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The Schlager mouse as a model of altered retinal phenotype

Neural Regeneration Research 2020年第3期15卷 512-518页

作者： lakshini Y.Herat Aaron l.Magno Márcio G.Kiuchi kristy l.jackson Revathy Carnagarin Geoffrey A.Head Markus P.Schlaich Vance B.Matthews Dobney Hypertension Centre School of Biomedical Science-Royal Perth Hospital UnitUniversity of Western AustraliaPerthAustralia Research Centre Royal Perth HospitalPerthAustralia Dobney Hypertension Centre School of Medicine-Royal Perth Hospital UnitUniversity of Western AustraliaPerthAustralia Neuropharmacology laboratory Baker Heart and Diabetes InstituteMelbourneAustralia Department of Cardiology and Department of Nephrology Royal Perth HospitalPerthAustralia

Hypertension is a risk factor for a large number of vision-threatening eye *** this study,we investigated for the first time the retinal neural structure of the hypertensive BPH/2J mouse(Schlager mouse)and compared it to its control counterpart,the normotensive BPN/3J *** BPH/2J mouse is a selectively inbred mouse strain that develops chronic hypertension due to elevated sympathetic nervous system *** compared to the BPN/3J strain,the hypertensive BPH/2J mice showed a complete loss of outer layers of the neural retina at 21 weeks of age,which was indicative of a severe vision-threatening disease potentially caused by *** elucidate whether the retinal neural phenotype in the BPH/2J strain was attributed to increased BP,we investigated the neural retina of both BPN/3J and BPH/2J mice at 4 weeks of *** preliminary results showed for the first time that the BPH/2J strain develops severe retinal neural damage at a young *** findings suggest that the retinal phenotype in the BPH/2J mouse is possibly due to elevated blood pressure and may be contributed by an early onset spontaneous mutation which is yet to be identified or a congenital defect occurring in this *** characterization of the BPH/2J mouse strain is likely to i)elucidate gene defects underlying retinal disease;ii)understand mechanisms leading to neural retinal disease and iii)permit testing of molecules for translational research to interfere with the progression of retinal *** animal experiments were performed with the approval of the Royal Perth Hospital Animal Ethics Committee(R535/17-18)on June 1,2017.

关键词： blood pressure eye hypertension mice neural regeneration retina Schlager mouse sympathetic nervous system

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Boundary element method (BEM) applied to the rough surface contact vs. BEM in computational mechanics

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Friction 2019年第4期7卷 359-371页

作者： Yang XU Robert l.jackson Mechanical Engineering Department Auburn University

In the numerical study of rough surfaces in contact problem, the flexible body beneath the roughness is commonly assumed as a half-space or a half-plane. The surface displacement on the boundary, the displacement components and state of stress inside the half-space can be determined through the convolution of the traction and the corresponding influence function in a closed-form. The influence function is often represented by the Boussinesq-Cerruti solution and the Flamant solution for three-dimensional elasticity and plane strain/stress, respectively. In this study, we rigorously show that any numerical model using the above mentioned half-space solution is a special form of the boundary element method(BEM). The boundary integral equations(BIEs) in the BEM is simplified to the Flamant solution when the domain is strictly a half-plane for the plane strain/stress condition. Similarly, the BIE is degraded to the Boussinesq-Cerruti solution if the domain is strictly a half-space. Therefore, the numerical models utilizing these closed-form influence functions are the special BEM where the domain is a half-space(or a half-plane). This analytical work sheds some light on how to accurately simulate the non-half-space contact problem using the BEM.

关键词： boundary element method rough surface contact half-space half-plane Flamant solution Boussinesq-Cerruti solution

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The influence of various grease compositions and silver nanoparticle additives on electrically induced rolling-element bearing damage

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Friction 2024年第4期12卷 796-811页

作者： Samuel BOND Robert l.jackson German MIllS Department of Chemistry and Biochemistry Auburn UniversityAuburn 36849-5412USA Department of Mechanical Engineering Auburn UniversityAuburn 36849-5412USA

leakage currents accelerate surface degradation of metal contacts via small scale arcing across lubricating films,but recent observations suggest that metallic nanoparticle additives in lubricants may be useful to improve contact *** findings prompted a study that examined electrically induced surface pitting of steel contacts in the presence of several lubricating greases including some containing nanometer-sized colloidal silver(Ag)*** rolling sphere-on-disk experiments were conducted under electro-tribological loads employing polyurea greases derived from mineral and synthetic base oils with and without *** forces and electrical resistance were monitored continuously during the tests;surface changes were characterized by means of optical spectroscopy,stylus profilometry,and scanning electron microscopy(SEM)including compositional analysis using energy dispersive spectroscopy(EDS).The observations demonstrate that surface pitting induced by arcing occurs mainly at the points were the rolling motion changes direction and that eroded metal is deposited along the wear ***-sized pits are formed which contain carbon and oxygen indicating that arcing causes decomposition of the hydrocarbon *** findings indicate a significant inhibition of pitting is induced by the Ag nanoparticles;some greases containing other additives exhibit a similar,although less pronounced,effect.

