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The Reduction of CENP-A Induces Senescence in Human Diploid Fibroblasts

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The Reduction of CENP-A Induces Senescence in Human Diploid ...

The 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics

作者： Kayoko maehara Kohta Takahashi Institute of Life Science Kurume University 1-1Hyakunen-KouenKurumeFukuoka839-0864Japan Institute of Life Science Kurume University 1-1Hyakunen-KouenKurumeFukuoka839-0864Japan

＜正＞Cellular senescence is a stable state of proliferative arrest,originally described by Hayflick and Moorhead in human *** cells in culture are identified by irreversible growth arrest,a large,flat cell morphology...

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陶瓷的超塑性

兵器材料科学与工程 1991年第12期14卷 57-67页

作者： Yasuhira maehara Terence G.Langdon 牟焕坤

人们现己认识到,超塑性是陶瓷的一种潜在的变形过程。这篇评述总结了起塑性的主要特征,并分析了陶瓷相变超塑性与结构超塑性的研究报告。分析表明,它与金属既存在相同之处,也存在不同之处。相同之处包括应变率随应力和晶粒大小而变化,... 详细信息

人们现己认识到,超塑性是陶瓷的一种潜在的变形过程。这篇评述总结了起塑性的主要特征,并分析了陶瓷相变超塑性与结构超塑性的研究报告。分析表明,它与金属既存在相同之处,也存在不同之处。相同之处包括应变率随应力和晶粒大小而变化,而重要的区别是必须考虑陶瓷中间玻璃相的作用。

关键词：陶瓷相变超塑性结构超塑性

Predicting Coronary Plaque Morphology Changes Based on Multimodality FSI Models Using Follow-Up IVUS and OCT Data

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医用生物力学 2019年第A1期34卷 93-94页

作者： Xiaoya Guo Don PGiddens David Molony Habib Samady Chun Yang Jie Zheng Mitsuaki Matsumura Gary SMintz Akiko maehara Liang Wang Dalin Tang Department of Mathematics Southeast UniversityNanjing210096China The Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of TechnologyAtlantaGA30332USA Department of Medicine EmoryUniversitySchool of MedicineAtlantaGA30307USA Mathematical Sciences Department Worcester PolytechnicInstituteWorcesterMA01609USA Mallinckrodt Institute of Radiology Washington UniversitySt.LouisMO63110USA The Cardiovascular Research Foundation Columbia UniversityNew YorkNY10022USA School of BiologicalScience and Medical Engineering Southeast UniversityNanjing210096China

Background Current bottleneck of patient-specific coronary plaque model construction is the resolution of in vivo medical *** threshold of cap thickness of vulnerable coronary plaques is 65 microns,while the resolution of in vivo coronary intravascular ultrasound(IVUS)images is 150-200 microns,which is not enough to identify vulnerable plaques with thin caps and construct accurate biomechanical plaque *** coherence tomography(OCT)with a 15-20μm resolution has the capacity to identify thin fibrous *** and OCT images could complement each other and provide for more accurate plaque morphology,especially,fibrous cap thickness measurements.A modeling approach combining IVUS and OCT was introduced in our previous publication for cap thickness quantification and more accurate cap stress/strain *** this paper,patient baseline and follow-up IVUS and OCT data were acquired and multimodality image-based Fluidstructure interaction(FSI)models combining 3D IVUS,OCT,angiography were constructed to better quantify human coronary atherosclerotic plaque morphology and plaque stress/strain conditions and investigate the relationship of plaque vulnerability and morphological and mechanical *** Baseline and 10-Month follow-up in vivo IVUS and OCT coronary plaque data were acquired from one patient with informed consent ***-registration and segmentation of baseline and follow-up IVUS and OCT images were performed for modeling *** and follow-up 3D FSI models based on IVUS and OCT were constructed to simulate the mechanical factors which integrating plaque morphology were employed to predict plaque *** 3D models were solved by ADINA(ADINA R&D,Watertown,MA,USA).The quantitative indices of cap thickness,lipid percentage were classified according to histological literatures and denoted as Cap Index and Lipid *** Index,Lipid Index and Morphological Plaque Vulnerability Index(MPVI)were chosen to quantify plaq

关键词： coronary plaque OCT IVUS vulnerability patient-specific FSI model

Analysis of the Factors for Displacement of Earth Retaining Wall with Twin-Stepped Construction

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World Journal of Engineering and Technology 2019年第1期7卷 114-121页

作者： Seiya Sakuma Kazuki maehara Takahiro Funatsu Akihiro Hamanaka Takashi Sasaoka Hideki Shimada Department of Earth Resources Engineering Faculty of Engineering Kyushu University Fukuoka Japan

The demand for specific earth retaining wall method is increasing, along with the advancement and overcrowding of underground space use, such as the?presence of close structures, in an urban area. The method is named stepped-twin?retaining wall. The feature of this method is to have inner and outer retaining walls and excavate the ground by two-step in order to minimize the effect of the excavation on neighboring existing structures. However, the design of the earth retaining wall is currently carried out by individual engineers based on their own experience. Therefore, it is crucial that the standard method of retaining wall using a two-step construction is established. As the first step toward the standardization, evaluation of factors affecting the ground behavior of the earth retaining wall was carried out. In particular, we picked up four major considerable factors, which are horizontal distance between the outer and inner walls, depth of outer wall embedment, mechanical properties of soil. The evaluation was done by using two dimensional FEM analysis and the results were summarized to make clear the effect of each factor.

