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Circadian rhythm disruption and endocrine-related tumors

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World Journal of Clinical Oncology 2024年第7期15卷 818-834页

作者： Christos Savvidis Efthymia Kallistrou Eleni Kouroglou Sofia Dionysopoulou Georgios Gavriiloglou Dimitra Ragia Vasiliki Tsiama Stella Proikaki konstantinos Belis Ioannis Ilias Department of Endocrinology Hippocration General HospitalAthens GR-11527Greece

This review delved into the intricate relationship between circadian clocks and physiological processes,emphasizing their critical role in maintaining *** by interlocked clock genes,the circadian timekeeping system regulates fundamental processes like the sleep-wake cycle,energy metabolism,immune function,and cell *** central oscillator in the hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles,while peripheral tissue clocks are influenced by cues such as feeding *** disruption,linked to modern lifestyle factors like night shift work,correlates with adverse health outcomes,including metabolic syndrome,cardiovascular diseases,infec-tions,and *** explored the molecular mechanisms of circadian clock genes and their impact on metabolic disorders and cancer *** associ-ations between circadian disruption and endocrine tumors,spanning breast,ovarian,testicular,prostate,thyroid,pituitary,and adrenal gland cancers,are *** work is associated with increased breast cancer risk,with PER genes influencing tumor progression and drug *** gene expression correlates with cisplatin resistance in ovarian cancer,while factors like aging and intermittent fasting affect prostate *** review underscored the intricate interplay between circadian rhythms and cancer,involving the regulation of the cell cycle,DNA repair,metabolism,immune function,and the tumor *** advocated for integrating biological timing into clinical consider-ations for personalized healthcare,proposing that understanding these connec-tions could lead to novel therapeutic *** supports circadian rhythm-focused therapies,particularly chronotherapy,for treating endocrine *** review called for further research to uncover detailed connections between circadian clocks and cancer,providing essential insights for targeted *** emphasized the importance of pub

关键词： Circadian rhythm Circadian disruption Shift work CLOCK gene Cancer Endocrine tumors Chronotherapy

Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?

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World Journal of Methodology 2024年第2期14卷 127-133页

作者： Serafeim-Chrysovalantis Kotoulas Kalliopi Domvri Alexandros Tsantos Ioanna Papagiouvanni Anastasia Michailidou Dionisios G Spyratos konstantinos Porpodis Ioanna Grigoriou Despina Papakosta Athanasia Pataka Intensive Care Unit Hippokration General HospitalThessaloniki 54642Greece Pulmonary Department-Oncology Unit Aristotle University of ThessalonikiThessaloniki 57010Greece 2nd Department of Internal Medicine General Hospital of Thessaloniki‘’Ippokration’’Thessaloniki 54642Greece Fourth Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642ThessalonikiGreece 2nd Propaedeutic Department of Internal Medicine General Hospital of Thessaloniki“Ippokration”Thessaloniki 54642Greece Department of Pulmonary Aristotle University of ThessalonikiThessaloniki 57001Greece Respiratory Failure Clinic Papanikolaou General HospitalThessloniki 57001Greece Department of Respiratory Medicine Aristotle Univ ThessalonikiSch MedG Papanikolaou HospResp Failure UnitAristotle University of ThessalonikiThessaloniki 57001Greece

BACKGROUND Electronic cigarettes(ECs)have been promoted as alternatives to traditional *** investigate ECs’effects on respiratory system,especially in patients with respiratory *** We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy *** were subjucted to pulmonary function tests(PFTs),impulse oscillometry(IOS),fraction exhaled Nitric Oxide(FeNO),exhaled breathe condensate(EBC)and biomarker measurements before and after vaping one nicotinecontaining *** The increase in FeNO 30 minutes after EC,reflecting airway inflammation,significantly correlated with increase of residual volume(RV),total lung capacity,respiratory impedance at 5 Hz(Z5Hz)and respiratory resistance at 5 and 20 Hz(R5Hz and R20Hz).No significant correlations were found between EBC biomarkers'changes and respiratory *** This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.

关键词： Asthma Electronic cigarette Airway inflammation Lung function Impulse oscillometry FeNO

Improving service regularity for high-frequency bus services with rescheduling and bus holding

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第5期8卷 778-794页

作者： konstantinos Gkiotsalitis Centre for Transport Studies Department of Civil EngineeringUniversity of TwenteEnschedeThe Netherlands

In high-frequency bus services,maintaining the service regularity is a critical *** service regularity is directly related to the excessive waiting times(EWT) of passengers at bus *** a regular service,the EWT is minimized resulting in even headways between consecutive buses of the same *** this study,we propose the combined use of rescheduling and bus holding to improve passengers’ excessive waiting *** model the dynamic rescheduling and bus holding problem as an integer nonlinear program(INLP) and we prove its *** model considers the constraints of the original timetable e an issue that is usually neglected from most dynamic control *** the NP-hardness of our mathematical program,we introduce a problem-specific heuristic to explore efficiently the solution *** convergence rate of the proposed heuristic is tested against other solution methods,including simulated annealing with linear cooling,hill climbing and branch and bound with multi-start sequential quadratic *** addition,simulations with the use of actual operational data from a major bus operator in Asia Pacific demonstrate an up to 35% potential EWT improvement for a minor increase of 6% to the travel times of onboard passengers.

