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Indocyanine green plasma clearance rate and 99mTc-galactosyl human serum albumin single-photon emission computed tomography evaluated preoperative remnant liver

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World Journal of Clinical Cases 2022年第25期10卷 8844-8853页

作者： Kentaro Iwaki Satoshi Kaihara Ryosuke Kita koji Kitamura Hiroki Hashida Kenji Uryuhara Department of Surgery Kobe City Medical Center General HospitalKobe 650-0046HyogoJapan

BACKGROUND Preoperative evaluation of future remnant liver reserves is important for safe *** the remnant is small,preoperative portal vein embolization(PVE)is *** volume analysis has been the primary method of preoperative evaluation,although functional examination may be more *** have used the functional evaluation liver using the indocyanine green plasma clearance rate(KICG)and 99mTc-galactosyl human serum albumin single-photon emission computed tomography(99mTc-GSA SPECT)for safe *** To analyze the safety of our institution’s system for evaluating the remnant liver *** We retrospectively reviewed the records of 23 patients who underwent preoperative *** types of remnant liver KICG were defined as follows:Anatomical volume remnant KICG(a-rem-KICG),determined as the remnant liver anatomical volume rate×KICG;and functional volume remnant KICG(frem-KICG),determined as the remnant liver functional volume rate based on 99mTc-GSA SPECT×*** either of the remnant liver KICGs were>0.05,a hepatectomy was *** factors were *** defined the marginal group as patients with a-rem-KICG of0.05 and compared the postoperative outcomes between the marginal and not marginal(both a-rem-KICG and f-rem-KICG>0.05)*** All 23 patients underwent planned *** hepatectomy,right trisectionectomy and left trisectionectomy were in 16,6 and 1 cases,*** mean of blood loss and operative time were 576 mL and 474 min,*** increased amount of frem-KICG was significantly larger than that of a-rem-KICG after PVE(0.034 vs 0.012,P=0.0273).The not marginal and marginal groups had 17(73.9%)and 6(26.1%)patients,*** complications of Clavian-Dindo classification grade II or higher and post-hepatectomy liver failure were observed in six(26.1%)and one(grade A,4.3%)patient,*** 90-d mortality was *** marginal group had no

关键词： 99mTc-galactosyl human serum albumin single-photon emission computed tomography Hepatectomy Indocyanine green Indocyanine green plasma clearance rate Liver function evaluation Remnant liver reserve

Long-term survival of the Sister Mary Joseph nodule originating from breast cancer:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8205-8211页

作者： koji Kanayama Maki Tanioka Yoshitsugu Hattori Takuya Iida Mutsumi Okazaki Department of Plastic and Reconstructive Surgery The University of TokyoTokyo 113-8655Japan Department of Medical Oncology National Cancer Center HospitalTokyo 104-0045Japan

BACKGROUND A Sister Mary Joseph nodule(SMJN)is an uncommon cutaneous metastasis found in the umbilicus,indicating an advanced *** typically originate from intra-abdominal sources,rarely from breast *** suggests a poor prognosis with a median survival of approximately 8 mo after *** patients with SMJNs is challenging,as most receive limited palliative care *** optimal strategy for long-term survival of these patients remains *** SUMMARY A 58-year-old female,previously diagnosed with right breast cancer 17 years ago and underwent breast-conserving surgery,adjuvant radiotherapy,and endocrine therapy,presented with a 2-cm umbilical *** years previously,metastases were detected in the right supraclavicular,infraclavicular,hilar,and mediastinal lymph *** umbilical nodule emerged four years before the date of presentation,confirmed as a skin metastasis of primary breast cancer upon excisional *** initial removal,the nodule recurred and grew,leading to her referral to our *** patient underwent extensive excision of the umbilical tumor and immediate abdominal wall *** therapy was continued *** years later,no local recurrence was observed,and the patient continued to work full-time,achieving over 9 years of survival following SMJN *** This case study aimed to identify the optimal strategy for achieving extended survival outcomes in patients with SMJN through comprehensive *** presented a case of the longest survival in a patient after undergoing a multidisciplinary treatment *** findings underscore the significance of adopting a multimodal treatment approach comprising timely and wide excision along with adjunctive *** approach can control the disease,prolong survival,and improve the quality of life in patients with SMJN.

