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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez jose j.Gil-Cosano Esther Ubago-Guisado Francisco j.Llorente-Cantarero juan Francisco Pascual-Gázquez kirsten K.Ness Vicente Martinez-Vizcaino jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

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SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet jane C.Burns kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20j(Gamma).The third wave had Delta strains(clades 21A,21I,and 21j),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

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Angling of hybrid sunfish from a hatchery pond with potential implications for community fisheries

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Aquaculture and Fisheries 2023年第1期8卷 91-95页

作者： Brian G.Blackwell Matthew j.ward Todd M.Kaufman South Dakota Department of Game Fish and Parks603 East 8th AvenueWebsterSD57274USA South Dakota Department of Game Fish and Parks44437139A StreetWaubaySD57273USA

Hatcheries are frequently called upon to produce catchable-sized fish for stocking community fishing *** attributes of fish selected for stocking into community ponds are that they are easy to produce in a hatchery system to sizes anglers are interested in catching and they provide anglers with high catch rates once *** sunfish[male Bluegill(Lepomis macrochirus)×female Green Sunfish(***)]have attributes that potentially make them attractive for use in community fishing *** assessed initial angler catch rates of 100 stocked hybrid sunfish in a 0.12-ha hatchery pond and after being subjected to angling(four,1-hr catch-and-release fishing events with five anglers).We also investigated whether catch rates would change following a supplemental stocking of an additional 100 hybrid sunfish(four,1-hr catch-and-release fishing events with five anglers).The anal fin of each fish in the second stocking was hole punched to differentiate them from those of the first stocking and fish caught by anglers were hole punched in the caudal fin each time they were caught before being released back into the *** catch rates were highest during initial fishing events that followed stocking(9.2 fish/angler hr and 18.0 fish/angler hr)and substantially declined in subsequent events(≤3.4 fish/angler hr).Catches of the newly stocked fish and previously stocked fish contributed to the high catch following the supplemental ***(80%)of the fish were caught in the first 30 min of each event and 45%were caught during the first 10 *** were able to catch 88%of the fish from the first stocking and 67%from the second stocking at least *** mortality occurred during the study as all fish were recovered when the pond was *** results suggest that hybrid sunfish will potentially provide high initial catch rates following stocking into community ponds,but managers should expect reduced catch rates following initial fishing even without h

关键词： Hybrid sunfish Angling Community fishing ponds

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对250位成年双胞胎的宏基因组鸟枪法测序发现影响肠道菌群的遗传与环境因素

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科学新闻 2017年第4期 186-186页

作者： Hailiang Xie Ruijin Guo Huanzi Zhong Qiang Feng Zhou Lan Bingcai Qin kirsten j.ward Matthew A.jackson Yan Xia Xu Chen Bing Chen Huihua Xia Changlu Xu Fei Li Xun Xu jumana Yousuf Al-Aama Huanming Yang jian Wang Karsten Kristiansen jun Wang Claire j.Steves jordana T.Bell 李俊桦 Timothy D.Spector 贾慧珏深圳华大基因研究院宏基因组研究所霍华德休斯医学研究所北卡罗来纳大学教堂山分校

文章简介肠道菌群通常被看作是影响人体健康的环境因素。双胞胎这一群体是系统地解析塑造肠道菌群的遗传与环境因素的绝佳对象。本研究首次对较大规模的双胞胎人群(取自Twin UK队列的250人)的粪便样品进行宏基因组鸟枪法测序,并构建最... 详细信息

文章简介肠道菌群通常被看作是影响人体健康的环境因素。双胞胎这一群体是系统地解析塑造肠道菌群的遗传与环境因素的绝佳对象。本研究首次对较大规模的双胞胎人群(取自Twin UK队列的250人)的粪便样品进行宏基因组鸟枪法测序,并构建最完整参考基因集。研究发现肠道菌群

关键词：肠道菌群双胞胎深圳华大基因研究院宏基因组测序

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Phenotypic plasticity is maintained despite geographical isolation in an African cichlid fish,Pseudocrenilabrus multicolor

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Integrative Zoology 2014年第1期9卷 85-96页

作者： kirsten E.WIENS Erika CRISPO Lauren j.CHAPMAN Department of Pathology New York University School of MedicineNew YorkNYUSA Department of Biology and Health Sciences Pace UniversityNew YorkNYUSA Department of Biology McGill UniversityMontrealQuebecCanada Wildlife Conservation Society BronxNew YorkUSA

