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Positron emission tomography complete metabolic response as a favorable prog-nostic predictor in esophageal cancer following neoadjuvant chemotherapy with docetaxel/cis-platin/5-fluorouracil

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World Journal of Clinical Oncology 2021年第4期12卷 249-261页

作者： kosuke suzuki Tsuyoshi Etoh Tomotaka Shibata Kohei Nishiki Shoichi Fumoto Yoshitake Ueda Hidefumi Shiroshita Norio Shiraishi Masafumi Inomata Department of Gastroenterological and Pediatric Surgery Oita UniversityYufu 879-5593OitaJapan Department of Surgery Oita Nakamura HospitalOita 870-0022Japan

BACKGROUND 18F-fluorodeoxyglucose-positron emission tomography(PET)/computed tomography is useful in diagnosing lymph node and distant metastases of esophageal ***,its value for predicting survival is *** To evaluate the value of PET complete metabolic response(CMR)as a prognostic predictor for esophageal *** Between June 2013 and December 2017,58 patients with squamous cell esophageal cancer who underwent neoadjuvant chemotherapy(NAC)in Oita University were enrolled in this retrospective cohort *** were clinically staged using fluorodeoxyglucose-PET/computed tomography before and after *** NAC,maximal standardized uptake value≤2.5 was defined as PET-CMR,and maximal standardized uptake value>2.5 was defined as *** compared short-term outcomes between the PET-CMR group and non-PET-CMR group and evaluated prognostic factors by univariate and multivariate *** The PET-CMR group included 22 patients,and the non-PET-CMR group included 36 *** were no significant differences in intraoperative and post operative complications between the two ***-year relapse-free survival and overall survival in the PET-CMR group were significantly more favorable than those in the non-PET-CMR group(38.6 mo vs 20.8 mo,P=0.021;42.8 mo vs 25.1 mo,P=0.011,respectively).PET-CMR was a significant prognostic factor in terms of relapse-free survival by univariate analysis(hazard ratio:2.523;95%confidence interval:1.034–7.063;P<0.041).Particularly,PET-computed tomography negative N was an independent prognostic factor of relapse-free survival and overall survival by multivariate *** PET-CMR after NAC is considered a favorable prognostic factor for esophageal *** by PET-computed tomography could be useful in clinical decision making for esophageal cancer.

关键词： Esophageal cancer Neoadjuvant chemotherapy Positron emission tomography/computed tomography Complete metabolic response Prognostic factor Docetaxel,cisplatin plus 5-fluorouracil

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New acetogenin katsuurallene from Laurencia saitoi collected from Katsuura, Japan

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Natural Products and Bioprospecting 2022年第1期12卷 121-127页

作者： Yu Minamida Hiroshi Matsuura Takahiro Ishii Miyu Miyagi Yuto Shinjo kosuke Sato Takashi Kamada Yoshihiro Mihara Iwao Togashi Keisuke Sugimoto Tsuyoshi Abe Norio Kikuchi Minoru suzuki Advanced Course of Applied Chemistry National Institute of TechnologyAsahikawa CollegeShunkodai 2-2-1-6AsahikawaHokkaido 071-8142Japan Department of Materials Chemistry National Institute of TechnologyAsahikawa CollageShunkodai 2-2-1-6AsahikawaHokkaido 071-8142Japan Department of Biosciences and Biotechnology Faculty of AgricultureUniversity of the Ryukyus1 SenbaruNishiharaOkinawa 903-0213Japan Department of Materials and Life Science Faculty of Science and TechnologyShizuoka Institute of Science and Technology2200-2 ToyosawaFukuroiShizuoka 437-8555Japan Department of Medicinal Chemistry Faculty of Pharmaceutical SciencesHokkaido University of ScienceMaeda 715-4-1Teine-kuSapporoHokkaido 006-8590Japan The Hokkaido University Museum Hokkaido UniversityN10 W8Kita-kuSapporoHokkaido 060-0810Japan Coastal Branch of Natural History Museum and Institute Chiba123 YoshioKatsuuraChiba 299-5242Japan Department of Life Science Graduate School of Engineering ScienceAkita University1-1 Tegatagakuen-machiAkita 010-8502Japan

We examined the chemical constitution of the red alga Laurencia saitoi Perestenko,collected from Katsuura,Boso Peninsula,Chiba Prefecture,*** specimen produced a new polyhalogenated acetogenin,named katsuural-lene(1),which structure was determined by the spectral methods,along with known diterpene,deoxyparguerol(2)and triterpene,thyrsiferol(3).In this paper we describe the structural elucidation of katsuurallene together with some biological activities.

