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Update on the Diagnosis and Treatment of Combined Hepatocellular Cholangiocarcinoma

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 210-217页

作者： Kai-Jian Chu Yoshikuni Kawaguchi Han Wang Xiao-Qing Jiang kiyoshi Hasegawa Biliary Surgical Department No.1 Eastern Hepatobiliary Surgical HospitalThe Naval Medical UniversityShanghaiChina Hepato-Biliary-Pancreatic Surgery Division Department of SurgeryGraduate School of MedicineThe University of TokyoTokyoJapan Department of Pathology Eastern Hepatobiliary Surgical HospitalThe Naval Medical UniversityShanghaiChina

Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a unique type of liver tumor that contains both hepatocellular carcinoma and cholangiocarcinoma components within a single *** fifth edition of the World Health Organization classification provides a definition and diagnostic criteria for ***,the heterogeneous histomorphology and presentation resulting from variation of the proportion of each component poses challenges for clinical diagnosis and treatment.A diagnosis of cHCC-CCA may be suggested by the synchronous elevation of serum tumor markers for hepatocellular carcinoma and cholangiocarcinoma,a mixed enhancement pattern on imaging,and a discrepancy between the elevation of tumor marker and the imaging enhancement *** examination using hematoxylin and eosin staining is considered the gold standard for diagnosing cHCC-CCA,and comprehensive examination of resection or biopsy specimens is crucial for an accurate ***,there is no standard treatment for cHCC-CCA,and surgery is the *** hepatectomy with lymphadenectomy is among the recommended surgical *** role of liver transplantation in the management of cHCC-CCA is still *** chemoembolization may be effective for unresectable cHCC-CCA,particularly for hypervascular ***,the available evidence does not support systemic therapy for advanced *** prognosis of cHCC-CCA is generally poor,and there is no established staging *** research is needed to better understand the histogenesis and clinical management of *** review provides an overview of the current literature on cHCC-CCA with a focus on its clinical characteristics,pathological diagnosis,and management.

关键词： Combined hepatocellular-cholangiocarcinoma Clinical characteristics Imaging characteristics Pathological diagnosis Treatment

Heavy metal pollution of river water and eco-friendly remediation using potent microalgal species

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Water Science and Engineering 2024年第1期17卷 41-50页

作者： Amudham Radha Amal Raj Prabhakaran Mylsamy V.Sivasankar B.Sathish Kumar kiyoshi Omine T.G.Sunitha Phycological Research Laboratory Research Department of BotanyPachaiyappa's College(Affiliated to University of Madras)Chennai 600030India Research Department of Chemistry Pachaiyappa's College(Affiliated to University of Madras)Chennai 600030India Department of Botany Sri Vidya Mandir Arts&Science College(Autonomous)KatteriUthangarai 636902India Department of Civil Engineering School of Engineering.Nagasaki UniversityNagasaki-Daigaku1-14 Bunkyo-machiNagasaki 8528521Japan

Pollution of rivers is mainly caused by anthropogenic activities such as discharge of effluent from industrial facilities,maintenance of sewage/effluent treatment plants,and dumping of solid waste on river *** study dealt with the pollution issues of the Cooum River in the well-known city of Chennai in South *** samples from 27 locations were collected and analyzed for 12 elements,including Ba,B,and Al,as well as heavy metals such as Pb,Cr,Mn,Fe,Co,Ni,Cu,Zn,and *** samples showed levels of these elements that exceeded World Health Organization *** correlation analysis revealed the inter-dependency among elements,and the contribution of each element based on factor loadings showed its percentage contribution compared to *** samples from six significant locations were chosen for remediation with three algae:Chlorella vulgaris,Scenedesmus dimorphus,and Phormedium *** uptake of pollutants led to the continuous growth of algae during the incubation period of 15 d,effectively removing heavy metals from the river *** increasing levels of algal counts and the chlorophyll a content confirmed the algal growth during the incubation period,followed by a declining stage after the incubation *** scanning electron microscopic images of algae before and after the remediation showed no remarkable modification of morphological *** study showed that the uptake of heavy metals using algae is an effective water pollution remediation measure,making the process practicable in the field on a large scale in the near future.

