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中国寄生虫病防治杂志 1994年第1期7卷 32-34页

作者：钱宝珍宋昌存 ThomasK.kristensen 浙江省医学科学院寄生虫病研究所丹麦血吸虫病研究所

本项工作对湖北钉螺指名亚种三个地理种群的酯酶等8种酶进行了等位基因电泳图象的比较研究。结果表明8种酶系统在钉螺三个地理种群内均具有活性,表现11个基因位点。三种群间遗传距离(D)分别为0.005432,0.015428和0.005686。

关键词：电泳等位基因酶钉螺

Acoustic Myography in Assessment of Isokinetic and Isometric Muscle Strength in a Healthy Danish Population

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Journal of Biomedical Science and Engineering 2020年第12期13卷 235-253页

作者： Else Marie Bartels Waqas Ahmed Jack Kvistgaard Olsen Eva Littrup Andersen Bente Danneskiold-Samsøe Lars-Erik kristensen Henning Bliddal Cecilie Rødgaard Bartholdy Adrian P. Harrison The Parker Institute Copenhagen University Hospital Bispebjerg and Frederiksberg Denmark Department of Neurology Copenhagen University Hospital Bispebjerg and Frederiksberg Denmark Department of Veterinary and Animal Sciences Faculty of Health Science University of Copenhagen Copenhagen Denmark

Isokinetic and isometric force measurements involving a dynamometer setup are widely used in training and in muscle assessment. For further understanding of the method, we investigated the activation of key functional muscles during isokinetic and isometric movements. During force measurements in an isokinetic Biodex System 3 ProTM, acoustic myography (AMG) was applied. Ten healthy subjects (5 men/5 women) in each decade from 20 to 69 years of age participated in the study. Measurements were carried out during extension and flexion of the ankle, knee and elbow joints. Muscle fibre use was measured by efficiency (E-score) and fibre recruitment (temporal (T-score) and spatial (S-score) summation). AMG measurements showed good reproducibility, and the recruitment pattern of muscle fibres did not change with gender or age. Overall, a significantly higher E-score (P < 0.05) was found at the lower angular velocities than at the higher ones, indicating a lower level of muscle efficiency at higher velocities. Muscles used for knee movement exhibited higher scores than muscles associated with the ankle and elbow joints, most likely related to the greater degree of force production at this joint compared to the ankle and elbow. The ability to activate and inactivate muscle fibres during periods of isokinetic activity becomes increasingly more difficult as the velocity increases. When assessing training effects in sports or rehabilitation, AMG in parallel with isokinetic measurements adds important additional information by giving a measure of possible improvements in efficiency and fibre use.

关键词： Muscle Strength Acoustic Myography Range of Motion Muscle Fibre Use

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氨制冷系统在工业领域的成功应用

制冷与空调 2019年第1期19卷 61-66页

作者： Niels P Vestergaard Torben Funder-kristensen 肖伦黄志华丹佛斯自动控制管理(上海)有限公司

在冷链规模不断扩大、制冷剂环保要求不断上升的趋势下,氨以其独特的制冷特性和高效能,不仅是大型工业制冷的主流制冷剂,近年来更是广泛应用于小型制冷系统中。氨是优质的天然工质,制冷效率高,但同时氨也是有毒气体,本文就如何更安全更... 详细信息

在冷链规模不断扩大、制冷剂环保要求不断上升的趋势下,氨以其独特的制冷特性和高效能,不仅是大型工业制冷的主流制冷剂,近年来更是广泛应用于小型制冷系统中。氨是优质的天然工质,制冷效率高,但同时氨也是有毒气体,本文就如何更安全更有效地使用氨展开了论述。理想情况下是所有制冷系统的设计都应该遵循"四标准三能力"。在计划设计一个新的氨制冷系统时,工艺、安全和对环境产生的影响等要求都必须要考虑进去。系统设计方法和原则是决定整个系统安全的关键。要确保制冷系统安全运行,就要对风险和危害进行细节分析,包括对在系统投运前和投运后的"近似事故"进行研究调查。不仅如此,还要关注所有安全项,对所有的安全因素逐个评估,并确保最佳实践得以实施,确保整个系统处于低风险等级。