关键词： Excavation Behavior Earth Retaining Wall Finite Element Method

Management of thrombocytopenia due to liver cirrhosis:A review

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World Journal of Gastroenterology 2014年第10期20卷 2595-2605页

作者： Hiromitsu Hayashi Toru Beppu Ken Shirabe Yoshihiko maehara Hideo Baba Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto 860-8556 Japan Department of Surgery and Science Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582 Japan

Thrombocytopenia is a common complication in liver disease and can adversely affect the treatment of liver cirrhosis,limiting the ability to administer therapy and delaying planned surgical/diagnostic procedures because of an increased risk of *** factors,including splenic sequestration,reduced activity of the hematopoietic growth factor thrombopoietin,bone marrow suppression by chronic hepatitis C virus infection and anti-cancer agents,and antiviral treatment with interferon-based therapy,can contribute to the development of thrombocytopenia in cirrhotic *** these factors,the major mechanisms for thrombocytopenia in liver cirrhosis are(1)platelet sequestration in the spleen;and(2)decreased production of thrombopoietin in the *** treatment options,including platelet transfusion,interventional partial splenic embolization,and surgical splenectomy,are now available for severe thrombocytopenia in cirrhotic *** thrombopoietin agonists and targeted agents are alternative tools for noninvasively treating thrombocytopenia due to liver cirrhosis,their ability to improve thrombocytopenia in cirrhotic patients is under investigation in clinical *** this review,we propose a treatment approach to thrombocytopenia according to our novel concept of splenic volume,and we describe the current management of thrombocytopenia due to liver cirrhosis.

关键词： Liver cirrhosis Thrombocytopenia Thrombopoietin Pa

Lung Injury Resulting from Fluted Silastic Soft Drain Extraction under Negative Pressure Suction

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Open Journal of Thoracic Surgery 2013年第3期3卷 73-75页

作者： Susumu Isoda Tamizo Kimura Kenji Nishimura Nozomu Yamanaka Shingo Nakamura Tadaaki maehara Department of Cardiovascular Surgery National Defense Medical College Tokorozawa Japan Department of Cardiovascular Surgery National Defense Medical College Tokorozawa Japan.

We experienced two cases of lung injury resulting from fluted silastic drain extraction under reservoir-generated negative pressure suction. In the first case, a 67-year-old man underwent coronary artery bypass grafting. A 19 Fr BLAKE drain was placed at the pericardial cavity, the mediastinum, and the left thoracic cavity. All three drains were connected to J-VAC reservoirs. After removing the drains (which maintained the negative pressure), subcutaneous emphysema and hemopneumothorax occur. A trocar catheter was inserted. Bleeding and the air leak terminated within a day. In the second case, a 73-year-old man underwent aortic valve replacement. Right pneumothorax occurred after the removal of the pleural cavity drain, which maintained the negative pressure generated by the reservoir. We inserted a trocar catheter, and the air leak terminated within a day. We hypothesized that the reservoir-generated negative pressure causes the pleura to enter the groove of the drain and become damaged during extraction. We stopped using a reservoir to connect to the fluted silastic drain placed at the pleural cavity and removed the negative pressure when extracting the pleural cavity drain. Since implementing this change, we have not experienced a similar lung injury in more than 500 cardiac surgery patients.

关键词： Complication Extraction Lung Injury Negative Pressure Silastic Drain

Dietary polyphenols and colorectal cancer risk:The Fukuoka colorectal cancer study

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World Journal of Gastroenterology 2013年第17期19卷 2683-2690页

作者： Zhen-Jie Wang Keizo Ohnaka Makiko Morita Kengo Toyomura Suminori Kono Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko maehara Takeshi Okamura koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka Department of Preventive Medicine Graduate School of Medical Sciences Kyushu University Department of Geriatric Medicine Graduate School of Medical Sciences Kyushu University Departments of Surgery and Oncology Graduate School of Medical Sciences Kyushu University Departments of Surgery and Science Graduate School of Medical Sciences Kyushu University Department of Gastroenterological Surgery National Kyushu Cancer Center Division of Surgery National Kyushu Medical Center Department of Surgery Fukuoka University Chikushi Hospital Department of Regenerative Medicine and Transplantation Faculty of Medicine Fukuoka University Division of Surgery Fukuoka City Hospital13-1 Yoshizuka-honmachi Hakata-ku Fukuoka 812-0046 Japan Division of Surgery Hamanomachi General Hospital Division of Surgery Fukuoka Red Cross Hospital

