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Clinical Effects of a Plant Extract Mixture Containing Rhus verniciflua and Other Herbs in Tumor Bearing Dogs

Journal of Cancer Therapy 2016年第7期7卷 464-470页

作者： Francisco Clemente-Vicario C. Guillermo Couto kohei suruga Yasuhiro Komatsu C. A. Tony Buffington William C. Kisseberth Department of Veterinary Clinical Sciences The Ohio State University College of Veterinary Medicine Columbus OH USA International Operation Department (FM Center for R & D) Kibun Foods Inc. Tokyo Japan Kitasato Institution for Life Science Kitasato University Tokyo Japan Sun R & D Institute for Natural Medicines Co. Inc. Tokyo Japan

Dog owners are increasingly seeking treatment when their pets develop cancers. As in human cancer patients, dogs with cancer are commonly treated with complementary and alternative therapies, including herbal medicines and nutritional supplements. A novel antitumor agent was developed from six different herbs including Rhus verniciflua (Rv-PEM01). The components were established from traditional herbal medicine and designed to affect antitumor activity and maintain host immune function. Previous studies identified anti-proliferative activity in human, murine and canine cancer cell lines. In this clinical study the safety and tolerability of Rv-PEM01 were evaluated in pet dogs with spontaneously occurring cancers. Twelve dogs were treated orally daily for 30 days in escalating dose (4 - 10 mg/kg orally once daily) cohorts. Rv-PEM01 was well tolerated;only transient mild elevations in BUN were observed in 2 dogs. Although tumor response was not a primary endpoint for this study, stable disease was maintained for 30 days in 5 (42%) of the dogs. In conclusion, Rv-PEM01 was found to be safe and well tolerated in the dosage range tested. Future studies should evaluate higher dosages of Rv-PEM01 in dogs with cancer, and specifically address other potential benefits of Rv-PEM01 in canine cancer patients, including correlative assessments of immune function, quality of life and owner satisfaction.

关键词： Rhus verniciflua Dog Cancer Complementary and Alternative Medicine

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Hemopoietic Formulae Rearranged Leukocyte Subsets and Implication for Use against the Type of Constitution and Infectious Agent for Further Modification to Future

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Open Journal of Immunology 2015年第3期5卷 183-198页

作者： Nobuo Yamaguchi Wataru Hiruma kohei suruga Nurmuhamamt Amat Dilxat Yimit Parida Hoxur Daisuke Sakamoto Kazuhiro Okamoto Shan-Yu Su Department of Fundamental Research for CAM Kanazawa Medical University Ishikawa Japan Ishikawa Natural Medicinal Products Research Center Ishikawa Japan International Operation Department (FM Center for R & D) Kibun Foods Inc. Tokyo Japan Traditional Uighur Medicine Department Xinjiang Medical University Urumchi China Traditional Chinese Medicine Hospital Xinjiang Medical University Urumchi China Department of Otolaryngology Kanazawa Medical University Ishikawa Japan Department of Chinese Medicine China Medical University Hospital Taiwan School of Post-Baccalaureate Chinese Medicine College of Chinese Medicine China Medicinal University Taiwan