关键词： Laurencia Rhodomelaceae Acetogenin Triterpene Diterpene Biological activity

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A COMPREHENSIVE SOFTWARE SUITE FOR THE ANALYSIS OF CDNAS

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Genomics, Proteomics & Bioinformatics 2005年第3期3卷 179-188页

作者： KAZUHARU ARAKAWA HARUO suzuki kosuke FUJISHIMA KENJI FUJIMOTO SHO UEDA MOTOMU MATSUI MASARU TOMITA INSTITUTE FOR ADVANCED BIOSCIENCES KEIO UNIVERSITY FUJISAWA 252-8520 JAPAN BIOINFORMATICS PROGRAM OF THE GRADUATE SCHOOL OF MEDIA AND GOV- ERNANCE KEIO UNIVERSITY FUJISAWA 252-8520 JAPAN INSTITUTE FOR ADVANCED BIOSCIENCES KEIO UNIVERSITYFUJISAWA 252-8520 JAPAN

We have developed a comprehensive software suite for bioinformatics research of cDNAs; it is aimed at rapid characterization of the features of genes and the proteins they code. Methods implemented include the detection of translation initia- tion and termination signals, statistical analysis of codon usage, comparative study of amino acid composition, comparative modeling of the structures of product proteins, prediction of alternative splice forms, and metabolic pathway reconstruction. The software package is freely available under the GNU General Public License at http： / /***/ data/cdna/.

关键词： cDNA bioinformatics, software

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Clinical features of cardiac nodularity-like appearance induced by Helicobacter pylori infection

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World Journal of Gastroenterology 2020年第35期26卷 5354-5361页

作者： Toshihiro Nishizawa kosuke Sakitani Hidekazu suzuki Shuntaro Yoshida Yosuke Kataoka Yousuke Nakai Hirotoshi Ebinuma Takanori Kanai Osamu Toyoshima Kazuhiko Koike Department of Gastroenterology Toyoshima Endoscopy ClinicTokyo 1570066Japan Department of Gastroenterology Narita HospitalInternational University of Health and WelfareChiba 2868520Japan Department of Gastroenterology Sakitani Endoscopy ClinicChiba 2740825Japan Department of Internal Medicine Tokai University School of MedicineKanagawa 2591193Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 1138655Japan Department of Internal Medicine Keio University School of MedicineTokyo 1608582Japan

We have previously reported that Helicobacter pylori(***)-associated nodular gastritis could occur in both the antrum and the *** nodularity-like appearance(hereafter,called as cardiac nodularity)had a high predictive accuracy for the diagnosis of *** *** the previous study,we included only the patients who were evaluated for *** infection for therst time,and excluded patients with a history of ***,the prevalence and clinical features of cardiac nodularity remains *** To perform this cross-sectional study to explore the characteristics of cardiac *** Consecutive patients who underwent esophagogastroduodenoscopy betweenMay,2017 and August,2019 in the Toyoshima Endoscopy Clinic were enrolled in this *** included ***-negative,***-positive,and *** patients,and excluded patients with unclear *** status and eradication *** infection was diagnosed according to serum *** antibody and the urea breath test or *** nodularity was defined as a miliary nodular appearance or the presence of scattered whitish circular small colorations within 2 cm of the esophagogastric *** was visualized as whitish in the narrow-band imaging *** collected data on the patients’baseline *** A total of 1078 patients were finally *** ***-negative patients,cardiac nodularity and antral nodularity were recognized in 0.14%*** ***-positive patients,cardiac nodularity and antral nodularity were recognized in 54.5%and 29.5%,*** ***-eradicated patients,cardiac nodularity and antral nodularity were recognized in 4.5%and 0.6%,*** frequency of cardiac nodularity was significantly higher than that of antral nodularity in ***-positive and-eradicated *** frequencies of cardiac nodularity and antral nodularity in ***-eradicated patients were significa

关键词： Cardia Nodularity Helicobacter pylori Diagnosis Gastritis

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En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer

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World Journal of Gastrointestinal Oncology 2017年第9期9卷 372-378页

作者： Yuji Kaneda Hiroshi Noda Yuhei Endo Nao Kakizawa kosuke Ichida Fumiaki Watanabe Takaharu Kato Yasuyuki Miyakura Koichi suzuki Toshiki Rikiyama Department of Surgery Saitama Medical CenterJichi Medical UniversitySaitama 330-8503Japan

