Is there an association between Helicobacter pylori infection and irritable bowel syndrome? A meta-analysis

作     者：Qin Xiang Ng Nadine Xinhui Foo Wayren Loke Yun Qing Koh Vanessa Jing Min Seah Alex Yu Sen Soh Wee Song Yeo 

作者机构：MedicineMOH Holdings Pte LtdSingapore 099253Singapore General and Community PsychiatryInstitute of Mental HealthSingapore 117597Singapore Department of General MedicineTan Tock Seng Hospital11 Jalan Tan Tock SengSingapore 308433Singapore Department of Gastroenterology and HepatologyNational University HospitalNational University Health SystemSingapore 119074Singapore Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2019年第25卷第37期

页      面：5702-5710页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Irritable bowel syndrome Functional Helicobacter pylori Infection Metaanalysis 

摘      要：BACKGROUND Irritable bowel syndrome(IBS)is a prevalent and debilitating gastrointestinal *** has reported persistent,low-grade mucosal inflammation and significant overlaps between patients with IBS and those with dyspepsia,suggesting a possible pathogenic role of Helicobacter pylori(***)in *** study therefore aimed to provide the first systematic review and meta-analysis on the association between *** infection and *** To investigate the association between *** infection and *** Using the keywords“*** OR Helicobacter OR Helicobacter pylori OR infectionAND“irritable bowel syndrome OR IBS,a preliminary search of PubMed,Medline,Embase,Cochrane Database of Systematic Reviews,Web of Science,Google Scholar and WanFang databases yielded 2924 papers published in English between 1 January 1960 and 1 June *** were also made to search grey *** A total of 13 clinical studies were systematically reviewed and nine studies were included in the final ***-effects meta-analysis found a slight increased likelihood of *** infection in patients with IBS,albeit this was not statistically significant(pooled odds ratio 1.47,95%confidence interval:0.90-2.40,P=0.123).It must also be acknowledged that all of the available studies reported only crude odd *** eradication therapy also does not appear to improve IBS *** publication bias was not observed in the funnel plot,there was a high degree of heterogeneity amongst the studies included in the meta-analysis(I2=87.38%).CONCLUSION Overall,current evidence does not support an association between IBS and *** *** rigorous and detailed studies with larger sample sizes and after *** eradication therapy are warranted.