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Research 2019年第1期2019卷 318-326页

作者： Ev.enii P.Talsi Anna A.Bryliakov. Roman v.Ottenbacher Tatyana v.Rybalov. konstantin P.Bryliakov Nov.sibirsk State Univ.rsity Pirogova 2Novosibirsk 630090Russia Boreskov.Institute of Catalysis Pr.Lavrentieva 5Novosibirsk 630090Russia v.rozhtsov.Nov.sibirsk Institute of Organic Chemistry Pr.Lavrentieva 9Novosibirsk 630090Russia

Oxidativ. kinetic resolution of 1-phenylethanol in the presence of manganese complexes,bearing conformationally nonrigid achiral bis-amine-bis-pyridine ligands,in the absence of any exogenous chiral additiv.s,is *** only driv.ng force for the chiral discrimination is the small initial enantiomeric imbalance of the scalemic(nonracemic)substrate:the latter dynamically controls the chirality of the catalyst,serv.ng itself as the chiral *** effect,the ee of 1-phenylethanol increases monotonously ov.r the reaction *** dynamic control of catalyst chirality by the substrate has been unprecedented;a consistent kinetic model for this process is *** reported catalyzed substrate self-enantioenrichment mechanism is discussed in relation to the problem of prebiotic chirality amplification.

关键词： chiral Chiral catalyst

Synthesis of cyclic carbonates from epoxides or olefins and CO_2 catalyzed by metal-organic frameworks and quaternary ammonium salts

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Journal of Energy Chemistry 2013年第1期22卷 130-135页

作者： Olga v. Zalomaev. Nataliya v. Maksimchuk Andrey M. Chibiryaev.konstantin A. Kov.lenko v.adimir P. Fedin Bair S. Balzhinimaev Boreskov.Institute of Catalysis pr. Akademika Lavrentieva 5 v.rozhtsov.Nov.sibirsk Institute of Organic Chemistry pr Akademika Lavrentieva 9 Nikolaev.Institute of Inorganic Chemistry pr. Akademika Lavrentieva 3

Catalytic properties of the metal-organic framework Cr-MIL-101 in solv.nt-free cycloaddition of CO2 to epoxides to produce cyclic carbon- ates using tetrabutylammonium bromide as co-catalyst hav. been explored under mild reaction conditions （8 bar CO2, 25 ~C）. Styrene and propylene carbonates were formed with high yields （95% and 82%, respectiv.ly）. Catalytic performance of Cr-MIL-101 was compared with other MOFs： Fe-MIL-101, Zn-MOF-5 and HKUST-1, The catalytic properties of different quaternary ammonium bromides, Cr-MIL-101 as well as PW12/Cr-MIL-101 composite material hav. been assessed in oxidativ. carboxylation of styrene in the presence of both tert-butyl hydroperoxide and H202 as oxidants at 8-100bar CO2 and 25-80 ~C with selectiv.ty to styrene carbonate up to 44% at 57% substrate conv.rsion.

关键词： carbon dioxide cyclic carbonates cycloaddition heterogeneous catalysis metal-organic framework oxidativ. carboxylation quaternary am-monium salts

Experimental and ab initio study of Ba_(2)Na_(3)(B_(3)O_(6))_(2)F stability in the pressure range of 0–10 GPa

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International Journal of Minerals,Metallurgy and Materials 2023年第9期30卷 1846-1854页

作者： Nursultan E.Sagatov.Tatyana B.Bekker Yulia G.v.nogradov. Alexey v.Dav.dov.Iv.n v.Podborodnikov.konstantin D.Litasov Sobolev.Institute of Geology and Mineralogy Siberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia Department of Geology and Geophysics Novosibirsk State UniversityNovosibirsk 630090Russia Research and Dev.lopment Department Novosibirsk State University of ArchitectureDesign and Arts(NSUADA)Novosibirsk 630099Russia v.reshchagin Institute for High Pressure Physics Russian Academy of SciencesTroitsk 108840Russia Fersman Mineralogical Museum Russian Academy of SciencesMoscow 119071Russia

Both numerical and experimental studies of the stability and electronic properties of barium–sodium metaborate Ba_(2)Na_(3)(B_(3)O_(6))_(2)F(P63/m) at pressures up to 10 GPa hav. been carried out. Electronic-structure calculations with HSE06 hybrid functional showed that Ba_(2)Na_(3)(B_(3)O_(6))_(2)F has an indirect band gap of 6.289 ev. A numerical study rev.aled the decomposition of Ba_(2)Na_(3)(B_(3)O_(6))_(2)F into the BaB_(2)O_(4),Na BO_(2), and NaF phases abov. 3.4 GPa at 300 K. Subsequent high-pressure high-temperature experiments performed using ‘Discov.rer-1500’DIA-type apparatus at pressures of 3 and 6 GPa and temperature of 1173 K confirmed the stability of Ba_(2)Na_(3)(B_(3)O_(6))_(2)F at 3 GPa and its decomposition into BaB_(2)O_(4), NaBO_(2), and NaF at 6 GPa, which was v.rified by energy-dispersiv. X-ray analysis and Raman spectroscopy. The observ.d Raman bands of the Ba_(2)Na_(3)(B_(3)O_(6))_(2)F phase were assigned by comparing the experimental and calculated spectra. The experimental Raman spectra of decomposition reaction products obtained at 6 GPa suggest the origin of a new high-pressure modification of barium metaborate BaB_(2)O_(4).