Gene flow among populations in different selective environments should favor the evolution of phenotypic plasticity over local *** in development is a common response to long-term hypoxia in some widespread African fishes,including Pseudocrenilabrus multicolor,a cichlid that exploits both normoxic(high oxygen)rivers/lakes and hypoxic(low oxygen)*** studies have shown that fish from normoxic and hypoxic sites differ in many traits,including gill size,brain size and body shape,and that much of this vari-ation reflects developmental ***,these earlier studies focused on areas in Uganda where gene flow between swamp and river or lake populations is *** this study we tested the hypothesis that ***-color from a relatively isolated lake population(Lake Saka,Uganda)exhibit low levels of plasticity in traits re-lated to oxygen *** broods of *** from Lake Saka were reared under low and high dis-solved oxygen,and traits related to gill size,brain mass and body shape were ***,both gill size and brain mass showed high levels of developmental *** suggest that high levels of plasticity,particularly in the gill size of ***,reflects low costs of maintaining the plastic response,even in rela-tively isolated populations.

关键词： brain geometric morphometrics gills hypoxia riverine fish

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一种新的筛板塔负荷系数关联式

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化工装备技术 1990年第3期11卷 34-35页

作者： Thomas j.ward 倪翔

蒸馏塔和吸收塔塔径计算通常基于最大允许气速,而确定气速需要知道负荷系数C_F值。图1为负荷系数与气液动能参数F_(LV)的关联图,参变数是塔板间距t_o动能参数F_(LV)液体质量流速LM_L、气体质量流速VM_v(单位为磅/秒)以及两者的流体密度... 详细信息

蒸馏塔和吸收塔塔径计算通常基于最大允许气速,而确定气速需要知道负荷系数C_F值。图1为负荷系数与气液动能参数F_(LV)的关联图,参变数是塔板间距t_o动能参数F_(LV)液体质量流速LM_L、气体质量流速VM_v(单位为磅/秒)以及两者的流体密度ρ_L、ρ_V有关。

关键词：筛板塔负荷系数关联式

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液态和气态氮对铝挤压生产率的影响

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模具技术 1989年第2期 4-11页

作者： Thomas j.ward 张水忠

作为一种有效的惰性保护方法,气态氮已在铝挤压业中使用了一段时间,以减少模具模口部分出口端氧化物的形成。Heffron和Hull[1]报道说,氮提供了一种不易形成氧化物的保护气氛,这样提高了表面质量,并增加了挤压速度。在实际挤压过程中,通... 详细信息

作为一种有效的惰性保护方法,气态氮已在铝挤压业中使用了一段时间,以减少模具模口部分出口端氧化物的形成。Heffron和Hull[1]报道说,氮提供了一种不易形成氧化物的保护气氛,这样提高了表面质量,并增加了挤压速度。在实际挤压过程中,通过加工在模具垫板上的凹槽,吹入一股稳定的氮气流,该氮气就取代了空气,在挤压品四周形成一层惰性保护气氛。为了降低挤压工艺温度,并有利于提高挤压速度,对模具进行了冷却[2,3]。

关键词：液态氮气态氮铝材挤压生产率

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Exploring the utility of the Chasing Principle:influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension

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Acta Pharmaceutica Sinica B 2019年第1期9卷 194-201页

作者： Scheyla Daniela Siqueira j?rgensen Thomas Rades Huiling Mu kirsten Graeser Anette Müllertz Department of Pharmacy Faculty of Health and Medical Sciences University of Copenhagen Roche Pharma Research and Development Therapeutic Modalities Roche Innovation Center Basel