关键词：氨天然工质制冷高效能安全低风险

The 2017 Oslo conference report on neglected tropical diseases and emerging/re-emerging infectious diseases-focus on populations underserved

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Infectious Diseases of Poverty 2019年第3期8卷 106-106页

作者： Katharina Klohe John Amuasi Joyce Moriku Kaducu Ingeborg Haavardsson Ekaterina Bogatyreva Kristine Husoy Onarheim Wendy Harrison Frederik kristensen Clarissa Prazeres da Costa Andrea S.Winkler Department of Neurology Center for Global HealthTechnical University of MunichMunichGermany Center for Global Health Institute for Medical MicrobiologyImmunology and HygieneTechnical University of MunichMunichGermany 不详

Background:In 2017,the Centre for Global Health(CGH)at the University of Oslo in collaboration with the Coalition for Epidemic Preparedness Innovations(CEPI)and the Norwegian Agency for Development Cooperation(Norad)held a meeting to discuss together with leading figures in disease control,research and development the issue of neglected tropical diseases and emerging/re-emerging infectious *** commentary has taken up this discussion and the conclusions drawn at this meeting to make a case for the opportunity the Sustainable Development Goals(SDGs)provide in highlighting the interconnectedness of factors that are relevant in the successful fight against neglected tropical diseases(NTDs)and emerging infectious diseases(EIDS).Main body:Despite NTDs being endemic and EIDS being epidemic,in order to prevent both disease groups effectively,it is important to appreciate that they share essential health determining faaors,namely:neglect,poverty,a lack of access to clean water and sanitation facilities and an absence of or severely limited provision of healthcare as well as in many cases a zoonotic *** of looking to"simple disease management for the answer,the SDGs help to understand the interplay of multiple priority areas and thereby help to promote a more holistic approach to addressing these two disease ***:Their commonalities mean that the Global Health community should leverage opportunities and efforts in the prevention and elimination of both NTDs and *** so using a One Health approach is considered to offer a"public health best-buy".Concrete solutions are proposed.

关键词： Neglected tropical diseases Emerging infeaious diseases One health SDGs Poverty Neglea

急性缺血性卒中患者中肌钙蛋白T升高的发生率和意义

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世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 14-15页

作者： Jensen J.K. kristensen S.R. Bak S. 郭俊 Department of Cardiology Odense University Hospital Odense Dr.

已有报道指出，急性缺血性卒中患者的肌钙蛋白水平升高。在此项前瞻性研究中，检查244例无明显缺血性心脏病的急性缺血性卒中患者中肌钙蛋白升高的发生率及其特征。在入院的最初5d，每日检测肌钙蛋白T（TnT）和肌酸激酶-MB（CK-MB）浓... 详细信息

已有报道指出，急性缺血性卒中患者的肌钙蛋白水平升高。在此项前瞻性研究中，检查244例无明显缺血性心脏病的急性缺血性卒中患者中肌钙蛋白升高的发生率及其特征。在入院的最初5d，每日检测肌钙蛋白T（TnT）和肌酸激酶-MB（CK-MB）浓度并进行12导联心电图检查。对TnT水平≥0．10μg／L的患者进行心肌灌注显影检查，并与TnT未升高的对照者进行比较。患者平均随访19±7个月，以全因死亡为临床终点。分别在10％和9％的患者中检出TnT（〉0．03μg／L）和CK—MB水平（≥10μg／L）升高。TnT升高的患者中心力衰竭和（或）肾衰竭的发生率更高。与对照者相比，TnT水平≥0．10μg／L患者的静息心肌灌注显影检查中灌注异常并不更常见或更显著。

