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Inbreeding and genetic load in a pair of sibling grouse species:Tetrastes sewersowi and ***

Avian Research 2024年第2期15卷 265-270页

作者： Kai Song Tom van der Valk Bin Gao peter Halvarsson Yun Fang Wendong Xie Siegfried klaus Zhiming Han Yue-Hua Sun Jacob Hoglund Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China Animal Ecology Department of Ecology and GeneticsUppsala UniversityNorbyvagen 18DUppsala75236Sweden Department of Cell and Molecular Biology Uppsala75273Sweden Unit of Parasitology Department of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesPO Box 7036Uppsala75007Sweden Lindenhohe 5 JenaD-07749Germany The State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China

Genetic load and inbreeding are recognized as important factors to be considered in conservation *** levels of both can increase the risk of population extinction by negatively impacting fitness-related characters in many species of plants and animals,including humans(inbreeding depression).Genomic tech-niques are increasingly used in measuring and understanding genetic load and inbreeding and their importance in evolution and *** used whole genome resequencing data from two sibling grouse species in subarctic Eurasia to quantify *** found a large range of inbreeding measured as FROH(fraction of runs of homozygosity)in individuals from different populations of Chinese Grouse(Tetrastes sewerzowi)and Hazel Grouse(***).FROH estimated from genome-wide runs of homozygosity(ROH)ranged from 0.02 to 0.24 among Chinese Grouse populations and from 0.01 to 0.44 in Hazel *** from a population of Chinese Grouse residing in the Qilian mountains and from the European populations of Hazel Grouse(including samples from Sweden,Germany and Northeast Poland)were the most inbred(FROH ranged from 0.10 to 0.23 and 0.11 to 0.44,respectively).These levels are comparable to other highly inbred populations of *** Grouse from northern China and Chinese Grouse residing in the Qinghai-Tibetan Plateau showed relatively lower inbreeding *** of the ratio between deleterious missense mutations and synonymous mutations revealed higher levels in Chinese Grouse as compared to Hazel *** results are possibly explained by higher fixation rates,mutational melt down,in the range-restricted Chinese Grouse compared to the wide-ranging Hazel ***,when we compared the relatively more severe class of loss-of-function muta-tions,Hazel Grouse had slightly higher levels than Chinese Grouse,a result which may indicate that purifying selection(purging)has been more efficient in Chinese Grouse on this class of mutations.

关键词： Genetic load Inbreeding Purifying selection Qinghai-Tibetan Plateau ROH Tetrastes

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No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

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Translational Neurodegeneration 2019年第1期8卷 127-133页

作者： Franziska Hopfner Stefanie HMüller Dagmar Steppat Joanna Miller Nele Schmidt klaus-peter wandinger Frank Leypoldt Daniela Berg Andre Franke Wolfgang Lieb Lukas Tittmann Monika Balzer-Geldsetzer Simon Baudrexel Richard Dodel Ruediger Hilker-Roggendorf Elke Kalbe Jan Kassubek Thomas Klockgether Inga Liepelt-Scarfone Brit Mollenhauer Petra Neuser Kathrin Reetz Oliver Riedel Claudia Schulte Jörg BSchulz Annika Spottke Alexander Storch Claudia Trenkwalder Hans-Ulrich Wittchen Karsten Witt Ullrich Wüllner Günther Deuschl Gregor Kuhlenbäumer Department of Neurology University Hospital Schleswig HolsteinArnold-Heller Str.324105 KielGermany Center of Blood Transfusion University Hospital Schleswig HolsteinKiel&LübeckGermany Department of Clinical Chemistry University Hospital Schleswig-HolsteinKielGermany Institute of Clinical Molecular Biology University Hospital Schleswig-HolsteinKielGermany Institute of Epidemiology University Hospital Schleswig-HolsteinKielGermany Chair of Geriatric Medicine University Hospital EssenEssenGermany Department of Neurology Philipps-University MarburgMarburgGermany Department of Neurology Goethe UniversityFrankfurt/MainGermany Brain Imaging Center Goethe UniversityFrankfurt/MainGermany Department of Medical Psychology|Neuropsychology and Gender Studies&Center for Neuropsychological Diagnostics and Intervention(CeNDI) University Hospital CologneCologneGermany Psychological Gerontology Institute of GerontologyUniversity of VechtaVechtaGermany Department of Neurology University of UlmUlmGermany Department of Neurology University of Bonnand German Center for Neurodegenerative Diseases(DZNE)BonnGermany Center for Neurology Hertie Institute for Clinical Brain ResearchDepartment of Neurodegenerative DiseasesUniversity of TübingenTübingenGermany DZNE German Center for Neurodegenerative DiseasesTübingenGermany Paracelsus-Elena-Klinik KasselGermany Institute of Neuropathology and Department of Neurosurgery University Medical Center GöttingenGöttingenGermany Coordinating Centre for Clinical Trials Philipps-UniversityMarburgGermany Department of Neurology RWTH Aachen UniversityAachenGermany JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen UniversityAachenGermany Leibniz Institute for Prevention Research and Epidemiology-BIPS Achterstrasse 3028359 BremenGermany Department of Neurology Technische Universität Dresden01307 DresdenGermany German Center for Neurodegenerative Diseases(DZNE) Research Site Rostock18147 RostockGerma

Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting *** measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric *** phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive ***:NMDA antibodies were analysed in the serum of patients and controls using well established validated *** used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic ***:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both *** IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson ***:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease *** Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own.

关键词： NMDA antibody NMDA IgA/IgM antibodies Parkinson disease Cognitive impairment

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TBSSvis:Visual analytics for Temporal Blind Source Separation

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Visual Informatics 2022年第4期6卷 51-66页

作者： Nikolaus Piccolotto Markus Bögl Theresia Gschwandtner Christoph Muehlmann klaus Nordhausen peter Filzmoser Silvia Miksch TU Wien Institute of Visual Computing&Human-Centered TechnologyFavoritenstrasse 9–11A-1040 ViennaAustria Erste Group Bank AG Am Belvedere 1A-1100 ViennaAustria TU Wien Institute of Statistics and Mathematical Methods in EconomicsWiedner Hauptstrasse 8–10A-1040 ViennaAustria University of Jyväskylä Department of Mathematics and StatisticsFI40014 JyväskyläFinland

Temporal Blind Source Separation(TBSS)is used to obtain the true underlying processes from noisy temporal multivariate data,such as *** has similarities to Principal Component Analysis(PCA)as it separates the input data into univariate components and is applicable to suitable datasets from various domains,such as medicine,finance,or civil *** TBSS’s broad applicability,the involved tasks are not well supported in current tools,which offer only text-based interactions and single static *** are limited in analyzing and comparing obtained results,which consist of diverse data such as matrices and sets of time ***,parameter settings have a big impact on separation performance,but as a consequence of improper tooling,analysts currently do not consider the whole parameter *** propose to solve these problems by applying visual analytics(VA)*** primary contribution is a design study for TBSS,which so far has not been explored by the visualization *** developed a task abstraction and visualization design in a user-centered design ***-specific assembling of well-established visualization techniques and algorithms to gain insights in the TBSS processes is our secondary *** present TBSSvis,an interactive web-based VA prototype,which we evaluated extensively in two interviews with five TBSS *** and observations from these interviews show that TBSSvis supports the actual workflow and combination of interactive visualizations that facilitate the tasks involved in analyzing TBSS results.

关键词： Blind source separation Ensemble visualization Visual analytics Parameter space exploration

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糖尿病患者足溃疡减压指南(2023年更新版)——《国际糖尿病足工作组:糖尿病相关的足病预防与管理指南(2023)》的一部分

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感染、炎症、修复 2024年第1期25卷 1-22页

作者： Sicco A.Bus David G.Armstrong Ryan T.Crews Catherine Gooday Gustav Jarl klaus Kirketerp-Moller Vijay Viswanathan peter A.Lazzarini on behalf of the International Working Group on the Diabetic Foot 陈燕刘斌张晓诗邓武权(译) 王爱萍许樟荣(审校) Amsterdam UMC University of AmsterdamDepartment of Rehabilitation MedicineAmsterdamthe Netherlands Amsterdam Movement Sciences program Rehabilitation&DevelopmentAmsterdamthe Netherlands Southwestern Academic Limb Salvage Alliance(SALSA) Department of SurgeryKeck School of Medicine of University of Southern California(USC)Los AngelesCaliforniaUSA Dr.William M.Scholl College of Podiatric Medicine's Center for Lower Extremity Ambulatory Research(CLEAR)at Rosalind Franklin University North ChicagoIllinoisUSA Elsie Bertram Diabetes Centre Norfolk and Norwich University HospitalsNorwichUK Department of Prosthetics and Orthotics Faculty of Medicine and HealthÖrebro UniversityÖrebroSweden University Health Care Research Center Faculty of Medicine and HealthÖrebro UniversityÖrebroSweden Copenhagen Wound Healing Center Bispebjerg University HospitalCopenhagenDenmark Steno Diabetes Center CopenhagenDenmark MV Hospital for Diabetes ChennaiIndia School of Public Health and Social Work Queensland University of TechnologyBrisbaneAustralia Allied Health Research Collaborative The Prince Charles HospitalBrisbaneAustralia 不详重庆大学附属中心医院重庆400014 东部战区空军医院糖尿病足中心江苏南京210002 战略支援部队特色医学中心北京100101