AIM:To investigate the associations between dietary intake of polyphenols and colorectal cancer. METHODS:The study subjects were derived from the Fukuoka colorectal cancer study, a community-based case-control study. The study subjects were 816 cases of colorectal cancer and 815 community-based controls. The consumption of 148 food items was assessed by a computer-assisted interview. We used the consumption of 97 food items to estimate dietary intakes of total, tea and coffee polyphenols. The Phenol-Explorer database was used for 92 food items. Of the 5 foods which were not listed in the Phenol-Explorer Database, polyphenol contents of 3 foods (sweet potatoes, satoimo and daikon) were based on a Japanese study and 2 foods (soybeans and fried potatoes) were estimated by ORAC-based polyphenol contents in the United States Department of Agriculture Database. Odds ratios (OR) and 95%CI of colorectal cancer risk according to quintile categories of intake were obtained by using logistic regression models with adjustment for age, sex, residential area, parental history of colorectal cancer, smoking, alcohol consumption, body mass index 10 years before, type of job, leisure-time physical activity and dietary intakes of calcium and n-3 polyunsaturated fatty ***:There was no measurable difference in total or tea polyphenol intake between cases and controls, but intake of coffee polyphenols was lower in cases than in controls. The multivariate-adjusted OR of colorectal cancer according to quintile categories of coffee polyphenols (from the first to top quintile) were 1.00 (referent), 0.81 (95%CI:0.60-1.10), 0.65 (95%CI:0.47-0.89), 0.65 (95%CI:0.46-0.89) and 0.82 (95%CI:0.60-1.10), respectively (P trend = 0.07). Similar, but less pronounced, decreases in the OR were also noted for the third and fourth quintiles of total polyphenol intake. Tea polyphenols and non-coffee polyphenols showed no association with colorectal cancer risk. The sitespecific analysis, based on 4

关键词： Colorectal cancer Colon cancer Rectal cancer Polyphenols Coffee Tea

Papillary Fibroelastoma of the Papillary Muscle of the Tricuspid Valve: Reconstruction of the Papillary Muscle

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Open Journal of Thoracic Surgery 2013年第3期3卷 69-72页

作者： Susumu Isoda Tamizo Kimura Kenji Nishimura Nozomu Yamanaka Shingo Nakamura Tadaaki maehara Department of Cardiovascular Surgery National Defense Medical College Tokorozawa Japan.

Cardiac papillary fibroelastoma is the third most frequent primary cardiac tumor, after myxoma and fibroma. A papillary fibroelastoma that arises from the papillary muscle is rare. We removed a papillary fibroelastoma located at the anterior papillary muscle of the tricuspid valve. The papillary muscle needed reconstruction. We used the loop technique to adjust the length of the papillary muscle and performed annuloplasty by using an artificial ring.

关键词： Papillary Fibroelastoma Papillary Muscle Tricuspid Valve Valve Plasty

Therapeutic strategy for postoperative recurrence in patients with non-small cell lung cancer

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World Journal of Clinical Oncology 2014年第5期5卷 1048-1054页

作者： Tokujiro Yano Tatsuro Okamoto Seiichi Fukuyama Yoshihiko maehara Department of Thoracic Surgery National Hospital Organization Beppu Medical Center Department of Surgery and Science Graduate School of Medical Sciences Kyushu University

Postoperative recurrence occurs in approximately half of patients with non-small cell lung cancer(NSCLC), even after complete resection. Disease recurrence after surgical resection reduces the patient's life expectancy sharply. The prognosis after postoperative recurrence is considered to largely depend on both the mode of first recurrence(distant, locoregional or combined) and the treatment modality:(1) The majority of cases of postoperative recurrence involve distant metastasis with or without locoregional recurrence. Platinum-based systemic chemotherapy is practically accepted as the treatment for these diseases on the basis of evidence for original stage Ⅳ disease. The advent of both pemetrexed and molecular-targeted drugs has improved the survival of nonsquamous NSCLC and changed the chemotherapeutic algorithm for NSCLC;(2) Among patients with distant metastatic recurrence without locoregional recurrence at the primary tumor site, the metastasis is often limited in both organ and number. Such metastases are referred to as oligometastases. Local therapy, such as surgical resection and radiotherapy, has been suggested to be the first-line treatment of choice foroligometastatic recurrence; and(3) While locoregional recurrence is likely to cause troublesome symptoms, it is a potentially limited disease. Therefore, providing local control is important, and radiation is usually beneficial for treating local recurrence. In order to obtain better control of the disease and provide treatment with curative intent in patients with limited disease, the administration of concurrent platinum-based chemoradiotherapy is recommended according to the results of originally nonresectable stage ⅢA and ⅢB disease.

关键词： Non-small cell lung cancer Postoperative recurrence Distant metastasis Oligometastases Local treatment Locoregional recurrence