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Anxiety and depression propensities in patients with acute toxic liver injury

World Journal of Gastroenterology 2013年第47期19卷 9069-9076页

作者： Jeong Ill Suh Jeong Kyu Sakong Kwan Lee Yong Kook Lee Jeong Bae Park Dong Joon Kim Yeon Seok SeoDepartment of Internal medicine korea university Anam Hospital korea university college of medicine Seoul 136-705 South korea Jae Dong Lee Soon Young Ko Byung Seok Lee Seok Hyun Kim Byung Seok Kim Young Seok Kim Heon Ju Lee In Hee Kim Joo Hyun Sohn Tae Yeob Kim Byung Min Ahn Department of Internal medicine Dongguk University Gyeongju HospitalDongguk University College of MedicineGyeongju 780-350South Korea Department of Psychiatry Dongguk University Gyeongju HospitalDongguk University College of MedicineGyeongju 780-350South Korea Department of Preventive medicine Dongguk University College of MedicineGyeongju 780-350South Korea Department of Internal medicine Hallym University Medical CenterHallym University College of MedicineChuncheon 200-704South Korea Department of Internal medicine Konkuk University Chungju HospitalKonkuk University College of MedicineChungju 380-704South Korea Department of Internal medicine Chungnam National University HospitalChungnam University College of MedicineDaejeon 301-721South Korea Department of Internal medicine Daegu Catholic University Medical CenterDaegu Catholic University College of MedicineDaegu 705-718South Korea Department of Internal medicine Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 420-767South Korea Department of Internal medicine Yeungnam University Medical CenterYeungnam University College of MedicineDaegu 705-703South Korea Department of Internal medicine Chonbuk National University HospitalChonbuk National University College of MedicineJeonju 561-712South Korea Department of Internal medicine Hanyang University Guri HospitalHanyang University College of MedicineGuri 471-701South Korea Department of Internal medicine Hwain Metro HospitalChunan 331-959South Korea

AIM:To investigate anxiety and depression propensities in patients with toxic liver ***:The subjects were divided into three groups:a healthy control group(Group 1,n=125),an acute non-toxic liver injury group(Group 2,n=124),and a group with acute toxic liver injury group caused by noncommercial herbal preparations(Group 3,n=126).These three groups were compared and evaluated through questionnaire surveys and using the Hospital Anxiety-Depression Scale(HADS),Beck Anxiety Inventory(BAI),Beck Depression Inventory(BDI),and the hypochondriasis ***:The HADS anxiety subscale was 4.9±2.7,5.0±3.0 and 5.6±3.4,in Groups 1,2,and 3,*** HADS depression subscale in Group 3 showed the most significant score(5.2±3.2,6.4±3.4 and 7.2±3.4in Groups 1,2,and 3,respectively)(Pmedicines,such as herbs and plant preparations,are important for understanding toxic liver injury.

关键词： Liver injury Herb Toxic Anxiety Depression

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Arecoline inhibits catecholamine release from perfused rat adrenal gland

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Acta Pharmacologica Sinica 2006年第1期27卷 71-79页

作者： Dong-yoon LIM II-sik KIM Department of Pharmacology,college of medicine,Chosun university,Gwangju 501-759,korea Department of Pharmacology College of Medicine Chosun University Gwangju Korea