关键词： electric motor bearings wheel bearings electric vehicles arcing electrically induced bearing damage pitting leakage current stray current

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Pullthrough pitfalls in treating Hirschsprung disease

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World Journal of Pediatric Surgery 2024年第3期7卷 237-241页

作者： kristy l Rialon Jacob C langer Pediatric Surgery Texas Children's HospitalHoustonTexasUSA Surgery Baylor College of MedicineHoustonTexasUSA General and Pediatric Surgery The Hospital for Sick ChildrenToronto0ntarioCanada

INTRODUCTION Complications after a pullthrough for Hirschsprung disease can occur either early or late in the postoperative period.A small number of these patients may require reoper-ation,with rates varying from 3%to 28%at a large volume colorectal center.12 Indications for reoperation include stricture,leak,fistula,transition zone pullthrough or retained agan-glionosis,retained Soave cuff,or a Duhamel *** of these may manifest as obstruc-tive symptoms or constipation,which can be seen in 11%to 42%of patients.

关键词： patients Hirschsprung colorectal

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Himalayas as a global hot spot of springtime stratospheric intrusions:Insight from isotopic signatures in sulfate aerosols

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Research in Cold and Arid Regions 2024年第1期16卷 5-13页

作者： Kun Wang ShiChang Kang Mang lin PengFei Chen Chaoliu li XiuFeng Yin Shohei Hattori Teresa l.jackson JunHua Yang YiXi liu Naohiro Yoshida Mark HThiemens State Key laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences(CAS)LanzhouGansu 730000China State Key laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryCASGuangzhouGuangdong 510640China University of Chinese Academy of Sciences Beijing 100049China International Center for Isotope Effects Research(ICIER) School of Earth Sciences and EngineeringNanjing UniversityNanjingJiangsu 210023China Frontiers Science Center for Critical Earth Material Cycling State Key Laboratory for Mineral Deposits ResearchSchool of Earth Sciences and EngineeringNanjing UniversityNanjingJiangsu 210023China Department of Chemical Science and Engineering School of Materials and Chemical TechnologyTokyo Institute of Technology4259 Nagatsuta-choMidori-kuYokohamaKanagawa 226-8502Japan Department of Chemistry and Biochemistry University of California San DiegoLa JollaCA 92093-0021USA Earth-life Science Institute Tokyo Institute of TechnologyMeguro-kuTokyo 152-8551Japan National Institute of Information and Communications Technology KoganeiTokyo 184-8795Japan

Downward transport of stratospheric air into the troposphere(identified as stratospheric intrusions)could potentially modify the radiation budget and chemical of the Earth's surface *** the highest and largest plateau on earth,the Tibetan Plateau including the Himalayas couples to global climate,and has attracted widespread attention due to rapid warming and cryospheric *** studies recognized strong stratospheric intrusions in the Himalayas but are poorly understood due to limited direct evidences and the complexity of the meteorological dynamics of the third ***^(35)S is a radioactive isotope predominately produced in the lower stratosphere and has been demonstrated as a sensitive chemical tracer to detect stratospherically sourced air mass in the planetary boundary ***,we report 6-month(April–September 2018)observation of^(35)S in atmospheric sulfate aerosols(^(35)SO_(4)^(2-))collected from a remote site in the Himalayas to reveal the stratospheric intrusion phenomenon as well as its potential impacts in this *** the sampling campaign,the^(35)SO_(4)^(2-)concentrations show an average of 1,070±980 atoms/m^(3).In springtime,the average is 1,620±730 atoms/m^(3),significantly higher than the global existing data measured so *** significant enrichments of^(35)SO_(4)^(2-)measured in this study verified the hypothesis that the Himalayas is a global hot spot of stratospheric intrusions,especially during the springtime as a consequence of its unique geology and atmospheric *** combined with the ancillary evidences,e.g.,oxygen-17 anomaly in sulfate and modeling results,we found that the stratospheric intrusions have a profound impact on the surface ozone concentrations over the study region,and potentially have the ability to constrain how the mechanisms of sulfate oxidation are affected by a change in plateau atmospheric properties and *** study provides new observational constraints on stra