关键词： Sister Mary Joseph nodule Breast cancer Cutaneous metastasis Long-term survival Abdominal wall reconstruction Case report

Recurrent ventricular arrhythmia due to aconite intoxication successfully treated with landiolol:A case report

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World Journal of Clinical Cases 2023年第22期11卷 5303-5308页

作者： Chiaki Matsuo koji Yamamoto Hidetada Fukushima Daisuke Yajima Hiroyuki Inoue Department of Emergency and Critical Care Medicine Nara Medical UniversityKashihara City 634-8522NaraJapan Department of Forensic Medicine School of MedicineInternational University of Health and WelfareNarita City 286-8686ChibaJapan

BACKGROUND Ventricular arrhythmias,such as ventricular tachycardia and fibrillation,are the main causes of death in patients with aconite *** SUMMARY A 51-year-old man presented to our emergency department because he was vomiting after ingesting aconite root to attempt *** arrival,the patient was hemodynamically unstable,and his electrocardiogram revealed polymorphic ventricular extrasystoles and non-sustained ventricular *** was immediately administered for ventricular ***,the patient remained *** administered continuous intravenous landiolol as the ventricular arrhythmia worsened,gradually suppressing *** patient returned to sinus rhythm 16 h after arriving at the *** aconitum alkaloids act on voltage-gated Na+-channels and induce ventricular or supraventricular *** suppresses sympathetic nerve activity through its blocking effect,preventing *** Landiolol can be a therapeutic option for amiodarone-refractory ventricular arrhythmias caused by aconite intoxication.

关键词： Aconite Landiolol Amiodarone Arrhythmia Toxicology Case report

Hybrid femtosecond laser three-dimensional micro-and nanoprocessing:a review

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International Journal of Extreme Manufacturing 2019年第1期1卷 52-63页

作者： koji Sugioka RIKEN Center for Advanced Photonics WakoSaitama 351-0198Japan

The extremely high peak intensity associated with ultrashort pulse width of femtosecond(fs)lasers enabled inducing nonlinear multiphoton absorption in materials that are transparent to the laser *** importantly,focusing the fs laser beam inside the transparent materials confined the nonlinear interaction to within the focal volume only,realizing three-dimensional(3D)micro/*** 3D capability offers three different processing schemes for use in fabrication:undeformative,subtractive,and ***,a hybrid approach of different schemes can create much more complex 3D structures and thereby promises to enhance the functionality of the structures ***,hybrid fs laser 3D microprocessing opens a new door for material *** paper comprehensively reviews different types of hybrid fs laser 3D micro/nanoprocessing for diverse applications including fabrication of functional micro/nanodevices.

关键词： femtosecond laser 3D processing hybrid processing microdevice nanodevice

Bell Operator Method to Classify Local Realistic Theories

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Chinese Physics Letters 2010年第3期27卷 29-32页

作者： koji Nagata Department of Agriculture and of Veterinary Medicine National Research Center for Protozoan Diseases University of Obihiro West 2-13 Inada Obihiro Hokkaido 080-8555 Japan

We review the historical fact of multipartite Bell inequalities with an arbitrary number of settings. An explicit local realistic model for the values of a correlation function, given in a two-setting Bell experiment （two-setting model）, works only for the specific set of settings in the given experiment, but cannot construct a local realistic model for the values of a correlation function, given in a continuous-infinite settings Bell experiment （infinite-setting model）, even though there exist two-setting models for all directions in space. Hence, the two-setting model does not have the property that the infinite-setting model has. Here, we show that an explicit two-setting model cannot construct a local realistic model for the values of a correlation function, given in an M-setting Bell experiment （M-setting model）, even though there exist two-setting models for the M measurement directions chosen in the given M-setting experiment. Hence, the two-setting model does not have the property that the M-setting model has.

关键词： Quantum information and quantum mechanics

Pathogenesis of NSAID-induced gastric damage:Importance of cyclooxygenase inhibition and gastric hypermotility

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World Journal of Gastroenterology 2012年第18期18卷 2147-2160页

作者： koji Takeuchi Department of Pharmacology and Experimental Therapeutics Division of Pathological SciencesKyoto Pharmaceutical UniversityKyoto 607-8414Japan