AIM To assess the usefulness of en bloc right hemicolectomy with pancreaticoduodenectomy(RHCPD) for locally advanced right-sided colon cancer(LARCC).METHODS We retrospectively reviewed the database of Saitama Medical Center, Jichi Medical University, between January 2009 and December 2016. During this time, 299 patients underwent radical right hemicolectomy for right-sided colon cancer. Among them, 5 underwent RHCPD for LARCC with tumor infiltration to adjacent organs. Preoperative computed tomography(CT) was routinely performed to evaluate local tumor infiltration into adjacent organs. During the operation, we evaluated the resectability and the amount of infiltration into the adjacent organs without dissecting the adherent organs from the cancer. When we confirmed that radical resection was feasible and could lead to R0 resection, we performed RHCPD. The clinical data were carefully reviewed, and the demographic variables, intraoperative data, and postoperative parameters were *** The median age of the 5 patients who underwent RHCPD for LARCC was 70 years. The tumors were located in the ascending colon(three patients) and transverse colon(two patients). Preoperative CT revealed infiltration of the tumor into the duodenum in all patients, the pancreas in four patients, the superior mesenteric vein(SMV) in two patients, and tumor thrombosis in the SMV in one patient. We performed RHCPD plus SMV resection in three patients. Major postoperative complications occurred in 3 patients(60%) as pancreatic fistula(grade B and grade C, according to International Study Group on Pancreatic Fistula Definition) and delayed gastric empty. None of the patients died during their hospital stay. A histological examination confirmed malignant infiltration into the duodenum and/or pancreas in 4 patients(80%), and no patients showed any malignant infiltration into the SMV. Two patients were histologically confirmed to have tumor thrombosis in the SMV. All of the tumors had c

关键词： Locally advanced right-sided colon cancer Right hemicolectomy Malignant infiltration Inflammatory adhesion Pancreaticoduodenectomy

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Helicobacter pylori infection in subjects negative for high titer serum antibody

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World Journal of Gastroenterology 2018年第13期24卷 1419-1428页

作者： Osamu Toyoshima Toshihiro Nishizawa Masahide Arita Yosuke Kataoka kosuke Sakitani Shuntaro Yoshida Hiroharu Yamashita Keisuke Hata Hidenobu Watanabe Hidekazu suzuki Department of Gastroenterology Toyoshima Endoscopy Clinic Department of Pathology Pathology and Cytology Laboratory Japan Medical Education Center Keio University School of Medicine

AIM To investigate the clinicopathological features of the patients testing negative for high titer serum antiHelicobacter pylori(H. pylori) *** The antibody titers were measured using antigens derived from Japanese individuals. ^(13)C-urea breath test-positive individuals were defined as having H. pylori infection. We investigated the demographic characteristics, laboratory data, endoscopic findings including Kyoto classification of gastritis, and histology in negative-high titer patients without H. pylori eradication therapy. Kyoto classification consisted of scores for gastric atrophy, intestinal metaplasia, enlarged folds, nodularity, and *** Of the 136 subjects enrolled, 23(17%) had H. pylori infection. Kyoto classification had an excellent area under the receiver operating characteristics curve(0.886, 95% confidence interval: 0.803-0.968, P = 3.7 × 10^(-20)) for predicting H. pylori infection with a cutoff value of 2. Further, Kyoto classification, H. pylori density, and neutrophil activity had high accuracies(89.7%, 96.3%, and 94.1%, respectively). Kyoto classification was independent of the demographic and laboratory parameters in multivariate *** Endoscopic Kyoto classification of gastritis is a useful predictor of H. pylori infection in negative-high titer antibody patients.

关键词： Kyoto classification Gastritis Helicobacter pylori Antibody Endoscopy

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Plasma copeptin concentration is a predictor of tolvaptan efficacy in patients with hepatic ascites

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Portal Hypertension & Cirrhosis 2023年第3期2卷 109-114页

作者： Fumimasa Tomooka Kei Moriya Takahiro Kubo Akihiko Shibamoto Jyunya suzuki Satoshi Iwai Soichi Takeda Yuki Fujimoto Masahide Enomoto Koji Murata Yuki Tsuji Yukihisa Fujinaga Koh Kitagawa Norihisa Nishimura Hiroaki Takaya kosuke Kaji Hideto Kawaratani Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji Department of Gastroenterology and Hepatology Nara Medical UniversityKashiharaJapan Department of Gastroenterology Nara Prefectural General Medical CenterShichijo-NishimachiJapan

