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Spectrum of COVID-19 induced liver injury:A review report

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World Journal of Hepatology 2024年第4期16卷 517-536页

作者： Lokjan Singh Anil Kumar Maya Rai Bibek Basnet Nishant Rai Pukar Khanal kok-song Lai Wan-Hee Cheng Ahmed Morad Asaad Shamshul Ansari Department of Microbiology Karnali Academy of Health ScienceTeaching HospitalJumla 21200KarnaliNepal Health Sciences Asian College of Advance StudiesPurbanchal UniversitySatdobato 24122LalitpurNepal Department of Biotechnology Graphic Era(Deemed to be University)Dehradun 248002UttarakhandIndia Department of Pharmacology&Toxicology KLE College of PharmacyBelagaviKLE Academy of Higher Education and ResearchBelagavi 590010KarnatakaIndia Division of Health Sciences Abu Dhabi Women's CollegeHigher Colleges of TechnologyAbu Dhabi 41012United Arab Emirates Health and Life Sciences INTI International UniversityNilai 71800Malaysia Department of Microbiology College of MedicineZagazig UniversityZagazig 44519Egypt

The coronavirus disease 2019(COVID-19)pandemic has caused changes in the global health system,causing significant setbacks in healthcare systems *** pandemic has also shown resilience,flexibility,and creativity in reacting to the *** severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection targets most of the respiratory tract,resulting in a severe sickness called acute respiratory distress syndrome that may be fatal in some *** the lung is the primary organ targeted by COVID-19 viruses,the clinical aspect of the disease is varied and ranges from asymptomatic to respiratory ***,due to an unorganized immune response and several affected mechanisms,the liver may also experience liver cell injury,ischemic liver dysfunction,and drug-induced liver injury,which can result in respiratory failure because of the immune system’s disordered response and other compromised processes that can end in multisystem organ *** with liver cirrhosis or those who have impaired immune systems may be more likely than other groups to experience worse results from the SARS-CoV-2 *** thus intend to examine the pathogenesis,current therapy,and consequences of liver damage concerning COVID-19.

关键词： Autoimmune liver disease COVID-19 Clinical manifestation of liver Drug-induced liver injury SARS-CoV-2

Utilization of waste vanadium-bearing resources in the preparation of rare-earth vanadate catalysts for semi-hydrogenation of α,β-unsaturated aldehydes

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Frontiers of Chemical Science and Engineering 2022年第12期16卷 1793-1806页

作者： Yang Zhang Guowu Zhan Yibo song Yiping Liu Jiale Huang Shu-Feng Zhou kok Bing Tan Qingbiao Li College of Chemical Engineering Integrated Nanocatalysts Institute(INCI)Huaqiao UniversityXiamen 361021China College of Food and Biology Engineering Jimei UniversityXiamen 361021China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China

Recycling industrial solid waste not only saves resources but also eliminates environmental concerns of toxic ***,we proposed a new strategy for the utilization of petrochemical-derived carbon black waste,a waste vanadium-bearing resource(V>30000 ppm(10−6)).Chemical leaching was employed to extract metallic vanadium from the waste and the leachate containing V was used as an alternative raw material for the fabrication of vanadate *** the screening of various metal cations,it was found that the contaminated Na^(+)during the leaching process showed strong competitive coordination with the vanadium ***,by adding foreign Ce^(3+)and Y^(3+)cations,two rare-earth vanadates,viz.,flower-like CeVO_(4)and spherical YVO_(4)nanomaterials,were successfully *** techniques such as scanning electron microscopy,transmission electron microscopy,X-ray diffraction,energy-dispersive X-ray spectroscopy,Fourier-transform infrared,and N2 physisorption were applied to analyze the physicochemical properties of the waste-derived ***,we found that rare-earth vanadate catalysts exhibited good activities toward the semi-hydrogenation ofα,β-unsaturated *** conversion of cinnamaldehyde and cinnamic alcohol selectivity were even higher than those of the common CeVO_(4)prepared using pure chemicals(67.2%vs.27.7%and 88.4%vs.53.5%).Our work provides a valuable new reference for preparing vanadate catalysts by the use of abundant vanadium-bearing waste resources.