Aim:To study the effect of arecoline,an alkaloid isolated from Areca catechu,onthe secretion of catecholamines (CA) evoked by cholinergic agonists and themembrane depolarizer from isolated perfused rat adrenal ***:Adrenalglands were isolated from male Sprague-Dawley *** adrenal glands wereperfused with Krebs bicarbonate solution by means of a peristaltic *** CAcontent of the perfusate was measured directly using the fluorometric ***:Arecoline (0.1-1.0 mmol/L) perfused into an adrenal vein for 60 min pro-duced dose-and time-dependent inhibition in CA secretory responses evoked byacetylcholine (ACh) (5.32 mmol/L),1.1-dimethyl-4-phenyl piperazinium iodide(DMPP) (100μmol/L for 2 min) and 3-(m-choloro-phenyl-carbamoyl-oxy)-2-butynyltrimethyl ammonium chloride (McN-A-343)(100μmol/L for 2 min).However,lowerdoses of arecoline did not affect CA secretion of high K~+(56 mmol/L);higherdoses greatly reduced CA secretion of high K~+.Arecoline also failed to affectbasal catecholamine ***,in adrenal glands loaded with arecoline(0.3 mmol/L),CA secretory response evoked by Bay-K-8644 (10μmol/L),an activa-tor of L-type Ca2+channels,was markedly inhibited,whereas CA secretion bycyclopiazonic acid(10μmol/L),an inhibitor of cytoplasmic Ca2+-ATPase,was *** (30μmol/L),which was perfused into the adrenal gland for 60min,however,initially enhanced ACh-evoked CA secretory *** timeelapsed,these responses became more inhibited,whereas the initially enhancedhigh K~+-evoked CA release *** secretion evoked by DMPP and McN-A-343 was significantly depressed in the presence of ***:Arecoline dose-dependently inhibits CA secretion from isolated perfused rat ad-renal gland evoked by activation of cholinergic *** lower doses arecolinedoes not inhibit CA secretion through membrane depolarization,but at largerdoses it *** inhibitory effect of arecoline may be mediated by blocking thecalcium inf

关键词： arecoline catecholamine secretion adrenal gland nicotine

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Diffusion tensor imaging of neural tract injury in a patient with hypoxic-ischemic brain injury

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Neural Regeneration Research 2010年第23期5卷 1825-1828页

作者： Ji Heon Hong,Sung Ho Jang Department of Physical medicine and Rehabilitation,college of medicine,Yeungnam university,Daegu 705-717,Republic of korea Department of Physical medicine and Rehabilitation College of MedicineYeungnam University Sung Ho Jang

Hypoxic-ischemic brain injury （HI-BI） is one of the most common causes of severe neurological disability, Some studies have reported diffusion tensor imaging （DTI） findings of neonatal patients with HI-BI. However, very little is known about DTI in the adult brain. The present study reports on a 15-year-old male patient with HI-BI, who exhibited no specific focal lesions on conventional brain MRI at 5 weeks. However, neural tract injuries were revealed by DTI. Seven control subjects were also evaluated. The patient suffered from cardiac arrest due to ventricular fibrillation for a period of 10 15 minutes. At 4 weeks after onset of cardiac arrest, although he was conscious and alert, he exhibited mild quadriparesis and severe cognitive dysfunction. DTI was acquired at 5 weeks after HI-BI onset. Decreased fractional anisotropy or voxel number of neural tracts suggested partial injury of the corticospinal tract, fornix, and cingulum. Disruptions of the fornix and cingulum on DTI confirmed neural tract injury. DTI could serve as a useful tool for evaluating the state of neural tracts in patients with HI-BI.

关键词： hypoxic-ischemic brain injury diffusion tensor imaging hemiparesis corticospinal tract

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Hormonal replacement therapy and aging: Asian practical recommendations on testosterone supplementation

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Asian Journal of Andrology 2003年第4期5卷 339-344页

作者： Young Chan Kim Yonsei university college of medicine korean Sexual and Men's Health Center 135-911 Seoul Korea

Profound and diffuse alterations in the production of gonadal and adrenal androgens as well as growth hormone are associated with aging. To convey this concept more appropriately, partial endocrine deficiency in the aging male (PEDAM) was introduced as a term for the phenomenon of hormonal alterations in the aging male. Hormones responsible for some of the manifestations associated with male aging are testosterone, growth hormone, dehydroepiansdrosterone (DHEA), melatonin, thyroid hormones and leptin. Of these, testosterone has been widely investigated and its beneficial and adverse effects on male bodily systems are relatively well established. However, a serious body of confusion and misunderstandings surrounding the diagnosis, treatment and monitoring of men suspected of having androgen deficiency has been raised. Therefore, it is timely to provide practical criteria for diagnosis and treatment to avoid misconception about the use of testosterone in the aging male. To provide an understanding and information of the issues, the following headings are summarized: (1) Important clinical consideration on testosterone supplementation in the aging male; (2) Asian practical recommendations on testosterone supplementation in the aging male.

