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Application of IITM-RANS3D to free-fall water entry of prismatic and non-prismatic finite wedges

水动力学研究与进展B辑:英文版 2023年第3期35卷 417-430页

作者： Shaswat Saincher kshitij srivastava R.Vijayakumar V.Sriram Center for Maritime Experiments to Maritime Experience(ME2ME) Indian Institute of Technology MadrasChennaiIndia Department of Ocean Engineering Indian Institute of Technology MadrasChennaiIndia

High-speed watercraft and ships undergo coupled motions which make the front portion of the hull exit and violently re-enter *** induces short-term slamming loads that may compromise the structural integrity of the *** slamming of the bow can be modeled as straight wedges of different deadrise angles(DRAs)falling into water from different *** advent of computational fluid dynamics has allowed the problem of wedge-slamming to be simulated using the full Navier-Stokes equations thus complementing the pioneering studies based on ***,most researchers are opting to use commercial software to simulate the wedge-impact problem as it allows access to overset meshing algorithms which are robust in modeling the wedge as a moving *** boundary methods(EBMs)offer some advantages over overset meshing in that the mesh only needs to be generated once and Cartesian mesh-based solvers can be ***,the application of EBMs to wedge-impact has been limited in the literature and merits further *** this context,we investigate the applicability of the fast-fictitious-domain(FFD)based embedded boundary treatment to simulate the violent water-entry of *** extend our in-house Navier-Stokes model IITM-RANS3D to handle floating bodies through integration of a rigid-body dynamics solver and an algorithm to embed three-dimensional stereolithography(STL)geometries as solids over a Cartesian *** proposed algorithm is extensively benchmarked against variable DRA wedge-slamming experiments reported in the literature as well as constant DRA wedge-slamming experiments performed *** good agreement is reported in terms of the time-history of hydrodynamic impact pressures measured at various locations on the hull as well as the wedge motion responses thus demonstrating the suitability of FFD for simulating the coupled hydrodynamics of slamming for simplified hull geometries.

关键词： Wedge water entry slamming fast-fictitious-domain IITM-RANS3D experiments

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RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 788-806页

作者： Ankit srivastava Deeksha Rikhari Sameer srivastava Department of Biotechnology Motilal Nehru National Institute of TechnologyAllahabadUttar Pradesh 211004India

R-spondins are secretory proteins localized in the endoplasmic reticulum and Golgi bodies and are processed through the secretory *** the R-spondin family,RSPO2 has emanated as a novel regulator of Wnt signaling,which has now been acknowledged in numerous in vitro and in vivo *** is an abnormal growth of cells that proliferates and spreads uncontrollably due to the accumulation of genetic and epigenetic factors that constitutively activate Wnt signaling in various types of *** cancer (CRC) begins when cells in the colon and rectum follow an indefinite pattern of division due to aberrant Wnt activation as one of the key ***-long progress in research on R-spondins has demonstrated their oncogenic function in distinct cancer types,particularly *** a critical regulator of the Wnt pathway,it modulates several phenotypes of cells,such as cell proliferation,invasion,migration,and cancer stem cell ***,RSPO mutations,gene rearrangements,fusions,copy number alterations,and altered gene expression have also been identified in a variety of cancers,including *** this review,we addressed the recent updates regarding the recurrently altered R-spondins with special emphasis on the RSPO2 gene and its involvement in potentiating Wnt signaling in *** addition to the compelling physiological and biological roles in cellular fate and regulation,we propose that RSPO2 would be valuable as a potential biomarker for prognostic,diagnostic,and therapeutic use in CRC.

关键词： CRC Gene fusion R-Spondins RSPO2 Therapeutics Wnt signaling

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Optimizing sampling frequency of surface and downhole measurements for efficient stick-slip vibration detection

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Petroleum 2024年第1期10卷 30-38页

作者： Saket srivastava Aditya Sharma Catalin Teodoriu Mewbourne School of Petroleum and Geological Engineering The University of Oklahoma

