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Ibutilide and novel indexes of ventricular repolarization in persistent atrial fibrillation patients

World Journal of Cardiology 2013年第7期5卷 242-246页

作者： Panagiotis Korantzopoulos konstantinos P Letsas Anna Kotsia Giannis Baltogiannis Kallirroi Kalantzi konstantinos Kyrlas John A Goudevenos Department of Cardiology University of Ioannina Medical School45110 IoanninaGreece Second Department of Cardiology Evangelismos General Hospital of Athens10675 AthensGreece

AIM: To examine the effect of ibutilide on novel indexes of repolarization in patients with persistent atrial fibrillation (AF). METHODS: We studied consecutive patients scheduled for elective electrical cardioversion. Intravenous ibutilide (1+1mg) was administered before the electrical cardioversion while close electrocardiographic (ECG) monitoring was performed. ECG indexes such as corrected QT interval (QTc), the interval from the peak until the end of T wave (Tpe), and the Tpe/QT ratio were measured before ibutilide infusion and 10 min after the end of infusion. RESULTS: The final study population consisted of 20 patients (mean age: 67.1±9.9 years, 10 men). Six patients were cardioverted pharmacologically and did not proceed to electrical cardioversion. Two patientsdeveloped short non-sustained episodes of torsades de pointes ventricular tachycardia. All but one of the aforementioned ECG indexes increased significantly after ibutilide administration. In specific, the QTc interval increased from 442 ± 29 to 471 ± 37 ms (P=0.037), the Tpe interval in precordial leads from 96 ms (range 80-108 ms) to 101 ms (range 91-119 ms) (P=0.021), the Tpe interval in lead Ⅱ from 79 ms (range 70-88 ms) to 100 ms (range 87-104 ms) (P<0.001), the Tpe/QT ratio in precordial leads from 0.23 ms (range 0.18-0.26 ms) to 0.26 ms (range 0.23-0.28 ms) (P=0.028), and the Tpe interval dispersion from 25 ms (range 23-30 ms) to 35 ms (range 27-39 ms) (P=0.012). However, the Tpe/QT ratio in lead II did not change significantly. CONCLUSION: Ibutilide increases the duration and dispersion of ventricular repolarization. The prognostic value of Tpe and Tpe/QT in the setting of drug-induced proarrhythmia needs further study.

关键词： Ibutilide Ventricular repolarization Arrhythmic risk Proarrhythmia Dispersion of repolarization T peak-to-end T peak-to-end/QT ratio

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希腊克里特岛度假别墅

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现代装饰 2019年第7期 140-145页

作者： Nikos Lykoudis Ismene papappiliopoulou Marina Gkolfomitsou konstantinos Platyrrachos Katerina Argyropoulou Eleftheria Chatzi George Anastassakis 苏烨 Paly Architects

在克里特岛上,有一座倚靠在山岩之间,面朝大海,接受阳光洗礼的度假别墅,它的设计与构造创造出了一种与自然对话的方式。这座住宅别墅几乎倚靠在科图洛斯角山顶的岩石上,主要是由泥土材料构建而成,与户外的景观融为一体,细长的结构起到... 详细信息

在克里特岛上,有一座倚靠在山岩之间,面朝大海,接受阳光洗礼的度假别墅,它的设计与构造创造出了一种与自然对话的方式。这座住宅别墅几乎倚靠在科图洛斯角山顶的岩石上,主要是由泥土材料构建而成,与户外的景观融为一体,细长的结构起到抵御北风的作用,视野广阔,还能在住宅里俯瞰到南面的克里特海。坚固的L形石墙延续山体的走势,成为另一种姿态,在潜移默化中定义了室内空间的所有布局。

关键词：克里特岛

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Academic hospital staff compliance with a fecal immunochemical test-based colorectal cancer screening program

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World Journal of Gastrointestinal Oncology 2016年第8期8卷 629-634页

作者： Georgia Vlachonikolou Paraskevas Gkolfakis Athanasios D Sioulas Ioannis S Papanikolaou Anastasia Melissaratou Giannis-Aimant Moustafa Eleni Xanthopoulou Gerasimos Tsilimidos Ioanna Tsironi Paraskevas Filippidis Chrysoula Malli George D Dimitriadis konstantinos Triantafyllou Hepatogastroenterology Unit Second Department of Internal Medicine and Research Institute Attikon University General Hospital Medical School University of Athens

