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SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia bainto Helen Harvey Adriana H.Tremoulet Jane C.burns kirsten b.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

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原发性免疫缺陷病患者肿瘤发生情况:美国免疫缺陷网络注册患者肿瘤发病率分析

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中华临床免疫和变态反应杂志 2018年第2期12卷 236-246页

作者： Paul C.Mayor Kevin H.Eng Kelly L.Singel Scott I.Abrams Kunle Odunsi kirsten b.moysich Ramsay Fuleihan Elizabeth Garabedian Patricia Lugar Hans D.Ochs Francisco A.bonilla Rebecca H.buckley Kathleen E.Sullivan Zuhair K.ballas Charlotte Cunningham-Rundles brahm H.Segal 白炜曾小峰中国医学科学院北京协和医学院北京协和医院风湿免疫科

研究背景评估了在美国免疫缺陷网络(USIDNET)注册的原发性免疫缺陷病(PIDDs)患者的总体和器官特异性肿瘤发病率,并与监测、流行病学和最终结果项目(SEER)数据库中经年龄校正的人群的肿瘤发病率进行比较。目的假设PIDD患者由于免疫功能受... 详细信息

研究背景评估了在美国免疫缺陷网络(USIDNET)注册的原发性免疫缺陷病(PIDDs)患者的总体和器官特异性肿瘤发病率,并与监测、流行病学和最终结果项目(SEER)数据库中经年龄校正的人群的肿瘤发病率进行比较。目的假设PIDD患者由于免疫功能受损,肿瘤发病率会增加。方法将2003年至2015年在USIDNET注册中心注册的PIDD (n=3658)患者的总体和器官特异性肿瘤发病率进行评估,并与SEER数据库中经年龄校正的人群发病率进行比较。结果与年龄相匹配的SEER人群相比,观察到PIDD患者罹患肿瘤的相对危险率为1. 42倍(P<0. 001)。PIDD的男性患癌症的风险是年龄校正的男性人群的1. 91倍(P<0. 001),而PIDD女性患者的总体肿瘤发病率与经年龄校正的女性人群相比并无差异。对SEER数据库中最常见的4个恶性肿瘤——肺癌、结肠癌、乳腺癌和前列腺癌的发病率进行分析,PIDD患者中这些肿瘤的发病没有显著增加。男性和女性PIDD患者的淋巴瘤发病率均显著增加(男性10倍,P<0. 001;女性8. 34倍,P<0. 001)。结论 PIDD患者的肿瘤发病率较高。在特定的PIDD人群中淋巴瘤发病率的增高是导致总体肿瘤发病率提高的主要原因,而常见的实体肿瘤的风险没有增加。这些数据表明免疫系统在预防特定肿瘤方面有一定的作用。

关键词：原发性免疫缺陷病普通变异性免疫缺陷病肿瘤白血病淋巴瘤美国免疫缺陷网络

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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iboneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides biomedical Research Institute of Cordoba(IMIbIC) Cordoba 14004Spain CIbERObN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(abMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with abMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific abMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure abMD(g/cm2).Associations between muscle strength and abMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low abMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower abMD Z-scores at all sites(b=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low abMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low abMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower abMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： bone health Childhood cancer DXA Lean mass Resistance training

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Diabetes, its impact on peripheral nerve regeneration： lessons from pre-clinical rat models towards nerve repair and reconstruction

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Neural Regeneration Research 2018年第1期13卷 65-66页

作者： kirsten Haastert-Talini Lars b. Dahlin Institute of Neuroanatomy and Cell biology Hannover Medical School Hannover Germany Center for Systems Neuroscience (ZSN) Hannover Germany Department of Translational Medicine-Hand Surgery Lund University Lund Sweden Department of Hand Surgery Skane University Hospital Malmo Sweden

The global number of patients with type 1 and type 2 diabetes is about to increase substantially in the coming decades. The reasons for this are two-fold, at first there is actual increase in incidence of type 1 diabetes and at second there is global increase in living expectancy and a high prevalence of patients with type 2 diabetes among the elderly. The diabetic condition is affiliated with reduced peripheral nervous system maintenance, such as peripheral neuropathies （Juster-Switlyk and Smith, 2016） that may be more common in men.

