长期使用FK506(他克莫斯)治疗全身型重症肌无力

作     者：Konishi T. Yoshiyama Y. Takomori M. Saido T. 王晓琳 

作者机构：Department of Neurology Utano National Hospital8 Ondoyama-cha Narutaki Kyoto 616-8255 Japan Dr. 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第7期

页      面：32-32页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：重症肌无力 FK506 身型 myasthenia gravis 莫斯 短期使用 强的松龙 减少率 administration 

摘      要：Efficacy and safety of long term use of FK506 (2-4.5 mg/ day)for a maximum of two years were evaluated in 12 patients with generalised myasthenia gravis (MG) . At the end of the study,eight patients (67%) showed improvement in either MG score or Activities in Daily Living score, and prednisolone dosage could be redu ced in seven patients (58%), with a mean reduction ratio of 37%. Long term use of FK506 for MG can be more effective than short term administration, with no s erious side effects.