This article reviews the pathogenic mechanism of nonsteroidal anti-inflammatory drug(NSAID)-induced gastric damage,focusing on the relation between cyclooxygenase(COX) inhibition and various functional ***,such as indomethacin,at a dose that inhibits prostaglandin(PG) production,enhance gastric motility,resulting in an increase in mucosal permeability,neutrophil infiltration and oxyradical production,and eventually producing gastric *** lesions are prevented by pretreatment with PGE 2 and antisecretory drugs,and also via an atropine-sensitive mechanism,not related to antisecretory *** neither rofecoxib(a selective COX-2 inhibitor) nor SC-560(a selective COX-1 inhibitor) alone damages the stomach,the combined administration of these drugs provokes gastric ***-560,but not rofecoxib,decreases prostaglandin E 2(PGE 2) production and causes gastric hypermotility and an increase in mucosal ***-2 mRNA is expressed in the stomach after administration of indomethacin and SC-560 but not *** up-regulation of indomethacin-induced COX-2 expression is prevented by atropine at a dose that inhibits gastric *** addition,selective COX-2 inhibitors have deleterious influences on the stomach when COX-2 is overexpressed under various conditions,including adrenalectomy,arthritis,and Helicobacter *** summary,gastric hypermotility plays a primary role in the pathogenesis of NSAID-induced gastric damage,and the response,causally related with PG deficiency due to COX-1 inhibition,occurs prior to other pathogenic events such as increased mucosal permeability;and the ulcerogenic properties of NSAIDs require the inhibition of both COX-1 and COX-2,the inhibition of COX-1 upregulates COX-2 expression in association with gastric hypermotility,and PGs produced by COX-2 counteract the deleterious effect of COX-1 inhibition.

关键词：胃粘膜损伤非甾体抗炎药发病机理 COX-2抑制剂环氧化酶 COX-1 前列腺素E 致病机制

Dopamine as a growth differentiation factor in the mammalian brain

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Neural Regeneration Research 2020年第3期15卷 390-393页

作者： koji Ohira Laboratory of Nutritional Brain Science Department of Food Science and Nutrition Mukogawa Women’s University

The catecholamine,dopamine,plays an important role in the central nervous system of mammals,including executive functions,motor control,motivation,arousal,reinforcement,and *** of the dopaminergic system lead to diseases of the brains,such as Parkinson’s disease,Tourette’s syndrome,and *** addition to its fundamental role as a neurotransmitter,there is evidence for a role as a growth differentiation factor during *** studies suggest that dopamine regulates the development ofγ-aminobutyric acidergic interneurons of the cerebral ***,in adult brains,dopamine increases the production of new neurons in the hippocampus,suggesting the promoting effect of dopamine on proliferation and differentiation of neural stem cells and progenitor cells in the adult *** this mini-review,I center my attention on dopaminergic functions in the cortical interneurons during development and further discuss cell therapy against neurodegenerative diseases.

关键词： γ-aminobutyric acidergic interneuron adult neurogenesis cerebral cortex dopamine GABA medial ganglionic eminence migration striatum

Will GHz burst mode create a new path to femtosecond laser processing?

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International Journal of Extreme Manufacturing 2021年第4期3卷 56-59页

作者： koji Sugioka RIKEN Center for Advanced Photonics 2-1 HirosawaWako-shiSaitama 351-0198Japan

The GHz burst mode of femtosecond laser pulses can significantly improve ablation efficiency without deteriorating ablation ***,various parameters involved in GHz burst mode make it difficult to optimize the processing for practical *** this Perspective,the author gives the history,current status,and future challenges and prospects of this new strategy to answer the question,'will GHz burst mode create a new path to femtosecond laser processing?'

关键词： laser femtosecond mode

Shock Wave Observation in Narrow Tubes for a Parametric Study on Micro Wave Rotor Design

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Journal of Thermal Science 2008年第2期17卷 134-140页

作者： koji Okamoto Mikiya Araki Department of Aeronautics and Astronautics University of Tokyo Department of Mechanical Engineering Gunma University

波浪转子被期望急速地改进微煤气的汽轮机的表演。在波浪转子设计，转子速度被试管长度主要决定。因此，当它可以产出更厚的墙界面层时，一个更长的试管更好让使小型化的波浪转子在轴承和润滑油系统避免困难，冲击波驱散等等。在现在的... 详细信息

波浪转子被期望急速地改进微煤气的汽轮机的表演。在波浪转子设计，转子速度被试管长度主要决定。因此，当它可以产出更厚的墙界面层时，一个更长的试管更好让使小型化的波浪转子在轴承和润滑油系统避免困难，冲击波驱散等等。在现在的学习，一台试验性的仪器被造设想波浪转子在由 schlieren 的一个狭窄的试管的内部流动动力学方法和激光 Doppler 风力测定。另外，试管的不同长度被采用并且与相比调查墙磨擦的效果。最后， 2D 数字模拟被执行，结果与实验的那些相比。

关键词：短波转子震动波不稳定流推进装置参数设置