关键词： Himalayas Stratospheric intrusions Cosmogenic^(35)SO_(4)^(2-) Ozone Atmospheric oxidation

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多尺度粗糙度对接触面真实接触面积的影响

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润滑与密封 2015年第6期40卷 76-80页

作者：张晓寒 Robert l.jackson 孟文俊太原科技大学机械工程学院山西太原030024 Mechanical Engineering Auburn Universityauburnusa36849

当两个粗糙面在力的作用下相互接触时,只有表面上的微凸体相互接触。这些微凸体的接触影响着接触面的摩擦、磨损并且决定着两接触面之间的导电性和热传递功能。这些微凸体存在于各个不同的尺度下,并且形状也不相同。运用堆叠式多尺度接... 详细信息

当两个粗糙面在力的作用下相互接触时,只有表面上的微凸体相互接触。这些微凸体的接触影响着接触面的摩擦、磨损并且决定着两接触面之间的导电性和热传递功能。这些微凸体存在于各个不同的尺度下,并且形状也不相同。运用堆叠式多尺度接触模型对典型的加工表面进行分析,研究多尺度粗糙度对接触面真实接触面积的影响。结果表明,在塑性接触和弹塑性接触情况下,接触表面的多尺度粗糙度对于真实的接触面积和接触力均都有着很大的影响,不同表面之间的接触面积和平均接触压力以一个数量级的大小变化。研究结果表明某些加工工艺得到的表面或许更适合于作为设备中相互接触的表面。

关键词：粗糙表面接触表面凸起多尺度接触模型

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供热设备火灾的调查

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消防技术与产品信息 2000年第5期13卷 49-52页

作者： Arthur l.jackson 韩蕾开封市消防支队防火处

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斜坡沉积层系碎屑贯入体的形态、分布和发育：挪威陆缘莫吕斜坡上白垩统凯里组的地震实例

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石油地质科技动态 2008年第3期 42-62页

作者： Christopher A．-l.jackson 梁慧（译）白振瑞（校）

一项三维地震、井下和岩心的综合研究揭示了挪威陆缘莫吕（Malφy）斜坡的上白垩统层段有一系列斜坡水道和扇沉积层系发育。由于它们的含砂量很高且发育在以泥岩为主的层序内，这些斜坡沉积层系在地震反射剖面上表现为一组强振幅反射。... 详细信息

一项三维地震、井下和岩心的综合研究揭示了挪威陆缘莫吕（Malφy）斜坡的上白垩统层段有一系列斜坡水道和扇沉积层系发育。由于它们的含砂量很高且发育在以泥岩为主的层序内，这些斜坡沉积层系在地震反射剖面上表现为一组强振幅反射。这些上白垩统沉积层系的侧翼及其上部发育有两类振幅异常，在横剖面和平面图上都呈现特殊的形态。第一类振幅异常与层面呈不整合接触，倾角10～20°，高度可达100ms，一般发育在斜坡沉积层系的边缘。第二类振幅异常是与层面整合的，在横剖面上长度可达400m，可以发育在不整合振幅异常的中段或其上端。在三维空间中，发育于斜坡沉积层系边缘的陡倾振幅异常形成了翼状构造，它们是沿着斜坡沉积层系的长轴方向延伸的。根据它们同上白垩统斜坡沉积层系的紧密空间联系和推测的含砂量，可以将与层面不整合和与层面整合的振幅异常分别解释为源自上白垩统斜坡沉积层系的碎屑岩墙和岩床。虽然这些砂体的最初超压机理并不明确，但可以推测盆地流体运移进入这些封闭的沉积砂体以及砂体在低渗透率泥岩中的快速埋藏可能都发挥了作用。在沉积层系边缘发育有最大规模的碎屑岩墙，这表明是埋藏的沉积层系附近的差异压实作用和强制褶皱作用诱发了碎屑的重新活动和贯入作用，并决定了碎屑贯入体后来的几何形态和分布。本项研究论证的斜坡碎屑层系沉积后的再活动和贯入作用，对斜坡沉积层系的油气勘探和开采具有重要意义，因为这种作用明显改变了储层的初始形态，并最终形成了规模足够大、可以作为独立勘探目标的碎屑贯入岩体。