关键词： Diabetes length

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Quality of life after curative liver resection: A single center analysis

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World Journal of Gastroenterology 2010年第19期16卷 2388-2395页

作者： Helge bruns kirsten Krtschmer Ulf Hinz Anette brechtel Monika Keller Markus W büchler Peter Schemmer Department of General Surgery Ruprecht-Karls-University 69120 Heidelberg Germany Psychosomatic Medicine Section Psychooncology Ruprecht-Karls-University 69120 Heidelberg Germany

AIM: To evaluate quality of life (QoL) after curative liver resection and identify variables associated with decreased QoL. METHODS: From October 2001 to July 2004, 323 patients underwent liver resection. At 3-36 mo after discharge, 188 patients were disease free. QoL was assessed using the Short Form (SF)-12 Health Survey with mental and physical component scales (SF-12 MCS and PCS), supplemented with generic questions concerning pain and liver-specific items. RESULTS: Sixty-eight percent (128/188) returned the questionnaire, which was completed in 75% (96/128) of cases. Median SF-12 PCS and MCS were 46.7 (inter- quartile range: 34.2-53.9) and 54.1 (42.8-58.2). Fifty percent were pain free with a median symptom score of 1.75 (1.38-2.13). PCS was higher after major hepatec-tomy [57% (55/96)] compared to minor resection (P = 0.0049), which represented an improved QoL. QoL was not affected by sex but by age compared to the general German population. MCS was higher after liver surgery for metastatic disease [55.9 (47.5-58.8)] compared to primary carcinoma [49.6 (36.5-55.1)] and benign disease [49.2 (37.7-56.3)] (P = 0.0317). There was no correlation between length of postoperative period and QoL. Pain, def iciencies in everyday life and a high symptom score significantly decreased MCS and PCS. CONCLUSION: Most patients were only marginally affected even after major liver resection; however, minor complications were associated with decreased SF-12 MCS and PCS and need careful attention.

关键词： Quality of life Liver resection

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The computerized LASSI-bC Test versus the Standard LASSI-L Paper-and-Pencil Version in Community-based-Samples

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Advances in Alzheimer's Disease 2024年第1期13卷 11-25页

作者： Rosie E. Curiel Cid Alexandra Ortega Ubbo Visser Marcela Kitaigorodsky D. Diane Zheng Diana Hincapie kirsten Horne Crenshaw Ashleigh beaulieu brooke bosworth Liz Gallardo Emory Neer Sofia Ramirez Elizabeth A. Crocco Mike Georgiou Efrosyni Sfakianaki David A. Loewenstein Center for Cognitive Neuroscience and Aging and Department of Psychiatry and behavioral Sciences Miller School of Medicine University of Miami Miami FL USA Department of Computer Sciences University of Miami Coral Gables FL USA Nova Southeastern University Fort Lauderdale FL USA Department of Radiology and Nuclear Medicine Miller School of Medicine University of Miami Miami FL USA

Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by Aβ load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-brief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L. Their performance was compared with 62 CU older adults and 52 aMCI participants examined using the LASSI-bC. After adjustment for covariates (degree of initial learning, sex, education, and language of evaluation) both the standard and computerized versions distinguished between aMCI and CU participants. The performance of CU and aMCI groups using either form was relatively commensurate. Importantly, an optimal combination of Cued b2 recall and Cued b1 intrusions on the LASSI-bC yielded an area under the ROC curve of .927, a sensitivity of 92.3% and specificity of 88.1%, relative to an area under the ROC curve of .815, a sensitivity of 72.5%, and a specificity of 79.1% obtained for the paper-and-pencil LASSI-L. Overall, the LASSI-bC was comparable, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-bC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built-in audio recording of responses.