关键词： petrochemical solid wastes vanadium recovery resource utilization nanomaterials semi-hydrogenation

Effects of age on live streaming viewer engagement:a dual coding perspective

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Journal of Management Analytics 2022年第4期9卷 435-447页

作者： Fei Liu Yijing Li Xiaofei song Zhao Cai Eric T.K.Lim Chee-wee Tan Department of Information Technology and InnovationAntai College of Economics and ManagementShanghai Jiao Tong UniversityShanghaiPeople’s Republic of China Department of Management and Marketing The Hong Kong Polytechnic UniversityHong KongPeople’s Republic of China University of Nottingham Ningbo China NingboPeople’s Republic of China School of Information Systems and Technology Management UNSWSydneyAustralia Department of Digitalization Copenhagen Business SchoolCopenhagenDenmark

Though the emerging live streaming industry has attracted growing attention,the dominant yanzhi category where streamers mostly interact with the audience through amateur talent shows and casual chats has not been widely *** decode the mechanism behind the popularity of yanzhi streamers,this study draws on Dual Coding Theory(DCT)to posit that age estimated from a streamer’s face and voice can influence the level of viewer *** validate our hypothesized relationships,274 one-minute video records ahead of a viewer commenting or/and gifting were collected and analyzed via deep learning *** results attest to the negative effects of both facial and vocal age on viewer engagement,while their interaction has a positive impact on viewer engagement.

关键词： live streaming age viewer engagement dual coding theory deep learning

Sperm hyaluronidase is critical to mammals'fertilization for its ability to disperse cumulus-oocyte complex layer

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Asian Journal of Andrology 2022年第4期24卷 411-415页

作者： Dong-Won Seol Sang Hoon Joo Young-Hyun Kim Bong-Seok song Bo-Woong Sim Sun-Uk Kim Soojin Park Gabbine wee Ekyune Kim Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF)Daegu 41061Korea College of Pharmacy Catholic University of DaeguGyeongbuk 38430Korea National Primate Research Center(NPCR) Korea Research Institute of Bioscience and BiotechnologyChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyChungcheongbuk-do 28116Korea Department of Biochemistry and Molecular Biology Melvin and Bren Simon Comprehensive Cancer CenterIndiana University School of MedicineIndianapolisIN 46202USA

Glycosylphosphatidylinositol-anchored sperm hyaluronidases have long been believed to assist in sperm penetration through the cumulus-oocyte complex(COC);however,their role in mammalian fertilization remains ***,we have shown that hyaluronidase 5(Hyal5)/Hyal7 double-knockout(dKO)mice produce significantly fewer offspring than their wild-type(WT)counterparts because of defective COC *** infertility is mainly caused by a low sperm *** can be further exacerbated by the deficiency of sperm hyaluronidase,which disperses the cumulus cells of the outer layer of the *** the current study,we evaluated the effects of a low count of Hyal-deficient sperm and conditions of ovulated oocytes on the fertilization rate using a mouse *** results demonstrated that a low sperm count further decreases the in vitro fertilization(IVF)rate of Hyal-deficient dKO *** addition,the dKO spermatozoa resulted in a fertilization rate of 12.5%upon fertilizing COCs with a thick cumulus layer,whereas the IVF rate was comparable to that of WT spermatozoa when oocytes with a thin or no cumulus layer were ***,we proved that the IVF rate of dKO spermatozoa could be recovered by adding rat spermatozoa as a source of sperm *** results suggest that a deficiency of proteins involved in fertilization,such as sperm hyal,has a vital role in fertilization.

关键词： HYAL5 HYAL7 cumulus-oocyte complex fertilization infertility sperm hyaluronidase

Micromanaging autophagy with microRNAs to drive cancer metastasis

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Journal of Cancer Metastasis and Treatment 2019年第9期4卷 39-51页

作者： Gracie wee Ling Eng Venetia Jing Tong kok Jit Kong Cheong Department of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Medical Sciences Cluster Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore

While we made great strides in the early detection of a handful of cancers, many other cancers are still detected at fairly later stages, thus hindering the deployment of effective surgical or therapeutic intervention to change their dismal clinical outcomes. The arduous journey of cancer cells from the primary tumor to colonize distant secondary organs or tissues begins with their ability to activate or deactivate various cellular processes at will, including the autophagy machinery. In this review, we discuss how circulatory cancer cells from primary tumors could selectively mobilize different subsets of microRNAs (miRNAs) to enable autophagic recycling of nutrients during their search for secondary sites to colonize and to disable such cell survival programs once they have successfully established at distant organs or tissues. We also discuss how this new miRNA-autophagy-metastasis axis can be targeted by the emerging RNA Medicine toolkit.