减轻组织的机械性压力在治愈糖尿病相关的足溃疡所需的多种干预措施中最为重要。本文是2023年国际糖尿病足工作组(IWGDF)发布的减压治疗促进糖尿病相关的足溃疡愈合的循证指南,也是对2019年IWGDF指南的更新。我们遵循推荐、评估、发展... 详细信息

减轻组织的机械性压力在治愈糖尿病相关的足溃疡所需的多种干预措施中最为重要。本文是2023年国际糖尿病足工作组(IWGDF)发布的减压治疗促进糖尿病相关的足溃疡愈合的循证指南,也是对2019年IWGDF指南的更新。我们遵循推荐、评估、发展和评价分级(GRADE)方法学,以患者-干预-比较-结局(patient-intervention-control-outcome,PICO)模式设计临床问题和重要结果,进行系统评价和Meta分析,制定评判表汇总,为每个问题编写推荐和理由。每项推荐都是基于系统综述中发现的证据,在无证据情况下则采用专家意见,以及对判断项目的GRADE等级总结进行仔细权衡,包括可预期和不可预期的影响、证据的确定性、患者价值、所需资源、成本效益、公平性、可行性和可接受性。为了治愈糖尿病患者神经性前足底或中足底溃疡,要使用不可拆卸的齐膝高减压装置作为首选减压干预措施。如果患者存在对不可拆卸减压装置的禁忌证或不能耐受,考虑使用可拆卸齐膝(或踝)高减压装置作为减压干预措施的第二选择。如果无可用的减压装置,考虑使用合适的鞋具结合毡制泡沫作为减压干预措施的第三选择。如果这种非手术减压治疗不能治愈前足底溃疡,可以考虑跟腱延长术、跖骨头切除术、关节置换术或跖骨截骨术。为了治疗继发于屈趾畸形的神经性足底或小趾远端溃疡,可行趾屈肌腱切开术。为了促进后足、非足底或并发感染或缺血的溃疡的愈合,提出了进一步的推荐。所有推荐都已在减压临床路径中进行了总结,以帮助促进本指南在临床实践中的实施。这些减压推荐将帮助医务人员为糖尿病相关的足溃疡患者提供最佳的治疗和预后,降低患者感染、住院和截肢的风险。

关键词：糖尿病足溃疡减压减压装置指南国际糖尿病足工作组

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IEC 61850 as Backbone for Smart PAC Systems

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CSEE Journal of Power and Energy Systems 2016年第4期2卷 15-22页

作者： klaus-peter Brand ABB Switzerland PGGA-AUABaden 5400Switzerland

This paper discusses a working definition of smartness in protection,automation and control systems(PACS)in substations.A summary is given about the standard IEC 61850 features that support smartness,i.e.,the data model,the multiple communication services,and the system configuration description language(SCL).With help of known examples of application functions for control,supervision,and protection,the building of smart systems out of the modules of IEC 61850 is *** the possible architectures,the standardized redundancy is *** process bus is exploited in detail since it is seen by users as the core of a smart *** this context,attention is given also to the time synchronization in theµs range over the communication network,a rather new part of the *** the last part,all features are summarized and it is concluded that IEC 61850 may really be named the backbone for smart PAC systems.

关键词： Automation communication control IEC 61850 process bus protection smart systems substations

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Conservation genomics of sibling grouse in boreal forests reveals introgression and adaptive population differentiation in genes controlling epigenetic variation

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Zoological Research 2022年第2期43卷 184-187页

作者： Kai Song Bin Gao peter Halvarsson Yun Fang Siegfried klaus Ying-Xin Jiang Jon E.Swenson Zhi-Ming Han Yue-Hua Sun Jacob Hoglund Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Animal Ecology Department of Ecology and GeneticsUppsala UniversityUppsala 75236Sweden Unit of Parasitology Department of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesUppsala 75007Sweden Lindenhöhe 5 Jena D-07749Germany Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesAs NO-1432Norway State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The Chinese Grouse(Tetrastes sewerzowi) and Hazel Grouse(T. bonasia) are sibling species that are well-adapted to harsh high-altitude and latitude habitats. In the current study, we sampled and sequenced 29 Chinese Grouse(n=16) and Hazel Grouse(n=13) from eight locations in China, Sweden,Germany, and northeast Poland to analyze population genetic diversity and structure, introgression, and local adaptation.