This study assessed the influence of the composition of drug-free SNEDDS co-dosed with aqueous suspensions of carvedilol(CAR), cinnarizine(CIN) or R3040 on drug solubilization in a twocompartment in vitro lipolysis model. Correlation of drug log P or solubility in SNEDDS with drug solubilization during in vitro lipolysis in the presence of drug-free SNEDDS was assessed. SNEDDS with varying ratios of soybean oil:Maisine 35-1(1:1, w/w) and Kolliphor RH40, with ethanol at 10%(w/w) were used. SNEDDS were named F65, F55 and F20(numbers refer to the percentage of lipids) and aqueous suspensions without drug-free SNEDDS(F0) were also analyzed. While the ranking order of drug solubilization was F65? F55? F204F0 for CAR; F65? F554F204F0 for CIN and F65? F55? F204F0 for R3040-with higher CAR solubilization than for R3040 and CIN-the ranking of S_(eq)of CAR, CIN and R3040 in SNEDDS was F65 o F55o F20, F65? F554F20 and F654F554F20, respectively. Therefore, the composition of SNEDDS influenced the solubilization of CIN, but not CAR and R3040. Furthermore, high S_(eq) in SNEDDS did not reflect high drug solubilization. As CAR(log P 3.8) showed higher solubilization than CIN(log P 5.8) and R3040(log P 10.4), a correlation between drug log P and drug solubilization was observed.

关键词： Self-nanoemulsiying drug delivery system(SNEDDS) Chasing principle Two-compartment in vitro lipolysis Rat gastrointestinal conditions Drug solubilization

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The phenotype and activation status of regulatory T cells during Friend retrovirus infection

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Virologica Sinica 2014年第1期29卷 48-60页

作者： jara j.joedicke kirsten K.Dietze Gennadiy Zelinskyy Ulf Dittmer Institute for Virology University Hospital EssenUniversity of Duisburg-Essen

The suppressive capacity of regulatory T cells （Tregs） has been extensively studied and is well established for many *** expansion,accumulation,and activation of Tregs in viral infections are of major interest in order to find ways to alter Treg functions for therapeutic *** are able to dampen effector T cell responses to viral infections and thereby contribute to the establishment of a chronic *** the Friend retrovirus （FV） mouse model,Tregs are known to expand in all infected *** better understand the characteristics of these Treg populations,their phenotype was analyzed in *** acute FV-infection,Tregs became activated in the spleen and bone marrow,as indicated by various T cell activation markers,such as CD43 and ***,Tregs in the bone marrow,which contains the highest viral loads during acute infection,displayed greater levels of activation than Tregs from the *** expansion was driven by proliferation but no FV-specific Tregs could be *** Tregs in FV-infection did not produce Granzyme B （GzmB） or tumor necrosis factor α （TNFα）,which are thought to be a potential mechanism for their suppressive ***,Tregs expressed inhibitory markers,such as TIM3,PD-1 and *** TIM3 and PD-L1 with antibodies during chronic FV-infection increased the numbers of activated *** data may have important implications for the understanding of Treg functions during chronic viral infections.

关键词： regulatory T cells Friend retrovirus Vβ5+ Treg activation marker

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Australian sugarcane soldier fly’s salivary gland transcriptome in response to starvation and feeding on sugarcane crops

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Insect Science 2020年第4期27卷 708-720页

作者： Kayvan Etebari Karel R.Lindsay Andrew L.ward Michael j.Furlong School of Biological Sciences The University of QueenslandBrisbaneQLDAustralia Sugar Research Australia Te KowaiQLDAustralia Sugar Research Australia IndooroopillyQLDAustralia

The soldier fly is an endemic pest of sugarcane in *** numbers of larvae can cause significant damage to roots and reduce the crop *** is known about the composition and function of the soldier fly salivary gland,its secretions,and their roles in insect—plant *** this study,we performed transcriptome analysis of the salivary glands of starved and sugarcane root-fed soldier fly larvae.A total of 31119 highly expressed assembled contigs were identified in the salivary glands and almost 50%of them showed high levels of similarity to known proteins in Nr *** all the obtained contigs,only 9727 sequences contain an open reading frame of over 100 amino *** 31%of contigs were predicted to encode secretory proteins,including some digestive and detoxifying enzymes and potential *** known salivary secreted peptides such as serine protease,cysteine proteinase inhibitors,antimicrobial peptides and venom proteins were among the top 100 highly expressed *** gene expression analysis revealed significant modulation of 850 transcripts in salivary glands upon exposure to plant roots or starvation ***,we identified some venom proteins which were significantly upregulated in the salivary glands of soldier fly larvae exposed to sugarcane *** other insects and nematodes some of these proteins have been used to manipulate host plant defense systems and facilitate the invasion of the host *** findings provide a further insight into the identification of potential effector proteins involved in soldier fly-sugarcane interactions.

关键词： Inopus salivary gland soldier fly sugarcane pest transcriptome

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