关键词： Traffic engineering Rescheduling Bus holding Dynamic control Combinatorial optimization Bus bunching

Billroth II anastomosis combined with brown anastomosis reduce reflux gastritis in gastric cancer patients

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World Journal of Methodology 2024年第1期14卷 71-79页

作者： Grigorios Christodoulidis Marina Nektaria Kouliou konstantinos Eleftherios Koumarelas konstantinos Argyriou Garyfallia Apostolia Karali konstantinos Tepetes Department of General Surgery University Hospital of LarissaLarissa 41110Greece Department of Gastroenterology University Hospital of LarissaLarissa 41334Greece

BACKGROUND The surgeon performing a distal gastrectomy,has an arsenal of reconstruction techniques at his disposal,Billroth II among *** anastomosis performed during a Billroth II procedure has shown evidence of superiority over typical Billroth II,in terms of survival,with no impact on postoperative morbidity and *** To compare Billroth II vs Billroth II and Braun following distal gastrectomy,regarding their postoperative *** Patients who underwent distal gastrectomy during 2002-2021,were separated into two groups,depending on the surgical technique used(Billroth II:74 patients and Billroth II and Braun:28 patients).The daily output of the nasogastric tube(NGT),the postoperative day that NGT was removed and the day the patient started per os feeding were *** complications were at the same time *** were then statistically *** There was difference in the mean NGT removal day and the mean start feeding *** total postoperative NGT output was lower in Braun group(399.17 mL vs 1102.78 mL)and it was statistically significant(P<0.0001).Mean daily postoperative NGT output was also statistically significantly lower in Braun *** to the postoperative follow up 40 patient experienced bile reflux and alkaline gastritis from the Billroth II group,while 9 patients who underwent Christodoulidis G et *** II and Braun compared with Billroth II WJM https://*** 2 March 20,2024 Volume 14 Issue 1 Billroth II and Braun anastomosis were presented with the same conditions(P<0.05).CONCLUSION There was evidence of superiority of Billroth II and Braun vs typical Billroth II in terms of bile reflux,alkaline gastritis and NGT output.

关键词： Billroth II Billroth II and Braun Reconstruction techniques Gastrectomy Distal gastrectomy

Spatiotemporal graph queries on geographic databases under a conceptual abstraction scale

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Geo-Spatial Information Science 2014年第2期17卷 110-118页

作者： Panagiotis PARTSINEVELOS konstantinos PAPADAKIS konstantinos MAKANTASIS Laboratory of Geodesy and Geomatics Engineering Department of Mineral Resources EngineeringTechnical University of CreteUniversity CampusChania 73100CreteGreece Department of Electronic and Computer Engineering Technical University of CreteUniversity CampusChania 73100CreteGreece Computer Vision and Decision Support Laboratory Production and Management DepartmentTechnical University of CreteUniversity CampusChania 73100CreteGreece

Visual queries assist non-expert users to extract information from spatial databases in an intuitive and natural approach,making Geographic information systems comprehensive and efficient for a wide range of applications.A common visual means of querying takes the form of drawings or graphs,under which many spatial ambiguity and translation errors *** this study,common query attributes extracted from user graphs such as spatial topology,size,cardinality,and proximity are regarded under a conceptual moderation ***,the system/user may concentrate on various conceptual combinations of ***,time is incorporated to support spatiotemporal queries for changing scenes and moving ***,relative,and absolute scaling is possible according to the data-set and application at *** theoretic approach is implemented under a prototype user interface system,called *** this prototype,a user may extract scene-based relations in an automatically inferred fashion,or include single object-oriented relations when all possible relations seem ***,a natural language description of the query is extracted upon which the user may select the desired query *** on a spatial database demonstrates the concepts of predefined draw objects,scaling relaxation,conceptual abstraction,and scene,object-and textual-oriented transitions that promote query expressiveness and restrain ambiguities.

关键词： visual queries spatial topology spatiotemporal queries graph and sketch queries query by example

Supporting decision-making processes for selecting fire safety measures for road tunnels

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第3期9卷 473-489页

作者： Panagiotis Ntzeremes konstantinos Kirytopoulos School of Mechanical Engineering National Technical University of AthensAthens 10682Greece

Selecting fires safety measures for road tunnels relies mainly on strict regulatory requirements. However, the choice should also be based on many different criteria and ranking of alternatives should take place. Existing methods exhibit lack in dealing rigorously with measures’ selection amongst different alternatives. This paper contributes to the body of knowledge by proposing a novel method, named EVADE, which aims to incorporate diverse stakeholders’ views and provide a meaningful ranking of *** do so, it estimates the tunnel level of safety taking into account only any standard measures existing. Subsequently, the performance of additional measures is ***, a list of the most significant criteria that are valuable to judge the appropriateness of selected measures is introduced. The relative importance amongst the decision criteria is calculated through the Analytic Hierarchy Process, based on the expert opinion. Sensitivity analysis through Monte Carlo simulation is embedded to allow for a meaningful prioritization of the decision criteria. Thus, the alternatives’ ranking comes as a distribution instead of a single number, providing the decision-maker richer information for selecting the most suitable measure(s) according to the specific tunnel situation. At last, a typical tunnel is examined to showcase the utilization of the method.

