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World Journal of Pediatrics 2020年第6期16卷 623-628页

作者： Yukari Atsumi Hiroshi Sakakibara Yoshihiko Morikawa koichi miyata Hiroyuki Yamagishi Masahiro Misawa Masaru Miura Department of General Pediatrics Tokyo Metropolitan Children's Medical Center.TokyoJapan Clinical Research Support Center.Tokyo Metropolitan Children's Medical Center TokyoJapan Department of Cardiology.Tokyo Metropolitan Children's Medical Center.Tokyo Japan Department of Pediatrics Keio University School of MedicineTokyo.Japan Department of Pediatrics Tokyo Metropolitan Bokutoh HospitalTokyoJapan National Center for Global Health and Medicine.1-21-1.Toyama Shinjuku-kuTokyo 162-8655.Japan

Background Although Kawasaki disease(KD)is known to cause anemia,the relationship between its prognosis and hemoglobin level is less well *** We herein performed a secondary analysis of data from a previous study(Post-RAISE).Children aged 6 months to 2 years at the time of KD diagnosis were *** hemoglobin was defined as a decrease>10%on post-treatment day 2 compared with the level prior to the initial *** Of 1253 KD cases,treatment resistance was observed in 209(17%)and was significantly more frequent in the decreased hemoglobin group(37/167 vs.172/1086,P=0.041).Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment(odds ratio 1.53;95%confidence interval 1.00-2.33;P=0.048).Conclusions Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.

关键词： Anemia Inflammation Hepcidin Kawasaki disease

Evaluation of plant behavior during the accident at Fukushima Daiichi Nuclear Power Station

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IMPROVEMENT OF SHUTDOWN RISK MONITOR FUNCTION IN FT-FREE USING BDD

作者： miyata koichi NISHINO Shoichiro Tokyo Electric Power Company

The Great East Japan Earthquake that occurred at 14:46 on March 11,2011,caused all off-site power to be lost at Fukushima Daiichi Nuclear Power Station（NPS）,but the emergency diesel generators（EDGs） started up,and the electric power necessary for reactor safety was *** 15:27 the first tsunami was observed,which far exceeded the design basis of the power plant and caused the loss of almost all safety functions of core cooling and *** a result,the reactor core was damaged in Units 1 to 3,and hydrogen explosions destroyed the reactor buildings（R/Bs） of Units 1,3 and ***,since the spent fuel pool（SFP） cooling was also lost,external water was injected into the *** Units 1 and 3,since depressurization of primary containment vessel（PCV） through the vent from suppression chamber（S/C） was completed,release of radioactive materials was *** the other hand the PCV vent was not successful in Unit *** data rose sharply before noon on March 15 when Unit 2 PCV pressure dropped considerably and steam was seen coming from Unit 2 R/*** blowing toward the north-northwest direction prevailed that day and rain fell in that direction at night,so it is likely that the contamination in high contamination zones around the plant resulted from a release of radioactive materials from Unit 2 R/B on March *** the field surveys and the design of the PCV,it is expected that the leak might have occurred at the seal of the PCV top head *** addition,as a result of evaluating the release of radioactive materials,the vent operations and the explosions at the R/Bs were not considered a major cause of contamination.

关键词： core damage MAAP hydrogen explosion release of radioactive materials

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Assessing efficacy of standard impregnation techniques on die-cast aluminum alloys using X-ray micro-CT

第十三届国际核工程大会

作者： Yuichi Iwata koichi miyata Tepco Systems Corporation

In Japan,it is established by the nuclear regulation that the maintenance of the safety systems is carded out during shutdown,and the online maintenance of these systems is ***,a l

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China Foundry 2024年第3期21卷 276-286页

作者： Ajith Bandara koichi Kan Katanaga Yusuke Natsuto Soga Akifumi Koike Toru Aoki Hamamatsu TSC Chuo Hatsumei Institute322 lida-choMinami-kuHamamatsu435-0028Japan Graduate School of Medical Photonics ShizuokaUniversityJohoku 3-5-1HamamatsuShizuoka432-8561Japan ANSeeN Inc Johoku 3-5-1HamamatsuShizuoka432-8561Japan Research Institute of Electronics ShizuokaUniversityJohoku 3-5-1HamamatsuShizuoka432-8561Japan

