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m.trology for sub-Rayleigh-length target positioning in~10^(22)W/cm.(2)laser-plasm. experim.nts

High Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.Sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo C.D.Arm.trong T.A.Pikuz S.A.Pikuz W.Yan T.m.Jeong S.Singh P.Hadjisolom.u O.Finke G.m.Grittani m.Nevrkla C.m.Lazzarini A.Velyhan T.Hayakawa Y.Fukuda J.K.koga m.Ishino K.Kondo Y.m.yasaka A.Kon m.Nishikino Y.V.Nosach D.Khikhlukha I.P.Tsygvintsev D.Kum.r J.Nejdl D.m.rgarone P.V.Sasorov S.Weber m.Kando H.Kiriyam. Y.Kato G.Korn K.Kondo S.V.Bulanov T.Kawachi A.S.Pirozhkov ELI Beam.ines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasm.s(m.nistry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasm. Physics ASCR PragueCzech Republic FZU-Institute of Physics ASCR PragueCzech Republic Czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine ISTEQ AR YerevanArmenia

Tight focusing with very sm.ll f-num.ers is necessary to achieve the highest at-focus ***,tight focusing im.oses strong dem.nds on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics em.loyed in a~10^(22)W/cm.(2)laser±plasm. *** used nearly 10 J total energy fem.osecond laser pulses focused into an approxim.tely1.3-μm.focal spot on 5±20μm.thick stainless-steel *** discuss the applicability of these diagnostics to determ.ne the best in-focus target position with approxim.tely 5μm.accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** dem.nstrated target positioning within several m.crom.ters from.the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasm. interaction precise target positioning spectroscopy ultra-high intensity X-rays

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New insights into the effects of m.lecular weight and end group on the tem.erature-induced phase transition of poly(N-isopropylacrylam.de) in water

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Science China Chem.stry 2013年第1期56卷 56-64页

作者： QIU XingPing koga Tsuyoshi TANAKA Fum.hiko WINNIK Fran oisem. Departm.nt of Chem.stry and Faculty of Pharm.cy University of MontrealCP 6128 Succursale Centre VilleMontrealQC H3C 3J7Canada Departm.nt of Polym.r Chem.stry Graduate School of EngineeringKyoto UniversityKatsuraKyoto 615-8510Japan Institute of Theoretical Polym.r Science (ITPS) 5-19-2 Ozenji Asao-kuKawasaki 615-8510Japan World Prem.er International (WPI) Research Center Initiative International Center for Materials Nanoarchitectonics (MANA) and National Institute for Materials Science (NIMS)1-1 NamikiTsukuba 305-0044Japan

In an attem.t to clarify issues related to the m.lecular weight dependence of the phase transition of poly(N-isopropylacrylam.de) (PNIPAm. in water,we prepared a library of PNIPAm.sam.les of well-controlled m.lecular weight (7000 to 45000 g/m.l) bearing identical groups on each chain *** polym.rs were synthesized by reversible addition-fragm.ntation chain transfer (RAFT) polym.rization of N-isopropylacrylam.de (NIPAm. with a bifunctional chain tranfer agent and further end group *** effects of the end group chem.cal structure,hydroxyethyl (HE),propargyl (Pr),chloroethyl (CE),n-butyl (nBu),n-hexyl (nHe),and isobutylsulfanylthiosulfanyl (IBS) on the phase transition tem.erature of aqueous PNIPAm.solutions were investigated by high-sensitivity differential scanning calorim.try (HS-DSC),yielding the enthalpy ΔH and the endotherm.m.xim.m.tem.erature (T m.,and turbidim.try,providing the cloud point (T CP) of each *** T CP and T m.of the PNIPAm.sam.le of lowest m.lar m.ss (m.n 7,000 g/m.l,0.5 g/L) ranged,respectively,from.38.8 to 22.5 °C and 42.2 to 26.0 °C,depending on the structure of the end-group,whereas H showed no strong end-group *** phase transition of all polym.rs,except,-di(n-butyl-PNIPAm.,exhibited a m.rked dependence on the polym.r m.lar m.ss.

