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Comparative phytochemical analysis of Coffea benghalensis Roxb. Ex Schult, Coffea arabica L. and Coffea liberica Hiern

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Asian Pacific Journal of Tropical Medicine 2018年第8期11卷 480-485页

作者： éva Brigitta Patay ágnes Alberti Orsolya Csernák Szilvia Stranczinger Nóra Pap Department of Pharmacognosy Faculty of Pharmacy University of Pécs Department of Pharmacognosy Faculty of Pharmacy Semmelweis University Department of Plant Biology Faculty of Sciences University of Pécs

Objective: To make phytochemical studies of the leaf, pericarp and seed of Coffea benghalensis(C. Benghalensis) compared with those of the widely known Coffea arabica and Coffea liberica. Methods: The sample extracts were prepared by Soxhlet-extraction. Polyphenol content was analyzed by HPLC-ESI-MS/MS, the identification was carried out based on the retention time, UV and mass spectra of standards and literature data of the detected compounds. Results: Phenolic acids like caffeoylquinic acids, dicaffeoylquinic acids, feruloylquinic acids and coumaroylquinic acid, as well as mangiferin were detected as main constituents in all extracts. Procyanidin trimers were present exclusively in the leaves. In C. benghalensis, main constituents were 5-caffeoylquinic acid and 4-caffeoylquinic acid. Flavan-3-ols were described in all immature and mature pericarp and leaf extracts. Even though 4-feruloylquinic acid was described in both immature and mature seed, dicaffeoylquinic acids were identified only in the mature seed extracts. Mangiferin was present in the leaf, mature pericarp and seed. Conclusions: These analyses provide new chemotaxonomical data for the selected coffees, especially for C. benghalensis. Due to its high polyphenol content, our results indicate its significance of providing new data as a possible source for industry.

关键词： Coffee LC-MS Polyphenols Caffeoylquinic acids

Effects of Stress, Depression, and Problem Drinking on Suicidal Ideation among Korean Workers

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International Journal of Mental Health Promotion 2021年第2期23卷 189-199页

作者： Yun-Jung Choi Mi-ra Won Youn-Joo Um Red Cross College of Nursing Chung-Ang UniversitySeoulKorea Department of Nursing Daewon University CollegeJecheonKorea Graduate School of Nursing Chung-Ang UniversitySeoulKorea

The mental health of workers is an important issue that affects not only individuals and their families but also workplaces and ***,it is necessary to regularly evaluate and analyze workers’mental health status,including levels of stress,depression,and addictive behaviors to apply thesefindings in creating mental health promotion *** study aims to provide basic data that would facilitate early intervention for workers’mental health problems by analyzing factors such as stress,depression,and problem drinking that can affect suicidal *** April 15 to October 25,2019,a survey was conducted with 165 workers across six workplaces in a Korean *** was performed using descriptive statistics,correlation,and simple and multiple regression analyses using the R statistics program *** was no difference in suicidal ideation scores based on the participants’general characteristics,while there was a significant positive correlation among stress,depression,problem drinking,and suicidal *** addition,severe depression,severe stress,and severe problem drinking had significant effects on suicidal ideation,and among the subitems of stress,somatic symptoms had an effect on suicidal *** addition,severe stress,somatic symptoms,depression,and severe problem drinking had a significant effect on suicidal ideation in males but not in *** is necessary to identify the effects of stress,depression,drinking problems,and suicide on workers’mental health,and evaluate their mental health systemati-cally and regularly to recognize whether active psychiatric treatment and nursing intervention are necessary as well as preventive *** addition,it is meaningful to pay attention to the suicide ideation of adult workers and provide basic data to promote systematic public health policies on mental health.

关键词： Alcohol depression mental health stress suicidal ideation

Glutamine metabolism in cancer therapy

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Cancer Drug Resistance 2018年第3期1卷 126-138页

作者： Tra-Ly Nguyen raúl V.Durán Institut Européen de Chimie et Biologie INSERM U1218Universitéde Bordeaux2 Rue Robert Escarpit33607 PessacFrance.

The amino acid glutamine plays a key role in the metabolism of highly proliferating *** malignant transformation,cancer cells modify the consumption and processing of glutamine to sustain cell growth and *** some cases,these cancer cells become addicted to ***,targeting the metabolism of glutamine has been developed during last years as a potential strategy against *** this review,we summarized the last advances in our knowledge about the role of glutamine metabolism in cancer therapy.