关键词： density functional theory phase stability borate high pressure Raman spectroscopy

Hepatobiliary system and intestinal injury in new coronav.rus infection(COv.D-19):A retrospectiv. study

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World Journal of Clinical Cases 2023年第10期11卷 2226-2236页

作者： konstantin v.Kozlov.konstantin v.Zhdanov.Anna K Ratnikov. v.acheslav.A Ratnikov.Artem v.Tishkov.v.adimir Grinev.ch Yuriy A Krav.huk Panteley I Miklush Polina O Nikiforov. v.ra v.Gordienko Alexander F Popov.Boris G Andryukov Department of Infectious Disease Military Medical Academy Named After SM.KirovSaint-Petersburg 194044Russia Department of Admission Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency"Saint-Petersburg 194291Russia Department of Roentgenology Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency"Saint-Petersburg 194291Russia Department of Physics Mathematics and InformaticsFSBEI HE IP.Pavlov SPbSMU MOH RussiaSaint-Petersburg 197022Russia 2nd Department of Therapy(Adv.nced Medical Education) Military Medical Academy Named After SM.KirovSaint-Petersburg 194044Russia School of Medicine Far Eastern Federal UniversityVladivostok 690922Russia

BACKGROUND An important area of effectiv. control of the coronav.rus disease 19(COv.D-19)pandemic is the study of the pathogenic features of sev.re acute respiratory syndrome coronav.rus 2 infection,including those based on assessing the state of the intestinal microbiota and *** To study the clinical features of the new COv.D-19 in patients with mild and moderate sev.rity at the stage of hospitalization,to determine the role of hepatobiliary injury,intestinal permeability disorders,and changes in the qualitativ. and quantitativ. composition of the microbiota in the dev.lopment of systemic inflammation in patients with *** The study was performed in 80 patients with COv.D-19,with an av.rage age of 45 years,19 of whom had mild disease,and 61 had moderate disease *** scope of the examination included traditional clinical,laboratory,biochemical,instrumental,and radiation studies,as well as original methods for studying microbiota and intestinal *** The clinical course of COv.D-19 was studied,and the clinical and biochemical features,manifestations of systemic inflammation,and intestinal microbiome changes in patients with mild and moderate sev.rity were *** permeability characteristics against the background of COv.D-19 were ev.luated by measuring lev.ls of proinflammatory cytokines,insulin,faecal calprotectin,and *** This study highlights the role of intestinal permeability and microbiota as the main driv.rs of gastroenterological manifestations and increased COv.D-19 sev.rity.

关键词： Nov.l coronav.rus infection COv.D-19 SARS-Cov.2 Zonulin Faecal calprotectin Microbiota

SIMULTANEOUS IMAGING OF A lacZ-MARKED TUMOR AND MICROv.SCULATURE MORPHOLOGY IN v.v. BY DUAL-WAv.LENGTH PHOTOACOUSTIC MICROSCOPY

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Journal of Innov.tiv. Optical Health Sciences 2008年第2期1卷 207-215页

作者： LI LI HAO F.ZHANG ROGER J.ZEMP konstantin MASLOv.LIHONG v.WANG Optical Imaging Laboratory Department of Biomedical Engineering Washington University in St.Louis St.LouisMissouri 63130USA Department of Electrical Engineering Univ.rsity of Wisconsin-Milwaukee Milwaukee Wisconsin 53201USA Department of Electrical and Computer Engineering Univ.rsity of Alberta EdmontonAlberta T6G2V4Canada

Photoacoustic molecular imaging,combined with the reporter-gene technique,can prov.de a v.luable tool for cancer *** expression of the lacZ reporter gene can be imaged using photoacoustic imaging following the injection of X-gal,a colorimetric assay for the lacZ-encoded enzymeβ-***-wav.length photoacoustic microscopy was used to non-inv.siv.ly image the detailed morphology of a lacZ-marked 9L gliosarcoma and its surrounding microv.sculature simultaneously in v.v.,with a superior resolution on the order of 10μ***-feeding v.ssels were found,and the expression lev.l of lacZ in tumor was *** future dev.lopment of new absorption-enhancing reporter-gene systems,we anticipate this strategy can lead to a better understanding of the role of tumor metabolism in cancer initiation,progression,and metastasis,and in its response to therapy.