A hemopoietic formula (HF) in traditional Chinese medicine (TCM) usually consists of more than six single herbs. We seek to look into changes of immune-competent cells by two commonly utilized HF, including Shi-Quan-Da-Bu-Tang (SDT) and Bu-Zong-Ye-Qi-Tang (BYT). However, the effects of both formulae on levels of leukocyte subsets are not yet defied. After administration of immno-suppressant to animals, the effects by HFs on the augmentation for subsets of leukocytes, CD positive cell counts of lymphocytes, and the cytokine-producing cells are measured. Our results show that SDT augments the level of lymphocytes, while BYT increases the level of granulocytes. In our clinical study with 15 healthy volunteers, positive cells for CD2, CD11b, CD14, IL-4, IL-1β and IFN-γ in peripheral blood are increased significantly 15 days after the ingestion of HFs. In rodents, compromised host as well as normal animal is administered with cancer chemotherapeutic agent (Mytomycin-C). Our observations show that SDT regulates phagocyte activities of the immune system, introducing it against intracellular parasite, and that BYT augments intercellular pathogen through humoral immunity. We discuss the significance and mechanism of HFs on the level of leukocyte subsets in number and function that are considered to be potential indicators for the evaluation of TCM modalities. We also propose an idea that TCM exhibits tonic effects via enhancing the ability to fight against infection and bacteria, as well as turning the multi-drug resistant bacteria to the sensitive ones. Together with these evidences, we suggest an ideal remedy for the compromised to fight host against pathogens. Moreover, we try to modify these hemopoietic formulae to more digestive forms. This modification brings to the significant lifted up for antibody producing cells and anti-oxidative activity for phagocytic cells.

关键词： Traditional Chinese Medicine Cancer Chemotherapeutic Agent Compromised Host Intracellular Infectious Agent Intercellular Infectious agent

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Antitumor Effects and Acute Oral Toxicity Studies of a Plant Extract Mixture Containing <i>Rhus verniciflua</i>and Some Other Herbs

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Open Journal of Immunology 2015年第1期5卷 39-49页

作者： Wataru Hiruma kohei suruga Kazunari Kadokura Tsuyoshi Tomita Ayaka Miyata Yoshihiro Sekino Masahiko Kimura Nobuo Yamaguchi Yasuhiro Komatsu C. A. Tony Buffington Nobufumi Ono International Operation Department (FM Center for R & D) Kibun Foods Inc. Tokyo Japan Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan Ishikawa Natural Medicinal Products Research Center Ishikawa Japan Department of Fundamental Research for CAM Kanazawa Medical University Ishikawa Japan Kitasato Institution for Life Science Kitasato University Tokyo Japan Sun R & D Institute for Natural Medicines Co. Inc. Tokyo Japan Department of Veterinary Clinical Sciences The Ohio State University College of Veterinary Medicine Columbus USA

A novel antitumor agent was developed from six kinds of herbs containing Rhus verniciflua (Rv-PEM01). The components were traditionally established for each formula for traditional medicine. The formula was designed to affect antitumor effect as well as maintain host immune functions. First, we investigated the antiproliferative activities of Rv-PEM01 on human and canine tumor cell lines in vitro, and on antitumor effects using BALB/cAJcl-nu/nu mice in vivo. Acute oral toxicity of Rv-PEM01 was also investigated in vivo in ddY mice. Rv-PEM01 exhibited antiproliferative activities against PC-3 (IC50: 0.328 ± 0.081 mg/ml), A549 (IC50: 0.520 ± 0.070 mg/ml), D-17 (IC50: 0.124 ± 0.037 mg/ml) and MRC-5 (IC50: 0.505 ± 0.058 mg/ml) cells. Luteolin 7-β-D-glucopyranoside and apigenin 7-β-D-glucopyranoside were identified as the main active compounds in Rv-PEM01 by HPLC analysis. The single dose toxicity study of Rv-PEM01 did not result in any deaths or abnor-malities in daily behavior, body weight gain, or anatomical observations at necropsy. Thus, so we could not calculate the 50% lethal dose (LD50) in mice, but it would be higher than 5.0 g/kg. Treat- ment with Rv-PEM01 at a dose of 2.5 g/kg tended to show antitumor activities on mice bearing Colon26 tumors compared with the control group. It was concluded that the formula was a safe antitumor agent with no side effects on mouse physiological function as judged by survival and organ weight.

