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向海洋要淡水核能海水淡化项目在不断发展

国际原子能机构通报 2001年第2期43卷 5-8页

作者： t.konishi B.M.MISRA IAEA核动力处核技术发展科印度巴巴原子研究中心淡化部

世界的淡水需求在不断增加。2000年世界水论坛在其最新的预测中,特别强调了到2025年世界不断发展的城市对淡水的日益需求。淡水的可再生资源约为40 000立方千米。其中,仅提取了10%,消费5%。原因是,这些资源在地理上和季节上分布不均。显... 详细信息

世界的淡水需求在不断增加。2000年世界水论坛在其最新的预测中,特别强调了到2025年世界不断发展的城市对淡水的日益需求。淡水的可再生资源约为40 000立方千米。其中,仅提取了10%,消费5%。原因是,这些资源在地理上和季节上分布不均。显然,为了实现淡水资源的可持续发展和管理,应该使用所有可供使用的适当技术,包括核技术和相关技术。一种具体方案是海水淡化。一些国家正在增强其从海洋获取淡水的能力(见第6页图)。运行淡化设备所需的能量。

关键词：核能海水淡化淡水资源国际合作

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风藤中新的木脂素及其对一氧化氮产生的抑制作用

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国外医药（植物药分册） 2006年第3期21卷 123-123页

作者： konishi t [英] 徐嵬（摘）杨秀伟（校）

作者从风藤Piper futokadsura *** Zucc．地上部分的甲醇提取物中分得3个新的四氢呋喃木脂素futokadsurin A（1）、B（2）和C（3），同时还分得9个已知新木脂素类（-）-襄五脂素（4）、（-）-zuonin—A（5）、（-）-acuminatin（6）、（... 详细信息

作者从风藤Piper futokadsura *** Zucc．地上部分的甲醇提取物中分得3个新的四氢呋喃木脂素futokadsurin A（1）、B（2）和C（3），同时还分得9个已知新木脂素类（-）-襄五脂素（4）、（-）-zuonin—A（5）、（-）-acuminatin（6）、（-）-加尔巴新（7）、（-）-galbelgin（8）、（-）-加尔格拉文（9）、（-）-蔚瑞昆森（10）、桢楠素F（11）和（-）-machilusin（12）等。

关键词：新木脂素类抑制作用一氧化氮甲醇提取物四氢呋喃地上部分

长期使用FK506(他克莫斯)治疗全身型重症肌无力

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 32-32页

作者： konishi t. Yoshiyama Y. takomori M. Saido t. 王晓琳 Department of Neurology Utano National Hospital8 Ondoyama-cha Narutaki Kyoto 616-8255 Japan Dr.

Efficacy and safety of long term use of FK506 (2-4.5 mg/ day)for a maximum of two years were evaluated in 12 patients with generalised myasthenia gravis (MG) . At the end of the study,eight patients (67%) showed improvement in either MG score or Activities in Daily Living score, and prednisolone dosage could be redu ced in seven patients (58%), with a mean reduction ratio of 37%. Long term use of FK506 for MG can be more effective than short term administration, with no s erious side effects.

关键词：重症肌无力 FK506 身型 myasthenia gravis 莫斯短期使用强的松龙减少率 administration

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非增强血流抑制技术MR成像检测腔内动脉瘤修复术后内漏并发症:与增强Ct对比的可行性研究

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国际医学放射学杂志 2017年第2期 233-233页

作者： K.Mori t.Saida F.Sato Y.Uchikawa t.konishi t.Ishiguro 赵蕾 Department of Radiology Faculty of Medicine University of Tsukuba

摘要目的评价MR非增强运动敏感稳态(MSDE)准备平衡快速梯度回波(BtFE)序列用于腔内动脉瘤修复术(EVAR)后内漏检测的可行性。方法对46例主动脉和/或髂

关键词：修复术腔内动脉瘤血流抑制技术 MR 内漏 Ct

Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer

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World Journal of Gastroenterology 2022年第32期28卷 4649-4667页

作者： tomoyuki Fukami Atsushi Shiozaki toshiyuki Kosuga Michihiro Kudou Hiroki Shimizu takuma Ohashi tomohiro Arita Hirotaka konishi Shuhei Komatsu takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Yukiko Morinaga Eiichi konishi Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Pathology Kyoto City HospitalKyoto 604-8845Japan Department of Pathology Kyoto Prefectural University of MedicineKyoto 602-8566Japan