关键词： Mild Cognitive Impairment Proactive Semantic Interference LASSI-L Computerized Cognitive Assessment

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Early Detection of Lung Cancer Using CT Scan and bronchoscopy in a High Risk Population

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Journal of Cancer Therapy 2012年第4期3卷 388-396页

作者： Vijayvel Jayaprakash Gregory M. Loewen Samjot S. Dhillon kirsten b. moysich Martin C. Mahoney Sai Yendamuri D. Kyle Hogarth Mary E. Reid Cancer Prevention and Population Sciences Roswell Park Cancer Institute Buffalo USA Department of Medicine Roswell Park Cancer Institute Buffalo USA Department of Social and Preventive Medicine State University of New York at Buffalo Buffalo USA Department of Thoracic Surgery Roswell Park Cancer Institute Buffalo USA Pulmonary Oncology Sacred Heart Medical Center Spokane USA Section of Pulmonary and Critical Care Medicine University of Chicago Chicago USA

background: Computed tomography (CT) and bronchoscopy have been shown to improve the detection rates of peripheral and central lung cancers (LC), respectively. However, the performance of the combination of CT and bronchoscopy in detecting LC, in high-risk patients, is not clear. Patients & Methods: This prospective study included 205 high-risk patients with a history of at least 2 of the following risk factors: (1) heavy smoking;(2) aero-digestive cancer;(3) pulmonary asbestosis or;(4) chronic obstructive pulmonary disease. Patients were offered chest X-ray, sputum cytology, conventional white-light followed by autofluorescence beonchoscopy (WL/AFb) and low-dose spiral CT both at baseline and follow-up visits. Results: Seven patients (3.4%) were diagnosed with LC or carcinoma in-situ (CIS) at baseline: CT evaluation detected 5 LC/CIS, while WL/AFb evaluation also identified 5 LC/CIS, 2 of which were not detected on CT. Six (85%) of these baseline lesions were early stage (0/IA). The relative-sensitivity of CT with WL/ AFb was 40% better than CT alone. On four year follow-up, 20 patients (9.8%) were diagnosed with an LC/CIS. CT with WL/AFb detected 19 cases (95%), whereas CT alone detected 15 cases (75%). Conclusion: bimodality surveillance with spiral CT and WL/AFb can improve the detection of early stage LCs among high-risk

关键词： Lung Cancer Screening Surveillance CT Scan bronchoscopy

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Exploring the utility of the Chasing Principle:influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension

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Acta Pharmaceutica Sinica b 2019年第1期9卷 194-201页

作者： Scheyla Daniela Siqueira J?rgensen Thomas Rades Huiling Mu kirsten Graeser Anette Müllertz Department of Pharmacy Faculty of Health and Medical Sciences University of Copenhagen Roche Pharma Research and Development Therapeutic Modalities Roche Innovation Center Basel

This study assessed the influence of the composition of drug-free SNEDDS co-dosed with aqueous suspensions of carvedilol(CAR), cinnarizine(CIN) or R3040 on drug solubilization in a twocompartment in vitro lipolysis model. Correlation of drug log P or solubility in SNEDDS with drug solubilization during in vitro lipolysis in the presence of drug-free SNEDDS was assessed. SNEDDS with varying ratios of soybean oil:Maisine 35-1(1:1, w/w) and Kolliphor RH40, with ethanol at 10%(w/w) were used. SNEDDS were named F65, F55 and F20(numbers refer to the percentage of lipids) and aqueous suspensions without drug-free SNEDDS(F0) were also analyzed. While the ranking order of drug solubilization was F65? F55? F204F0 for CAR; F65? F554F204F0 for CIN and F65? F55? F204F0 for R3040-with higher CAR solubilization than for R3040 and CIN-the ranking of S_(eq)of CAR, CIN and R3040 in SNEDDS was F65 o F55o F20, F65? F554F20 and F654F554F20, respectively. Therefore, the composition of SNEDDS influenced the solubilization of CIN, but not CAR and R3040. Furthermore, high S_(eq) in SNEDDS did not reflect high drug solubilization. As CAR(log P 3.8) showed higher solubilization than CIN(log P 5.8) and R3040(log P 10.4), a correlation between drug log P and drug solubilization was observed.