Aims:No solid evidence-based opinion was raised regarding predictors of the degree of ascites reduction with *** retrospective cohort study aimed to examine whether serum copeptin concentration is a useful predictor of ***:The study population consisted of 80 patients with liver cirrhosis treated with tolvaptan for hepatic ascites effusions at Nara Medical University Hospital from May 2014 to December ***-three patients who lost>1.5 kg of body weight in the first week after starting tolvaptan were classified as good responders and the remaining 37 as poor *** laboratory parameters were measured immediately before the start of tolvaptan therapy to examine factors associated with predicting its ***:In the univariate analysis,no significant differences with respect to age(67.6 vs.69.8 years,p>0.05),sex,body mass index(24.8 vs.23.7 kg/m^(2),p>0.05),Child-Pugh score(9.4 vs.9.7,p>0.05),and Model for End-stage Liver Disease score(11 vs.12,p>0.05)were found between the two ***,aspartate transferase and alanine transaminase(ALT)levels were significantly lower in the good response group(52.9±56.3 vs.68.8±50.7 U/L,p<0.05;26.2±30.6 vs.40.5±33.5 U/L,p<0.01),whereas serum copeptin and serum sodium concentrations were significantly higher(57.1±15.0 vs.45.8±16.0 pg/mL,p<0.01;136.3±3.4 vs.133.8±5.8 mEq/L,p<0.05).In the multivariate analysis,serum copeptin concentration and ALT were statistically significant factors(p<0.01,p<0.05).Regression analysis of the association between the tolvaptan efficacy for refractory ascites and pretreatment serum copeptin concentration showed that a copeptin concentration cutoff of 45.9 pg/mL could predict treatment efficacy with a sensitivity,specificity,and area under the curve of 76.7%,59.5%,and 0.71%,***:Serum copeptin concentration may be a predictor of tolvaptan efficacy for refractory ascites effusion in Japanese patients with liver cirrhosis.

关键词： ascites copeptin decompensated liver cirrhosis diuretics tolvaptan

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Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity,atrophy,and age:A cross-sectional study

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World Journal of Gastroenterology 2018年第35期24卷 4061-4068页

作者： Osamu Toyoshima Toshihiro Nishizawa kosuke Sakitani Tadahiro Yamakawa Yoshiyuki Takahashi Nobutake Yamamichi Keisuke Hata Yasuyuki Seto Kazuhiko Koike Hidenobu Watanabe Hidekazu suzuki Gastroenterology Toyoshima Endoscopy ClinicTokyo 157-0066Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Surgical Oncology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastrointestinal Surgery Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Pathology and Cytology Laboratory Japan Tokyo 166-0003Japan Medical Education Center Keio University School of MedicineTokyo 160-8582Japan

AIM To clarify the role of serum anti-Helicobacter pylori(H. pylori) antibody titers in gastric *** In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophagogastroduodenoscopy and their first evaluation for H. pylori infection using a serum antibody test. We excluded patients with a history of eradication therapy. The participants were divided into four groups according to their E-plate serum antibody titer. Patients with serum antibody titers < 3, 3-9.9, 10-49.9, and ≥ 50 U/m L were classified into groups A, B, C, and D, respectively. RESULTS In total, 874 participants were analyzed with 70%, 16%, 8.7%, and 5.1% of them in the groups A, B, C, and D, respectively. Patients in group C were older than patients in groups A and B. Gastric open-type atrophy, intestinal metaplasia, enlarged folds, diffuse redness, and duodenal ulcers were associated with a high titer. Regular arrangements of collecting venules, fundic gland polyps, superficial gastritis, and gastroesophageal reflux disease were related to a low titer. Multivariate analysis revealed that nodularity(P = 0.0094), atrophy(P = 0.0076), and age 40-59 years(vs age ≥ 60 years, P = 0.0090) were correlated with a high serum antibody titer in H. pylori-infected patients. Intestinal metaplasia and atrophy were related to age ≥ 60 years in group C and *** Serum antibody titer changes with age, reflects gastric mucosal inflammation, and is useful in predicting the risk of gastric cancer.

关键词： Antibody Helicobacter pylori Gastritis Gastric cancer Endoscopy

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Composition of conjugated linoleic acid and fatty acid n-3/n-6 ratio in Japanese Aigamo duck

Composition of conjugated linoleic acid and fatty acid n-3/n...

