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New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

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Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis Ma krystyna Rytel Yu Chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

Nitrate reduction capacity of the oral microbiota is impaired in periodontitis:potential implications for systemic nitric oxide availability

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International Journal of Oral Science 2024年第1期16卷 52-61页

作者： Bob T.Rosier William Johnston Miguel Carda-Diéguez Annabel Simpson Elena Cabello-Yeves krystyna Piela Robert Reilly Alejandro Artacho Chris Easton Mia Burleigh Shauna Culshaw Alex Mira Department of Genomics and Health FISABIO FoundationCenter for Advanced Research in Public HealthValenciaSpain Department of Biological and Biomedical Sciences Glasgow Caledonian UniversityGlasgowUK Oral Sciences University of Glasgow Dental SchoolSchool of MedicineDentistry and NursingCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowUK Sport and Physical Activity Research Institute University of the West of ScotlandBlantyreScotland Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas(IBV-CSIC)ValenciaSpain CIBER Center for Epidemiology and Public Health MadridSpain

The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important for oral health and results in nitric oxide formation that can improve cardiometabolic conditions. Studies of bacterial composition in subgingival plaque suggest that nitrate-reducing bacteria are associated with periodontal health, but the impact of periodontitis on nitrate-reducing capacity(NRC)and, therefore, nitric oxide availability has not been evaluated. The current study aimed to evaluate how periodontitis affects the NRC of the oral microbiota. First, 16S rRNA sequencing data from five different countries were analyzed, revealing that nitratereducing bacteria were significantly lower in subgingival plaque of periodontitis patients compared with healthy individuals(P < 0.05 in all five datasets with n = 20–82 samples per dataset). Secondly, subgingival plaque, saliva, and plasma samples were obtained from 42 periodontitis patients before and after periodontal treatment. The oral NRC was determined in vitro by incubating saliva with 8 mmol/L nitrate(a concentration found in saliva after nitrate-rich vegetable intake) and compared with the NRC of 15healthy individuals. Salivary NRC was found to be diminished in periodontal patients before treatment(P < 0.05) but recovered to healthy levels 90 days post-treatment. Additionally, the subgingival levels of nitrate-reducing bacteria increased after treatment and correlated negatively with periodontitis-associated bacteria(P < 0.01). No significant effect of periodontal treatment on the baseline saliva and plasma nitrate and nitrite levels was found, indicating that differences in the NRC may only be revealed after nitrate intake. Our results suggest that an impaired NRC in periodontitis could limit dietary nitrate-derived nitric oxide levels, and the effect on systemic health should be explored in future studies.

关键词： impaired intake nitrate

Characterization of the fate of lipids in activated sludge

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Journal of Environmental Sciences 2008年第5期20卷 536-542页

作者： Kangala B.Chipasa krystyna Medrzycka Chemical Faculty Gdansk University of Technology Narutowicza 11/1280-952 GdanskPoland.

Experiments were carded out to characterize the transformation of lipids in activated sludge under aerobic conditions. Results showed that the overall lipid content in the effluent could not be reduced to values below 300 mg/L from an initial content of 2,000 mg/L. However, the contents of individual fatty acids underwent drastic decreases and increases during all microbial growth phases. These changes in contents of individual fatty acids showed that fatty acids were used as substrates by microorganisms as well as released into the wastewater as by-products. We have therefore suggested a novel model of transformation of lipids in activated sludge, showing that utilization of microbial activity for complete removal of lipids from wastewater is limited.

关键词： activated sludge biodegradation lipids/fatty acids microbial by-products wastewater treatment

Emissions of fluorides from welding processes

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Journal of Environmental Sciences 2015年第11期27卷 179-183页

作者： Malgorzata Szewczynska Emilia Pagowska krystyna Pyrzynska Department of Chemical and Aerosol Hazards Central Institute for Labour Protection-National Research Institute Faculty of Chemistry University of Warsaw

The levels of fluoride airborne particulates emitted from welding processes were investigated. They were sampled with the patented IOM Sampler, developed by J. H Vincent and D. Mark at the Institute of Occupational Medicine（IOM）, personal inhalable sampler for simultaneous collection of the inhalable and respirable size fractions. Ion chromatography with conductometric detection was used for quantitative analysis. The efficiency of fluoride extraction from the cellulose filter of the IOM sampler was examined using the standard sample of urban air particle matter SRM-1648 a. The best results for extraction were obtained when water and the anionic surfactant N-Cetyl-N-N-Ntrimethylammonium bromide（CTAB） were used in an ultrasonic bath. The limits of detection and quantification for the whole procedure were 8 μg/L and 24 μg/L, respectively The linear range of calibration was 0.01–10 mg/L, which corresponds to 0.0001–0.1 mg of fluorides per m3 in collection of a 20 L air sample. The concentration of fluorides in the respirable fraction of collected air samples was in the range of 0.20–1.82 mg/m3, while the inhalable fraction contained 0.23–1.96 mg/m3 of fluorides during an eight-hour working day in the welding room.