Utilizing lightweight Al alloys in various industrial applications requires achieving precise pressure tightness and leak *** pressure impregnation(VPI)with thermosetting polymers is commonly used to address leakage defects in die-cast Al *** this study,the efficacy of the VPI technique in sealing alloy parts was investigated using a combination of nondestructive micro X-ray computed tomography(micro XCT)and a standard leak *** results demonstrate that the commonly used water leak test is insufficient for determining the sealing ***,micro XCT shows distinct advantages by enabling more comprehensive *** reveals the presence of a low atomic number impregnates sealant within casting defects,which has low grey contrast and allows for visualizing primary leakage paths in *** effective atomic number of impregnated resin is 6.75 and that of Al alloy is 13.69 by dual-energy X-ray *** research findings will contribute to enhancing the standard VPI process parameters and the properties of impregnating sealants to improve quality assurance for impregnation in industrial metals.

关键词： nondestructive testing Al alloy die-casting vacuum pressure impregnation micro X-ray computed tomography duel-energy X-ray CT

Controlling a peristaltic robot inspired by inchworms

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Biomimetic Intelligence & Robotics 2024年第1期4卷 88-96页

作者： Yanhong Peng Hiroyuki Nabae Yuki Funabora koichi Suzumori Department of Information and Communication Engineering Graduate School of EngineeringNagoya UniversityNagoya 464-8601Japan Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan

This study presents an innovative approach in soft robotics,focusing on an inchworm-inspired robot designed for enhanced transport *** explore the impact of various parameters on the robot’s performance,including the number of activated sections,object size and material,supplied air pressure,and command execution *** a series of controlled experiments,we demonstrate that the robot can achieve a maximum transportation speed of 8.54 mm/s and handle loads exceeding 100 g,significantly outperforming existing models in both speed and load *** findings provide valuable insights into the optimization of soft robotic design for improved efficiency and adaptability in transport *** research not only contributes to the advancement of soft robotics but also opens new avenues for practical applications in areas requiring precise and efficient object *** study underscores the potential of biomimetic designs in robotics and sets a new benchmark for future developments in the field.

关键词： McKibben artificial muscles Bionics Soft robotics Soft actuator Bio-inspired robotics

High-temperature corrosion of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho)environmental barrier coating materials by volcanic ash

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1628-1638页

作者： Ayahisa Okawa Son Thanh Nguyen Tadachika Nakayama Thi-Mai-Dung Do Hisayuki Suematsu Shu Yin Takuya Hasegawa Tsuneo Suzuki Takashi Goto koichi Niihara Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan Department of Creative Engineering National Institute of TechnologyKushiro 084-0916Japan Extreme Energy-Density Research Institute Nagaoka University of TechnologyNagaoka 940-2188Japan Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan

Rare-earth silicates are promising environmental barrier coatings(EBCs)that can protect SiC_(f)/Si C_(m)substrates in next-genera tion gas turbine ***,RE_(2)Si_(2)O_(7)(RE=Yb and Ho)shows potential as an EBC due to its coefficient of thermal expansion(CTE)compatible with substrates and high resistance to water vapor *** target operating temperature for next-generation tur bine blades is 1400°*** is inevitable during adhesion to molten volcanic ash,and thus,understanding the corrosion behavior o the material is crucial to its *** study investigates the high-temperature corrosion behavior of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho).Samples were prepared using a solid-state reaction and hot-press *** were then exposed to volcanic ash at 1400°C for 224,and 48 *** 48 h of exposure,volcanic ash did not react with Yb_(2)Si_(2)O_(7)but penetrated its interior,causing *** Ho_(2)Si_(2)O_(7)was partially dissolved in the molten volcanic ash,forming a reaction zone that prevented volcanic ash melts from penetrating the *** increasing heat treatment time,the reaction zone expanded,and the thickness of the acicular apatite grains increased The Ca:Si ratios in the residual volcanic ash were mostly unchanged for Yb_(2)Si_(2)O_(7)but decreased considerably over time for Ho_(2)Si_(2)O_(7).Th Ca in volcanic ash was consumed and formed apatite,indicating that RE^(3+)ions with large ionic radii(Ho>Yb)easily precipitated apatit from the volcanic ash.