关键词： Road tunnel Critical infrastructure Decision-making Quantitative-risk-assessment

Effects of glucose-lowering agents on ischemic stroke

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World Journal of Diabetes 2017年第6期8卷 270-277页

作者： konstantinos Avgerinos konstantinos Tziomalos First Propedeutic Department of Internal Medicine Medical SchoolAristotle University of ThessalonikiAHEPA Hospital54636 ThessalonikiGreece

Diabetes mellitus(DM) is a major risk factor for cardiovascular events, including ischemic stroke. Moreover, ischemic stroke appears to be more severe in these patients and to be associated with less favorable outcomes. However, strict glycemic control does not appear to reduce the risk of ischemic stroke. On the other hand, newer glucose-lowering agents(glucagon-like peptide 1 receptor agonists and sodiumglucose cotransporter 2 inhibitors) reduced the risk of cardiovascular events in recent randomized, placebocontrolled trials. Semaglutide also reduced the risk of ischemic stroke. These benefits are independent of glucose lowering and might be due to the favorable effects of these agents on body weight and blood pressure. Pioglitazone also reduced the risk of recurrent stroke in patients with insulin resistance or type 2 DM but the unfavorable safety profile limits its use. In contrast, sulfonylureas and dipeptidyl peptidase 4 inhibitors have a neutral effect on cardiovascular morbidity and might be less attractive options in this high-risk population.

关键词： Antidiabetic treatment Ischemic stroke Cardiovascular events Glucose regulation Neuroprotection

Evaluating the role of risk assessment for road tunnel fire safety: A comparative review within the EU

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第3期6卷 282-296页

作者： Panagiotis Ntzeremes konstantinos Kirytopoulos School of Mechanical Engineering National Technical University of Athens Athens 15780 Greece School of Natural and Built Environments University of South Australia Adelaide South Australia 5001 Australia

Fire is the foremost critical event for road tunnels’ safety. Therefore, the European Commission introduced the Directive 2004/54/EC for enhancing tunnels’ safety since they constitute a key element of the Trans-European Road Network. The Directive has established a common ground for tunnels’ safety evaluation providing certain minimum requirements while introducing officially the use of risk assessment. Despite the signifi-cant progress, this paper illustrates that further efforts are needed. Through a comparative review of the risk assessment methods, questions about the level of harmonisation of the framework are raised. Moreover, considerable problems are highlighted, like the incorporation of the new trends emerging from the literature or the deficiencies on addressing significant issues of the analysis, such as the risk acceptance criteria and the behaviour of trapped-users. These problems can affect the risk assessment process causing both significant discrepancies and deficiencies at the estimated level of tunnels’ ***, thus, the deficiencies and limitations of the methods, this paper contributes to i) the discourse for initiating relevant studies to enhance tunnels’ fire safety in Europe and worldwide, and ii) the harmonisation of risk assessment methods.

关键词： Road tunnel Safety Fire Risk assessment

Liver iron content determination by magnetic resonance imaging

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World Journal of Gastroenterology 2010年第13期16卷 1587-1597页

作者： konstantinos Tziomalos Vassilios Perifanis 1st Propedeutic Department of Internal Medicine Medical School Aristotle University of Thessaloniki AHEPA University Hospital Thalassemia Unit Hippokration Hospital

Accurate evaluation of iron overload is necessary to establish the diagnosis of hemochromatosis and guide chelation treatment in transfusion-dependent anemia. The liver is the primary site for iron storage in patients with hemochromatosis or transfusion-dependent anemia, therefore, liver iron concentration (LIC) accurately re? ects total body iron stores. In the past 20 years, magnetic resonance imaging (MRI) has emerged as a promising method for measuring LIC in a variety of diseases. We review the potential role of MRI in LIC determination in the most important disorders that are characterized by iron overload, that is, thalassemia major, other hemoglobinopathies, acquired anemia, and hemochromatosis. Most studies have been performed in thalassemia major and MRI is currently a widely accepted method for guiding chelation treatment in these patients. However, the lack of correlation between liver and cardiac iron stores suggests that both organs should be evaluated with MRI, since cardiac disease is the leading cause of death in this population. It is also unclear which MRI method is the most accurate since there are no large studies that have directly compared the different available techniques. The role of MRI in the era of genetic diagnosis of hemochromatosis is also debated, whereas data on the accuracy of the method in other hematological and liver diseases are rather limited. However, MRI is a fast, non-invasive and relatively accurate diagnostic tool for assessing LIC, and its use is expected to increase as the role of iron in the pathogenesis of liver disease becomes clearer.

关键词： Thalassemia major Iron overload Magnetic resonance imaging Liver Hemochromatosis Desferrioxamine Deferiprone Deferasirox Thalassemia inter media Myelodysplastic syndromes