关键词： Fluorides Particle size distribution Welding processes

Systemic therapy for cervical carcinoma–current status

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Chinese Journal of Cancer Research 2018年第2期30卷 209-221页

作者： krystyna Serkies Jacek Jassem Department of Oncology and Radiotherapy Medical University of Gdańsk

Two major treatment modalities in cervical cancer are radiation therapy（RT） and surgery. Chemotherapy continues to be the main form of systemic therapy adjunctive to definitive local therapies, and is used for ***-based regimens, administered concurrently with both definitive and postoperative RT, were demonstrated to provide significant survival benefits, whereas the beneficial effect of concurrent chemoradiotherapy in later-stage disease was smaller. The role of chemotherapy in addition to RT in IB1/IIA1 cervical cancer patients not undergoing surgery remains undefined. Likewise, the role of chemotherapy in combination with postoperative RT for patients with intermediate-risk factors for recurrence has not yet been verified. The recent standard for chemoradiotherapy is cisplatin alone administered weekly. Other cisplatin-based or non-cisplatin-based regimens have not been subjected to large clinical studies. The benefits of consolidation chemotherapy after chemoradiation for locally advanced cervical cancer are still undetermined. Neoadjuvant cisplatin-based chemotherapy followed by surgery has shown survival benefits, however its role in the era of chemoradiotherapy remains unclear. The combination of cisplatin and paclitaxel is considered a standard regimen in the palliative setting. There is no standard of care for second-line systemic therapy in advanced cervical *** combined with palliative chemotherapy（cisplatin/paclitaxel or topotecan/paclitaxel） in the first-line treatment for recurrent/metastatic cervical cancer significantly improves overall survival when compared to chemotherapy alone. The role of immunotherapy in cervical cancer remains to be established. The optimal combined modality treatment including systemic therapy for cervical tumors of non-squamous histology remains a matter of debate. Ongoing accumulation of data on genomic and proteomic characteristics provides insight into the molecular heterogeneity of cervica

关键词： Cervical cancer chemotherapy targeted therapy immunotherapy

Comprehensive use of the Gutenberg–Richter law and geotomography for improving seismic hazard evaluation in hard coal mines

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International Journal of Coal Science & Technology 2023年第1期10卷 48-59页

作者： Józef Dubiński krystyna Stec Jacek Krupanek Central Mining Institute 40-166 KatowicePoland Polish Mining Group Ltd. Mine MysłowiceWesołaPoland

Mining-induced seismicity occurs in numerous underground mines worldwide where extraction is conducted at great depths or in areas characterised by complex tectonic *** is accompanied by rock bursts,which result in the loss of working functionality and the possibility of accidents among *** issue of a constant and reliable seismic hazard evaluation is of key signifcance for both the safety of miners and the stability of *** on its improvement is directed at developing new interpretive solutions and *** nature of the presented solution is the complex interpretation of seismological data that characterise rock mass seismicity and of underground measurement results in the form of a map presenting the longitudinal wave propagation velocity distribution in the rock surrounding the mined coal *** solution was tested in hard coal mines located in the Upper Silesian Coal *** mines are equipped with a modern seismological system enabling the constant monitoring of seismicity together with hazard level evaluation as well as with seismic apparatus for conducting periodic measurements of the seismic wave propagation velocity before the mining *** seismic hazard evaluation criteria were determined based on the obtained results,involving the anomaly of the Gutenberg–Richter law“b”value and the maximum longitudinal seismic wave propagation velocity in the roof *** obtained experience and the result validation of this new comprehensive hazard evaluation method confrm its practical usefulness and indicate the directions of improvement for the solution in question.

关键词： Induced seismicity Rock bursts Mine seismology Gutenberg-Richter law Seismic geotomography

Natural Organic Amendments for Improved Phytoremediation of Polluted Soils:A Review of Recent Progress

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Pedosphere 2016年第1期26卷 1-12页

作者： Alina WISZNIEWSKA Ewa HANUS-FAJERSKA Ewa MUSZYIISKA krystyna CIARKOWSKA Institute of Plant Biology and Biotechnology Faculty of Biotechnology and HoricultureUniversity of AgricultureKrakow 31-425(Poland) Department of Soil Science and Soil Protection Faculty of Agriculture and EconomicsUniversity of AgricutureKrakow 31-120(Poland)