关键词： Heavy metal Cooum river Phycoremediation Microalgae Factor analysis

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基于离子液体的深度除湿技术及应用探索

工程热物理学报 2024年第10期45卷 2958-2964页

作者：曹博文殷勇高 Giannetti Niccolo Saito kiyoshi 东南大学能源与环境学院南京210096 低碳型建筑环境设备与系统节能教育部工程研究中心南京210096 早稻田大学基础科学与工程研究生院东京169-0072 早稻田大学早稻田高等研究所东京169-8050 早稻田大学应用力学和航空航天工程系东京169-8555

液体深度除湿是实现低湿度行业低碳转型的一种有效途径。目前,具有深度除湿潜力(极低蒸气压、非结晶和无腐蚀)的离子液体是传统盐溶液的理想替代。本研究搭建了离子液体深度除湿实验平台,并分析了不同运行工况下的除湿性能。结果表明:降... 详细信息

液体深度除湿是实现低湿度行业低碳转型的一种有效途径。目前,具有深度除湿潜力(极低蒸气压、非结晶和无腐蚀)的离子液体是传统盐溶液的理想替代。本研究搭建了离子液体深度除湿实验平台,并分析了不同运行工况下的除湿性能。结果表明:降膜/鼓泡吸收方式均能实现较高的深度除湿效果,最低出风含湿量可降至2.0 g/kg(da)以下。同时,对于进口含湿量为3.3 g/kg(da)的低湿工况,降膜装置的除湿效率仅为40%左右。然而,鼓泡装置的除湿效率可达到81%,有效开发了离子液体的深度除湿潜力。此外,总结了两种吸收方式的先进性与适用性,为离子液体深度除湿技术的应用提供指导。

关键词：深度除湿离子液体除湿性能实验研究

Clues for diagnosing misplaced central venous catheter in the right ascending lumbar vein during right femoral venous access

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World Journal of Clinical Cases 2024年第24期12卷 5473-5475页

作者： Joho Tokumine kiyoshi Moriyama Tomoko Yorozu Department of Anesthesiology Kyorin University School of MedicineMitaka 181-8611TokyoJapan

The right ascending lumbar vein is difficult to detect on anteroposterior abdominalradiographs because it overlaps with the inferior vena cava on *** observation by medical providers may be a cue ***,knowledge of catheter misplacement of the right ascendinglumbar vein is also necessary,because misplacement cannot be suspected withoutthat awareness.

关键词： Central venous catheter Ascending lumbar vein Femoral vein Catheter misplacement Anteroposterior abdominal X-ray

Diagnostic utility of small-caliber and conventional endoscopes for gastric cancer and analysis of endoscopic false-negative gastric cancers

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World Journal of Gastrointestinal Endoscopy 2013年第9期5卷 440-445页

作者： Hiromi Kataoka kiyoshi mizuno Noriyuki Hayashi Mamoru Tanaka Hirotaka Nishiwaki Masahide Ebi Tsutomu Mizoshita Yoshinori Mori Eiji Kubota Satoshi Tanida Takeshi Kamiya Takashi Joh Department of Gastroenterology and Metabolism NagoyaCity University Graduate School of Medical Sciences Division of Endoscopy Nagoya Toei Clinic