关键词： Autophagy miRNAs cancer metastasis

Antimicrobial activity and mode of action of terpene linalyl anthranilate against carbapenemase-producing Klebsiella pneumoniae

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Journal of Pharmaceutical Analysis 2021年第2期11卷 210-219页

作者： Shun-Kai Yang Khatijah Yusoff Mokrish Ajat Wai-Sum Yap Swee-Hua Erin Lim kok-song Lai Department of Cell and Molecular Biology Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400SerdangSelangorMalaysia Department of Microbiology Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400SerdangSelangorMalaysia Department of Veterinary Preclinical Sciences Faculty of Veterinary MedicineUniversiti Putra Malaysia43400SerdangSelangorMalaysia Department of Biotechnology Faculty of Applied SciencesUCSI University56000CherasKuala LumpurMalaysia Health Sciences Division Abu Dhabi Women’s CollegeHigher Colleges of Technology41012Abu DhabiUnited Arab Emirates

Mining of plant-derived antimicrobials is the major focus at current to counter antibiotic resistance. This study was conducted to characterize the antimicrobial activity and mode of action of linalyl anthranilate(LNA) against carbapenemase-producing Klebsiella pneumoniae(KPC-KP). LNA alone exhibited bactericidal activity at 2.5%(V/V), and in combination with meropenem(MPM) at 1.25%(V/V). Comparative proteomic analysis showed a significant reduction in the number of cytoplasmic and membrane proteins,indicating membrane damage in LNA-treated KPC-KP cells. Up-regulation of oxidative stress regulator proteins and down-regulation of oxidative stress-sensitive proteins indicated oxidative stress. Zeta potential measurement and outer membrane permeability assay revealed that LNA increases both bacterial surface charge and membrane permeability. Ethidium bromide influx/efflux assay showed increased uptake of ethidium bromide in LNA-treated cells, inferring membrane damage. Furthermore, intracellular leakage of nucleic acid and proteins was detected upon LNA treatment. Scanning and transmission electron microscopies again revealed the breakage of bacterial membrane and loss of intracellular materials. LNA was found to induce oxidative stress by generating reactive oxygen species(ROS) that initiate lipid peroxidation and damage the bacterial membrane. In conclusion, LNA generates ROS, initiates lipid peroxidation, and damages the bacterial membrane, resulting in intracellular leakage and eventually killing the KPC-KP cells.

关键词： Comparative proteomic KPC-KP Linalyl anthranilate Membrane damage ROS

渐进性抗阻训练对痉挛型脑性瘫痪儿童活动和参与能力的影响

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中国中西医结合儿科学 2024年第04期16卷 277-280页

作者：宋凡旭赵宏博庞伟佳木斯大学康复医学院/佳木斯大学附属第三医院脑瘫康复科

目的在国际功能、残疾和健康分类(儿童青少年版)(ICF-CY)层面下，探讨渐进性抗阻训练对脑性瘫痪(简称脑瘫)儿童活动和参与能力的影响，为提高脑瘫儿童临床治疗效果提供依据。方法研究对象为2021年1～12月在佳木斯大学附属第三医院收... 详细信息

目的在国际功能、残疾和健康分类(儿童青少年版)(ICF-CY)层面下，探讨渐进性抗阻训练对脑性瘫痪(简称脑瘫)儿童活动和参与能力的影响，为提高脑瘫儿童临床治疗效果提供依据。方法研究对象为2021年1～12月在佳木斯大学附属第三医院收治的痉挛型双瘫脑瘫儿童40例，随机分为对照组和观察组各20例。对照组接受常规康复训练，观察组接受渐进性抗阻训练和常规康复训练，每组均治疗3个月。治疗前后分别给予儿童功能独立性评定量表(wee-FIM)、中文版残疾儿童能力评定量表(PEDI)、日常生活活动能力评定量表(ADL)、活动的游戏性检查表(TOP)评定，评估两组儿童活动和参与能力。结果观察组治疗后wee-FIM、PEDI、ADL和TOP评分均高于对照组，差异有统计学意义(P<0.05)。结论渐进性抗阻训练可有效改善痉挛型双瘫脑瘫儿童的活动和参与能力。