Drilling vibrations significantly impact drilling operations with high costs due to early downhole equipment failure and loss of productive time. Stick-slip vibrations, a severe form of torsional vibrations,is known to be present up to 50% of total drilling time, making it a topic of immense concern and research. An ongoing discussion in the industry is regarding the reliability of surface measurements for early detection of severe downhole bit sticking. Moreover, most surface measurements are sampled at lower frequency rates closer to 1 Hz. Recently, the implementation of advanced data acquisition modules in downhole subs has greatly improved our understanding of drilling vibrations through high resolution data, sampled up to 10 kHz. However, with a wide range of sampling frequency to choose from different available tools, a critical question remains unanswered. What is an optimal and adequate sampling frequency for early detection of downhole vibrations using both surface and downhole measurements?The paper addresses the question with a focus on stick-slip vibrations through an experimental investigation. Stick slip tests are repeated for different sampling frequencies of surface and downhole measurements and the stick slip index for each case is calculated. The stick-slip index varies for different sampling frequency even though the vibration tests remain completely identical. It was inferred that sampling frequency of measurements greatly impact the detection of downhole vibrations. Even though stick-slip vibrations are characteristically low frequency vibrations(≤2Hz), a minimum of 10Hz sampling frequency is recommended for detection of stick-slip vibrations. Moreover, all characteristics of stick-slip vibrations including bit sticking, bit RPM peaks and negative bit RPMs are clearly observed at a minimum of 100Hz sampling rate.

关键词： Stick-slip

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Trace fossil evidences of an Early Miocene paleoseismic event and depositional regime change from the Kutch(Kachchh) Basin

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Journal of Palaeogeography 2024年第1期13卷 165-180页

作者： Ayush srivastava Sudipta Dasgupta Krishanu Chatterjee Mohuli Das Bombay Ichnos Research Group Department of Earth SciencesIndian Institute of Technology Bombay(lIT Bombay)PowaiMumbaiMaharashtra400076India

Unconsolidated siliciclastic sediments can undergo post-burial deformation, which leads to the formation of distinctive sedimentary structures, known as soft-sediment deformation structures(SSDS). The presence of a series of sand volcanoes confined to a particular lithostratigraphic horizon can represent a paleoseismic activity and, thereby, exemplifies the concept of “seismite”. The Kutch Basin has been a tectonically active region since the initiation of eastern Gondwana rifting followed by a tectonic inversion during the Cenozoic due to the collision of the Indian and Eurasian plates. A stratum-bound series of sand volcanoes belonging to the Khari Nadi Formation(KNF) is exposed along the banks of Khari River. They separate the shallow marine deposits below and non-marine deposits above with their characteristic marine and paleosol trace fossil suites, respectively. Although a seismogenic origin has been much debated for the SSDS,the ichnofabric analysis of the sand-volcano-bearing stratum unequivocally points toward such an origin under a shallow seafloor condition. In addition to the sedimentary regime change from an open shallow-marine setting to a continental depositional environment concomitant with basinal uplift, the behavior of the burrowing crustaceans testifies to a syn-depositional development of a fault network associated with the fluidization, sand volcanism, and the resilience of the trace-producers in surviving those processes until the sedimentary regime change in the overlying strata. Although the ichno-sedimentological evidence apparently differs from the previous works that proposed a continuous base-level rise from the beginning of deposition of the Khari Nadi Formation up to the middle part of the overlying Chhasra Formation, the paleoseismic activity,its ichnologic signature, and the depositional regime change refer to a higher-resolution(i.e., lower-order)sequence-stratigraphic change causing a short-duration regression within a longer-durat

关键词： Sand volcano Seismite Ichnology Khari Nadi Formation Kutch Basin Kachchh Basin

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IDS-INT:Intrusion detection system using transformer-based transfer learning for imbalanced network traffic

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Digital Communications and Networks 2024年第1期10卷 190-204页

作者： Farhan Ullah Shamsher Ullah Gautam srivastava Jerry Chun-Wei Lin School of Software Northwestern Polytechnical UniversityXian710072ShaanxiChina Knowledge Unit of Systems and Technology University of Management and TechnologySialkot 51040Pakistan Department of Math and Computer Science Brandon UniversityBrandonMB R7A 6A9Canada Department of Computer Science and Math Lebanese American UniversityBeirut1102Lebanon Western Norway University of Applied Sciences BergenNorway Research Centre for Interneural Computing China Medical UniversityTaichungTaiwanChina