AIM: To analyze the diagnostic utility of a small-caliber endoscope(SC-E) and clinicopathological features of false-negative gastric cancers(FN-GCs). METHODS: A total of 21638 esophagogastroduodenoscopy(EGD) gastric cancer(GC) screening examinations were analyzed. Secondary endoscopic examinations(n = 3352) were excluded because most secondary examinations tended to be included in the conventional endoscopy(C-E) group. Detection rates of GCs and FN-GCs were compared between SC-E and C-E groups. FN-GC was defined as GC performed with EGD within the past 3 years without GC detection. Macroscopic types, histopathological characteristics and locations of FN-GCs were compared with firstly foundgastric cancers(FF-GCs) in detail. RESULTS: SC-E cases(n = 6657) and C-E cases(n = 11644), a total of 18301 cases, were analyzed. GCs were detected in 16(0.24%) SC-E cases and 40 C-E(0.34%) cases(P = 0.23) and there were 4 FN-GCs(0.06%) in SC-E and 13(0.11%) in C-E(P = 0.27), with no significant difference. FN-GCs/GCs ratio between SC-E and C-E groups was not significantly different(P = 0.75). The comparison of endoscopic macroscopic types of FN-GCs tended to be a less advanced type(P = 0.02). Histopathologically, 70.6% of FN-GCs were differentiated and 29.4% undifferentiated type. On the other hand, 43.0% of FF-GCs were differentiated and 53.8% undifferentiated type, so FN-GCs tended to be more differentiated type(P = 0.048). CONCLUSION: The diagnostic utility of SC-E for the detection of GCs and FN-GCs was not inferior to that of C-E. Careful observation for superficially depressed type lesions in the upper lesser curvature region is needed to decrease FN-GCs.

关键词： Gastric cancer Small-caliber endoscope False-negative gastric cancer

小麦胚芽活性肽通过AMPK/SIRT1改善大鼠肝脏衰老损伤的作用机制研究

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中国科学：生命科学 2024年第3期54卷 537-547页

作者：汪芳罗涛陈烩铃 kiyoshi Itagaki 宋海昭熊玲王銮凤沈新春南京财经大学食品科学与工程学院江苏省现代粮食流通与安全协同创新中心江苏高校粮油质量安全控制及深加工重点实验室南京210023 Harvard Medical School Boston 02115USA

小麦胚芽作为小麦面粉加工过程中产生的副产品,资源极为丰富,但一直以来未能得到充分合理的利用.本研究以课题组前期获得的麦胚活性肽ADWGGPLPH(ADW)为对象,以自然增龄的SD大鼠作为肝脏老化损伤的动物模型,9月龄大鼠作为对照,用麦胚源... 详细信息

小麦胚芽作为小麦面粉加工过程中产生的副产品,资源极为丰富,但一直以来未能得到充分合理的利用.本研究以课题组前期获得的麦胚活性肽ADWGGPLPH(ADW)为对象,以自然增龄的SD大鼠作为肝脏老化损伤的动物模型,9月龄大鼠作为对照,用麦胚源活性肽持续灌胃干预至21月龄,研究麦胚源活性肽对自然增龄大鼠肝脏老化损伤的影响,并结合H2O2诱导衰老HepG2细胞模型初步探明其分子机制.结果表明,麦胚源活性肽ADW能够增加大鼠血清及肝脏中SOD,T-AOC,GSH-Px,CAT等抗氧化酶活性,同时降低MDA水平,改善大鼠肝脏中氧化应激水平;降低血清及肝脏中IL-6,IL-1β,MMP3,TNF-α水平,并且增加抗炎因子IL-10分泌,改善增龄大鼠肝脏中炎症环境;麦胚源活性肽干预后肝脏结构明显好转、脂肪空泡减少、细胞排列整齐,ALT以AST水平均显著下降.麦胚源活性肽能够有效地改善老化肝脏中细胞的结构及生长状态异常,减少增龄过程中肝脏质量损失,降低了衰老标志蛋白P53和P21的表达量,减轻肝脏老化损伤程度并减缓了肝脏的老化进程.通过加入抑制剂、激活剂、siRNA等手段,初步阐明麦胚源活性肽能够通过激活AMPK/Sirt1信号通路以调控衰老相关进程.本研究对于开发健康老龄化膳食结构以及麦胚资源的精深利用具有十分重大的意义.