关键词：斜坡沉积边缘发育上白垩统几何形态三维地震层系碎屑陆缘

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Do coyotes Canis latrans influence occupancy ot prey in suburban forest fragments？

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Current Zoology 2016年第1期62卷 1-6页

作者： Brandon M. JONES Michael V. COVE Marcus A. lASHlEY Victoria l. jackson Department of Biology and Agriculture University of Central Missouri Warrensburg M0 64093 USA Department of Applied Ecology North Carolina State University Raleigh NC 27695 USA Department of Forestry and Environmental Resources North Carolina State University Raleigh NC 27695 USA Department of Wildlife Fisheries and Aquaculture Mississippi State University Starkville MS 39762 USA

With the extirpation of apex predators from many North American systems, coyotes Canis latrans have become the de facto top predator and are ubiquitous members of most ecosystems. Keystone predators aid in maintaining ecosystem function by regulating the mammal community through direct predation and instilling the landscape of fear, yet the value of coyotes regulating systems to this capacity is understudied and likely variable across environments. Since coyotes are common in the Midwestern United States, we utilized camera traps and occupancy analyses to as- sess their role in regulating the distribution of mammalian herbivores in a fragmented suburban ecosystem. Forest cover was a strong positive predictor of white-tailed deer Odocoileus virginianus detection, while coyote occurrence had a negative effect. Coyotes exerted a negative effect on squirrel （Sciurus spp.） and eastern cottontail rabbit Sylvilagus floridanus occurrence, while urban cover was a positive predictor for the prey species＇ occurrence. These results suggest all 3 species behaviorally avoid coyotes whereby deer seek denser forest cover and squirrels and cottontails mitigate risk by increasing use of urban areas. Although previous studies reveal limited influence of coyote on the rest of the carnivore guild in suburban systems, we suggest coyotes play an important role in regulating the herbivorous mammals and hence may provide similar eco- logical, benefits in urban/suburban forest fragments through trophic cascades. Furthermore, since hunting may not be allowed in urban and suburban habitats, coyotes might also serve as the pri- mary regulator of nuisance species occurring at high abundance such as white-tailed deer and squirrels.

关键词： camera traps coyote deer rabbit squirrel urban wildlife.

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Cenozoic reactivation along the late Triassic Ganzi-litang suture,eastern Tibetan Plateau

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Geoscience Frontiers 2020年第3期11卷 1069-1080页

作者： W.T.jackson Jr. D.M.Robinson A.l.Weislogel X.Jian Department of Earth Sciences University of South AlabamaMobileAL36688USA Department of Geological Sciences and Center for Sedimentary Basin Studies The University of AlabamaTuscaloosaAL35487USA Department of Geography and Geology West Virginia UniversityMorgantownWV26506USA State Key laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China

The spatial-temporal development of Cenozoic reactivation along Mesozoic suture zones in the Tibetan Plateau are first-order parameters needed for assessing models of plateau *** Ganzi-litang suture,in the eastern Tibetan Plateau,developed in the late Triassic because of subduction and closure along the eastern branch of the Paleo-Tethys *** the city of litang,the Ganzi-litang suture is defined by a melange sequence with faultbound,synorogenic nonmarine strata along the western and eastern flanks,suggesting post-Triassic structural *** present detrital zircon U-Pb geochronology and field data to determine the timing and style of reactivation along the Ganzi-litang suture,as well as sedimentary provenance of nonmarine strata.A reverse fault placing melange rock on top of nonmarine strata along the eastern flank of the Ganzi-litang suture indicates a contractional deformational regime during *** clast counts indicate a local sediment source of recycled Ganzi-litang suture and Yidun terrane *** zircons indicate a localized provenance consisting of recycled material from Triassic Yidun Arc plutons and Triassic Yidun Group turbidite rock.A weighted mean average of Cenozoic zircon grains(n=10) establishes a maximum depositional age of41.5 ± 1.2 Ma for nonmarine strata in the Ganzi-litang *** interpret the maximum depositional age of the nonmarine strata to represent the upper-limit for structural reactivation along the Ganzi-litang suture while undeformed Neogene strata in the suture zone represent the lower-limit;thereby bracketing structural reactivation from ca.42-25 *** results provide enhanced spatial-temporal resolution for Cenozoic deformation in the eastern Tibetan Plateau.

关键词： Nonmarine strata Yidun terrane Tibetan plateau Zircon Suture zone Reactivation

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