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Tsc1/Tsc2 complex: A molecular target of capsaicin for protection against testicular torsion induced injury in rats

Chinese Herbal Medicines 2019年第2期11卷 216-221页

作者： Nasim Javdan Seyed Abdulmajid Ayatollahi Muhammad Iqbal Choudhary Safaa Al-Hasani Farzad Kobarfard kobra mokhtarian Majid Khoshmirsafa Athar Ata Phytochemistry Research Center Shahid Beheshti University of Medical Sciences Tehran 19839-63U3 Iran Department of Chemistry Richardson College for the Environmental Science Complex The University of Winnipeg Winnipeg R3C 1X6 Canada Department of Pharmacognosy School of Pharmacy Shahid Beheshti University of Medical Sciences Tehran 19839-63113 Iran International Center for Chemical and Biological Sciences H.E.J. Research Institute of Chemistry University of Karachi Karachi 75270 Pakistan Reproductive Medicine Unit University of Schleswig-Holstein Luebeck 24105 Germany Department of Medicinal Chemistry Shaheed Beheshti School of Pharmacy Tehran J9839-63113 Iran Medical Plant Research Center Basic Health Sciences Institute Shahrekord University of Medical Sciences Shahrekord 14747-17531 Iran Department of Immunology School of Medicine Iran University of Medical Sciences Tehran 14496-14535 Iran

Objective: The detailed knowledge about protective effects of capsaicin(cap) and involved mechanisms against testicular torsion(TT) is still not available ***: Male Wistar rats were assigned into four major cohorts:(i) sham,(ii) TT,(iii) three subgroups subjected to TT and different doses of cap(100, 500, and 1000 μg/mL), and(iv) three subgroups of healthy animals subjected to various concentrations of cap. The animals were decapitated at 24 h after reperfusion, and the evaluation of protein expression was performed by Western blotting assay. At 72 h after reperfusion, apoptotic cell death and tissue injury were evaluated by TUNEL nuclear and H&E staining,***: The results showed that cap administration following TT significantly increased the expression of tuberous sclerosis proteins 1 and 2(Tsc1/Tsc2) in a dose-dependent manner(P < 0.05). Cap decreased cell apoptosis at highest dose. Likewise, cap contributed to the preservation of tubular morphology and decreased tissue injury at the highest tested concentration(1000 μg/m L).Conclusion: Collectively, our findings demonstrate the validity of cap as a therapeutic agent against TT through targeting Tsc1/Tsc2 in a dose-dependent manner.

关键词： capsaicin cell survival molecular targets testicular torsion Tsc1/Tsc2 complex

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Design and Fabrication of a Passive Pelvic Orthosis for Treadmill Walking Rehabilitation

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Journal of Bionic Engineering 2023年第3期20卷 1036-1048页

作者： Ali mokhtarian Abbas Fattah Mehdi Keshmiri Department of Mechanical Engineering Khomeinishahr BranchIslamic Azad UniversityKhomeinishahr***Iran Department of Mechanical Engineering Isfahan University of TechnologyIsfahan***Iran

The pelvis plays a significant role in creating smooth and efficient motion during gait. In this study, an orthosis is designed to support pelvis motion of patients with the inability to walk. This assistive device is un-powered and consists of only passive elements. By focusing on the motion of the lower extremities during treadmill walking, a 3D dynamic model of the human body is simulated through a coupled optimization process. Based on two approaches of direct and inverse dynamics, the optimization problems are defined to derive optimum structural parameters of the pelvic orthosis. The optimization results of the direct dynamics problem indicate good matches between the optimized time plots of pelvis rotations with corresponding desired ones. Moreover, by solving the inverse dynamics problem, the minimum value of torque vector of the hip joint of the stance leg during a gait cycle is obtained. Furthermore, by utilizing a prototype of the orthosis, preliminary experiments are conducted on a normal user to validate the model and to investigate the feasibility of using the device for rehabilitation. For this purpose, the rotational movements of the pelvis and energy consumption of the subject in two cases with and without the device are compared during gait on a treadmill. Decreased energy consumption and the compliant motion of the pelvis while using the device verify simulation results and confirm the favorable performance of the assistive device for pelvic support during walking rehabilitation.