关键词： hormone alteration recommendation testosterone supplementation aging male

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Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis

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Acta Pharmacologica Sinica 2006年第10期27卷 1359-1366页

作者： Ha-young LEE~(2,3,4) Eun-ha SHIN~(2,4) Yoe-sik BAE~(2,3,5) ~2Medical Research Center for Cancer Molecular Therapy,college of medicine,Dong-A university,Busan 602-714,korea,~3Department of Biochemistry,college of medicine,Dong-A university,Busan 602-714,korea Medical Research Center for Cancer Molecular Therapy College of Medicine Dong-A University Busan Korea Department of Biochemistry College of Medicine Dong-A University Busan Korea

Aim:To investigate the effects of sphingosylphosphorylcholine(SPC)on humanmonocyte-derived dendritic cell(DC)***:Human DC were gen-erated from peripheral blood monocytes by culturing them with granulocyte mac-rophage-colony stimulating factor and *** effect of SPC on the DCchemotactic migration was measured by chemotaxis *** signalingevent involved in the SPC-induced DC chemotaxis was investigated with severalinhibitors for specific *** expression of the SPC receptors was examinedby reverse transcription polymerase chain ***:We found that SPCinduced chemotactic migration in immature DC(iDC)and mature DC(mDC).Interms of SPC-induced signaling events,mitogen activated protein kinase activa-tion and Akt activation in iDC and mDC were ***-induced chemotaxiswas mediated by extracellular signal-regulated protein kinase and phosphoino-sitide-3-kinase,but not by calcium in both iDC and *** mDC expressovarian cancer G protein-coupled receptor 1,but not G protein-coupled receptor 4,iDC do not express any of these *** examine the involvement of sphin-gosine-1-phosphate(S1P)receptors,we checked the effect of an S1P receptorantagonist(VPC23019)on SPC-induced DC ***23019 did not affectSPC-induced DC ***:The results suggest that SPC may playa role in regulating DC trafficking during phagocytosis and the T cell-stimulatingphase,and the unique SPC receptor,which is different from SIP receptors,isinvolved in SPC-induced chemotaxis.

关键词： dendritic cells sphingosylphosphorylcho line chemotaxis pertussis toxin-sensitive G protein extracellular signal regulated protein kinase

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Laser Surface Hardening of 9CrSi Steel

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Journal of Materials Science & Technology 2002年第1期18卷 17-20页

作者： Nunghee RYU and Sunggoon KANGDivision of Materials Science and Engineering, college of Engineering, Hanyang university, korea [ Manuscript received August 7, 2001, in revised form September 20, 2001] Div. of Mat. Sci. and Eng. Coll. of Eng. Hanyang Univ. Hanyang South Korea

The effects of laser hardening parameters such as beam power, beam diameter and scanning rate on microstructure and hardness of 9CrSi steel were investigated. The microstructure of the surface layer of 9CrSi steel was changed from pearlite to martensite, retained austenite and carbide by laser hardening. The depth of the hardened layer increased with increasing laser energy density and the surface hardeness increased by 3-5 times as high as the untreated steel. The laser hardened surface had good wear resistance due to martensite and carbide in the surface layer. The wear mode at low speed was abrasive, while the wear mode at high speed was adhesive.

关键词： Laser hardening Martensite Hardeness Phase trasformation

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Altered pharmacokinetics of zalcitabine by concurrent use of NSAIDs in rats

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Acta Pharmacologica Sinica 2006年第1期27卷 119-122页

作者： Yo-han OH~2 Hyo-kyung HAN college of Pharmacy,Chosun university,Gwangju 501-759,korea college of Pharmacy Chosun University Gwangju Korea

Aim:To investigate the pharmacokinetic interactions between zalcitabine andnonsteroidal anti-inflammatory drugs (NSAIDs) in ***:Zalcitabinewas administered to rats via an iv injection (20 mg/kg) in the presence or absenceof ketoprofen or naproxen (20 mg/kg),and the pharmacokinetic parameters weredetermined by using non-compartmental ***:Compared with thecontrol (zalcitabine alone),pretreatment with ketoprofen or naproxen 30 min priorto intravenous administration of zalcitabine significantly altered the pharmacoki-netic profiles of zalcitabine in *** clearance of zalcitabine was reduced byapproximately 3-4-fold in the presence of ketoprofen or ***,systemic exposure (AUC) to zalcitabine in the rats pretreated with ketoprofen ornaproxen was significantly greater than that for the control group given *** terminal plasma half-life of zalcitabine was also prolonged by 4-5-foldin the presence of ketoprofen or ***:The NSAIDs ketoprofenand naproxen effectively altered the pharmacokinetics of ***,concomitant use of ketoprofen or naproxen in patients being treated with zalcitabinemay necessitate close monitoring for potential drug interactions.