关键词： northeast adapted controlling

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Changes in various metabolic parameters in blood and milk during experimental Escherichia coli mastitis for primiparous Holstein dairy cows during early lactation

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Journal of Animal Science and Biotechnology 2015年第1期6卷 37-46页

作者： Kasey M Moyes Torben Larsen peter S?rensen klaus L Ingvartsen Department of Animal and Avian Sciences University of Maryland142 Animal Sciences BuildingMD 20742-231120910 College ParkMDUSA Department of Animal Science Faculty of Science and TechnologyAarhus University

Background： The objective of this study was to characterize the changes in various metabolic parameters in blood and milk during IMI challenge with Escherichia coli （E. coh. for dairy cows during early lactation. Thirty, healthy primiparous Holstein cows were infused （h = 0） with -20-40 cfu of live E. coil into one front mammary quarter at -4-6 wk in lactation. Daily feed intake and milk yield were recorded. At -12, 0, 3, 6, 12, 18, 24, 36, 48, 60, 72, 96, 108, 120, 132, 144, 156, 168, 180 and 192 h relative to challenge rectal temperatures were recorded and quarter foremilk was collected for analysis of shedding of E. coil Composite milk samples were collected at -180, -132, -84, -36, -12, 12, 24, 36, 48, 60, 72, 84, 96, 132 and 180 h relative to challenge （h=0） and analyzed for lactate dehydrogenase （LDH）, somatic cell count, fat, protein, lactose, citrate, beta-hydroxybutyrate （BHBA）, free glucose （fglu）, and glucose-6-phosphate （G6P）. Blood was collected at -12, 0, 3, 6, 12, 18, 24, 36, 60, 72, 84, 132 and 180 h relative to challenge and analyzed for plasma non-esterified fatty acids （NEFA）, BHBA and glucose concentration. A generalized linear mixed model was used to determine the effect of IMI challenge on metabolic responses of cows during early lactation. Results： By 12 h, E. coli was recovered from challenged quarters and shedding continued through 72 h. Rectal temperature peaked by 12 h post-challenge and returned to pre-challenge values by 36 h post-IMI challenge. Daily feed intake and milk yield decreased （P 〈0.05） by 1 and 2 d, respectively, after mastitis challenge. Plasma BHBA decreased （12 h, P 〈0.05） from 0.96± 1.1 at 0 h to 0.57±0.64 mmol/L by ]8 h whereas concentration of plasma NEFA （78 h） and glucose （24 h） were significantly greater, 11 and 27%, respectively, after challenge. In milk fglu, lactose, citrate, fat and protein yield were lower whereas yield of BHBA and G6P were higher after challenge when compared to pre-challenge values. Conclusion

关键词： Cow Early lactation Escherichia coli Metabolism

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Use of Internet Technology for the Improvement of Execution Management in Geotechnical Engineering Projects

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Tsinghua Science and Technology 2008年第S1期13卷 132-137页

作者： peter Degebrodt Marcus Mejstrik Frank Rackwitz Stavros Savidis Frank Schley klaus-peter Holz Chair of Soil Mechanics and Geotechnical Engineering Berlin Institute of Technology Lehrstuhl Bauinformatik Brandenburg University of Technology at Cottbus

An internet-based information and monitoring platform for the specific requirements of geotechnical engineering projects is presented. The platform is based on a hybrid-model approach consisting of a model-based information management system and a resource management system, the latter also referred to as DCMS. Project key information can be accessed via the main user interface, the 'graphical navigator'. The graphical navigator provides also a direct access to additional information in the DCMS. Prompt reac-tion in exceptional situations as well as in daily work gets an extensive support. In practical applications it has been proven that this platform seems to be an adequate tool especially for risk assessment and management in geotechnical engineering projects. Components and advantages of the platform as well as ex periences from the applications are presented and discussed in the paper.

