早期子宫颈鳞癌中的E-钙黏附素和连环蛋白

作     者：Van De Putte G. Kristensen G.B. Baekelandt M. 张丽娟 

作者机构：Department of Gynecolo g ic Oncol-og yThe Norweg ian Radium HospitalMontebello0310OsloNorway 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第2期

页      面：41-42页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：子宫颈鳞癌 钙黏附素 连环蛋白 全子宫切除术 淋巴结清扫术 单克隆抗体检测 阳性细胞 病理参数 目的蛋白 免疫组织化学 

摘      要：*** examine the prognostic significance of the protein expression of E-cadherin,α-,β-,andγ-catenin in early squamous cervical carcinoma (SCC).*** studied 219patients who underwent r adical hysterectomy and bilateral lymphadenectomy at ou r institution for stage IB SCC between 1987and *** istochemistry using monoclonal antibodies against E-cadherin,α-,β-,andγ-catenin was used to examine protein *** patients who underwent hysterectom y for uterine prolapse served as *** ne expression for E-cadherin,α-,β-,andγ-catenin was decreased and low expression(≤50%positive cells)was found in 198/219(90%),154/219(70%),157/219(72%),and 181/219(83%)tumors,respectively,and high(50%pos-itive cells)in 21/219(10%),65/219(30%),62/219(28%),and 38/219(17%)tumors,*** u-nivariate analysis,all classical c linicopathological param-eters but none of the investigated pr oteins were associated with *** multivariate analysis,only deep stromal invasion was independently related to ***-sion.E-cadherin,α-,β-,andγ-catenin were not inde-pendently associated with prognosis in stage IB SCC.