A network intrusion detection system is critical for cyber security against llegitimate *** terms of feature perspectives,network traffic may include a variety of elements such as attack reference,attack type,a subcategory of attack,host information,malicious scripts,*** terms of network perspectives,network traffic may contain an imbalanced number of harmful attacks when compared to normal *** is challenging to identify a specific attack due to complex features and data imbalance *** address these issues,this paper proposes an Intrusion Detection System using transformer-based transfer learning for Imbalanced Network Traffic(IDS-INT).IDS-INT uses transformer-based transfer learning to learn feature interactions in both network feature representation and imbalanced ***,detailed information about each type of attack is gathered from network interaction descriptions,which include network nodes,attack type,reference,host information,***,the transformer-based transfer learning approach is developed to learn detailed feature representation using their semantic ***,the Synthetic Minority Oversampling Technique(SMOTE)is implemented to balance abnormal traffic and detect minority ***,the Convolution Neural Network(CNN)model is designed to extract deep features from the balanced network ***,the hybrid approach of the CNN-Long Short-Term Memory(CNN-LSTM)model is developed to detect different types of attacks from the deep *** experiments are conducted to test the proposed approach using three standard datasets,i.e.,UNsWNB15,CIC-IDS2017,and *** explainable AI approach is implemented to interpret the proposed method and develop a trustable model.

关键词： Network intrusion detection Transfer learning Features extraction Imbalance data Explainable AI Cybersecurity

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Cooperative Spectrum Sensing Deployment for Cognitive Radio Networks for Internet of Things 5G Wireless Communication

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Tsinghua Science and Technology 2024年第3期29卷 698-720页

作者： Thulasiraman Balachander Kadiyala Ramana Rasineni Madana Mohana Gautam srivastava Thippa Reddy Gadekallu SRM Institute of Science and Technology Tamil Nadu 603203India Lebanese American University Beirut 1102Lebanonand also with Chaitanya Bharathi Institute of TechnologyHyderabad 500075India Chaitanya Bharathi Institute of Technology Hyderabad 500075India Brandon University BrandonR7A 0A1CanadaChinaMedical UniversityTaichung 404327Chinaand Lebanese American UniversityBeirut 1102Lebanon Department of Electrical and Computer Engineering Lebanese American UniversityBeirut 1102Lebanon

Recently,Cooperative Spectrum Sensing(CSS)for Cognitive Radio Networks(CRN)plays a significant role in efficient 5G wireless *** sensing is a significant technology in CRN to identify underutilized *** CSS technique is highly applicable due to its fast and efficient performance.5G wireless communication is widely employed for the continuous development of efficient and accurate Internet of Things(IoT)networks.5G wireless communication will potentially lead the way for next generation IoT *** has established significant consideration as a feasible resource to improve identification performance by developing spatial diversity in receiving signal strength in *** this paper,an optimal CSS for CRN is performed using Offset Quadrature Amplitude Modulation Universal Filtered Multi-Carrier Non-Orthogonal Multiple Access(OQAM/UFMC/NOMA)*** of spectrum and bandwidth utilization is a key challenge in CRN for IoT 5G wireless *** optimal solution for CRN in IoT-based 5G communication should be able to provide optimal bandwidth and CSS,low latency,Signal Noise Ratio(SNR)improvement,maximum capacity,offset synchronization,and Peak Average Power Ratio(PAPR)*** Energy Efficient All-Pass Filter(EEAPF)algorithm is used to eliminate *** deployment approach improves Quality of Service(QoS)in terms of system reliability,throughput,and energy *** in-depth experimental results show that the proposed methodology provides an optimal solution when directly compares against current existing methodologies.

关键词： cooperative spectrum sensing cognitive radio network Internet of Things offset quadratureamplitude modulation universal filtered multi-carrier non-orthogonal multiple access

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AGGREGATE SPECIAL FUNCTIONS TO APPROXIMATE PERMUTING TRI-HOMOMORPHISMS AND PERMUTING TRI-DERIVATIONS ASSOCIATED WITH A TRI-ADDITIVEψ-FUNCTIONAL INEQUALITY IN BANACH ALGEBRAS

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Acta Mathematica Scientia 2024年第1期44卷 311-338页

作者： Safoura Rezaei ADERYANI Azam AHADI Reza SAADATI Hari M.srivastava School of Mathematics Iran University of Science and TechnologyNarmakTehranIran Department of Mathematics and Statistics Universtity of VictoriaVictoriaCanada Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402China Department of Mathematics and Informatics Azerbaijan University71 Jeyhun Hajibeyli StreetAZ1007BakuAzerbaijan Section of Mathematics International TelematicUniversity UninettunoI-00186RomeItaly

In this paper,we define a new class of control functions through aggregate special *** class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.

