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国外金属材料 1989年第4期 29-35页

作者： koba,k 晋阳

用铟射性同位素亚化学计量萃取法同时测定标准参考材料中镉,铟和锡

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国外锡工业 1989年第4期17卷 42-45页

作者： koba.,k 许孙曲

Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

TRISim:A Triage Simulation System to Exploit and Assess Triage Operations for Hospital Managers-Development,Validation and Experiment

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Computer Modeling in Engineering & Sciences 2017年第2期113卷 117-149页

作者： A.koba yashi k.Suginuma M.Furui chi Graduate School of Industrial Technology Nihon University College of Industrial Technology Nihon University

Triage is a method for determining the priority of patients’treatment to improve survival *** triage methods are used in hospitals,and they are applied after performing an evaluation based on standard methods such as the Japan Triage Acuity Scale(JTAS)or Emergency Severity Index(ESI).It is important to consider the characteristics of all the hospitals when assigning triage methods and emergency levels to them;the hospital managers make these *** propose a multi-agent simulation method to support the hospital managers in employing the triage protocols according to their *** developed a prototype simulation system called TRISim to explore and assess the triage *** this paper,we provide an overview of TRISim and present our experimental results to validate the system.

关键词： Multi-agent simulation MAS triage simulation JTAS ESI MTS emergency department

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Noise Characteristics of Centrifugal Blower with Low Solidity Cascade Diffuser(Noise Reduction by means of Small Groove Located at LSD Blade Leading Tip)

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Journal of Thermal Science 2009年第4期18卷 321-324页

作者： Tengen MURAkAMI Masahiro ISHIDA Daisaku SAkAGUCHI Yu koba Graduate School of Science and Technology Nagasaki University

This paper deals with the effect of the blade tip-groove of the low solidity cascade diffuser (LSD) on the blowercharacteristic and the noise generated by the LSD. The small grooves were set up at the root and/or tip near theleading edge of the LSD blade. In order to clarify the mechanism of noise increase due to LSD and also to reducethe noise, the relationships between the noise increase based on the LSD, the LSD performance and the secondaryflow formed additionally by the tip-groove were investigated experimentally as well as numerically, especiallyanalyzing flow behaviors in the LSD in view points of flow separation on the suction surface of the LSD bladeand the secondary flow on the side walls. By reducing the stagnation region smaller near the root and/or tip of theLSD blade leading edge, the secondary flow behavior changes remarkably around the LSD blade, as a result, thenoise level and the blower characteristics vary. It can be concluded that, by means of a small tip-groove locatedonly at the shroud side near the LSD blade leading edge, the noise generated by the LSD can be reduced withoutdeteriorations of the LSD performance and the blower characteristics as well.

关键词： Centrifugal blower Low solidity cascade diffuser Noise Diffuser performance Secondary flow

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词： Nanofluidics

FEM Modeling of Crack Propagation in a Model Multiphase Alloy

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Journal of Materials Science & Technology 2006年第1期22卷 59-65页

作者： Lihe QIAN Seishi NISHIDO Hiroyuki TODA Toshiro koba YASHI Department of Production Systems Engineering Toyohashi University of Technology Toyohashi 441-8580 Japan IT Promotion Department Aisin Takaoka Co. Ltd. 1 Tennoh Takaokashin-machi Toyota 473-8501 Japan

In this paper, several widely applied fracture criteria were first numerically examined and the crack-tip-region Jntegral criterion was confirmed to be more applicable to predict fracture angle in an elastic-plastic multiphase material. Then, the crack propagation in an idealized an elastic-plastic finite element method. The variation dendritic two-phase AI-7%Si alloy was modeled using of crack growth driving force with crack extension was also demonstrated. It is found that the crack path is significantly influenced by the presence of α-phase near the crack tip, and the crack growth driving force varies drastically from place to place. Lastly, the simulated fracture path in the two-phase model alloy was compared with the experimentally observed fracture path.

关键词： Al-Si alloys Fracture criterion Fracture path Numerical simulation Finite element method (FEM) Multiphase microstructure