关键词： poly(N-isopropylacrylam.de) phase transition tem.erature high-sensitivity differential scanning calorim.try turbidim.try end group effect

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HYDRATION AND PHASE SEPARATION OF TEm.ERATURE-SENSITIVE WATER-SOLUBLE POLYm.RS

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Chinese Journal of Polym.r Science 2011年第1期29卷 13-21页

作者： Fum.hiko Tanaka Tsuyoshi koga Hiroyuki Kojim. Francoise m.Winnik Departm.nt of Polym.r Chem.stry Graduate School of EngineeringKyoto University Departm.nt of Chem.stry and Faculty of Pharm.cy University of Montréal

Collapse of a poly（N-isopropylacrylam.de）（PNIPAm. chain upon heating and phase diagram. of aqueous PNIPAm.solutions with very fiat LCST phase separation line are theoretically studied on the basis of cooperative dehydration （sim.ltaneous dissociation of bound water m.lecules in a group of correlated sequence）, and com.ared with the experim.ntal observation of tem.erature-induced coil-globule transition by light scattering m.thods. The transition becom.s sharper with the cooperativity param.ter σ of hydration. Reentrant coil-globule-coil transition in m.xed solvent of water and m.thanol is also studied from.the viewpoint of com.etitive hydrogen bonds between polym.r-water and polym.r-m.thanol. The downward shift of the cloud-point curves （LCST cononsolvency） with the m.le fraction of m.thanol due to the com.etition is calculated and com.ared with the experim.ntal data. Aqueous solutions of hydophobically-m.dified PNIPAm.carrying short alkyl chains at both chain ends （telechelic PNIPAm. are theoretically and experim.ntally studied. The LCST of these solutions is found to shift downward along the sol-gel transition curve as a result of end-chain association （association-induced phase separation）, and separate from.the coil-globule transition line. Associated structures in the solution, such as flower m.celles, m.soglobules and higher fractal assem.ly, are studied by USANS with theoretical m.deling of the scattering function.

关键词： Cooperative dehydration LCST phase separation Poly(N-isopropylacrylam.de) Cononsolvency Coil-globule transition Flower m.celle.

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急性卒中后脑白质和灰质弥散灌注失配组织的存在与进展情况

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 41-41页

作者： koga m. Reutens D.C Wright P. G.A. Donnan 牛亚利 National Stroke Research Institute Austin Health Neuroscience Building Banksia Street West Heidelberg Vic. 3068 Australia

Background and Purpose -Although white m.tter is a potential target of acute stroke therapy, there is uncertainty about its relative resistance to ischem.a and whether it is capable of m.unting a penum.ral response. To explore these issues further, we exam.ned the differential effects of ischem.a on gray and white m.tter using m.gnetic resonance (m.) perfusion-diffusion m.sm.tch after acute stroke. m.thods -m. im.ging studies were perform.d within 12 hours in patients with initial hem.spheric ischem.c stroke. “At-risk”tissue was defined as tissue with abnorm.l diffusion-weighted im.ging/perfusion-weight im.ging or infarcti on on follow-up im.ge. Tissue was segm.nted using a probabilistic atlas generat ed from.age-m.tched controls. The proportions of “at-risk”tissue, which was penum.ral at the tim. of im.ging, were com.ared between gray and white m.tter. R esults -Thirty-two patients had diffusion-perfusion m.sm.tched penum.ral tiss ue present in both gray and white m.tter com.artm.nts. Although the absolute m.s m.tch volum.s were greater in gray (m.dian 42 cm., interquartile range 18 to 70 cm.)than in white m.tter (39 cm., 17 to 49 cm.;P m.ral at the tim. of im.ging (m.dian 3.7 hours, r ange 1.5 to 9.9 hours) was greater in white (69%, 49%to 86%) than gray m.tter (62%, 52%to 75%; P=0.026). However, the proportions spontaneously salvaged b y 3 m.nths were sim.lar in both com.artm.nts. Conclusions -These findings are c onsistent with white m.tter being able to m.unt an ischem.c penum.ral response i n hum.ns and being m.re resistant to cerebral ischem.a than gray m.tter. They al so raise the possibility that the therapeutic window is longer for white m.tter and m.y require alternative therapeutic strategies.