关键词： Cancer glutamine glutamoptosis metabolism mammalian target of rapamycin

mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan

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World Journal of Gastroenterology 2015年第25期21卷 7814-7823页

作者： Tünde Halász Gábor Horváth Gabriella Pár klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai Second Department of Pathology Semmelweis University Department of Pathology Military Hospital Hepatology Center of Buda 1111 BudapestHungary First Department of Medicine University of Pécs Second Department of Internal Medicine Semmelweis University MTA-SE Tumor Progression Research Group Semmelweis University

AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis ***: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) ***: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P ral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune live

关键词： Expression FibroScan Liver fibrosis METAVIR microRNA miR-122

Climate Change Impacts on Environmental Hazards on the Great Hungarian Plain, Carpathian Basin

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International Journal of Disaster Risk Science 2014年第2期5卷 136-146页

作者： Gábor Mezosi Teodóra Bata Burghard C.Meyer Viktória Blanka Zsuzsanna Ladányi Department of Physical Geography and Geoinformatics University of SzegedEgyetem u.2-6Szeged 6722Hungary

The potential impacts of climate change on the Great Hungarian Plain based on two regional climate models,REMO and ALADIN,were analyzed using indicators for environmental *** the climate parameters(temperature,precipitation,and wind)will change in the two investigated periods(2021–2050 and 2071–2100),their influences on drought,wind erosion,and inland excess water hazards are modeled by simple predictive *** hazards on arable lands will increasingly affect the productivity of agriculture compared to the reference period(1961–1990).The models predict an increase between 12.3%(REMO)and 20%(ALADIN)in the first period,and between 35.6%(REMO)and 45.2%(ALADIN)in the second *** increase of wind erosion hazards is not as obvious(+15%for the first period in the REMO model).Inland excess water hazards are expected to be slightly reduced(-4 to 0%)by both model predictions in the two periods without showing a clear tendency on *** three indicators together give a first regional picture of potential hazards of climate *** predictive model and data combinations of the regional climate change models and the hazard assessment models provide insights into regional and subregional impacts of climate change and will be useful in planning and land management activities.

关键词： Great inland drought

Liver dysfunction and SARS-CoV-2 infection

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World Journal of Gastroenterology 2021年第26期27卷 3951-3970页

作者： Abraham Edgar Gracia-ramos Joel Omar Jaquez-Quintana raúl Contreras-Omaña Moises Auron Department of Internal Medicine General HospitalNational Medical Center"La Raza"Instituto Mexicano del Seguro SocialMexico City 02990Mexico Gastroenterology Service and Department of Internal Medicine Faculty of MedicineUniversity Hospital"Dr.JoséE.González"Universidad Autónoma de Nuevo LeónMonterrey 64460Mexico Centro de Estudio e Investigación en Enfermedades Hepáticas y Toxicológicas(CEIHET) Pachuca 42184Mexico Departments of Hospital Medicine and Pediatric Hospital Medicine Cleveland ClinicClevelandOH 44195United States

Severe acute respiratory syndrome coronavirus 2 infection is the cause of coronavirus disease 2019(COVID-19),which predominantly affects the respiratory system;it also causes systemic and multi-organic *** damage is among the main extrapulmonary ***-19-associated liver injury is defined as any liver damage occurring during the disease course and treatment of COVID-19 in patients with or without pre-existing liver disease,and occurs in approximately one in five *** liver test results have been associated with a more severe course of COVID-19 and other complications,including *** linking COVID-19 to liver injury are *** consideration should be made for patients with pre-existing liver disease,such as metabolic dysfunction-associated fatty liver disease,chronic liver disease due to viral or autoimmune disease,liver transplant carriers,or cirrhosis,given the risk for more severe *** manuscript summarizes the current lines of evidence on COVID-19-associated liver injury regarding pathophysiology,clinical significance,and management in both patients with or without preexisting liver disease,to facilitate clinicians’access to updated information and patient ***,we mention the ideas and recommendations to be considered for future research.

关键词： SARS-CoV-2 Coronavirus COVID-19 Liver Liver diseases Liver failure Liver injury Cirrhosis

Effectiveness of menstruation hygiene skills training for adolescents with autism

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World Journal of Psychiatry 2023年第11期13卷 958-966页

作者： Meltem Kaydırak Büşra Yılmaz Merve Azak Çiğdem Bilge Department of Women Health and Gynecologic Nursing Istanbul University-CerrahpaşaFlorence Nightingale Faculty of NursingIstanbul 34381Türkiye Department of Pediatric Nursing Istanbul University-CerrahpaşaFlorence Nightingale Faculty of NursingIstanbul 34381Türkiye Department of Obstetrics and Women's Health Nursing Muğla SıtkıKoçman UniversityFaculty of Health SciencesMuğla 48000Türkiye

BACKGROUND Adolescents with autism spectrum disorder(ASD)may encounter many difficulties with their menstrual *** challenges that adolescents with ASD may face include understanding physical changes,coping with symptoms,emotional sensitivity,communication,personal care,and *** To evaluate the effect of menstrual hygiene skills training given to adolescents with ASD on their menstrual hygiene *** The study was conducted with 15 adolescents diagnosed with ASD by the single group pre-test and post-test model in three special education centers in Tü*** were collected with the Adolescent and Parent Information Form and the Adolescent-Specific Menstrual Hygiene Skill Registration *** While the mean age of adolescents was 16.06±0.88 years,the mean age of individuals responsible for adolescent care was 43.66±5.56 *** 60.0%of the adolescents noticed the onset of bleeding before training,this rate was 93.3%after *** Adolescent-Specific Menstrual Hygiene Skill Registration Form showed a statistically significant increase in the application steps after the *** difference between the menstrual hygiene skill scores of adolescents CONCLUSION The menstrual hygiene skills training given to adolescents with ASD was beneficial in increasing their menstrual hygiene *** individuals must take responsibility during menstruation and independently manage their continuous care activities.