关键词：小麦胚芽活性肽衰老 AMPK 肝脏

遏止少子化:日本家庭科课程的价值观教育对策

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外国教育研究 2024年第5期51卷 47-61页

作者：孙成唐木清志东北师范大学马克思主义学部吉林长春130024 筑波大学人间系日本筑波305-8577

面对日益严峻的人口少子化问题,日本有计划地在中小学家庭科课程中开展以遏止少子化为目的的价值观教育。从21世纪初开始,日本政府通过宏观规划、政策保障和课标融入等方式为家庭科课程设计了明确的家庭观、生育观和两性观教育内容,并... 详细信息

面对日益严峻的人口少子化问题,日本有计划地在中小学家庭科课程中开展以遏止少子化为目的的价值观教育。从21世纪初开始,日本政府通过宏观规划、政策保障和课标融入等方式为家庭科课程设计了明确的家庭观、生育观和两性观教育内容,并通过家政技能实践、“男女共学”和校社协同联动等方式深化青少年对组建家庭和养育后代的价值认同。近年来,中国“低生育率”问题愈加凸显,亟须有针对性地通过学校课程开展价值观教育,树立倡导积极的婚育观念,发挥好教育促进人口可持续发展的重要作用。

关键词：日本少子化家庭科课程价值观教育

Accuracy and Utility of Vessel Analysis Using Non-Contrast CT for Planning Endovascular Aortic Repair

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Open Journal of Medical Imaging 2024年第3期14卷 96-105页

作者： Midori Komita-Moriya Yukihisa Ogawa Akiyuki Kotoku Shintaro Nawata Kenji Kuramochi Yasuyoshi Ogawa kiyoshi Chiba Hiroshi Nishimaki Hidefumi Mimura Department of Radiology St. Marianna University School of Medicine Kanagawa Japan Department of Radiology Tokai University School of Medicine Hachioji Hospital Tokyo Japan Radiological Technology St. Marianna University School of Medicine Kanagawa Japan Department of Cardiovascular Surgery St. Marianna University School of Medicine Kanagawa Japan

Objectives: This study aimed to determine whether errors in vascular measurements would affect device selection in endovascular aortic repair (EVAR) by comparing measurements obtained using non-contrast computed tomography (NCT) with those obtained using contrast-enhanced CT (CECT). Materials and Methods: This single-center, retrospective study included 25 patients who underwent EVAR for abdominal aortic aneurysm at our institution. A 1-mm horizontal cross-sectional slice of NCT and CECT from each patient was retrospectively reviewed. The area from the abdominal aorta to the common iliac artery was divided into four zones. A centerline was created using the NCT by manually plotting the center points. Subsequently, the centerlines were automatically extracted and manually corrected during the arterial phase of CECT. The diameter and length of each zone were measured for each modality. The mean diameters and lengths of the target vessels were compared between NCT and CECT. Results: The measurements obtained using both methods were reproducible and demonstrated good agreement. The mean differences in vessel length and diameter measurements for each segment between NCT and CECT were not statistically significant, indicating good consistency. Conclusion: NCT may be useful for preoperative EVAR evaluation in patients with renal dysfunction or allergies to contrast agents.

关键词： Non-Contrast CT Vessel Analysis EVAR Contrast-Enhanced CT Abdominal Aortic Aneurysm

Challenges to Introduce Advanced Cooling Technology by the Utilization of Plural Cooling Velocity

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材料热处理学报 2004年第5期25卷 434-436页

作者： kiyoshi Funatani MSTInst Nagoya JAPAN

The control of cooling power is very important to introduce desired properties. Usually, higher the cooling rate higher the quench hardness and distortion and the optimization of cooling power is the base for good heat treatment. The change of cooling speed during quenching is one of the effective methods to balance hardness and distortion. Different form the general knowledge of the demerit of vapor blanket stage, oil with long vapor blanket stage is also one of effective methods to reduce distortion. The reduction of distortion with enough quench hardness seems to be possible by optimization of cooling condition by the help of computer simulation. The exhibition of higher core hardness than surface in through hardening steels experienced in the "Inverse quench hardening" was introduced by Prof. Tamura and Shimizu. This mechanism is well explained by Arimoto et al, by analysis of computer simulation. In this paper, plural steps cooling methods are compared, in relation with cooling curve and heat transfer coefficient that is necessary to simulate quench results and the possibility of advanced cooling technology is discussed.

关键词：变形硬度冷却曲线传热系数蒸汽掩蔽计算机模似