关键词： environmental barrier coating volcanic ash rare-earth disilicate corrosion

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混合磁悬浮系统零功率抗偏载控制方法研究

机械工程学报 2024年第8期60卷 360-369页

作者：赵川孙凤金俊杰徐方超张明 OKA koichi 沈阳工业大学机械工程学院沈阳110870 高知工科大学系统工学部高知7828502日本

针对混合磁悬浮洁净传送装置无法兼顾零功率和抗偏载悬浮的问题,提出一种磁铁可动式混合磁悬浮系统,并设计了其零功率抗偏载控制策略。该系统中一个磁极固定,其他两个磁铁可绕悬浮圆盘中心轴线转动,通过调节气隙长度和磁铁转动角度克服... 详细信息

针对混合磁悬浮洁净传送装置无法兼顾零功率和抗偏载悬浮的问题,提出一种磁铁可动式混合磁悬浮系统,并设计了其零功率抗偏载控制策略。该系统中一个磁极固定,其他两个磁铁可绕悬浮圆盘中心轴线转动,通过调节气隙长度和磁铁转动角度克服偏载引起的扰动力和扰动力矩,从而实现零稳态电流和抗偏载悬浮。首先建立系统的线性变参数模型,分析该系统实现零功率水平悬浮需要满足的条件。零功率抗偏载控制策略在比例-微分控制器中引入电流和气隙偏差的积分反馈,并应用质心观测器反求磁体转动角度,求解方法分别采用雅可比逆变换解析求解和查表法内插取值两种方法。试验结果表明,该系统能够在偏载条件下保持零功率水平悬浮,应用雅可比的连续控制策略具有更好的纠偏特性,稳态时电流波动范围小。

关键词：混合磁悬浮零功率控制抗偏载特性离散控制

Severe aconite poisoning successfully treated with veno-arterial extracorporeal membrane oxygenation:A case report

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World Journal of Clinical Cases 2024年第2期12卷 399-404页

作者： Saeko Kohara Yoshito Kamijo Ryoko Kyan Ichiro Okada Eiju Hasegawa Soichiro Yamada koichi Imai Asuka Kaizaki-Mitsumoto Satoshi Numazawa Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical CenterTokyo 1900014Japan Department of Clinical Toxicology Saitama Medical UniversitySaitama 3500495Japan Saitama Prefectural Institute of Public Health Saitama Prefectural Institute of Public HealthSaitama 3550133Japan Division of Toxicology Department of PharmacologyToxicology and TherapeuticsShowa University School of PharmacyTokyo 1428555Japan

BACKGROUND Most species of aconite contain highly toxic aconitines,the oral ingestion of which can be fatal,primarily because they cause ventricular *** describe a case of severe aconite poisoning that was successfully treated through venoarterial extracorporeal membrane oxygenation(VA-ECMO)and in which detailed toxicological analyses of the aconite roots and biological samples were performed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).CASE SUMMARY A 23-year-old male presented to the emergency room with circulatory collapse and ventricular arrhythmia after ingesting approximately half of a root labeled,“Aconitum japonicum Thunb”.Two hours after arrival,VA-ECMO was initiated as circulatory collapse became refractory to antiarrhythmics and *** hours after arrival,an electrocardiogram revealed a return to sinus *** patient was weaned off VA-ECMO and the ventilator on hospital days 3 and 5,*** hospital day 15,he was transferred to a psychiatric *** other half of the root and his biological samples were toxicologically analyzed using LC-MS/MS,revealing 244.3 mg/kg of aconitine and 24.7 mg/kg of mesaconitine in the *** on admission contained 1.50 ng/mL of *** hospital day 2,neither were *** on admission showed 149.09 ng/mL of aconitine and 3.59 ng/mL of mesaconitine,but these rapidly decreased after hospital day *** The key to saving the life of a patient with severe aconite poisoning is to introduce VA-ECMO as soon as possible.