关键词：肌钙蛋白T 急性缺血性卒中患者发生率心电图检查蛋白水平缺血性心脏病心肌灌注

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早期子宫颈鳞癌中的E-钙黏附素和连环蛋白

世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 41-42页

作者： Van De Putte G. kristensen G.B. Baekelandt M. 张丽娟 Department of Gynecolo g ic Oncol-og y The Norweg ian Radium HospitalMontebello0310OsloNorway

*** examine the prognostic significance of the protein expression of E-cadherin,α-,β-,andγ-catenin in early squamous cervical carcinoma (SCC).*** studied 219patients who underwent r adical hysterectomy and bilateral lymphadenectomy at ou r institution for stage IB SCC between 1987and *** istochemistry using monoclonal antibodies against E-cadherin,α-,β-,andγ-catenin was used to examine protein *** patients who underwent hysterectom y for uterine prolapse served as *** ne expression for E-cadherin,α-,β-,andγ-catenin was decreased and low expression(≤50%positive cells)was found in 198/219(90%),154/219(70%),157/219(72%),and 181/219(83%)tumors,respectively,and high(>50%pos-itive cells)in 21/219(10%),65/219(30%),62/219(28%),and 38/219(17%)tumors,*** u-nivariate analysis,all classical c linicopathological param-eters but none of the investigated pr oteins were associated with *** multivariate analysis,only deep stromal invasion was independently related to ***-sion.E-cadherin,α-,β-,andγ-catenin were not inde-pendently associated with prognosis in stage IB SCC.

关键词：子宫颈鳞癌钙黏附素连环蛋白全子宫切除术淋巴结清扫术单克隆抗体检测阳性细胞病理参数目的蛋白免疫组织化学

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超级高铁

城市环境设计 2019年第2期118卷 260-267页

作者： Erik Berg Kreider Adi Krainer Ashton Stare Cheyenne Vandevoorde Cristian Lera Daniele Pronesti Derek Wong Domenic Schmid Evan Wiskup Francesca Portesine Hugo Soo kristian Hindsberg Lam Le Nguyen Lasse kristensen Linda Halim Maureen Rahman Ovidiu Munteanu Pei Pei Yang Ryan Duval Stephen Steckel Terrence Chew Thomas Christoffersen Tore Banke Veronica Moretti Yehezkiel Wiliardy 曲鸿

BIG的创始合伙人比亚克评价说:"通过超级高铁,我们定义了一个由客舱和站门组成的交通出行生态系统。人们不必等车,也不再需要候车厅,超级高铁用接近超音速的速度将集体社会和个人自由联系在一起。在未来,这种崭新的出行方式将改变我们... 详细信息

BIG的创始合伙人比亚克评价说:"通过超级高铁,我们定义了一个由客舱和站门组成的交通出行生态系统。人们不必等车,也不再需要候车厅,超级高铁用接近超音速的速度将集体社会和个人自由联系在一起。在未来,这种崭新的出行方式将改变我们对时空的习惯认知,我们脑海中对城市版图的理解也将随之改变。"

关键词：传送器目的地 portal

丹麦úrhus县2型糖尿病随机人群中视网膜病变的患病率

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 8-9页

作者： Hove M.N. kristensen J.K. Lauritzen T. Bek T. 杨建刚 Department of Ophtha lmology úrhus University Hospital DK-8000 úrhus C Denmark

Purpose: To determine the prevalence of diabetic retinopathy and the causes of visual impairment in an unselected population of type 2 diabetes patients, and to describe the risk factors for developing diabetic retinopathy in this populat ion. Methods: A total of 10851 type 2 diabetes patients were identified in the c ounty of úrhus. A representative sample of 378 patients underwent a routine ocu lar examination, including fundus photography. Blood pressure and serum haemoglo bin A1c, total cholesterol, high density lipoprotein cholesterol, triglyceride a nd apolipoprotein a were measured. Results: The prevalence of diabetic retinopat hy in the type 2 diabetes population was 31.5%. In all, 2.9%had proliferative diabetic retinopathy and 5.3%had clinically significant macular oedema. Of the latter, 8/20 (40%) were newly identified and had not yet been lasertreated. The re was a positive correlation between severity of retinopathy and duration of di abetes, HbA1c, systolic blood pressure and treatment with insulin. None of the p atients had social blindness (visual acuity< 0.1), but 15/378 (4.0%) had develo ped visual impairment (VA < 0.3). Conclusion: The prevalence of diabetic retinop athy and visual impairment in this unselected type 2 diabetes population was low er than anticipated from the existing literature,and causes other than diabetic retinopathy contributed significantly to the occurrence of visual loss. A substa ntial number of the patients with vision-threatening diabetic maculopathy had n ot been referred for timely photocoagulation treatment.

