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Isolation and Expression Profiling of a CONSTANS-Like Gene and Two FLOWERING LOCUS T-Like Genes from Spinacia oleracea L.

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American Journal of Plant Sciences 2014年第26期5卷 4018-4028页

作者： Erika Abe Kaien Fujino kiyoshi masuda Yube Yamaguchi Graduate School of Agriculture Hokkaido University Sapporo Japan Research Faculty of Agriculture Hokkaido University Sapporo Japan Graduate School of Life and Environmental Sciences Osaka Prefecture University Sakai Japan

Spinach (Spinacia oleracea L.) develops leaf rosettes under short-day conditions, and starts reproductive growth including bolting and flowering under long-day conditions. Japanese people prefer Oriental spinach that bolts easily with a shorter photoperiod than European spinach. This is one of the main reasons that Oriental spinach is difficult to grow year-round. In order to understand spinach flowering mechanisms and obtain knowledge for spinach breeding, we isolated one CONSTANS-like (COL) and two FLOWERING LOCUS T (FT) homologs, which are key components of photoperiodic regulation of flowering time, from a Japanese cultivar. The expression of SoCOL1 showed diurnal rhythm with the highest expression at the end of the dark cycle. This diurnal rhythm is similar to the expression of BvCOL1 from sugar beet (Beta vulgaris), whose flower-promoting effect was observed when overexpressed in Arabidopsis. Phylogenetic analysis showed that SoCOL1 is the closest homolog of BvCOL1, suggesting that SoCOL1 is an ortholog of BvCOL1. SoFT1 and SoFT2 are closely related to BvFT1 and BvFT2, respectively. The expression of SoFT1 and SoFT2 were induced in advance of flower bud formation after changing the photoperiod, but the expression level of SoFT1 was much lower than SoFT2. Currently, we are speculating that SoFT2 is a flower-promoting factor of spinach, and that SoFT1 has a role in light signaling because the expression of SoFT1 showed a diurnal rhythm.

关键词： CONSTANS FLOWERING LOCUS T Spinacia oleracea L. Flower Bud Formation Photoperiod

Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 557-562页

作者： Toshiaki Tsurui Yuya Hirasawa Yutaro Kubota kiyoshi Yoshimura Takuya Tsunoda Department of Medical Oncology Showa UniversityTokyo 1428555Japan Department of Clinical Immuno Oncology Clinical Research Institute of Clinical Pharmacology and TherapeuticsShowa UniversityTokyo 1578577Japan

BACKGROUND Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer(CRC).Effective drainage is often im-possible before initiating systemic chemotherapy,owing to the liver’s diffuse metastatic ***,an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently *** SUMMARY The patient,a man in his 50s,presented with progressive fatigue and severe *** tomography revealed multiple hepatic masses with thick-ened walls in the sigmoid colon,which was pathologically confirmed as a well-differentiated *** RAS or BRAF mutations were *** Eastern Cooperative Oncology Group(ECOG)performance status(PS)score was *** drainage was impossible due to the absence of a dilated bile duct,and panitumumab monotherapy was promptly ***,the bilirubin level decreased and then normalized,and the patient’s PS improved to zero ECOG score after four cycles of therapy without significant adverse *** Anti-EGFR antibody monotherapy is a safe and effective treatment for RAS wild-type CRC and hepatic metastases with severe hyperbilirubinemia.

关键词： Colorectal neoplasms Panitumumab Chemotherapy Hyperbilirubinemia Jaundice Case report

Heavy metal pollution of river water and eco-friendly remediation using potent microalgal species

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Water Science and Engineering 2024年第1期17卷 41-50页

作者： Amudham Radha Amal Raj Prabhakaran Mylsamy V.Sivasankar B.Sathish Kumar kiyoshi Omine T.G.Sunitha Phycological Research Laboratory Research Department of BotanyPachaiyappa's College(Affiliated to University of Madras)Chennai 600030India Research Department of Chemistry Pachaiyappa's College(Affiliated to University of Madras)Chennai 600030India Department of Botany Sri Vidya Mandir Arts&Science College(Autonomous)KatteriUthangarai 636902India Department of Civil Engineering School of Engineering.Nagasaki UniversityNagasaki-Daigaku1-14 Bunkyo-machiNagasaki 8528521Japan