Environmental pollution caused by metals, radionuclides and organic pollutants affects quality of the biosphere: soil, water and ***, great efforts have been made to reduce, remove or stabilize contaminants in polluted sites. There has been increasing interest in phytoremediation—the use of plants to reduce concentration of pollutants or to render them harmless. This paper provides a brief review of recent progress in the research and practical application of phytoremediation techniques. Improvements in phytoremediation due to utilization of organic amendments, namely, agro- and industrial wastes(such as sugar beet residue, composted sewage sludge or molasses), biochar, humic substances, plant extracts and exudates are discussed, as well as their influences on soil structure and characteristics, plants growth and bioavailability of pollutants. Both plant-assisted phytoremediation and the use of natural materials in the absence of remediating plant are believed to be cost-effective and environmentally friendly approaches for soil cleanup. However,the characterization and quantification of a range of natural materials used in phytoremediation are essential in order to implement these approaches to practice.

关键词： agricultural wastes bioavailability biochar contamination natural chelators toxic elements

Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection

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World Journal of Gastroenterology 2005年第1期11卷 17-21页

作者： krystyna Stec-Michalska Slawomir Antoszczyk Grazyna Klupinska Barbara Nawrot Clinic of Gastroenterology and Internal Diseases Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences

AIM: To answer the question whether FHIT gene expression is affected by the family history of gastric carcinoma and the presence of Helicobacter pylori (Hpylori) in the gastric mucosa of patients with ***: FHIT gene expression in two different topographic sites of the gastric mucosa of twenty-one patients with dyspepsia and with or without familial gastric carcinoma, infected or not infected with H pylori, was evaluated by reverse transcription-PCR (RT-PCR) and IMAGE QUANT methods. A rapid urease test and histopathological examination were used to determine H pylori ***: In the gastric mucosa of patients with family histories of gastric carcinoma, the amount of FHIT protein mRNA was reduced down to 32%, and for patients with H pylori colonization, to 24% in comparison to controls with dyspepsia and without cancer in the family. FHIT expression was independent of the topography of specimens (corpus vsantrum), and for the control patients it was less sensitive to infection with H pylori. A considerable statistical difference in FHIT levels was observed in the gastric mucosa from the corpus of patients with family histories of gastric carcinoma in respect to H pylori colonization (P = 0.06). Macroscopic evaluation of the gastric mucosa demonstrated that pathologic changes classified according to the Sydney system had no significant influence on FHIT expression within each tested group of ***: Loss of FHIT expression was observed in patients with dyspepsia and family histories of gastric carcinoma, especially those infected with H pylori. Such results may constitute an early indication of the development of gastric carcinoma, which is associated with family factors including heredity and H pylori infection. The loss of the FHIT gene may serve as a marker for early diagnosis and prevention of gastric carcinoma, especially in context of early monitoring of H pylori infection in individuals with a record of familial stomach ca

关键词： Gastric cancer Helicobacter pylori infection FHIT protein

Usefulness of LED lightings in cereal breeding on example of wheat,barley and oat seedlings

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International Journal of Agricultural and Biological Engineering 2019年第6期12卷 32-37页

作者： Piotr Stefański Patrycja Siedlarz Przemysław Matysik krystyna Rybka Plant Breeding Strzelce Ltd.Co. ul.Główna 2099-307 StrzelcePoland Plant Breeding and Acclimatization Institute-National Research Institute 05-870 RadzikówPoland

The LED lightings in horticulture are becoming prevalent,due to their physical properties allowing reduction of electricity consumption and on modulation of light spectrum and *** present,LED lightings are not widely used by cereal breeding companies despite the fact that use of greenhouses is very *** is why,the present experiment was run to show the evidence of LED lightings usefulness in a cereal crops breeding *** wheat(Triticum aestivum,L.),spring barley(Hordeum vulgare,L.)and oat(Avena sativa,L.),one cultivar of each species,were used for the 9 week trial conducted in a greenhouse with strictly controlled temperature(22℃)and humidity(80%).As a light source,4 LED illuminators along with a high-pressure sodium and xenon lamps and a natural sunlight in non-shadowed area of the same greenhouse were *** illuminators were characterized by relatively high ratio of blue/red radiation(0.6-1.3)to force the stem shortening,since cereal seedlings with such a growth habit are preferred in greenhouse cultivation of *** was evidenced,that LED illuminators provided light suitable for cereals growth in a greenhouse,however each species had slightly different optimal light *** wheat and barley the best impact on stem shortening and also on time to heading had a LED illuminator with high multi wave-blue radiation whereas on the leaves width the illuminator with lowest blue/red *** oat seedlings a light source with highest light intensity and highest blue/red ratio seemed to be the most *** much differences in seedlings growth and time to heading suggested that there is a chance for construction of one universal type of LED illuminator designed for greenhouse stages of cereal crops breeding.

关键词： greenhouse light emitting diodes cost-effectiveness Triticum aestivum Hordeum vulgare Avena sativa