关键词： Pelvic support Passive orthosis Dynamic model Optimization Treadmill gait

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Determination of Vanadyl Porphyrins by Liquid-liquid Microextraction and Nano-baskets of p-tert-Calix[4]arene Bearing Di-[N-(X)sulfonye Carboxamide] and Di-(1-propoxy) in Ortho-cone Conformation

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Chemical Research in Chinese Universities 2012年第5期28卷 807-813页

作者： MOKHTARI Bahram POURABDOLLAH kobra Razi Chemistry Research Center(RCRC) Shahreza Branch Islamic Azad University

Dispersive liquid-liquid microextraction technique was introducd to remove the centrifuging step and conduct inclusion microextraction of charged porphyrins by nano-baskets. For nano-baskets of p-tert-calix[4]arene bearing di-[N-（X）sulfonyl carboxamide] and di-（1-propoxy） in ortho-cone conformation was synthesized and used. The related parameters including ligand concentration, the volume of water disperser, salt effect, and extraction time were optimized. The linear range, detection limit（S/N=3） and precision（RSD, n=6） were determined to be 0.2―50, 0.07 μg/L and 5.3%, respectively. The results reveal that the new approach is competitive analytical tool and an alternative of the traditional methods in the crude oil and related systems.

关键词： Nano-basket Dispersive liquid-liquid microextraction Vanadyl porphyrin Calixarene

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Separation of Salbutamol by Nano-baskets of Calix[4]arene Bearing Sulfonyl-carboxamides in Partial-cone Conformation

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Chemical Research in Chinese Universities 2012年第6期28卷 1112-1118页

作者： MOKHTARI Bahram POURABDOLLAH kobra Razi Chemistry Research Center(RCRC) Shahreza BranchIslamic Azad University

Salbutamol,which increases the muscle mass and decreases the adipose tissue,is misused as nutrient repartitioning agent in the *** novelty of this work is the determination of salbutamol in the livestock meat via new bonded-phases bearing eight derivatives of p-tert-calix[4]arene in partial-cone *** new synthesized bonded-phases were characterized and *** bonding interactions of solute and stationary-phases were examined and the main interactions were *** salbutamol levels in six samples of livestock meat were analyzed and the results reveal that for the best bonded-phases,the limit of detection（LOD） and limit of quantitation（LOQ） were 0.02 and 0.06 μg/mL,respectively.

关键词： Nano-basket Bonded-phase Partial-cone conformation Calixarene Salbutamol

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Determination of Dioxins in Blood Using Nano-baskets Doped in Emulsion Liquid Membranes

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Chemical Research in Chinese Universities 2013年第1期29卷 30-36页

作者： MOKHTARI Bahram POURABDOLLAH kobra Razi Chemistry Research Center(RCRC) Shahreza Branch Islamic Azad University Shahreza Iran

Extraction of dioxins from blood samples was carried out by inclusion-facilitated emulsion liquid membrane process. The novelty of this work is the application of nano-baskets of calixarene and emulsion liquid membranes in the selective and efficient preconcentration of dioxin. For this aim, four derivatives ofp-tert-calix[4]arene bearing different sulfonamide moieties were synthesized and their inclusion-extraction parameters were optimized including the calixarene＇s scaffold and concentration（as the carrier/demulsifier）, the diluent type in membrane, the phase and the treat ratio, mixing speed, and initial solute concentration. Determinations were followed by a gas chromatograph and the results reveal that under the optimized operating conditions, the preconcentration of dioxins was improved and the method achieved lower limit of detections（LODs）. Under optimal conditions, the figures of merits were determined to be LOD 1.0 pg/L, dynamic range 0.6--112.0 pg/L, RSD 5.5%（n=5）, and the maximum enrichment factor and recovery were determined to be 3.3 and 99%, respectively.

关键词： Nano-basket Dioxin Inclusion Calixarene Emulsion liquid membrane

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Contribution of biophysical and climate variables to the spatial distribution of wildfires in Iran

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Journal of Forestry Research 2023年第6期34卷 1763-1775页

作者： kobra Shojaeizadeh Mahmoud Ahmadi Abbasali Dadashi-Roudbari Department of Physical Geography Faculty of Earth SciencesShahid Beheshti UniversityTehranIran Department of Geography Ferdowsi University of MashhadMashhadIran

