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The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

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Cellular & Molecular Immunology 2011年第4期8卷 305-314页

作者： Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi kouichi tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku Department of Regional Cooperation for Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Advanced Preventive Medicine for Infectious Disease Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Respiratory Medicine Japanese Red-Cross Ishinomaki HospitalIshinomakiMiyagiJapan Department of Infection Control and Laboratory Diagnostics Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Clinical Microbiology with Epidemiological Research&Management and Analysis of Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Institute of Biomaterials and Bioengineering Tokyo Medical and Dental UniversityChiyoda-kuTokyoJapan Graduate School of Pharmaceutical Sciences Kyoto UniversityKyotoJapan

Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host ***,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of *** studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung ***,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain *** this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model ***,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing ***,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface *** findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of *** CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death.

关键词： CXCL12 CXCR4 lipopolysaccharides lung injury neutrophils

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Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第23期20卷 7381-7391页

作者： kouichi Miura Hirohide Ohnishi Department of Gastroenterology Akita University Graduate School of MedicineAkita 010-8543Japan

Emerging data have shown a close association between compositional changes in gut microbiota and the development of nonalcoholic fatty liver disease(NAFLD).The change in gut microbiota may alter nutritional absorption and *** addition,gut microbiota are a source of Toll-like receptor(TLR)ligands,and their compositional change can also increase the amount of TLR ligands delivered to the *** ligands can stimulate liver cells to produce proinflammatory ***,the gut-liver axis has attracted much interest,particularly regarding the pathogenesis of *** abundance of the major gut microbiota,including Firmicutes and Bacteroidetes,has been considered a potential underlying mechanism of obesity and NAFLD,but the role of these microbiota in NAFLD remains *** reports have demonstrated that certain gut microbiota are associated with the development of obesity and *** instance,a decrease in Akkermansia muciniphila causes a thinner intestinal mucus layer and promotes gut permeability,which allows the leakage of bacterial *** to increase Akkermansia muciniphila improve the metabolic parameters in obesity and *** children,the levels of Escherichia were significantly increased in nonalcoholic steatohepatitis(NASH)compared with those in obese *** can produce ethanol,which promotes gut ***,normalization of gut microbiota using probiotics or prebiotics is a promising treatment option for *** addition,TLR signaling in the liver is activated,and its downstream molecules,such as proinflammatory cytokines,are increased in *** data,TLR2,TLR4,TLR5,and TLR9 have been shown to be associated with the pathogenesis of ***,gut microbiota and TLRs are targets for NAFLD treatment.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Gut microbiota Toll-like receptor Probiotics Prebiotics

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An experimental study on self-output-control characteristics of micro downwind rotor with coning soft blades

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Science China(Technological Sciences) 2010年第1期53卷 100-104页

作者： EGUCHI Hidenori YOSHIDA kouichi NISHI Michihiro Sophia Engineering CO. Ltd.Kikugaoka 1-15-25KokuraminamiKitakyushu 802-0981Japan Mechanical Engineering Department Kyushu Institute of TechnologySensui-cho 1TobataKitakyushu 804-8550Japan Senior Academy Kyushu Institute of TechnologySensui-cho 1TobataKitakyushu 804-8550Japan

In this short paper,we have treated the aerodynamic performance of micro downwind rotor with coning soft blades *** test wind rotor has the tip diameter of 1.5 m and three two-dimensional NACA0018 blades of 0.15 m chord whose material is light,soft and pliable foam plastic for perfect *** the wind tunnel test,it is realized that the performance is manageable by the coning angle of the rotor *** the present case,an improvement of the performance in lower wind speeds is achieved by using the coning blade of 20°.Besides,owing to the torsional deformation of very soft blade,the self-power control characteristic is observed in every test rotor regardless of coning angle in the range of 0°-20° under the wind speed less than 12 m/s.

关键词： micro wind turbine downwind self-output-control coning angle soft blade aerodynamic performance

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Five-year survival following a medial pancreatectomy for an invasive ductal carcinoma from the body of the pancreas

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World Journal of Gastroenterology 2006年第5期12卷 822-824页

作者： Hideki Abe kouichi Tsuneyama Kazuhiro Tsukada Masatoshi Makuuchi Hepatobiliarypancreatic Division Department of SurgeryGraduate School of MedicineUniversity of TokyoTokyoJapan Department of Pathology Toyama Medical and Pharmaceutical UniversityToyamaJapan Second Department of Surgery Toyama Medical and Pharmaceutical University.ToyamaJapan

We report a rare case of a patient who survived for 5 years after undergoing a medial pancreatectomy for invasive ductal carcinoma originating from the body of the pancreas. A 63-year-old woman was diagnosed as a small cancer of the pancreatic body, and surgery was performed. Even though the tumor was a carcinoma, its small size prompted us to perform a medial pancreatectomy with regional lymph nodes dissection. Additional chemoradiation was performed and, five years after surgery, the patient is well with no signs of recurrence. Medial pancreatectomy for invasive ductal carcinoma has not ever been reported. Furthermore, long-term survival after a lumpectomy for invasive ductal carcinoma has never been reported in the literatures. The current case suggests that long-term survival in patients with invasive ductal carcinoma of the pancreas may be associated with the pathological or biological features of pancreatic carcinoma.