关键词： permuting tri-homomorphism in Banach algebra permuting tri-derivation on C*-algebra fixed point theorem Ulam-Hyers-Rassias stability aggregate special functions tri-additiveψ-functional inequality

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Natural product-based treatment potential for type 2 diabetes mellitus and cardiovascular disease

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World Journal of Diabetes 2024年第7期15卷 1603-1614页

作者： Dharmsheel Shrivastav Satyam Kumar Kumbhakar Shivangi srivastava Desh Deepak Singh Amity Institute of Biotechnology Amity University RajasthanJaipur 303002RajasthanIndia Department of Biotechnology Govt Veer Surendra Say P.G.CollegeGariaband 493889ChhattisgarhIndia Department of Life Science Chhatrapati Shahu ji Maharaj UniversityKanpur 208024Uttar PradeshIndia

BACKGROUND Type 2 diabetes(T2D)is a metabolic disease of impaired glucose utilization and a major cause of cardiovascular disease(CVD).The pathogenesis of both diseases shares common risk factors and mechanisms,and both are significant contributors to global morbidity and *** of natural products for T2D mellitus(T2DM)and CVD can be seen as a potential preventive and effective therapeutic *** To critically evaluate the therapeutic potential of natural products in T2D and coronary artery disease(CAD).METHODS By using specific keywords,we strategically searched the PubMed *** controlled trials(RCTs)were searched as the primary focus that examined the effect of natural products on glycemic control,oxidative stress,and antioxidant *** focused on outcomes such as low blood glucose levels,adjustment on markers of oxidative stress and *** screening fulllength papers,we included 9 RCTs in our review that met our inclusion *** In the literature search on the database,we found that various natural products like plant secondary metabolites play a diverse role in the management of *** ginseng,sesame oil and cocoa flavanols proved effective in lowering blood glucose levels and controlling blood pressure,which are key factors in managing T2DM and *** diabetic patients Melissa officinalis effectively reduce inflammation and shows diabetes *** fish oil and flaxseed oil reduced insulin levels and inflammatory markers,suggesting benefits for both *** lipid profile and endothelial function were enhanced by Nigella sativa oil and Terminalia chebula,which is significant for the management of cardiovascular risk factors in *** Bilberry extract also showed promise for improving glycemic control in patients with *** The high level of antioxidant,anti-inflammatory,and anti-angiogenic properties found in natural products makes them promising therapeutic opt

关键词： Type 2 diabetes mellitus Cardiovascular disease Natural products Antioxidants Oxidative stress Therapeutic impact Global burden

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Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada Siddiqui Aditi srivastava Aparna Misra Snober S.Mir Department of Biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India Department of Biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Department of Biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

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Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2885-2900页

作者： Porkizhi Arjunan Durga Kathirvelu Gokulnath Mahalingam Ashish Kumar Goel Uday George Zacharaiah Alok srivastava Srujan Marepally Center for Stem Cell Research(A Unit of inStem Bengaluru)Christian Medical College CampusBagayamVellore 632002Tamil NaduIndia Manipal academy for higher education Mangalore 576104KarnatakaIndia Department of Hematology Christian Medical College&HospitalVellore 632004Tamil NaduIndia Department of Hepatology Christian Medical College&HospitalVellore 632004Tamil NaduIndia

Inherited genetic disorders of the liver pose a significant public health *** transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive *** overcome these limitations,nucleic acid therapy provides a hopeful alternative that enables gene repair,gene supplementation,and gene silencing with suitable *** viral vectors are the most efficient and preferred for gene therapy,pre-existing immunity debilitating immune responses limit their *** a potential alternative,lipid nanoparticle-mediated vectors are being explored to deliver multiple nucleic acid forms,including pDNA,mRNA,siRNA,and ***,we discuss the broader applications of lipid nanoparticles,from protein replacement therapy to restoring the disease mechanism through nucleic acid delivery and gene editing,as well as multiple preclinical and clinical studies as a potential alternative to liver transplantation.

关键词： Lipid nanoparticle Liver disorders Gene therapy Gene editing Nucleic acid delivery pDNA mRNA siRNA ASO Clinical trials

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