AIM: To measure the compliance of an Academic Hospital staff with a colorectal cancer(CRC) screening program using fecal immunochemical test(FIT).METHODS: All employees of 'Attikon' University General Hospital aged over 50 years were thoroughly informed by a team of physicians and medical students about the study aims and they were invited to undergo CRC screening using two rounds of FIT(DyoniFOB~ Combo H, DyonMed SA, Athens, Greece). The tests were provided for free and subjects tested positive were subsequently referred for colonoscopy. One year after completing the two rounds, participants were asked to be re-screened by means of the same ***: Among our target population consisted of 211 employees, 59(27.9%) consented to participate, but only 41(19.4%) and 24(11.4%) completed the first and the second FIT round, respectively. Female gender was significantly associated with higher initial participation(P = 0.005) and test completion- first and second round-(P = 0.004 and P = 0.05) rates, respectively. Phy sician’s(13.5% vs 70.2%, P < 0.0001) participation and test completion rates(7.5% vs 57.6%, P < 0.0001 for the first and 2.3% vs 34%, P < 0.0001 for the second round) were significantly lower compared to those of the administrative/technical staff. Similarly, nurses participated(25.8% vs 70.2%, P = 0.0002) and completed the first test round(19.3% vs 57.6%, P = 0.004) in a significant lower rate than the administrative/technical staff. One test proved false positive. No participant repeated the test one year ***: Despite the well-organized, guided and supervised provision of the service, the compliance of the Academic Hospital personnel with a FIT-based CRC screening program was suboptimal, especially among physicians.

关键词： Colorectal cancer Screening Academic hospital staff Fecal immunochemical test Compliance

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展望5型磷酸二酯酶抑制剂的未来

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中华男科学杂志 2010年第2期16卷 191-191页

作者： konstantinos G Petros P 田斌群不详武汉大学中南医院 430071

5型磷酸二酯酶（PDE5）抑制剂起先被研究用于心血管疾病,而后则被研发并获准用于按需治疗勃起功能障碍（ED）。数年以前,西地那非被批准用于治疗肺动脉高压,因此重新引起了研究者对PDE5抑制剂治疗心血管疾病的兴趣。而且他达拉非每日一... 详细信息

5型磷酸二酯酶（PDE5）抑制剂起先被研究用于心血管疾病,而后则被研发并获准用于按需治疗勃起功能障碍（ED）。数年以前,西地那非被批准用于治疗肺动脉高压,因此重新引起了研究者对PDE5抑制剂治疗心血管疾病的兴趣。而且他达拉非每日一次的治疗方案也被用于治疗ED。鉴于PDE5在人体内的广泛分布并涉及多种生理功能,PDE5抑制剂未来的发展前景又将是怎样的呢？

关键词： 5型磷酸二酯酶抑制剂 PDE5抑制剂心血管疾病按需治疗勃起功能障碍肺动脉高压西地那非治疗方案

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Insulin action in muscle and adipose tissue in type 2 diabetes:The significance of blood flow

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World Journal of Diabetes 2015年第4期6卷 626-633页

作者： Vaia Lambadiari konstantinos Triantafyllou George D Dimitriadis Second Department of Internal Medicine Research Institute and Diabetes CentreAttikon University General HospitalAthens University Medical School

Under normal metabolic conditions insulin stimulates microvascular perfusion(capillary recruitment) of skeletal muscle and subcutaneous adipose tissue and thus increases blood flow mainly after meal ingestion or physical *** helps the delivery of insulinitself but also that of substrates and of other signalling molecules to multiple tissues beds and facilitates glucose disposal and lipid *** effect is impaired in insulin resistance and type 2 diabetes early in the development of metabolic dysregulation and reflects early-onset endothelial *** of insulin to increase muscle and adipose tissue blood flow results in decreased glucose *** fat depots,a blunted postprandial blood flow response will result in an insufficient suppression of lipolysis and an increased spill over of fatty acids in the circulation,leading to a more pronounced insulin resistant state in skeletal *** defect in blood flow response is apparent even in the prediabetic state,implying that it is a facet of insulin resistance and exists long before overt hyperglycaemia *** following review intends to summarize the contribution of blood flow impairment to the development of the atherogenic dysglycemia and dyslipidaemia.

关键词： Insulin resistance Muscle blood flow Glucoseuptake Adipose tissue blood flow Diabetes

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Machine Learning Meets the Semantic Web

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Artificial Intelligence Advances 2021年第1期3卷 71-78页

作者： konstantinos Ilias Kotis Konstantina Zachila Evaggelos Paparidis University of the Aegean 81100Greece

Remarkable progress in research has shown the efficiency of Knowledge Graphs(KGs)in extracting valuable external knowledge in various domains.A Knowledge Graph(KG)can illustrate high-order relations that connect two objects with one or multiple related *** emerging Graph Neural Networks(GNN)can extract both object characteristics and relations from *** paper presents how Machine Learning(ML)meets the Semantic Web and how KGs are related to Neural Networks and Deep *** paper also highlights important aspects of this area of research,discussing open issues such as the bias hidden in KGs at different levels of graph representation。

关键词： Knowledge graph Semantic web Ontology Machine learning Deep learning Graph neural networks

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Current imaging strategies for the evaluation of uterine cervical cancer

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World Journal of Radiology 2016年第4期8卷 342-354页

作者： Charis Bourgioti konstantinos Chatoupis Lia Angela Moulopoulos Department of Radiology School of MedicineNational and Kapodistrian University of AthensAretaieion Hospital