BACKGROUND Anoctamin 5(ANO5)/transmembrane protein 16E belongs to the ANO/transmembrane protein 16 anion channel *** comprise a family of plasma membrane proteins that mediate ion transport and phospholipid scrambling and regulate other membrane proteins in numerous cell *** studies have elucidated the roles and mechanisms of ANO5 activation in various cancer ***,it remains unclear whether ANO5 acts as a plasma membrane chloride channel,and its expression and functions in gastric cancer(GC)have not been *** to examine the role of ANO5 in the regulation of tumor progression and clinicopathological significance of its expression in *** Knockdown experiments using ANO5 small interfering RNA were conducted in human GC cell lines,and changes in cell proliferation,cell cycle progression,apoptosis,and cellular movement were *** gene expression profiles of GC cells were investigated following ANO5 silencing by microarray *** staining of ANO5 was performed on 195 primary tumor samples obtained from patients with GC who underwent curative gastrectomy between 2011 and 2013 at our *** Reverse transcription-quantitative polymerase chain reaction(PCR)and western blotting demonstrated high ANO5 mRNA and protein expression,respectively,in NUGC4 and MKN45 *** these cells,ANO5 silencing inhibited cell proliferation and induced *** addition,the knockdown of ANO5 inhibited G1-S phase progression,invasion,and *** results of the microarray analysis revealed changes in the expression levels of several cyclin-associated genes,such as CDKN1A,CDK2/4/6,CCNE2,and E2F1,in ANO5-depleted NUGC4 *** expression of these genes was verified using reverse transcription-quantitative *** staining revealed that high ANO5 expression levels were associated with a poor *** analysis identified high ANO5 expression as an independent prognostic fa

关键词： Anoctamin 5 Gastric cancer Cell cycle G1/S checkpoint Cell proliferation

Clinical characteristics of hepatoduodenal lymph node metastasis in gastric cancer

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World Journal of Gastroenterology 2015年第38期21卷 10866-10873页

作者： taisuke Imamura Shuhei Komatsu Daisuke Ichikawa toshiyuki Kosuga Kazuma Okamoto Hirotaka konishi Atsushi Shiozaki Hitoshi Fujiwara Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of Medicine

AIM: to assess the clinical features of hepatoduodenal lymph node(HDLN) metastasis and to clarify the optimal indication of HDLN ***: We investigated a total of 276 patients who underwent gastrectomy with extended lymphadenectomy,including HDLN dissection,for gastric cancer between 1999 and 2012. Of these,26 patients(9.4%) had HDLN metastasis. First,we investigated the clinicopathological characteristics,their perioperative clinical outcomes,such as postoperative complications,and prognostic outcomes between patients with and without HDLN metastasis. Second,we detected the prognostic factors,particularly in patients with HDLN metastasis. third,we assessed the therapeutic value of HDLN dissection to determine its optimal ***: the five-year overall survival rate of the patients with HDLN metastasis was 29%. Univariate and multivariate logistic regression analyses revealed that the tumour location(the middle or lower stomach [P = 0.005,OR = 5.88(95%CI: 1.61-38.1)] and p t category [t3 or t4,P = 0.017,OR = 4.45(95%CI: 1.28-21.3)] were independent risk factors for HDLNmetastasis. Cox proportional hazard analysis identified p N3 as an independent poor prognostic factor in the patients with HDLN metastasis [P = 0.021,HR = 5.17(95%CI: 1.8-292)]. For patients who underwent radical HDLN dissection,HDLN metastasis was a prognostic indicator in p N3 gastric cancer(P t not p N1-2(P = 0.602). Furthermore,the index of therapeutic value of HDLN dissection for gastric cancer in the middle or lower stomach and the upper stomach was 3.4 and 0.0,***: We suggest that HDLN dissection should be indicated for p N1 or p N2 gastric cancers located at the middle or lower stomach.