关键词： information & execution & risk management internet monitoring geotechnical engineering

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Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress

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Neuroprotection 2023年第1期1卷 9-19页

作者： Hannelore Ehrenreich Max Gassmann Luise Poustka Martin Burtscher peter Hammermann PhD Anna-Leena Sirén klaus-Armin Nave Kamilla Miskowiak Clinical Neuroscience Max Planck Institute for Multidisciplinary SciencesGöttingenGermany Institute of Veterinary Physiology and Zürich Center for Integrative Human Physiology University of ZürichZürichSwitzerland Department of Child and Adolescent Psychiatry and Psychotherapy University Medical Center GöttingenGöttingenGermany Faculty of Sports Science University of InnsbruckInnsbruckAustria HBL Investmentpartners GmbH München‐FrankfurtGermany Departments of Neurophysiology and Neurosurgery University of WürzburgWürzburgGermany Department of Neurogenetics Max Planck Institute for Multidisciplinary SciencesGöttingenGermany Psychiatric Centre Copenhagen University HospitalRigshospitaletCopenhagenDenmark Department of Psychology University of CopenhagenCopenhagenDenmark

Hypoxia is increasingly recognized as an important physiological driving force.A specific transcriptional program,induced by a decrease in oxygen(O2)availability,for example,inspiratory hypoxia at high altitude,allows cells to adapt to lower O2 and limited energy *** transcriptional program is partly controlled by and partly independent of hypoxia-inducible ***,this same transcriptional program is stimulated in the brain by extensive motor-cognitive exercise,leading to a relative decrease in O2 supply,compared to the acutely augmented O2 *** have coined the term“functional hypoxia”for this important demand-responsive,relative reduction in O2 *** hypoxia seems to be critical for enduring adaptation to higher physiological challenge that includes substantial“brain hardware upgrade,”underlying advanced ***-induced erythropoietin expression in the brain likely plays a decisive role in these processes,which can be imitated by recombinant human erythropoietin *** article review presents hints of how inspiratory O2 manipulations can potentially contribute to enhanced brain *** thereby provides the ground for exploiting moderate inspiratory plus functional hypoxia to treat individuals with brain ***,it sketches a planned multistep pilot study in healthy volunteers and first patients,about to start,aiming at improved performance upon motor-cognitive training under inspiratory hypoxia.

关键词： brain EPO circle erythropoietin functional hypoxia HIF human pilot study hyperoxia inspiratory oxygen manipulations motor-cognitive performance PBMC translation

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Drug treatment of functional dyspepsia

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World Journal of Gastroenterology 2006年第17期12卷 2694-2700页

作者： klaus Mnkemüller peter Malfertheiner Division of Gastroenterology Hepatology and Infectious Diseases Otto-von-Guericke Medical SchoolUniversity of MagdeburgMagdeburgGermany

有在药治疗以后的机能性消化不良的病人的征兆的改进经常在不超过 60% 病人不完全、获得。因为机能性消化不良是异构的疾病，这是可能的。尽管大进展与罗马的一致定义被完成了我和 II 标准，仍然关于机能性消化不良的定义有一些方面要... 详细信息

有在药治疗以后的机能性消化不良的病人的征兆的改进经常在不超过 60% 病人不完全、获得。因为机能性消化不良是异构的疾病，这是可能的。尽管大进展与罗马的一致定义被完成了我和 II 标准，仍然关于机能性消化不良的定义有一些方面要求澄清。罗马标准明确地认识到腹上部的疼痛或不快 must 是在作为受不了机能性消化不良标记的病人的占优势的抱怨。然而，这个严格的定义能在每天主要的照顾创造问题临床的实践，有机能性消化不良的病人在此与多重症状介绍。在开始药治疗前，向病人提供疾病过程和安慰的解释被建议。彻底的体格检查和实验室数据和内视镜检查法的明智的使用也被显示。一般来说，基于他们的主要症状与机能性消化不良对待病人的途径实际、有效。通常，病人们应该与如果占优势的症状是腹上部的，使用质子泵禁止者的镇压治疗伤害的酸或胃的食道的倒流症状被对待。尽管在机能性消化不良的 Helicobacter pylori (H pylori ) 的角色继续是争论的一件事，最近的数据显示有在有机能性消化不良的病人的 H pylori 的根除的谦虚却清楚的利益。另外， H pylori 是胃的致癌物，如果发现，它应该被消除。尽管为有 FD 的病人没有特定的食谱，在健康锻练和吃的习惯指导病人可能是有用的。

关键词：功能性消化不良药物治疗幽门螺杆菌细菌感染

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