关键词： Self-nanoemulsiying drug delivery system(SNEDDS) Chasing principle Two-compartment in vitro lipolysis Rat gastrointestinal conditions Drug solubilization

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The phenotype and activation status of regulatory T cells during Friend retrovirus infection

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Virologica Sinica 2014年第1期29卷 48-60页

作者： Jara J.Joedicke kirsten K.Dietze Gennadiy Zelinskyy Ulf Dittmer Institute for Virology University Hospital EssenUniversity of Duisburg-Essen

The suppressive capacity of regulatory T cells （Tregs） has been extensively studied and is well established for many *** expansion,accumulation,and activation of Tregs in viral infections are of major interest in order to find ways to alter Treg functions for therapeutic *** are able to dampen effector T cell responses to viral infections and thereby contribute to the establishment of a chronic *** the Friend retrovirus （FV） mouse model,Tregs are known to expand in all infected *** better understand the characteristics of these Treg populations,their phenotype was analyzed in *** acute FV-infection,Tregs became activated in the spleen and bone marrow,as indicated by various T cell activation markers,such as CD43 and ***,Tregs in the bone marrow,which contains the highest viral loads during acute infection,displayed greater levels of activation than Tregs from the *** expansion was driven by proliferation but no FV-specific Tregs could be *** Tregs in FV-infection did not produce Granzyme b （Gzmb） or tumor necrosis factor α （TNFα）,which are thought to be a potential mechanism for their suppressive ***,Tregs expressed inhibitory markers,such as TIM3,PD-1 and *** TIM3 and PD-L1 with antibodies during chronic FV-infection increased the numbers of activated *** data may have important implications for the understanding of Treg functions during chronic viral infections.

关键词： regulatory T cells Friend retrovirus Vβ5+ Treg activation marker

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A Traceable Cancer Model: DNA Damage, Fragile Site-SMGs, Mitotic Slippage, 4n-Genome-Reduction to Fitness-Gained, Initiating, 2n First Cells

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Journal of Cancer Therapy 2021年第6期12卷 365-386页

作者： kirsten H. Walen CROMOS Richmond CA USA

We have known since 1976 that cancer evolves clonally from one initiated normal human cell, the first cell. Today we see that this fact has been overshadowed from federal funding choice of the mutation theory (MT), which not yet has shown tumorigenesis-initiation in normal human cells. Our suggested, death signaled, stress model from time delayed S-period (replication slowness), causing repair instability from under-replicated lesions in repetitive DNAs, herein has the objective of revealing, significant literature support from a mini-review. We reasoned that early versus late S-period stress would have different outcomes: early the slowness affecting mitotic slippage with diploid re-replication to 4n cells whereas late-S, with milder stress effect, producing diploid cells. In cancer burden, near-half is diploid, but tetraploid solid tumors have the attention. The initial 4n cells were special with orderly genomic reductive division to diploid first cells with measurable fitness-gain from hours-reduced total cell cycle time. Experimental data from Coxsakie-B3 virus infected normal fibroblasts, reiterated 4n cell production from death-signaled recovery-cells with progressive cell-phenotypic changes to polygonal and roundness cell-shapes, indistinguishable from diagnostic/prognostic cancer morphology. The 4n cells showed a self-inflicted 90° turn of the 4n nucleus before division, affecting a perpendicular orientation of the fitness-gained first cells relative to neighbo

关键词： S-Period-DDR 2n-4n-90° Nuclear Turn Cytoskeleton/Cell Polarity Amitosis Time-Short Cell Cycle Fitness-Gain Aneuploidy Loss-of-Function Genetics Parasitic-Tumor Life Therapy-Possibilities

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