关键词： Gastric cancer Hepatoduodenal lymph node D2 lympha

Assessment the Optimal Effect of time of Repetition: Extrinsic Pulse Parameter on Gd-DtPA Enhanced, Spin-Echo t1-Weighted MR Images under Low Magnetic Field Strength

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第3期5卷 196-203页

作者： Bimali Sanjeevani Weerakoon toshiaki Osuga takehisa konishi Graduate School of Advanced Integration Science Chiba University Chiba Japan Department of Radiography/Radiotherapy Faculty of Allied Health Sciences University of Peradeniya Peradeniya Sri Lanka Center for Frontier Medical Engineering Chiba University Chiba Japan

the contrast agent concentration, the time of repetition (tR) and magnetic field strength are significant parameters that influence for the accurate signal intensity (SI) in quantitative Magnetic Resonance Imaging (MRI). therefore, this study was conducted to investigate and refine the dependence and the optimal effect of time of Repetition (tR) on the relationship between signal intensity and Gd-DtPA (Gadolinium-diethylene-triaminepenta-acetic acid) concentration, after applying two-dimensional (2D) Spin Echo (SE) pulse sequence under low-field MRI. In addition to that, the optimal concentration of Gd-DtPA at given sequence parameters at low-field MRI was also evaluated. A water-filled phantom was constructed for a range of Gd-DtPA concentrations (0 - 6 mmol/L) and the mean signal intensities (SIs) were assessed in the defined region of interest on t1-weighted images with different tR values (40 - 2000 ms). the generated signal-concentration curves for Gd-DtPA revealed that increasing tR was associated with the increase of the overall SIs and the maximum relationship between SI to concentration. Moreover, the required Gd-DtPA concentration to produce the maximum SI was associated to decrease with the increase of tR. In addition to this, the application of beyond 100 ms tR values in this study with relatively higher concentrations (beyond 1 - 2 mmol/L) has resulted predominantly non-linear patterns in the signal-concentration curves and it appears the saturation or decay of the SIs due to t2 effect. From these results, it can be suggested that the selection of relatively lower Gd-DtPA concentration ( mmol/L) with less than 800 ms (tR values can produce a better linear relationship between the concertation and SIs in t1-weighted SE low field contrast-enhanced MRI. Furthermore, this study also outlined the significance and necessity of the optimization of tR in SE sequence in low field MRI prior to a particular examination.

关键词： Gd-DtPA Concentration Spin Echo Pulse Sequence Signal Intensity time of Repetition t1-Weighted Images Low Field MRI

Postoperative Complications and Medium-term Follw-up of Laparoscopic-assisted Colectomy for Colorectal Cancer in a Personal Series

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Postoperative Complications and Medium-term Follw-up of Lapa...

Molecular Orientation Effect of Heat-Sealed PP Film on Peel Strength and Structure

第六次全国大肠癌会议暨中日韩大肠癌会议

作者： Fumio konishi Hideo Nagai Akihito Ozawa

＜正＞the intraoperative and postoperative complications of laparoscopic colectomy were analyzed in a consecutive personal series of 90 cases. the final histological diagnosis of these patients was adenoma of the colon in 8, carcinoma of the colon and rectum in 80, leiomyoma of the colon in 1 and Crohn’s disease in 1. the tNM staging of the carcinomas in our series was tis in 7, t1 in 21, t2 in 12 and t3 in 30, t4 in 10 cases. Six of the 90 cases had to be converted to open surgery. the reasons for conversion were

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Advances in Materials Physics and Chemistry 2015年第11期5卷 439-446页

作者： Kazushi Yamada Ken Miyata Reiichi konishi Kiyomi Okada tetsuya tsujii Kyoto Institute of technology Kyoto Japan Yamagata University Yamagata Japan Nakamoto Packs Co. Ltd. Osaka Japan PerkinElmer Japan Co. Ltd. Osaka Japan

Heat sealing properties are optimized by controlling temperature, pressure and dwell time, while film strength depends on the drawn ratio and the molecular orientation of the film. However, heat seal strength of polymer films with high drawn ratio shows lower peel strength, because the adhesion of films needs a higher heat sealing energy for molecular orientation relaxation at heat sealing. In the present study, polypropylene films with a drawn ratio of 1.0×, 1.5×, and 2.5× are heat sealed by using the heat sealing technique. the heat sealing condition is set to heat sealing time 1.0 s, sealing pressure 0.2 MPa, and heat sealing temperature 145°C. the effect of drawn ratio and stabilization temperature of PP films for peel strength are investigated using t-Peel test, DSC, Ft-IR, and Raman spectroscopy. As a result, it is found that the peel strength is decreased with increasing the drawn ratio and stabilization temperature of PP films. the difference of ?H and melting point from the result of DSC measurement are exhibited for 1.5× drawn ratio film as compared with 2.5× one. In addition, Ft-IR imaging and Raman line mapping reveal the influence and variation of high order structure for heat sealed parts of the drawn PP films.

关键词： Uniaxially-Extended Polypropylene Molecular Orientation Heat Sealing