dorsal attention network.More than 3 months of followup data revealed signs of recovery in structural and functional connectivity,as well as cognitive function,in 22 out of the 46 patients.Furthermore,better cognitive function was associated with more efficient networks.Finally,our data indicated that small-worldness in the acute stage could serve as a predictor of longitudinal ch

关键词： cognitive function cross-section follow-up functional connectivity graph theory longitudinal study mild traumatic brain injury prediction small-worldness structural connectivity subnetworks whole brain network

Experimental and numerical study on protective effect of RC blast wall against air shock wave

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第1期31卷 567-579页

作者： Xin-zhe Nian Quan-min Xie Xin-li Kong Ying-kang Yao kui Huang State Key Laboratory of Precision Blasting Jianghan UniversityWuhan430056China Hubei Key Laboratory of Blasting Engineering Jianghan UniversityWuhan430056China Hubei(Wuhan)Institute of Explosion and Blasting Technology Jianghan UniversityWuhan430056China College of Defense Engineering Army Engineering University of PLANanjing210007China Institute of Defense Engineering AMSPLALuoyang471023China

Prototype experiments were carried out on the explosion-proof performance of the RC blast wall.The mass of TNT detonated in the experiments is 5 kg and 20 kg respectively.The shock wave overpressure was tested in different regions.The above experiments were numerically simulated,and the simulated shock wave overpressure waveforms were compared with that tested and given by CONWEP program.The results show that the numerically simulated waveform is slightly different from the test waveform,but similar to CONWEP waveform.Through dimensional analysis and numerical simulation under different working conditions,the equation for the attenuation rate of the diffraction overpressure behind the blast wall was obtained.According to the corresponding standards,the degree of casualties and the damage degree of the brick concrete building at a certain distance behind the wall can be determined when parameters are set.The above results can provide a reference for the design and construction of the reinforced concrete blast wall.

关键词： Blast wall Shock wave Diffraction Overpressure Protection

Troy: Efficient Service Deployment for Windows Systems

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第1期33卷 313-322页

作者： Deyu ZHANG Yu XIE Mucong XU En CHENG Xiaoyan kui Bangwen HE Yunhao li School of Computer Science and Engineering Central South University

The modern university computer lab and kindergarden through 12th grade classrooms require a centralized solution to efficiently manage a large number of desktops. The existing solutions either bring virtualization overhead in runtime or requires loading a large image over 30 GB leading to an unacceptable network latency. In this work, we propose Troy which takes advantage of the differencing virtual hard disk techniques in Windows systems.As such, Troy only loads the modifications made on one machine to all other machines. Troy consists of two modules that are responsible to generate an initial image and merge a differencing image with its parent image, respectively. Specifically, we identify the key fields in the virtual hard disk image that links the differencing image and the parent image and find the modified blocks in the differencing images that should be used to replace the blocks in the parent image. We further design a lazy copy solution to reduce the I/O burden in image merging. We have implemented Troy on bare metal machines. The evaluation results show that the performance of Troy is comparable to the native implementation in Windows, without requiring the Windows environment.

关键词： Service deployment Virtual hard disk File system merging Windows system

Improved nuclear mass formula with an additional term from the Fermi gas model

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第5期35卷 131-138页

作者： Xiao-Yu Xu li Deng Ai-Xi Chen Hang Yang Amir Jalili Han-kui Wang School of Science Zhejiang Sci-Tech UniversityHangzhou 310018China

Nuclear mass is a fundamental property of nuclear physics and a necessary input in nuclear astrophysics.Owing to the complexity of atomic nuclei and nonperturbative strong interactions,conventional physical models cannot completely describe nuclear binding energies.In this study,the mass formula was improved by considering an additional term from the Fermi gas model.All nuclear masses in the Atomic Mass Evaluation Database were reproduced with a root-mean-square deviation(RMSD)of -1.86 MeV(1.92 MeV).The new mass formula exhibits good performance in the neutron-rich nuclear region.The RMSD decreases to 0.393 MeV when the ratio of the neutron number to the proton number is≥1.6.

关键词： Nuclear mass formula Neutron-rich nuclei Fermi-gas model

Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis:Implications for bone health

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第4期16卷 389-409页

作者： ling-ling Wang Zhan-Jin Lu Shun-kui Luo Yun li Zhe Yang Hong-Yun Lu Department of Gerontology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Endocrinology and Metabolism The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Endocrinology and Metabolism Zhuhai People’s Hospital(Zhuhai Clinical Medical College of Jinan Universitythe First Hospital Affiliated with Medical College of Macao University of Science and Technology)Zhuhai 519000Guangdong ProvinceChina

BACKGROUND Osteoporosis(OP)has become a major public health problem worldwide.Most OP treatments are based on the inhibition of bone resorption,and it is necessary to identify additional treatments aimed at enhancing osteogenesis.In the bone marrow(BM)niche,bone mesenchymal stem cells(BMSCs)are exposed to a hypoxic environment.Recently,a few studies have demonstrated that hypoxiainducible factor 2alpha(HIF-2α)is involved in BMSC osteogenic differentiation,but the molecular mechanism involved has not been determined.AIM To investigate the effect of HIF-2αon the osteogenic and adipogenic differentiation of BMSCs and the hematopoietic function of hematopoietic stem cells(HSCs)in the BM niche on the progression of OP.METHODS Mice with BMSC-specific HIF-2αknockout(Prx1-Cre;Hif-2αfl/fl mice)were used for in vivo experiments.Bone quantification was performed on mice of two genotypes with three interventions:Bilateral ovariectomy,semilethal irradiation,and dexamethasone treatment.Moreover,the hematopoietic function of HSCs in the BM niche was compared between the two mouse genotypes.In vitro,the HIF-2αagonist roxadustat and the HIF-2αinhibitor PT2399 were used to investigate the function of HIF-2αin BMSC osteogenic and adipogenic differentiation.Finally,we investigated the effect of HIF-2αon BMSCs via treatment with the mechanistic target of rapamycin(mTOR)agonist MHY1485 and the mTOR inhibitor rapamycin.RESULTS The quantitative index determined by microcomputed tomography indicated that the femoral bone density of Prx1-Cre;Hif-2αfl/fl mice was lower than that of Hif-2αfl/fl mice under the three intervention conditions.In vitro,Hif-2αfl/fl mouse BMSCs were cultured and treated with the HIF-2αagonist roxadustat,and after 7 d of BMSC adipogenic differentiation,the oil red O staining intensity and mRNA expression levels of adipogenesis-related genes in BMSCs treated with roxadustat were decreased;in addition,after 14 d of osteogenic differentiation,BMSCs treated with roxadustat exhibited increased expression of osteogenesis

关键词： Hypoxia-inducible factor-2α Bone marrow niche Bone mesenchymal stem cells Osteoporosis Osteogenic/adipogenic differentiation Mechanistic target of rapamycin signaling pathway