Pollution of rivers is mainly caused by anthropogenic activities such as discharge of effluent from industrial facilities,maintenance of sewage/effluent treatment plants,and dumping of solid waste on river *** study dealt with the pollution issues of the Cooum River in the well-known city of Chennai in South *** samples from 27 locations were collected and analyzed for 12 elements,including Ba,B,and Al,as well as heavy metals such as Pb,Cr,Mn,Fe,Co,Ni,Cu,Zn,and *** samples showed levels of these elements that exceeded World Health Organization *** correlation analysis revealed the inter-dependency among elements,and the contribution of each element based on factor loadings showed its percentage contribution compared to *** samples from six significant locations were chosen for remediation with three algae:Chlorella vulgaris,Scenedesmus dimorphus,and Phormedium *** uptake of pollutants led to the continuous growth of algae during the incubation period of 15 d,effectively removing heavy metals from the river *** increasing levels of algal counts and the chlorophyll a content confirmed the algal growth during the incubation period,followed by a declining stage after the incubation *** scanning electron microscopic images of algae before and after the remediation showed no remarkable modification of morphological *** study showed that the uptake of heavy metals using algae is an effective water pollution remediation measure,making the process practicable in the field on a large scale in the near future.

关键词： Heavy metal Cooum river Phycoremediation Microalgae Factor analysis

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高精度光学薄膜的制造

光学仪器 2001年第5期23卷 134-137页

作者：王明利增田清志京浜光膜工业株式会社

论述了 DWDM、GFF、CWDM等薄膜的制造 ,特别给出了 1 0 0 GHz　 DWDM的设计和误差分析。

关键词： DWDM GFF CWDM 光学薄膜制造光通信

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Clues for diagnosing misplaced central venous catheter in the right ascending lumbar vein during right femoral venous access

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World Journal of Clinical Cases 2024年第24期12卷 5473-5475页

作者： Joho Tokumine kiyoshi Moriyama Tomoko Yorozu Department of Anesthesiology Kyorin University School of MedicineMitaka 181-8611TokyoJapan

The right ascending lumbar vein is difficult to detect on anteroposterior abdominalradiographs because it overlaps with the inferior vena cava on *** observation by medical providers may be a cue ***,knowledge of catheter misplacement of the right ascendinglumbar vein is also necessary,because misplacement cannot be suspected withoutthat awareness.

关键词： Central venous catheter Ascending lumbar vein Femoral vein Catheter misplacement Anteroposterior abdominal X-ray

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基于离子液体的深度除湿技术及应用探索

工程热物理学报 2024年第10期 2958-2964页

作者：曹博文殷勇高 Giannetti Niccolo Saito kiyoshi 东南大学能源与环境学院低碳型建筑环境设备与系统节能教育部工程研究中心早稻田大学基础科学与工程研究生院早稻田大学早稻田高等研究所早稻田大学应用力学和航空航天工程系

液体深度除湿是实现低湿度行业低碳转型的一种有效途径。目前，具有深度除湿潜力(极低蒸气压、非结晶和无腐蚀)的离子液体是传统盐溶液的理想替代。本研究搭建了离子液体深度除湿实验平台，并分析了不同运行工况下的除湿性能。结果表明... 详细信息

液体深度除湿是实现低湿度行业低碳转型的一种有效途径。目前，具有深度除湿潜力(极低蒸气压、非结晶和无腐蚀)的离子液体是传统盐溶液的理想替代。本研究搭建了离子液体深度除湿实验平台，并分析了不同运行工况下的除湿性能。结果表明：降膜/鼓泡吸收方式均能实现较高的深度除湿效果，最低出风含湿量可降至2.0 g/kg(da)以下。同时，对于进口含湿量为3.3 g/kg(da)的低湿工况，降膜装置的除湿效率仅为40%左右。然而，鼓泡装置的除湿效率可达到81%，有效开发了离子液体的深度除湿潜力。此外，总结了两种吸收方式的先进性与适用性，为离子液体深度除湿技术的应用提供指导。

关键词：深度除湿离子液体除湿性能实验研究

小麦胚芽活性肽通过AMPK/SIRT1改善大鼠肝脏衰老损伤的作用机制研究

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中国科学：生命科学 2024年第3期54卷 537-547页

作者：汪芳罗涛陈烩铃 kiyoshi Itagaki 宋海昭熊玲王銮凤沈新春南京财经大学食品科学与工程学院江苏省现代粮食流通与安全协同创新中心江苏高校粮油质量安全控制及深加工重点实验室南京210023 Harvard Medical School Boston 02115USA

小麦胚芽作为小麦面粉加工过程中产生的副产品,资源极为丰富,但一直以来未能得到充分合理的利用.本研究以课题组前期获得的麦胚活性肽ADWGGPLPH(ADW)为对象,以自然增龄的SD大鼠作为肝脏老化损伤的动物模型,9月龄大鼠作为对照,用麦胚源... 详细信息