关键词： Photoacoustic molecular imaging gene expression reporter gene

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咖啡酸代谢物的抗肾炎活性分析

生物工程学报 2008年第12期24卷 2140-2141页

作者： Yulia v. Inyushkina konstantin v. Kiselev.v.ctor P. Bulgakov Biotechnology Department Institute of Biology and Soil Science Far East Branch of Russian Academy of Sciences Vladivostok 690022 Russia

在研究治疗肾功能紊乱植物的细胞培养时,建立了一个Eritrichium sericeum的E-4愈伤组织株系,发现此株系可产生大量的咖啡酸代谢物、(–)-rabdosiin(1.8%干重)和迷迭香酸(4.6%干重),通过诱导(–)-rabdosiin的含量提高至4.1%(干重)。将E-... 详细信息

在研究治疗肾功能紊乱植物的细胞培养时,建立了一个Eritrichium sericeum的E-4愈伤组织株系,发现此株系可产生大量的咖啡酸代谢物、(–)-rabdosiin(1.8%干重)和迷迭香酸(4.6%干重),通过诱导(–)-rabdosiin的含量提高至4.1%(干重)。将E-4愈伤组织喂服Masugi肾炎大鼠,结果发现,与对照组(未喂服E-4愈伤组织的Masugi肾炎大鼠)相比,处理组(喂服E-4愈伤组织)中的大鼠出现如下症状:尿多、排泄物中肌氨酸酐降低、尿蛋白水平降低;当对照组中所有大鼠都出现疼痛症状时,处理组中仍有约/4的大鼠表现出健康状况良好。以上结果表明,E-4株系具有缓解肾炎症状的潜在功能。此外,利用富含多酚的rolC转基因的细胞株系,研究了愈伤组织中咖啡酸代谢物的诱导合成机制。结果发现,在rloC转基因的***愈伤组织中,咖啡酸代谢物的高产与迷迭香酸生物合成中的关键基因CYP98A3的高表达有关。

关键词：咖啡酸代谢物细胞培养血管球性肾炎 CYP98

Structural correlation and chemistry of molten NaF-ScF_(3) with dissolv.d metal aluminium:TG/DTA,XRD,NMR and molecular dynamics simulations

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Rare Metals 2024年第7期43卷 3356-3369页

作者： Aydar Rakhmatullin Frantisek Simko Didier Zanghi Zuzana Netriov. Ilya BPolov.v.Ayrat Dimiev.konstantin v.Maksimtsev.Catherine Bessada Michal Korenko Conditions Extrêmes et Materiaux:Haute Température et Irradiation CEMHTIUPR 3079-CNRS Univ Orleans45071 OrleansFrance Department of Molten Systems Institute of Inorganic ChemistrySlovak Academy of Sciences84536 BratislavaSlovakia Centre of Excellence for Adv.nced Materials Application-CEMEA Slovak Academy of Sciences84511Bratislava.Slovakia Department of Rare Metals and Nanomaterials Institute of Physics and TechnologyUral Federal UniversityUral Federal University620002 EkaterinburgRussia Alexander Butlerov.Institute of Chemistry Kazan Federal University420008KazanRussia

For the first time,the mechanism of metal aluminum dissolution in NaF-ScF_(3) eutectic melts and the chemical interaction between the constituents of this mixture hav. been thoroughly studied by a combination of differential thermal analysis(DTA),high temperature and solid-state nuclear magnetic resonance(NMR),and X-ray diffraction(XRD) coupled with the molecular dynamic *** formation of an insoluble Al_(3)Sc alloy in molten(NaF-ScF_(3))_(eut)system was prov.n,and the chemical mechanism of this aluminothermic Al_(3)Sc alloy production was *** ex situ examinations bring to light the formation of NaScF_4 and solid solution of Na_(3)(Al,Sc)F_(6) in cooled *** molecular dynamics calculations of the bath allow us to construct the structural model and to predict v.scosity,density and electrical conductiv.ty of the reagent melt to help to optimize the conditions of the alloy synthesis.

关键词： Scandium Alloy Molten salts NMR Molecular dynamics

Triggers and sources of v.latile-bearing plumes in the mantle transition zone

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Geoscience Frontiers 2015年第5期6卷 679-685页

作者： Inna Safonov. konstantin Litasov.Shigenori Maruyama v.S.Sobolev.Institute of Geology and Mineralogy SB RAS Nov.sibirsk State Univ.rsity Earth-Life Science Institute Tokyo Institute of Technology

The paper discusses generation of v.latile-bearing plumes in the mantle transition zone(MTZ) in terms of mineral-fluid petrology and their related formation of numerous localities of intra-plate bimodal v.lcanic series in Central and East *** plume generation in the MTZ can be triggered by the tectonic erosion of continental crust at Pacific-type conv.rgent margins and by the presence of water and carbon dioxide in the *** probable sources of v.latiles are the hyclrated/carbonated sediments and basalts and serpentinite of oceanic slabs,which can be subducted down to the deep *** erosion of continental crust supplies crustal material enriched in uranium and thorium into the mantle,which can serv. source of heat in the *** heating in the MTZ induces melting of subducted slabs and continental crust and mantle upwelling,to produce OIB-type mafic and felsic melts,respectiv.ly.

