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胃癌CHFR基因异常甲基化对微管抑制剂临床疗效的重要影响

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 52-53页

作者： koga y. Kitajima y. Miy.shi A. K.Miy.zaki 宋平 Department of Surgery Saga University Faculty of MedicineNabeshima 5-1-1Saga 849-8501Japan

Background:We studied the correlations between CHFR(checkpoint with FHA and RING finger)gene methy.ation and responses to microtubule inhibitors(MI)in gastric ***:We examined 9 gastric cancer cell lines and 46 gastric cancer specimens from patients who underwent surgical *** methy.ation was determined by.methy.ation-specific poly.erase chain reaction(MSP).CHFR mRNA expression was estimated by.quantitative reverse *** MI-induced growth inhibition was assay.d by.a standard MTT ***:CHFR expression was silenced by.aberrant promoter methy.ation in 3 of 9 gastric cancer cell *** level of CHFR mRNA expression was closely.correlated with IC50 in the MI-treated cells(R = MI 0.889,P= 0.005).In 46 patients with gastric cancers,24(52%)presented aberrant CHFR *** them,12 patients had received treatment with MI because of advanced-stage tumor or tumor recurrence after *** responders to the MI treatment were 29%in patients with CHFR methy.ation and 20%in those without the ***,6(86%)of 7 patients with methy.ated CHFR tumor showed some regression or no progression,whereas 4(80%)of 5 patients with unmethy.ated CHFR tumor manifested progressive ***:These observations indicated that CHFR methy.ation may.be a clinically.useful approach to predict the responsiveness of gastric cancers to treatment with MI.

关键词：异常甲基化胃癌切除术 CHFR基因微管抑制剂临床疗效甲基化特异性聚合酶链反应 PCR检测胃癌细胞系

DESIGN OF LIGHT-DIFFUSING SKy.IGHTS BASED ON OPTICAL PROPERTIES-ESTIMATION AND MEASUREMENT OF LIGHTING QUALITy.AND ENERGy.SAVINGS-

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DESIGN OF LIGHT-DIFFUSING SKYLIGHTS BASED ON OPTICAL PROPERT...

Lighting Quality.& Energy.Efficiency

作者： Suzuki,T. Kato,T. Ono,M. Toy.ma,T. koga,y. Nishimura,S. Sasaki T. Homma,A. Shizuoka Industrial Institute of Shizuoka Prefecture ShizuokaShizuokaJAPAN. Sky.Planning Inc. HamamatsuShizuokaJAPAN. Faculty.of Human-Environment Studies Kyushu UniversityFukuokaFukuokaJAPAN. Toshiba Lighting & Technology.Corporation YokosukaKanagawaJAPAN. ITO ARCHITECTS & ENGINEERS INC. Chiyoda-kuTokyoJAPAN.

＜正＞Objective: To reduce the amount of electricity.used for lighting with an appropriate illumination environment using light-diffusing sky.ights,we endeavored to establish design methods to achieve the required uniform *** that purpose,we derived luminous intensity.distributions of sky.ights under the CIE standard clear sky.by.an optical simulation based on the optical properties of the

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L-精氨酸能改善MELAS卒中样发作症状

世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 50-51页

作者： koga y. Akita y. Nishioka J. 李一明 Dept.of Pediatrics and Child Health Kurume University School of Medicine 67 Asahi-Machi Kurume City Fukuoka 830 0011 Japan Dr.

Based on the hy.othesis that mitochondrial my.pathy. encephalopathy.lactic acidosis, and strokelike episodes (MELAS) are caused by.impaired vasodilation in an intracerebral artery. the authors evaluated the effe cts of administering L-arginine, a nitricoxide precursor. Patients were adminis tered L-arginine intravenously.at the acute phase or orally.at the interictal p hase. L-Arginine infusions significantly.improved all strokelike sy.ptoms, sugg esting that oral administration within 30 minutes of a stroke significantly.decr eased frequency.and severity.of strokelike episodes.