关键词： Rhus verniciflua Antitumor Antiproliferation Acute Toxicity

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A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 175-184页

作者： Katsuhisa Omagari Kazuhito suruga Akira Kyogoku Satomi Nakamura Ai Sakamoto ShintaNishioka Mayuko Ichimura Yuji Miyata Koichi Tajima Koichi Tsuneyama Kazunari Tanaka Department of Nutrition Faculty of Nursing and NutritionGraduate School of Human Health ScienceUniversity of NagasakiNagasakiJapan Division of Nutritional Science Graduate School of Human Health ScienceUniversity of NagasakiNagasakiJapan Agriculture and Forestry Technical Development Center Nagasaki PrefTea LaboratoryNagasakiJapan Agriculture and Forestry Technical Development Center Nagasaki PrefForest Research SectionNagasakiJapan Department of Pathology and Laboratory Medicine Tokushima University Graduate SchoolTokushimaJapan

Background:Established treatments for non-alcoholic steatohepatitis (NASH) are few, thus it is imperative to develop novel dietary strategies that can prevent NASH. A fermented mixed tea (FMT) made with Camellia japonica (Japanese camellia) and third- crop green tea leaves by tea-rolling processing was reported to reduce body weight and adipose tissue weight in Sprague-Dawley (SD) rats. Because visceral fat is one of the most important factors for the development of hepatic steatosis, this FMT supplementation can be a candidate dietary strategy for the prevention of NASH. Methods:Nine-week-old male SD rats were fed a high-fat and high-cholesterol (HFC) diets with or without FMT (camellia and third-crop green tea leaves at ratios of 1:5, 1:2 and 1:1) for 9 weeks (n=6–7/group). Histopathology, serology and expressions of ifbrogenetic, proinlfammatory, oxidative stress and lipid metabolism-related genes in the liver were evaluated. Results:Histologically, HFC diet with FMT at a ratio of 1:5 dramatically reduced NASH progression (14%) compared to the HFC diet without FMT (100%). FMT at a ratio of 1:5 reduced hepatic steatosis due to the activation of microsomal triglyceride transfer protein, and FMT at a ratio of 1:2 reduced mRNA levels of some proinlfammatory, lipid metabolism-related, ifbrogenic and oxidative stress marker genes. Conclusions:Our data suggest that FMT at a ratio of 1:5 or 1:2 likely possesses a preventive effect on NASH progression.

关键词： Camellia leaves green tea leaves fermented tea nonalcoholic steatohepatitis high-fat and high-cholesterol (HFC) diet

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蒙医传统牛角拔罐疗法治疗类风湿性关节炎临床研究

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中国民族医药杂志 2020年第7期26卷 34-37页

作者：娜仁苏如嘎都楞兰花布仁吉日嘎拉锡林郭勒蒙医医院内蒙古锡林浩特026000 蒙古国国立医科大学乌兰巴托不详

目的:探讨蒙医传统牛角拔罐疗法治疗类风湿性关节炎的临床疗效,为进一步研究提供可靠的临床依据。方法:将60例类风湿性关节炎患者随机分为观察组和对照组,各30例。观察组采用蒙医牛角拔罐疗法治疗,对照组采用蒙药治疗。21 d为1个疗程。... 详细信息

目的:探讨蒙医传统牛角拔罐疗法治疗类风湿性关节炎的临床疗效,为进一步研究提供可靠的临床依据。方法:将60例类风湿性关节炎患者随机分为观察组和对照组,各30例。观察组采用蒙医牛角拔罐疗法治疗,对照组采用蒙药治疗。21 d为1个疗程。治疗前后采用视觉模拟评分法(VAS)、简化McGill疼痛问卷进行疼痛评价,采用DAS28评分、健康评估问卷(HAQ)进行关节功能评价,另对治疗前后实验室相关指标方面进行差异性分析。结果:①观察组(DAS28)受试者对自身疾病活动性的综合评价显效率为60.00%,总有效率为86.67%;对照组显效率为23.33%,总有效率为70.00%。观察组显著优于对照组,两组间比较有显著差异(P0.05)。结论:蒙医传统牛角拔罐疗法治疗类风湿性关节炎疗效显著,具有疗程短、操作简便、经济负担轻、无毒无副作用等优势,值得临床推广应用。

关键词：蒙医传统牛角拔罐疗法类风湿关节炎临床观察

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