This study investigated the relationship between climate and biophysical variables in burned areas in *** fire burned area(FBA)product(Fire CCI 5.1.1),land surface temperature(MOD11C3C),vegetation index(MOD13A1),and climate variables such as temperature,wind speed,relative humidity,and volumetric soil moisture from the ERA5 reanalysis dataset were *** correlation coefficient was used to determine the relationship between biophysical and climate variables and fire *** results show that FBA increased by 1.7 hectares/decade from 2001 to *** high FBA in 2010(the black summer of Iran)was due to high temperatures and significant heatwaves that led to extensive *** anthropogenic activities are considered a significant cause of wildfires,several variables,including increased temperatures,less precipitation,relative humidity,and wind speed and direction,contribute to the extent and occurrence of *** country’s FBA hotspot is in the Arasbaran region during the summer *** and relative humidity are the most significant variables influencing the occurrence of *** results show the vulnerability of Iran s forests and their high potential for *** the frequency of fire occurrences in Iran and the limited equipment,fire prevention plans should be carried out by applying proper management in high-risk regions.

关键词： Wildfire Burned areas Vegetation index(Ⅵ) Air temperature Iran

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Efficient Multi-component Synthesis of Highly Substituted Imidazoles Utilizing P2O5/SiO2 as a Reusable Catalyst

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Chinese Journal of Chemistry 2011年第8期29卷 1635-1645页

作者： Shaterian, Hamid Reza Ranjbar, Mohammad Azizi, kobra Department of Chemistry Faculty of Sciences University of Sistan and Baluchestan PO Box 98135-674 Zahedan Iran

Phosphorus pentoxide supported on silica gel （P2O5/SiO2） has been used as an efficient and reusable catalyst for the one-pot pseudo four-component synthesis of 2,4,5-trisubstituted imidazoles from benzil or benzoin, aldehydes, and ammonium acetate. It was also used for four-component preparation of 1,2,4,5-tetrasubstituted imidazoles from benzil or benzoin, aldehydes, primary amine, and ammonium acetate under thermal solvent-free conditions. The remarkable features of this new procedure are high conversions, cleaner reaction, simple experimental and work-up procedures and also the catalyst can be easily separated from the reaction mixture and reused several times without any loss of its activity.

关键词： multicomponent reactions domino reactions phosphorus pentoxide supported on silica gel,2,4,5-trisubstituted imidazoles 1,2,4,5-tetrasubstituted imidazoles heterogeneous catalysis

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Environmental assessment of date(Phoenix doctylifera)production in Iran by life cycle assessment

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Information Processing in Agriculture 2018年第3期5卷 388-393页

作者： Reza Hesampour Aboubakr Bastani kobra Heidarbeigi Mechanical Engineering of Biosystems Department Ilam UniversityIlamIran

Environmental indicators have been considered as a main element of environmental impact assessments because of their role on decision and policy making in different fields of special environmental *** present study was conducted in order to evaluate date(Phoenix doctylifera)production in viewpoint of environmental indicators using life cycle assessment *** required information was collected by questionnaire and interview with farmers and experts in Khuzestan Province,*** SimaPro Software was used to calculate 11 different environmental indicators for producing one Tonne of the produced *** fuel,pesticides and nitrogen fertilizer had the highest shares in the studied environmental indicators.

关键词： Date Life cycle assessment Emissions Environmental indicators Khuzestan

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Selective Synthesis of 2-Aryl-l-benzylated-1 H-benzimidazoles

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Chinese Journal of Chemistry 2011年第11期29卷 2389-2393页

作者： Shaterian, Hamid Reza Fahimi, Nafiseh Azizi, kobra Department of Chemistry Faculty of Sciences University of Sistan and Baluchestan PO Box 98135-674 Zahedan lran

An efficient and simple procedure was developed for the green synthesis of various 2-aryl-l-ben- zylated-1H-benzimidazoles in high yields by condensation of o-phenylenediamine with aldehydes with P2O5/SiO2 as catalyst... 详细信息

关键词： synthetic methods aldehydes one-pot benzimidazoles heterogeneous catalyst solvent-free

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Efficient regeneration of aldehydes from their corresponding 1,3-oxathiolanes in the absence of solvent

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Chinese Chemical Letters 2011年第4期22卷 421-423页

作者： Farhad Shirini Seyyedeh kobra Mirhashemi Aysa Pourvali Masoumeh Abedini Department of Chemistry College of ScienceUniversity of GuilanRasht 41335Islamic Republic of Iran

A mild and efficient method for the oxidative deprotection of 1,3-oxathiolanes with Fe（NO3）3·9H2O and Cu（NO3）2·3H2O in the absence of solvent is reported.

关键词： Oxidative deprotection 1 3-Oxathiolanes Cu(NO3)2·3H2O Fe(NO3)3·9H2O Solvent-free conditions

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