小麦胚芽作为小麦面粉加工过程中产生的副产品,资源极为丰富,但一直以来未能得到充分合理的利用.本研究以课题组前期获得的麦胚活性肽ADWGGPLPH(ADW)为对象,以自然增龄的SD大鼠作为肝脏老化损伤的动物模型,9月龄大鼠作为对照,用麦胚源活性肽持续灌胃干预至21月龄,研究麦胚源活性肽对自然增龄大鼠肝脏老化损伤的影响,并结合H2O2诱导衰老HepG2细胞模型初步探明其分子机制.结果表明,麦胚源活性肽ADW能够增加大鼠血清及肝脏中SOD,T-AOC,GSH-Px,CAT等抗氧化酶活性,同时降低MDA水平,改善大鼠肝脏中氧化应激水平;降低血清及肝脏中IL-6,IL-1β,MMP3,TNF-α水平,并且增加抗炎因子IL-10分泌,改善增龄大鼠肝脏中炎症环境;麦胚源活性肽干预后肝脏结构明显好转、脂肪空泡减少、细胞排列整齐,ALT以AST水平均显著下降.麦胚源活性肽能够有效地改善老化肝脏中细胞的结构及生长状态异常,减少增龄过程中肝脏质量损失,降低了衰老标志蛋白P53和P21的表达量,减轻肝脏老化损伤程度并减缓了肝脏的老化进程.通过加入抑制剂、激活剂、siRNA等手段,初步阐明麦胚源活性肽能够通过激活AMPK/Sirt1信号通路以调控衰老相关进程.本研究对于开发健康老龄化膳食结构以及麦胚资源的精深利用具有十分重大的意义.

关键词：小麦胚芽活性肽衰老 AMPK 肝脏

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遏止少子化:日本家庭科课程的价值观教育对策

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外国教育研究 2024年第5期51卷 47-61页

作者：孙成唐木清志东北师范大学马克思主义学部吉林长春130024 筑波大学人间系日本筑波305-8577

面对日益严峻的人口少子化问题,日本有计划地在中小学家庭科课程中开展以遏止少子化为目的的价值观教育。从21世纪初开始,日本政府通过宏观规划、政策保障和课标融入等方式为家庭科课程设计了明确的家庭观、生育观和两性观教育内容,并... 详细信息

面对日益严峻的人口少子化问题,日本有计划地在中小学家庭科课程中开展以遏止少子化为目的的价值观教育。从21世纪初开始,日本政府通过宏观规划、政策保障和课标融入等方式为家庭科课程设计了明确的家庭观、生育观和两性观教育内容,并通过家政技能实践、“男女共学”和校社协同联动等方式深化青少年对组建家庭和养育后代的价值认同。近年来,中国“低生育率”问题愈加凸显,亟须有针对性地通过学校课程开展价值观教育,树立倡导积极的婚育观念,发挥好教育促进人口可持续发展的重要作用。

关键词：日本少子化家庭科课程价值观教育

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Accuracy and Utility of Vessel Analysis Using Non-Contrast CT for Planning Endovascular Aortic Repair

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Open Journal of Medical Imaging 2024年第3期14卷 96-105页

作者： Midori Komita-Moriya Yukihisa Ogawa Akiyuki Kotoku Shintaro Nawata Kenji Kuramochi Yasuyoshi Ogawa kiyoshi Chiba Hiroshi Nishimaki Hidefumi Mimura Department of Radiology St. Marianna University School of Medicine Kanagawa Japan Department of Radiology Tokai University School of Medicine Hachioji Hospital Tokyo Japan Radiological Technology St. Marianna University School of Medicine Kanagawa Japan Department of Cardiovascular Surgery St. Marianna University School of Medicine Kanagawa Japan

Objectives: This study aimed to determine whether errors in vascular measurements would affect device selection in endovascular aortic repair (EVAR) by comparing measurements obtained using non-contrast computed tomography (NCT) with those obtained using contrast-enhanced CT (CECT). Materials and Methods: This single-center, retrospective study included 25 patients who underwent EVAR for abdominal aortic aneurysm at our institution. A 1-mm horizontal cross-sectional slice of NCT and CECT from each patient was retrospectively reviewed. The area from the abdominal aorta to the common iliac artery was divided into four zones. A centerline was created using the NCT by manually plotting the center points. Subsequently, the centerlines were automatically extracted and manually corrected during the arterial phase of CECT. The diameter and length of each zone were measured for each modality. The mean diameters and lengths of the target vessels were compared between NCT and CECT. Results: The measurements obtained using both methods were reproducible and demonstrated good agreement. The mean differences in vessel length and diameter measurements for each segment between NCT and CECT were not statistically significant, indicating good consistency. Conclusion: NCT may be useful for preoperative EVAR evaluation in patients with renal dysfunction or allergies to contrast agents.

关键词： Non-Contrast CT Vessel Analysis EVAR Contrast-Enhanced CT Abdominal Aortic Aneurysm