关键词： Ductal carcinoma Medial pancreatectomy Pancreatic carcinoma

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An Accurate Numerical Scheme for Maxwell Equation with CIP-Method of Characteristics

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Communications in Computational Physics 2006年第2期1卷 311-335页

作者： Youichi Ogata Takashi Yabe kouichi Odagaki Department of Mechanical Sciences and Engineering Tokyo Institute of Technology2-12-1 Meguro-kuOokayama 152-8552Japan

A new multi-dimensional scheme for the Maxwell equations is established by the CIP method in combination with the method of characteristics(CIP-MOC).In addition,the CIP-MOC can be extended to arbitrary grid system by the Soroban grid without losing the third-order *** the accuracy fixed,the grid points required for the CIP are 40 times less than the conventional schemes like the FDTD in three *** solutions obtained by the CIP-MOC are compared with analytical solution and the FDTD in plane-wave scattering by a perfectly-conducting circular cylinder,and the CIP-MOC agrees very well with analytical *** Soroban grid is also applied to the Vlasov equation that describes the kinematics of plasmas that is frequently combined with the Maxwell *** adaptively moving points in velocity space are similar to the particle codes but can provide accurate solutions.

关键词： Maxwell equation Vlasov equation CIP method method of characteristics Soroban grid

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Successful treatment of advanced hepatocellular carcinoma by combined administration of 5-fluorouracil and pegylated interferon-a

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World Journal of Gastroenterology 2005年第34期11卷 5401-5403页

作者： Kazutaka Kurokohchi kouichi Takaguchi Keiji Kita Tsutomu Masaki Shigeki Kuriyama Third Department of Internal Medicine Kagawa University School of Medicine 1750-1 Ikenobe Miki-cho Kita-gun Kagawa 761-0793 Japan Department of Internal Medicine Kagawa Prefectural Central Hospital 5-4-16 Ban-cho Takamatsu Kagawa 760-8557 Japan

We report a case of hepatocellular carcinoma （HCC） treated successfully by transarterial chemoembolization （TACE） followed by combination therapy of 5-fluorouracil （5-FU） and pegylated interferon-α （PEG-IFN-α）. In the present case, the patient had massive and advanced HCC with a diameter of over 8 cm located in segment 7 （S7） of the liver. Furthermore, the tumor invaded into the major branch of the portal vein （Vp3）. After TACE, combined administration of 5-FU and PEG-IFN-α was performed for 5 too. HCC was totally eradicated and the serum levels of tumor markers were markedly decreased by the treatment. Although it has been reported that the combined use of conventional IFN-α and 5-FU showed striking effects on HCC in some cases, this case may suggest the more promising effect of PEG-IFN-α with a long-lasting effect, in the combined use with 5-FU for the treatment of massive advanced HCC.

关键词： Hepatocellular carcinoma 5-Fluorouracil Pegylated interferon-α Combination therapy

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Induction of adaptive response in utero by ionizing radiation:A radiation quality dependent phenomenon

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BIOCELL 2022年第10期46卷 2315-2325页

作者： BING WANG KAORU TANAKA kouichi MARUYAMA YASUHARA NINOMIYA TAKANORI KATSUBE MITSURU NENOI National Institutes for Quantum Science and Technology Chiba263-8555Japan

Investigation on possible induction of adaptive response(AR)by high-liner energy transfer(LET)particle radiation for protection against low-LET photon radiation-induced detrimental effects has not yet been performed in *** study verified if an AR could be induced by high-LET particle radiation from accelerated heavy ions against low-LET X-ray radiation-induced detrimental effects on fetal *** body irradiation of pregnant C57BL/6J mice were performed by delivering a priming dose ranging from 10 mGy to 320 mGy of particle radiation on gestation day 11 followed one day later by a challenge dose at 3500 mGy from X-ray *** monoenergetic beams of carbon,silicon and iron with the LET values of about 15,55,and 200 KeV/μm,respectively,were *** suppression by the priming radiation of the detrimental effects(fetal death,malformation,or low body weight)was used as the endpoints for judgment of a successful AR induction on gestation day *** of AR was not *** the other hand,the priming dose of high-LET particle radiation,in some cases,even increased the detrimental effects induced by the challenge dose from low-LET X-ray *** existence of AR induced by high-LET radiation in cultured mammalian cells in vitro and in certain tissues of laboratory mice in vivo was demonstrated,the present study did not suggest that low dose of high-LET particle radiation could induce an AR in fetal mice in utero under the setup of our experimental system.