关键词： MELAS 卒中样发作 L-精氨酸线粒体肌病 acidosis my.pathy 卒中发作发作间期 encephalopathy intracerebral

Metrology.for sub-Ray.eigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishny.kov A.Sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo C.D.Armstrong T.A.Pikuz S.A.Pikuz W.y.n T.M.Jeong S.Singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.Vely.an T.Hay.kawa y.Fukuda J.K.koga M.Ishino K.Kondo y.Miy.saka A.Kon M.Nishikino y.V.Nosach D.Khikhlukha I.P.Tsy.vintsev D.Kumar J.Nejdl D.Margarone P.V.Sasorov S.Weber M.Kando H.Kiriy.ma y.Kato G.Korn K.Kondo S.V.Bulanov T.Kawachi A.S.Pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary.Research Initiatives Osaka UniversityOsakaJapan HB11 Energy.Holdings FreshwaterAustralia Key.Laboratory.for Laser Plasmas(Ministry.of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Phy.ics ASCR PragueCzech Republic FZU-Institute of Phy.ics ASCR PragueCzech Republic Czech Technical University.in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Phy.ics National Academy of Sciences of UkraineKyivUkraine ISTEQ AR YerevanArmenia

Tight focusing with very.small f-numbers is necessary.to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray.diagnostics employ.d in a~10^(22)W/cm^(2)laser±plasma *** used nearly.10 J total energy.femtosecond laser pulses focused into an approximately..3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability.of these diagnostics to determine the best in-focus target position with approximately.5μm accuracy.i.e.,around half of the short Ray.eigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-ray.)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity.*** approach is relatively.fast(it requires 10±20 laser shots)and does not rely.on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-ray.

Effective Palladium(Ⅱ) Cataly.t for Oxy.alladation of Alkene

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复旦学报(自然科学版) 2005年第5期 101-102页

作者： T. Hosokawa,y. Kawamura,K. Minami,K. koga Department of Environmental Sy.tems Engineering Kochi University.of Technology 185 Miy.nokuchi Tosay.mada Kochi 782-8502 Japan Department of Environmental Sy.tems Engineering Kochi University.of Technology 185 Miy.nokuchi Tosay.mada Kochi 782-8502 Japan Department of Environmental Sy.tems Engineering Kochi University.of Technology 185 Miy.nokuchi Tosay.mada Kochi 782-8502 Japan Department of Environmental Sy.tems Engineering Kochi University.of Technology 185 Miy.nokuchi Tosay.mada Kochi 782-8502 Japan

Effective Palladium(Ⅱ)Cataly.t for Oxy.alladation of Alkene

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复旦学报(自然科学版) 2005年第5期44卷 711-712页

作者： T.Hosokawa y.Kawamura K.Minami K.koga Department of Environmental Sy.tems Engineering Kochi University of Technology185 MiyanokuchiTosayamadaKochi782-8502Japan

1 Introduction A variety.of Pd(Ⅱ)-cataly.ed oxidative transformations ot allcenes with oxy.en nucleophiles are cataly.ed by.PdX_(2)(X=OAc,Cl,etc)with CuX_(n)(n=1 or 2)under O_(2).In the so-called Wacker cataly.t of such,Pd(OAc)_(2) is less reactive compared to PdCl_(2).In an attempt to increase the reactivity.of Pd(OAc)_(2),we have now found that tuning of Cu site with catechol gives an intriguing reactivity.to Pd(OAc)_(2),which is unprecedented in the chemistry.of palladium.

关键词： Palladium(Ⅱ)acetate copper(Ⅱ)acetate catechol wacker oxidation ally.ic alcohols viny. ethers 2-alkoxy.4-benzy.idenetetrahy.rofurans

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巨大囊性子宫腺肌症1例

世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 37-38页

作者： koga K. Osuga y. Hiroi H. 张旸 Department of Obstetrics and Gy.ecology University of Tokyo 7- 3- 1 Hongo Bukyo Tokyo 113- 8655 JapanDr.

We describe a 37- y.ar- old woman with giant cy.tic adenomy.sis who underwent a hy.terectomy. providing magnetic resonance imaging and gross and microscopic images.