关键词：脑性瘫痪渐进性抗阻训练活动参与儿童

Escitalopram-induced liver injury: A case report and review of literature

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World Journal of Hepatology 2019年第10期11卷 719-724页

作者： Qin Xiang Ng Christl Suet Kwan Yong Wayren Loke wee song Yeo Alex Yu Sen Soh Institute of Mental Health Buangkok Green Medical ParkSingapore 539747Singapore MOH Holdings Pte Ltd Singapore 099253Singapore National University Hospital National University Health SystemSingapore 119074Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore

BACKGROUND Depression is a growing public health problem that affects over 350 million people globally and accounts for approximately 7.5%of healthy years lost due to ***,one of the first-line medications for the treatment of depression,is a selective serotonin reuptake inhibitor and one of the most commonly prescribed antidepressant medications *** thought to be generally safe and with minimal drug-drug interactions,we herein present an unusual case of cholestatic liver injury,likely secondary to escitalopram *** SUMMARY A 56-year-old Chinese lady presented with fever and cholestatic liver injury two weeks after initiation of escitalopram for the treatment of psychotic *** examination was *** investigations,including a computed tomography scan of the abdomen and pelvis and tests for hepatitis A,B and C and for autoimmune liver disease were ***,a diagnosis of escitalopram-induced liver injury was *** stopping escitalopram,repeat liver function tests showed downtrending liver enzymes with eventual normalization of serum aspartate aminotransferase and alanine aminotransferase one-week *** Clinicians should be aware of the possibility of escitalopram-induced liver injury when initiating depressed patients on antidepressant *** requires extra vigilance as most patients may remain *** of liver function tests could be considered after initiation of antidepressant treatment,especially in patients with pre-existing liver disease.

关键词： Depression Antidepressant Escitalopram Liver injury Drug-induced Druginduced liver injury

Is there an association between Helicobacter pylori infection and irritable bowel syndrome? A meta-analysis

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World Journal of Gastroenterology 2019年第37期25卷 5702-5710页

作者： Qin Xiang Ng Nadine Xinhui Foo Wayren Loke Yun Qing Koh Vanessa Jing Min Seah Alex Yu Sen Soh wee song Yeo Medicine MOH Holdings Pte LtdSingapore 099253Singapore General and Community Psychiatry Institute of Mental HealthSingapore 117597Singapore Department of General Medicine Tan Tock Seng Hospital11 Jalan Tan Tock SengSingapore 308433Singapore Department of Gastroenterology and Hepatology National University HospitalNational University Health SystemSingapore 119074Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore

BACKGROUND Irritable bowel syndrome(IBS)is a prevalent and debilitating gastrointestinal *** has reported persistent,low-grade mucosal inflammation and significant overlaps between patients with IBS and those with dyspepsia,suggesting a possible pathogenic role of Helicobacter pylori(***)in *** study therefore aimed to provide the first systematic review and meta-analysis on the association between *** infection and *** To investigate the association between *** infection and *** Using the keywords“*** OR Helicobacter OR Helicobacter pylori OR infection”AND“irritable bowel syndrome OR IBS”,a preliminary search of PubMed,Medline,Embase,Cochrane Database of Systematic Reviews,Web of Science,Google Scholar and WanFang databases yielded 2924 papers published in English between 1 January 1960 and 1 June *** were also made to search grey *** A total of 13 clinical studies were systematically reviewed and nine studies were included in the final ***-effects meta-analysis found a slight increased likelihood of *** infection in patients with IBS,albeit this was not statistically significant(pooled odds ratio 1.47,95%confidence interval:0.90-2.40,P=0.123).It must also be acknowledged that all of the available studies reported only crude odd *** eradication therapy also does not appear to improve IBS *** publication bias was not observed in the funnel plot,there was a high degree of heterogeneity amongst the studies included in the meta-analysis(I2=87.38%).CONCLUSION Overall,current evidence does not support an association between IBS and *** *** rigorous and detailed studies with larger sample sizes and after *** eradication therapy are warranted.

关键词： Irritable bowel syndrome Functional Helicobacter pylori Infection Metaanalysis