关键词： Autism Adolescent Menstruation Hygiene Training

Crossing the Rivers by Touching the Stones:Alternative Approaches in Technical and Vocational Education and Training From the People’s Republic of China and the Republic of Korea

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ECNU Review of Education 2023年第4期6卷 654-676页

作者：哈巍杨钋 Youngsup Choi Sungsup ra Ryotaro Hayashi Conor McCutcheon Peking University Korea University of Technology and Education Asian Development Bank New York University

Purpose:This study aims to answer the following questions:(1)Why have attempts to transplant Western vocational education models failed?(2)Is there anything we can learn from the experiences of Eastern Asian countries when developing their own vocational education models?Design/Approach/Methods:This study reviews the history of transplanting Western skill formation schemes into developing countries,an often-failed die-hard practice supported by both bilateral and multilateral ***:Our findings suggest that developing countries should design their technical and vocational education and training systems based on their unique cultural,sociological,and economic *** offers two alternative pathways based on the experiences of the People’s Republic of China and the Republic of ***/Value:These East Asian examples could broaden the perspectives of policymakers in developing countries aspiring to develop functional skill formation schemes.

关键词： Comparative education East Asia international development skill formation technical and vocational education and training

斯洛伐克西喀尔巴阡山脉Gemerská Poloma滑石-菱镁矿矿床中镁的交代作用(英文)

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岩石学报 2004年第4期20卷 773-790页

作者： Martin raDVANEC Peter KOD■ra Walter PROCHASKA Geological Survey of Slovak Republic Marku■ovská cesta 1 052 01 Spi■ská Nova Ves SlovakiaGeological Survey of Slovak RepublicDepartment of Geological Sciences University of Leoben A-8700 Leoben Austria Mlynska dolina 1 817 04 Bratislava Slovakia

Gemerska Poloma矿床是个重要的滑石矿床(储量20万吨),位于西喀尔巴阡山脉Germeric地区.部分滑石化的镁质碳酸盐体赋存在早古生代火山沉积杂岩体中(黑色片岩,变质泥岩),在Variscan变质作用(M1)过程中受到了绿泥石-黑云母带区域变质相的... 详细信息

Gemerska Poloma矿床是个重要的滑石矿床(储量20万吨),位于西喀尔巴阡山脉Germeric地区.部分滑石化的镁质碳酸盐体赋存在早古生代火山沉积杂岩体中(黑色片岩,变质泥岩),在Variscan变质作用(M1)过程中受到了绿泥石-黑云母带区域变质相的改造.这种原岩是石灰岩的矿体由白色-灰白或者灰色-黑色的菱镁矿与白云石1组成,被次生的白云石2和滑石脉切割.本次研究考察了两次变质事件(M1和M2)的几个连续的矿物组合,最早的组合包括铁白云石,镁菱铁矿与菱铁矿,(并与黑电气石,铁绿泥石,磷灰石,与伊利石-白云母伴生),它们以微小残留物形式产出在菱镁矿和白云石1中,其形成可能早于M1变质作用高峰期.M1变质事件的高峰期以富铁金云母,镁绿泥石1,镁电气石(黑电气石的边缘)和石英的组合为代表.在M1退变质作用过程中,发生了镁交代作用,开始是白云石1结晶,接下来形成菱镁矿,最后是以铁菱镁矿沿裂隙的形成而终.根据碳酸盐地质测温原理,M1变质事件的高峰期温度为460～490°C,变质矿物组合特征也支持这一测温结果.滑石,白云石2,与镁绿泥石2沿着镁碳酸盐岩石裂隙的发育,主要受到M2变质事件的影响,这个变质事件与较年青的Alpine造山事件有关.菱镁矿流体包裹体的研究表明,成矿流体具有复杂的组成,可能以MgCl2组分为主,主要来源于蒸发卤水的演化.原生流体包裹体的盐度～35(wt%MgCl2),均一温度变化范围是216～235℃.石英中流体包裹体也显示了以MgCl2组分为主的相似流体组成,但均一温度比较高,为248～313℃.如果假定石英与M1变质事件同期,那么由流体包裹体计算出的M1变质峰期压力范围是250～350MPa(9～13km),因此地温梯度是35～40℃/km.假定这个梯度在镁交代成矿过程中保持不变,那么相关流体在180～280MPa(7～11km)的压力下的温度为300～350℃.流体包裹体的淋滤分析表明,流体中Cl/Br与Na/Br都很高,说明流体具有蒸发特征.而在Gemeric地区只有在晚二叠纪到早三叠纪这段时间才有如此大量的卤水形成.因此,二叠纪的伸展构造运动与形成菱镁矿的热液系统的形成有关.

关键词：菱镁矿滑石白云石流体包裹体流体包裹体的化学地质温度计 P-T条件蒸发途径 Gemericum 喀尔巴阡山脉西部