关键词： zalcitabine ketoprofen naproxen pharmacokinetics drug interactions

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The Tendency of the Market and Technology of the Magnetic Materials in korea

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Journal of Materials Science & Technology 2000年第2期16卷 217-220页

作者： C.O.Kim and Y.Li (Engineering college, Chungnam National university, korea) Chungnam Natl Univ Coll Engn Taejon South Korea

The magnetic materials industry in korea started from the production of the ferrite and alnico magnet at the end of 1970s. At that time, most electronic company in korea imported the equipment parts and made them up. As one of electronic equipments, its development dropped behind other countries. In 1980s, with the revaluing upward of Japanese yen and the increment of the domestic need in korea, several new magnet manufacturing plants were built up.

关键词： The Tendency of the Market and Technology of the Magnetic Materials in korea

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Relationship between atrial natriuretic peptide-immunoreactive cells and microvessels in rat gastric mucosa

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Acta Pharmacologica Sinica 2006年第2期27卷 205-211页

作者： Chun-hui LI~(2,3) Zong-wei YANG~3 Zheng-ri YIN~3 Zheng JIN~3 De-gang XING~3 Lian-hua PIAO~3 Yong-chul KIM~4 Wen-xie XU~(2,5) ~2college of Life Science and Biotechnology.Shanghai Jiaotong university,Shanghai 200240,China:~3Department of Physiology.Yanbian university college of medicine.Yanji 133000.China ~4Department of Physiology,Chungbuk National university,college of medicine.Cheongju.Chungbuk 361-763,korea college of Life Science and Biotechnology Shanghai Jiaotong University Shanghai China Department of Physiology Yanbian University College of Medicine Yanji China Department of Physiology Chungbuk National University College of Medicine Cheongju Korea

Aim:To investigate the ultrastructural localization of atrial natriuretic peptide(ANP)-synthesizing cells and the relationship between ANP-synthesizing cellsand microvessels in rat gastric ***:Immunohistochemistry tech-niques and postembedding immunoelectron microscopy techniques were used tovalidate the findings regarding the expression of ANP-synthesizing cells and theultrastructural localization of ANP-synthesizing cells in the gastric ***-tochemistry techniques and the tannic acid-ferric chloride method(TA-Fe stain-ing method)were used to reveal microvessel density and the distribution of ANP-synthesizing cells in different regions of the ***:Cells expressingANP were localized and ANP-synthesizing cells were identified as enterochroma-ffin(EC)cells in the gastric ***-synthesizing cells existed in differentregions of the *** percentage ANP-synthesizing cells in the mucosawas greatest in the fundus(46.7%e5.3%),intermediate in the antrum(40.1%±4.5%),and least in the body(21.6%±3.6%).There was a positive relationshipbetween the percentage of ANP-synthesizing cells and the density of microvesselsin the antral mucosa,but not in the fundus or body ***:ANP issynthesized by EC cells in rat gastric mucosa,and ANP-synthesizing cells aremost dense in the gastric *** may act not only as a regional autocrineand/or paracrine regulator,but also as an endocrine regulatory peptide in thegastrointestinal tract.

关键词： atrial natriuretic factor enterochromaffin cells blood vessels gastric mucosa

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The Acute Toxicity Test of Neo-enfx in Mice

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饲料工业 2011年第13期 28-29页

作者： college of Veterinary medicine of Nanjing Agricultural university college of Veterinary medicine of Nanjing Agricultural university

Enrofloxacin, a third-generation quinolone, is a broad-spectrum antibacterial drug. It has activity against some bacteria, which include ***, klebsiella, salmonella, vibrio parahaemolyticus, staphylococcus aureus, pse... 详细信息

关键词： The Acute Toxicity Test of Neo-enfx in Mice Test oral

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