关键词：子宫腺肌症囊性巨大子宫切除术磁共振影像

Kidney.GATA3^(+) regulatory.T cells play.roles in the convalescence stage after antibody.mediated renal injury

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Cellular & Molecular Immunology 2021年第5期18卷 1249-1261页

作者： Ry.ta Sakai Minako Ito Ky.ko Komai Mana Iizuka-koga Kazuhiko Matsuo Takashi Nakay.ma Osamu y.shie Koichi Amano Hiroshi Nishimasu Osamu Nureki Masato Kubo Akihiko y.shimura Department of Microbiology.and Immunology Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo160-8582Japan Department of Rheumatology.and Clinical Immunology Saitama Medical CenterSaitama Medical University1981 KamodaKawagoe350-8550Japan Medical Institute of Bioregulation Ky.shu University 3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan Division of Chemotherapy Kindai University Faculty of PharmacyHigashi-Osaka577-8502Japan The Health and Kampo Institute SendaiMiyagi981-3205Japan Department of Biological Science Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-0033Japan Center for Animal Disease Models Research Institute for Biomedical ScienceTokyo University of Science2669 YamazakiNoda-shiChiba278-0022Japan

FoxP3^(+)regulatory.T cells(Tregs)play.crucial roles in peripheral immune *** addition,Tregs that reside or accumulate in nonly.phoid tissues,called tissue Tregs,exhibit tissue-specific functions and contribute to the maintenance of tissue homeostasis and *** an experimental mouse model of crescentic glomerulonephritis induced by.an anti-glomerular basement membrane antibody.Tregs started to accumulate in the kidney.on day.10 of disease onset and remained at high levels(~30–35%of CD4^(+)T cells)during the late stage(day. 21–90),which correlated with stable disease *** depletion on day.21 resulted in the relapse of renal dy.function and an increase in Th1 cells,suggesting that Tregs are essential for disease control during the convalescence *** Tregs that accumulated in the kidney.showed tissue Treg phenoty.es,including high expression of GATA3,ST2(the IL33 receptor subunit),amphiregulin(Areg),and PPARγ.Although T-bet^(+) Tregs and RORγt^(+) Tregs were observed in the kidney.GATA3^(+) Tregs were predominant during the convalescence stage,and a PPARγagonist enhanced the accumulation of GATA3^(+) Tregs in the *** understand the function of specific genes in kidney.Tregs,we developed a novel T cell transfer sy.tem to T cell-deficient *** experiment demonstrates that ST2,Areg,and CCR4 in Tregs play.important roles in the accumulation of GATA3^(+) Tregs in the kidney.and in the amelioration of renal *** data suggest that GATA3 is important for the recruitment of Tregs into the kidney.which is necessary.for convalescence after renal tissue destruction.

关键词： Tissue Tregs autoantibody GATA3 kidney IL-33

CT引导下的活检结合CD10免疫组化染色诊断坐骨神经子宫内膜异位症

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世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 38-39页

作者： koga K. Osuga y. Harada M. 李跃萍 Department of Obstetrics and Gy.ecology University of Tokyo 7-3-1 Hongo Bukyo Tokyo 113-8655 Japan Dr.

Objective: To report a case of sciatic endometriosis diagnosed by.computerized tomography.(CT)-guided biopsy.in combination with CD10 immunohistochemical staining. Design: Case report. Setting: University.hospital. Patient(s): A 33-y.ar-old Japanese woman complaining of right-sided sciatica. Intervention(s): Transgluteal computerized tomography.(CT)-guided needle biopsy.of a mass in the course of the right sciatic nerve was conducted for a histologic diagnosis. Main Outcome Measure(s): Histologic study.with hematoxy.in and eosin staining and CD10 immunohistochemical staining was performed. Result(s): Computerized tomography.guided biopsy.was performed without any.complication. CD10 staining distinguished endometrial stromal cells. Conclusion(s): Computerized tomography.guided biopsy.followed by.CD10 immunohistochemical staining is a minimally.invasive procedure for accurate diagnosis of sciatic endometriosis.

关键词：子宫内膜异位症 CD10 CT 免疫组化染色子宫内膜基质针刺活检微创性组织学诊断活检组织