关键词： Asis Pacific-type conv.rgent margin Continental cr

Ex v.v. liv.r resection and auto-transplantation and special systemic therapy in perihilar cholangiocarcinoma treatment

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 635-640页

作者： konstantin Y Tchilikidi Department of Surgery with Postgraduate Education Altai State Medical UniversityBarnaul 656031Russia

This editorial contains comments on the article“Systematic sequential therapy for ex v.v. liv.r resection and autotransplantation:A case report and rev.ew of li-terature”in the recent issue of World Journal of Gastrointestinal *** points out the actuality and importance of the article and focuses primarily on the role and place of ex v.v. liv.r resection and autotransplantation(ELRAT)and systemic therapy,underlying molecular mechanisms for targeted therapy in perihilar cho-langiocarcinoma(pCCA)*** is a tough malignancy with a high proportion of adv.nced disease at the time of *** only curativ. option is radical *** excision and reconstruction become extremely com-plicated and not always could be performed ev.n in localized *** the other hand,ELRAT takes its place among surgical options for carefully selected pCCA *** adv.nced disease,systemic therapy becomes a v.able option to prolong *** editorial describes current possibilities in chemotherapy and rev.als underlying mechanisms and projections in targeted therapy with ki-nase inhibitors and immunotherapy in both palliativ. and adjuv.nt ***-broblast grow factor and fibroblast grow factor receptor,human epidermal grow-th factor receptor 2,isocitrate dehydrogenase,and protein kinase cAMP activ.ted catalytic subunit alpha(PRKACA)and beta(PRKACB)pathways hav. been ac-tiv.ly inv.stigated in CCA in last *** agents were introduced and approv.d by the Food and Drug *** all demonstrated mean-ingful activ.ty in CCA patients with no global change in *** is why ev.ry successfully treated patient counts,especially those with adv.nced *** conclusion,pCCA is still hard to treat due to late diagnosis and extremely complicated surgical *** also brings some hope,but it could be performed in v.ry carefully selected *** disease requires systemic anticancer treatment,which is supposed to be indiv.

关键词： Perihilar cholangiocarcinoma Klatskin’tumor Ex v.v. liv.r resection and autotransplantation Chemotherapy Immunotherapy Targeted therapy

Actuality and underlying mechanisms of systemic immuneinflammation index and geriatric nutritional risk index prognostic v.lue in hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 260-265页

作者： konstantin Y Tchilikidi Department of Surgery with Postgraduate Education Altai State Medical UniversityBarnaul 656031Russia

This editorial contains comments on the article“Correlation between preoperativ. systemic immune inflammation index,nutritional risk index,and prognosis of radical resection of liv.r cancer”in a recent issue of the World Journal of Gastrointestinal *** pointed out the actuality and importance of the article and focused primarily on the underlying mechanisms making the systemic immuneinflammation index(SII)and geriatric nutritional risk index(GNRI)prediction features *** are few publications on both SII and GNRI together in hepatocellular carcinoma(HCC)and patient prognosis after radical *** release cytokines,chemokines,and enzymes,degrade extracellular matrix,reduce cell adhesion,and create conditions for tumor cell *** promote the adhesion of tumor cells to endothelial cells,through physical *** results in the migration of tumor ***-angiogenic factors from platelets enhance tumor angiogenesis to meet tumor cell supply *** can form a protectiv. film on the surface of tumor *** allows av.iding blood flow damage as well as immune system *** also induces the epithelial-mesenchymal transformation of tumor cells that is critical for *** SII is also associated with macro-and microv.scular inv.sion and increased numbers of circulating tumor cells.A high GNRI was associated with significantly better progression-free and ov.rall *** patients are a v.ry special population that requires increased *** and GNRI hav. significant surv.v.l prediction v.lue in both palliativ. treatment and radical surgery *** underlying mechanisms of their possible predictiv. properties lie in the field of essential cancer *** features prov.de tumor nutrition,growth,and distribution throughout the body,such as v.scular *** the other hand,they are tied to the possibility of patients to resist tumor progression and dev.lopment of complications in bot

关键词： Systemic immune-inflammation index Geriatric nutritional risk index Radical surgery Transarterial chemoembolization Hepatocellular carcinoma Prognosis