关键词：视网膜病变 rhus 眼底照相视力损害黄斑水肿眼科常规检查光凝治疗高密度脂蛋白载脂蛋白总胆固醇

2型糖尿病性视网膜病变的定量分析:筛选可预测继发于糖尿病黄斑病变的视力损害进展参数

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 12-13页

作者： Hove M.N. kristensen J.K. Lauritzen T. Bek T. 陈立军 Department of Op hthalmology Urhus University 'Hospital N.rrebrogade 44 8000 Urhus Denmark Dr.

Purpose: To describe whether quantitative assessment of early changes in the m orphology of retinopathy lesions can predict development of vision-threatening diabetic maculopathy. Methods: We used a nested case-control study, and we stud ied 11 type 2 diabetes patients who had developed visual loss secondary to diabe tic maculopathy. For each diabetes patient, we also studied three matched contro l patients who had been followed for a comparable period of time without develop ing visual loss. Fundus photographs describing the early development of retinopa thy were digitized and subjected to a full manual quantitative grading on a comp uter monitor. Differences in the early development of retinal morphology were co mpared between the two groups. The outcome parameters were changes in the number and area of haemorrhages and exudates in different regions of the fundus, and t he weighted distance of these lesions from the fovea and the optic disc. Results : In patients who developed visual loss secondary to diabetic maculopathy there was significant early progression in the total area and number of haemorrhages a nd exudates. The haemorrhages had progressed in all retinal areas except the area around th e optic disc and the temporal vascular arcades. The exudates had progressed temp orally from the fovea and in the retinal periphery. Conclusions: The results sug gest that a quantitative description of the regional development of early diabet ic retinopathy may help in identifying patients who will later develop vision-t hreatening maculopathy.

关键词：黄斑病变视力损害中心凹眼底图像视网膜区域形态学改变量化分级病例对照研究区域性发展

PNPLA3、TM6SF2和HSD17B13变异体对普通人群肝硬化和肝癌患病风险的综合影响

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临床肝胆病杂志 2020年第10期36卷 2278-2278页

作者：朱倩牛俊奇 GELLERT-kristensen H RICHARDSON TG DAVEY SMITH G 吉林大学第一医院感染病中心肝病科不详

【据Hepatology 2020年3月报道】PNPLA3、TM6SF2和HSD17B13变异体对普通人群肝硬化和肝癌患病风险的综合影响(作者Gellert-kristensen H等)作者假设脂肪肝的遗传风险评分(GRS)可影响肝硬化和肝细胞癌(HCC)的患病风险。来自丹麦的Gellert... 详细信息

【据Hepatology 2020年3月报道】PNPLA3、TM6SF2和HSD17B13变异体对普通人群肝硬化和肝癌患病风险的综合影响(作者Gellert-kristensen H等)作者假设脂肪肝的遗传风险评分(GRS)可影响肝硬化和肝细胞癌(HCC)的患病风险。来自丹麦的Gellert-kristensen等将3种遗传变异[含patatin样磷脂酶结构域蛋白3(PNPLA3)p.I148M;跨膜6,超家族成员2(TM6SF2)p.E167K;以及羟基类固醇17-β脱氢酶13(HSD17B13)rs72613567]组成危险因素评分(等位基因为0到6个).

关键词：患病风险普通人群变异体肝硬化磷脂酶脂肪肝肝癌类固醇