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第十五届国际药理学大会

作者： suzuki Tadahiko SATO Tetusuro KOFUJITA Hisayoshi SATO Itaru KOBAYASHI Haruo OKADA kosuke. Lab. Vet. Pharmacol. Dep.Paramedic. Sci.Facul. Agricul. Iwate Univ. and United Grad. School Vet.Sri..Gifu Univ. JAPAN. Facul.Agricul.. and United Grad. School Vet. Sri.. Gifu Univ. JAPAN. Facul.Agricul.. and United Grad. School Vet. Sri.. Gifu Univ. JAPAN. Dep.Disease Cont.Envir.Sci.. and United Grad. School Vet. Sri.. Gifu Univ. JAPAN. Lab. Vet. Pharmacol.. Dep. Paramedic. Sci.. and United Grad. School Vet. Sri.. Gifu Univ. JAPAN. Dep. Disease Cont.Envir.Sci.Iwate Univ. and United Grad. School Vet. Sri..Gifu Univ. JAPAN.

＜正＞ Conjugated linoleic acid （CLA） and alpha - linolenic acid （n-3） have various bioactivities. such as decreasing effects on body fat contents and anti-thrombotic or anti - platelet aggregation. In addition, there is competition mechanism between n - 3 and n - 6 fatty acid, and so the n - 3/n - 6 ratio seems to be more important in *** is no report on the fatty acid composition in Aigamo ducks （Japanese crossbreed of mallards and domestic ducks）. In the present study, we established measuring method for CLA by capillary gas chromatography and found, for the first time. 9c,11t CLA in fatty acids obtained from the duck （0.41±0.04 mg/g of lipid,n=5）. but not in those from chicken. Analysis of total fatty acid composition of the duck indicated that the n - 3/n - 6 ratio of the ducks is higher than that of chicken, suggesting Aigamo duck could be a healthy food material,since the ratio would be taken seriously rather than fatty acid contents in recent nutritional science.

关键词： fatty acid CLA n-3/n-6 Aigamo duck

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Comparison of endoscopic gastritis based on Kyoto classification between diffuse and intestinal gastric cancer

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World Journal of Gastrointestinal Endoscopy 2021年第5期13卷 125-136页

作者： Osamu Toyoshima Toshihiro Nishizawa Shuntaro Yoshida Tomonori Aoki Fumiko Nagura kosuke Sakitani Yosuke Tsuji Hayato Nakagawa Hidekazu suzuki Kazuhiko Koike Department of Gastroenterology Toyoshima Endoscopy ClinicTokyo 157-0066Japan Department of Gastroenterology and Hepatology International University of Health and WelfareNarita HospitalNarita 286-8520Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Internal Medicine Chitosefunabashi Ekimae ClinicTokyo 157-0054Japan Department of Gastroenterology Sakiatani Endoscopy ClinicNarashino 275-0026Japan Department of Gastroenterology and Hepatology Tokai University School of MedicineIsehara 259-1193Japan

BACKGROUND Gastric cancers can be categorized into diffuse-and intestinal-type cancers based on the Lauren histopathological *** two subtypes show distinct differences in metastasis frequency,treatment application,and ***,accurately assessing the Lauren classification before treatment is ***,studies on the gastritis endoscopy-based Kyoto classification have recently shown that endoscopic diagnosis has *** To investigate patient characteristics including endoscopic gastritis associated with diffuse-and intestinal-type gastric cancers in Helicobacter pylori(***)-infected *** Patients who underwent esophagogastroduodenoscopy at the Toyoshima Endoscopy Clinic were *** Kyoto classification included atrophy,intestinal metaplasia,enlarged folds,nodularity,and diffuse *** effects of age,sex,and Kyoto classification score on gastric cancer according to the Lauren classification were *** developed the Lauren predictive background score based on the coefficients of a logistic regression model using variables independently associated with the Lauren *** under the receiver operative characteristic curve and diagnostic accuracy of this score were *** A total of 499 ***-infected patients(49.6%males;average age:54.9 years)were enrolled;132 patients with gastric cancer(39 diffuse-and 93 intestinal-type cancers)and 367 cancer-free controls were *** cancer was independently associated with age≥65 years,high atrophy score,high intestinal metaplasia score,and low nodularity score when compared to the *** independently associated with intestinal-type cancer were age≥65 years(coefficient:1.98),male sex(coefficient:1.02),high intestinal metaplasia score(coefficient:0.68),and low enlarged folds score(coefficient:-1.31)when compared to diffuse-type *** Lauren predictive background score was defined as the sum of+2(age≥65 years),+1(

关键词： Gastric cancer Lauren classification Endoscopy Pathology Gastritis Kyoto classification

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