关键词： Aconite poisoning Fatal arrhythmia Veno-arterial extracorporeal membrane oxygenation Aconitine Mesaconitine Case report

Systemic RNAi of V-ATPase subunit B causes molting defect and developmental abnormalities in Periplaneta fuliginosa

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Insect Science 2019年第4期26卷 721-731页

作者： Kazuki Sato Keita miyata Sota Ozawa koichi Hasegawa Laboratory of Nematology Department of Applied Biological Sciences Saga University Honjo 1 Saga Japan The United Graduate School of Agricultural Sciences Kagoshima University Korimoto 1-21-24 Kagoshima Japan Department of Biomedical Sciences College of Life and Health Sciences Chubu University Kasugai Aichi Japan Department of Environmental Biology College of Bioscience & Biotechnology Chubu University Kasugai Aichi Japan

The vacuolar (H+)-ATPases (V-ATPases) are ATP-driven proton pumps with multiple functions in many organisms. In this study, we performed structural and functional analysis of vha55 gene that encodes V-ATPase subunit B in the smokybrown cockroach Periplaneta fuliginosa (Blattodea). We observed a high homology score of the deduced amino acid sequences between 10 species in seven orders. RNAi of the vha55 gene in R fuliginosa caused nymphal/nymphal molting defects with incomplete shedding of old cuticles, growth inhibition, as well as bent and wrinkled cuticles of thoraxes and abdominal segments. Since growth inhibition caused by vha55 RNAi did not interfere in the commencement of cockroach molting, molting timing and body growth might be controlled by independent mechanism. Our study suggested V-ATPases might be a good candidate molecule for evolutionary and developmental studies of insect molting.

关键词： Blattodea cockroach molting Periplaneta fuliginosa RNA interference vacuolar-type H+-ATPase

A Revised Classification of Primary Iron Overload Syndromes

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 346-356页

作者： Yasuaki Tatsumi Motoyoshi Yano Shinya Wakusawa Hiroaki Miyajima Tetsuya Ishikawa Shinsaku Imashuku Atsuko Takano Wataru Nihei Ayako Kato koichi Kato Hisao Hayashi Kentaro Yoshioka Kazuhiko Hayashi Department of Medical Biochemistry Faculty of Pharmaceutical SciencesToho UniversityFunabashiJapan Department of Gastroenterology Yokkaichi Municipal HospitalYokkaichiJapan Department of Medical Technology Shubun UniversityIchinomiyaJapan Department of Medicine and Neurology Tenryu Kohseikai ClinicHamamatsuJapan Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Department of Laboratory Medicine Uji-Tokushukai Medical CenterUjiJapan Department of Medicine Saiseikai Takaoka HospitalTakaokaJapan Department of Medicine Aichi-Gakuin University School of PharmacyNagoyaJapan Department of Gastroenterology FNPS Meijo HospitalNagoyaJapan

Background and Aims:The clinical introduction of hepcidin25(Hep25)has led to a more detailed understanding of its relationship with ferroportin(FP)and divalent metal transporter1 in primary iron overload syndromes(PIOSs).In 2012,we proposed a classification of PIOSs based on the Hep25/FP system,which consists of prehepatic aceruloplasminemia,hepatic hemochromatosis(HC),and posthepatic FP disease(FP-D).However,in consideration of accumulated evidence on PIOSs,we aimed to renew the ***:We reviewed the 2012 classification and retrospectively renewed it according to new information on ***:Iron-loading anemia was included in PIOSs as a prehepatic form because of the newly discovered erythroferrone-induced suppression of Hep25,and the state of traditional FP-D was remodeled as the BIOIRON *** key molecules responsible for prehepatic PIOSs are low transferrin saturation in aceruloplasminemia and increased erythroferrone production by erythroblasts in iron-loading *** PIOSs comprise four genotypes of HC,in each of which the synthesis of Hep25 is inappropriately reduced in the *** Hep25 synthesis is adequate in posthepatic PIOSs;however,two mutant FP molecules may resist Hep25 differently,resulting in SLC40A1-HC and FP-D,*** phenotypes are diagnosed using laboratory tests,including circulating Hep25,followed by suitable *** sequencing of the candidate genes may be outsourced to gene centers when *** kits for the prevalent mutations,such as C282Y,may be the first choice for a genetic analysis of HC in ***:The revised classification may be useful worldwide.

关键词： Ethnicity Ferroportin Hemochromatosis Hepcidin25 Iron overload syndrome