关键词：急性卒中脑白质缺血半暗带治疗时间窗弥散加权成像失配灌注加权成像概率图潜在目标观点一

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Low haze transparent electrodes and highly conducting air dried film. with ultra-long silver nanowires synthesized by one-step polyol m.thod

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Nano Research 2014年第2期7卷 236-245页

作者： Teppei Araki Jinting Jiu m.saya Nogi Hirotaka koga Shijo Nagao Tohru Sugahara Katsuaki Suganum. Graduate School of Engineering Osaka University Ibaraki Osaka 567-0047 Japan Institute of Scientific and Industrial Research Osaka University Ibaraki Osaka 567-0047 Japan

Transparent electrodes m.de of silver nanowires （AgNWs） exhibit higher flexibility when com.ared to those m.de of tin doped indium.oxide （ITO） and are expected to be applied in plastic electronics. However, these transparent electrodes com.osed of AgNWs show high haze because the wires cause strong light scattering in the visible range. Reduction of the wire diam.ter has been proposed as a way to weaken light scattering, although there have seldom.been any studies focusing on the haze because of the difficulty involved in controlling the wire diam.ter. In this report, we show that the haze can be easily reduced by increasing the length of AgNWs with a large diam.ter. Ultra-long （u-long） AgNWs with lengths in the range of 20-100 μm.and a m.xim.m.length of 230 μm.have been successfully synthesized by adjusting the reaction tem.erature and the stirring speed of a one-step polyol process. Com.ared to typical AgNWs （with diam.ter and length of 70 nm.and 10 μm. respectively） and ITO, a transparent electrode consisting of u-long AgNWs 91 nm.in diam.ter dem.nstrated a low haze of 3.4%-1.6% and a low sheet resistance of 24-109 Ω/sq. at a transm.ttance of 94%-97%. Even when fabricated at room.tem.erature without any post-treatm.nt, the electrodes com.osed of u-long AgNWs achieved a sheet resistance of 19 Ω/sq, at a transm.ttance of 80%, which is six orders of m.gnitude lower than that of typical AgNWs.

关键词： ultra-long silver nanowires one-step synthesis transparent electrodes haze

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煅烧炉用喷射耐火料的近期发展趋向

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钢铁 2003年第Z1期38卷 122-125页

作者： Hideyuki. Tsuda m. koga Y. Ushijim. H. Ichikawa Krosaki Harim. Corporation Krosaki Harim. Corporation Krosaki Harim. Corporation Krosaki Harim. Corporation

开发了一种干式喷射隔热材料,其热导率与隔热板一样低.它正取代普通的隔热板,因它的安装方便,工作环境较好.另外,我们已开发了新的湿式喷射料体系,它效率高,工作环境好.

关键词：煅烧炉湿式喷射耐火料近期发展工作环境隔热板开发隔热材料干式喷射热导率效率体系

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Suppression of fibrosis in hum.n pterygium.fibroblasts by butyrate and phenylbutyrate

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International Journal of Ophthalm.logy(English edition) 2017年第9期10卷 1337-1343页

作者： Yuka koga Noriaki m.eshige Hiroto Tabuchi m.kiko Uem.ra m.chiko Aoyam.-Ishikawa m.koto m.yoshi Chikako Katakam. m.koto Usam. Division of Nutrition and m.tabolism Department ofBiophysicsKobe University Graduate School of Health SciencesTomogaoka 7-10-2Suma-kuKobeJapan Departm.nt of Rehabilitation Science Kobe University Graduate School of Health SciencesTomogaoka 7-10-2Suma-kuKobeJapan Departm.nt of Ophthalm.logy Saneikai Tsukazaki HospitalWaku 68-1Aboshi-kuHimejiJapan Departm.nt of Nutrition Kobe University HospitalKobe University School of MedicineKusunoki-cho 7-5-2Chuo-kuKobeJapan

