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Inhibiting Protein Aggregation by Small Molecule-Based Colloidal Nanoparticles

Accounts of Materials Research 2022年第1期3卷 54-66页

作者： koushik debnath Ankan Kumar Sarkar Nihar R.Jana Nikhil R.Jana Department of Pharmacology and Regenerative Medicine College of MedicineUniversity of Illinois at ChicagoChicagoIllinois 60612United States Department of Biomedical Engineering College of MedicineUniversity of Illinois at ChicagoChicagoIllinois 60607United States School of Materials Sciences Indian Association for the Cultivation of ScienceKolkata 700032India

CONSPECTUS:Protein aggregation is associated with different human diseases such as Alzheimer’s,Huntington’s,Parkinson’s,diabetes type II,and *** no effective treatment exists for many of these diseases,particularly for neurological *** research focuses on understanding the origin of protein aggregation,nucleation−growth mechanism of protein aggregation,origin of cytotoxicity of protein aggregates,cellular response of toxic protein aggregates,progress of diseases at intra/extracellular space,and drug developments for respective *** issues are the identification of molecular drugs that can inhibit protein aggregation at early stage,lowering of toxicity due to protein aggregates,delivery of drugs to remote organ and intracellular space,clearing matured protein aggregates from cell/extracellular space/brain,and design of effective therapeutic *** and materials scientists have identified a wide variety of antiamyloidogenic small molecules,macromolecules,and *** is shown that antiamyloidogenic molecules prevent protein oligomerization via binding to protein,masking metal ions(via chelating with metal ions)that are responsible for protein aggregation via generating reactive oxygen species(ROS),and lowering protein−protein interaction via macromolecular crowding ***,nanoscale materials with curved surface and multiple chemical functional groups act as adsorption/binding sites of proteins,modulate nucleation−growth kinetics of protein aggregation,and delay/inhibit protein aggregation in many ***,performance of all these antiamyloidogenic materials needs significant improvement,and proper therapeutic strategies are required for effective drug *** this Account,we describe that the performance of antiamyloidogenic molecules can be greatly improved via appropriate design into colloidal and nanoparticle *** first discuss different human diseases that are linked with protein agg

关键词： integrating Huntington curved

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