关键词： Heavy particle radiation Adaptive response High liner energy transfer Teratogenesis Fetal mice

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Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy

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World Journal of Gastroenterology 2017年第4期23卷 668-675页

作者： kouichi Sakurai Hiroko Suda Yumi Ido Takayuki Takeichi Ayako Okuda Kiwamu Hasuda Masahiro Hattori Hattori Clinic Chuo-ku

AIMTo compare the effectiveness and safety of vonoprazan-based therapy with proton pump inhibitor (PPI)-based therapies to treat Helicobacter pylori (H. pylori).METHODSWe retrospectively analysed data from first-line (vonoprazan or PPI with 200 mg clarithromycin and 750 mg amoxicillin twice daily for 7 d) (n = 1353) and second-line (vonoprazan or PPI with 250 mg metronidazole and 750 mg amoxicillin twice daily for 7 d) (n = 261) eradication treatments for H. pylori -positive patients with associated gastrointestinal diseases from April 2014 to December 2015 at Hattori Clinic, Japan. The primary endpoint was the eradication rate, which was assessed with a full analysis set. The secondary endpoints were adverse events and related *** the first-line treatments, the eradication rates for vonoprazan, esomeprazol, rabeprazole, and lansoprazole were 87.9% (95%CI: 84.9%-90.5%), 71.6% (95%CI: 67.5%-75.5%), 62.9% (95%CI: 52.0%-72.9%), and 57.3% (95%CI: 50.4%-64.1%), respectively. The vonoprazan eradication rate was significantly higher than that of the PPIs (P < 0.01). Interestingly, smoking did not affect the H. pylori eradication rate in the vonoprazan group (P = 0.34), whereas it decreased the rates in the PPI groups (P = 0.013). The incidence of adverse events in the vonoprazan group was not different from the PPI group (P = 0.054), although the vonoprazan group exhibited a wider range of adverse events. Vonoprazan-based triple therapy was highly effective as a second-line treatment, with an eradication rate similar to that of PPI-based *** might be superior to PPIs in first-line H. pylori therapy, particularly for smokers. However, caution is required due to possible adverse events.

关键词： Helicobacter pylori Eradication treatment Vonoprazan Proton pump inhibitors Adverse event Smoking

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Effect of Wood Variables on the Properties of Wood Fiber-Polypropylene Composites

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Chinese Forestry Science and Technology 2002年第4期1卷 47-54页

作者： kouichi SETOYAMA Forestry and Forest Products Research Institute Japan

The effect of wood species (Chinese fir and Poplar), wood fiber content (10%, 25%, 40%) and wood fiber sizes (16 to 32 mesh, 32-65 mesh, above 65 mesh) on the properties of the wood fiber-Polypropylene composites were studied in this paper. The results indicate that the effect of wood fiber content and size in composite were more important than that of chosen wood species. Compared with polypropylene without wood fiber, the flexural strength of the composites increased when adding wood fiber into polypr...

关键词： wood fiber/polypropylene composite wood fiber content wood fiber size dynamic mechanical properties

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Evaluation of prognostic factors and scoring system in colonic perforation

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World Journal of Gastroenterology 2007年第23期13卷 3228-3231页

作者： Atsushi Horiuchi Yuji Watanabe Takashi Doi kouichi Sato Syungo Yukumi Motohira Yoshida Yuji Yamamoto Hiroki Sugishita Kanji Kawachi Department of Surgery 2 Ehime University School of Medicine

AIM: To study the significance of scoring systems assessing severity and prognostic factors in patients with colonic perforation. METHODS: A total of 26 patients (9 men, 17 women; mean age 72.7 ± 11.6 years) underwent emergency operation for colorectal perforation in our institution between 1993 and 2005. Several clinical factors were measured preoperatively and 24 h postoperatively. Acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ), Mannheim peritonitis index (MPI) and peritonitis index of Altona (PIA Ⅱ) scores were calculated preoperatively. RESULTS: Overall postoperative mortality rate was 23.1% (6 patients). Compared with survivors, non- survivors displayed low blood pressure, low serum protein and high serum creatinine preoperatively, and low blood pressure, low white blood cell count, low pH, low PaO2/FiO2, and high serum creatinine postoperatively. APACHE Ⅱ score was significantly lower in survivors than in non-survivors (10.4 ± 3.84 vs 19.3 ± 2.87, P = 0.00003). Non-survivors tended to display high MPI score and low PIA Ⅱ score, but no signif icant difference was identif ied. CONCLUSION: Pre- and postoperative blood pressure and serum creatinine level appear related to prognosis of colonic perforation. APACHE Ⅱ score is most associated with prognosis and scores ≥ 20 are associated with signif icantly increased mortality rate.

关键词： Scoring system Colonic perforation Prognostic factor

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