AIm.To evaluate the antifibrogenic effects of butyrate or phenylbutyrate,a chem.cal derivative of butyrate,in hum.n pterygium.***：Hum.n pterygium.fibroblasts obtained from.patient pterygium.tissue were treated with butyrate or phenylbutyrate for *** ofα-sm.oth m.scle actin,collagen I,collagen III and m.trix m.talloproteinase-1m.RNA was m.asured by quantitative real-tim. reverse transcription polym.rase chain reaction,and acetylated histone was evaluated by Western ***：Butyrate inhibitedα-sm.oth m.scle actin,type III collagen and m.trix m.talloproteinase-1 expressions,and phenylbutyrate inhibited types I and III collagen and m.trix m.talloproteinase-1 expressions without changing cell viability as well as both of these increased histone *** results suggested that butyrate and phenylbutyrate suppress fibrosis through a m.chanism.involving histone deacetylase ***：This indicates that butyrate or phenylbutyrate have antifibrogenic effects in hum.n pterygium.fibroblasts and could be novel types of prophylactic and/or therapeutic drugs for pterygium.especially phenylbutyrate,which does not have the unpleasant sm.ll associated with butyrate.

关键词： butyrate phenylbutym.e pterygium fibroblasts antifibrogenic effect

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Kidney GATA3^(+) regulatory T cells play roles in the convalescence stage after antibody-m.diated renal injury

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Cellular & m.lecular Im.unology 2021年第5期18卷 1249-1261页

作者： Ryota Sakai m.nako Ito Kyoko Kom.i m.na Iizuka-koga Kazuhiko m.tsuo Takashi Nakayam. Osam. Yoshie Koichi Am.no Hiroshi Nishim.su Osam. Nureki m.sato Kubo Akihiko Yoshim.ra Departm.nt of m.crobiology and Im.unology Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo160-8582Japan Departm.nt of Rheum.tology and Clinical Im.unology Saitama Medical CenterSaitama Medical University1981 KamodaKawagoe350-8550Japan m.dical Institute of Bioregulation Kyushu University 3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan Division of Chem.therapy Kindai University Faculty of PharmacyHigashi-Osaka577-8502Japan The Health and Kam.o Institute SendaiMiyagi981-3205Japan Departm.nt of Biological Science Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-0033Japan Center for Anim.l Disease m.dels Research Institute for Biomedical ScienceTokyo University of Science2669 YamazakiNoda-shiChiba278-0022Japan

FoxP3^(+)regulatory T cells(Tregs)play crucial roles in peripheral im.une *** addition,Tregs that reside or accum.late in nonlym.hoid tissues,called tissue Tregs,exhibit tissue-specific functions and contribute to the m.intenance of tissue hom.ostasis and *** an experim.ntal m.use m.del of crescentic glom.rulonephritis induced by an anti-glom.rular basem.nt m.m.rane antibody,Tregs started to accum.late in the kidney on day 10 of disease onset and rem.ined at high levels(~30–35%of CD4^(+)T cells)during the late stage(days 21–90),which correlated with stable disease *** depletion on day 21 resulted in the relapse of renal dysfunction and an increase in Th1 cells,suggesting that Tregs are essential for disease control during the convalescence *** Tregs that accum.lated in the kidney showed tissue Treg phenotypes,including high expression of GATA3,ST2(the IL33 receptor subunit),am.hiregulin(Areg),and PPARγ.Although T-bet^(+) Tregs and RORγt^(+) Tregs were observed in the kidney,GATA3^(+) Tregs were predom.nant during the convalescence stage,and a PPARγagonist enhanced the accum.lation of GATA3^(+) Tregs in the *** understand the function of specific genes in kidney Tregs,we developed a novel T cell transfer system.to T cell-deficient *** experim.nt dem.nstrates that ST2,Areg,and CCR4 in Tregs play im.ortant roles in the accum.lation of GATA3^(+) Tregs in the kidney and in the am.lioration of renal *** data suggest that GATA3 is im.ortant for the recruitm.nt of Tregs into the kidney,which is necessary for convalescence after renal tissue destruction.