Uterine cervical cancer still remains an important socioeconomic issue because it largely affects women of reproductive *** is highly depended on extent of the disease at diagnosis and,therefore,accurate staging is crucial for optimal *** cancer is clinically staged,according to International Federation of Gynecology and Obstetrics guidelines,but,currently,there is increased use of cross sectional imaging modalities [computed tomography(CT),magnetic resonance imaging(MRI),positron emission tomography-CT(PET-CT)] for the study of important prognostic factors like tumor size,parametrial invasion,endocervical extension,pelvic side wall or adjacent/distal organs involvement and lymph node *** indications also include cervical cancer follow-up,evaluation of tumor response to treatment and selection of suitable candidates for less radical surgeries like radical trachelectomy for fertility *** preferred imaging method for local cervical cancer evaluation is MRI;CT is equally effective for evaluation of extrauterine spread of the *** shows high diagnostic performance for the detection of tumor relapse and metastatic lymph *** aim of this review is to familiarize radiologists with the MRI appearance of cervical carcinoma and to discuss the indications of cross sectional imaging during the course of the disease in patients with cervical carcinoma.

关键词： Cervical cancer Computed tomography Positron emission tomography/computed tomography Magnetic resonance imaging Tumor staging

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Electrophysiologic testing guided risk stratification approach for sudden cardiac death beyond the left ventricular ejection fraction

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World Journal of Cardiology 2016年第1期8卷 112-113页

作者： konstantinos A Gatzoulis Dimitris Tsiachris Petros Arsenos Dimitris Tousoulis First Cardiology Division Hippokration Hospital University of Athens

Sudden cardiac death threats ischaemic and dilated cardiomyopathy patients. Anti- arrhythmic protection may be provided to these patients with implanted cardiac defibrillators(ICD), after an efficient risk stratification approach. The proposed risk stratifier of an impaired left ventricular ejection fraction has limited sensitivity meaning that a significant number of victims will remain undetectable by this risk stratification approach because they have a preserved left ventricular systolic function. Current risk stratification strategies focus on combinations of non invasive methods like T wave alternans, late potentials, heart rate turbulence, deceleration capacity and others, with invasive methods like the electrophysiologic study. In the presence of an electrically impaired substrate with formed post myocardial infarction fibrotic zones, programmed ventricular stimulation provides important prognostic information for the selection of the patients expected to benefit from an ICD implantation, while due to its high negative predictive value, patients at low risk level may also be detected. Clustering evidence from different research groups and electrophysiologic labs support an electrophysiologic testing guided risk stratification approach for sudden cardiac death.

关键词： Electrophysiologic study Risk stratification Sudden cardiac death Myocardial infarction Preserved ejection fraction

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Factors Influencing the Incidence of Heart Disease

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Journal of Pharmacy and Pharmacology 2022年第4期10卷 140-143页

作者： Iliadis Christos Tsaloglidou Areti Koukourikos konstantinos Kourkouta Lambrini Private Diagnostic Health Center of Thessaloniki 54623Greece Nursing Department International Hellenic UniversityThessaloniki57400Greece

Introduction:Understanding the causes of heart disease is a relatively new field in *** fact,heart disease was relatively rare before the early ***:The aim of this review study is to investigate the risk factors associated with the development of heart disease and its *** Methodology:A scrutinized review of the Greek and international literature was carried *** material of the study was manuscripts on the subject found in Greek and international electronic databases such as:Google Scholar,Mednet,PubMed and the Association of Hellenic Academic libraries(HEAL-Link).Results:The risk factors for the development of heart disease are metabolic factors,i.e.,hypertension,diabetes,cholesterol and obesity;environmental factors,i.e.,smoking,lack of physical activity or exercise,poor dietary patterns and alcohol consumption;and other factors such as age,gender,heredity,socioeconomic status and psychological ***:Heart diseases are multifactorial diseases and the only way to successfully treat them is to take into account all the risk factors for their development,and to treat them systematically.

关键词： Factors etiology incidence heart disease prevalence

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CRL4Wdr70 facilitates chromatin recruitment of Exo1 to promote long-range resection of double strand breaks

CRL4Wdr70 facilitates chromatin recruitment of Exo1 to promo...

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2014年第七届中国模式真菌研讨会

作者：曾鸣 Laifeng Ren Ken'Ichi Mizuno konstantinos Nestoras Haibin Wang Zizhi Tang Xiaobo Wang Liandi Guo Daochun Kong Qun He Lilin Du Antony M.Carr Cong Liu Sussex Centre for Genome Damage and Stability Centre School of Life SciencesUniversity of Sussex West China Second University Hospital Sichuan University

Homologous recombination(HR)is important for repairing potentially lethal DNA double strand breaks(DSBs)in the context of *** are resected by the combination action of the Mrell-Rad50-Nbsl(MRN),Ctpl,Exol and Rqhl-Top3-Dna2 factors to form the ssDNA substrates which initiate *** these DNA processing enzymes navigate nucleosome-packaged DNA remains poorly *** find that the fission yeast DCAF protein,Wdr70,is recruited to DSBs in complex with Ddbl and the Cullin4 ubiquitin ligase(CRL4).CRL4recruitment stimulates H2B lysine 119 mono-ubiquitination(uH2B)of chromatin both proximal

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