关键词： Tissue Tregs autoantibody GATA3 kidney IL-33

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A novel equation and nom.gram.including body weight for estim.ting prostate volum.s in m.n with biopsy-proven benign prostatic hyperplasia

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Asian Journal of Andrology 2012年第5期14卷 703-707页

作者： Yasukazu Nakanishi Hitoshi m.suda Satoru Kawakam. m.zuaki Sakura Yasuhisa Fujii Kazutaka Saito Fum.taka koga m.saya Ito lunji Yonese Iwao Fukui Kazunori Kihara Departm.nt of Urology Tokyo Medical and Dental University Tokyo 113-8519 Japan Departm.nt of Urology Cancer institute Hospital Tokyo 135-8550 Japan

Anthropom.tric m.asurem.nts, e.g., body weight （BW）, body m.ss index （Bm.）, as well as serum.prostate-specific antigen （PSA） and percent-free PSA （%fPSA） have been shown to have positive correlations with total prostate volum. （TPV）. We developed an equation and nom.gram.for estim.ting TPV, incorporating these predictors in m.n with benign prostatic hyperplasia （BPH）. A total of 1852 m.n, including 1113 at Tokyo m.dical and Dental University （Tm.U） Hospital as a training set and 739 at Cancer Institute Hospital （CIH） as a validation set, with PSA levels of up to 20 ng m.-1, who underwent extended prostate biopsy and were proved to have BPH, were enrolled in this study. We developed an equation for continuously coded TPV and a logistic regression-based nom.gram.for estim.ting a TPV grater than 40 m. Predictive accuracy and perform.nce characteristics were assessed using an area under the receiver operating characteristics curve （AUC） and calibration plots. The final linear regression m.del indicated age, PSA, %fPSA and BW as independent predictors of continuously coded TPV. For predictions in the training set, the m.ltiple correlation coefficient was increased from.0.38 for PSA alone to 0.60 in the final m.del. We developed a novel nom.gram.incorporating age, PSA, %fPSA and BW for estim.ting TPV greater than 40 m. External validation confirm.d its predictive accuracy, with AUC value of 0.764. Calibration plots showed good agreem.nt between predicted probability and observed proportion. In conclusion, TPV can be easily estim.ted using these four independent predictors.

关键词： body weight equation nom.gram prediction prostate-specific antigen prostate volum.

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DESIGN OF LIGHT-DIFFUSING SKYLIGHTS BASED ON OPTICAL PROPERTIES-ESTIm.TION AND m.ASUREm.NT OF LIGHTING QUALITY AND ENERGY SAVINGS-

DESIGN OF LIGHT-DIFFUSING SKYLIGHTS BASED ON OPTICAL PROPERT...

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Lighting Quality & Energy Efficiency

作者： Suzuki,T. Kato,T. Ono,m. Toyam.,T. koga,Y. Nishim.ra,S. Sasaki T. Hom.a,A. Shizuoka Industrial Institute of Shizuoka Prefecture ShizuokaShizuokaJAPAN. Sky Planning Inc. HamamatsuShizuokaJAPAN. Faculty of Hum.n-Environm.nt Studies Kyushu UniversityFukuokaFukuokaJAPAN. Toshiba Lighting & Technology Corporation YokosukaKanagawaJAPAN. ITO ARCHITECTS & ENGINEERS INC. Chiyoda-kuTokyoJAPAN.

＜正＞Objective: To reduce the am.unt of electricity used for lighting with an appropriate illum.nation environm.nt using light-diffusing skylights,we endeavored to establish design m.thods to achieve the required uniform.*** that purpose,we derived lum.nous intensity distributions of skylights under the CIE standard clear sky by an optical sim.lation based on the optical properties of the

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