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Da.a.driven a.a.ysis of chemica.s,proteins a.d pa.hwa.s a.socia.ed with pea.ut a.lergy:from molecula. networking to biologica. interpreta.ion

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Food Science a.d Huma. Wellness 2024年第3期13卷 1322-1335页

作者： Emma.uel Kemmler Julia. Bra.n Florent Fa.chère Sa.ine Dölle-Bierke kirsten Beyer Robert Preissner Ma.gitta.Worm Priya.ka.Ba.erjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“Der Simulierte Mensch”a.science fra.ework of Technische Universität Berlin a.d Cha.ité-Universitätsmedizin Berlin Berlin 10115Germany Cha.ité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of a.lergy a.d Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pedia.rics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Pea.ut a.lergy is ma.orly rela.ed to severe food induced a.lergic *** food including cow's milk,hen's eggs,soy,whea.,pea.uts,tree nuts(wa.nuts,ha.elnuts,a.monds,ca.hews,peca.s a.d pista.hios),fish a.d shellfish a.e responsible for more tha. 90%of food ***,we provide promising insights using a.la.ge-sca.e da.a.driven a.a.ysis,compa.ing the mecha.istic fea.ure a.d biologica. releva.ce of different ingredients presents in pea.uts,tree nuts(wa.nuts,a.monds,ca.hews,peca.s a.d pista.hios)a.d ***,we ha.e a.a.ysed the chemica. compositions of pea.uts in different processed form ra.,boiled a.d *** the da.a.driven a.proa.h we a.e a.le to genera.e new hypotheses to expla.n why nuclea. receptors like the peroxisome prolifera.or-a.tiva.ed receptors(PPa.s)a.d its isoform a.d their intera.tion with dieta.y lipids ma. ha.e significa.t effect on a.lergic *** results obta.ned from this study will direct future experimea.ta. a.d clinica. studies to understa.d the role of dieta.y lipids a.d PPa.isoforms to exert pro-infla.ma.ory or a.ti-infla.ma.ory functions on cells of the inna.e immunity a.d influence a.tigen presenta.ion to the cells of the a.a.tive immunity.

关键词： a.lergy informa.ics Knowledge-gra.h Da.a.a.a.ysis Food a.lergy Peroxisome prolifera.or-a.tiva.ed receptors Fa.ty a.ids

Sa.S-CoV-2 va.ia.ts a.e a.socia.ed with different clinica. courses in children with MIS-C

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World Journa. of Pedia.rics 2024年第2期20卷 143-152页

作者： a.dres F.Moreno Roja. Emelia.Ba.nto Helen Ha.vey a.ria.a.H.Tremoulet Ja.e C.Burns kirsten B.Dummer Depa.tment of Pedia.rics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Ka.a.a.i Disea.e Resea.ch Center La JollaCAUSA Depa.tment of Pedia.rics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Depa.tment of Pedia.rics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Ba.kground Recent infection with Sa.S‑CoV-2 in children ha. been a.socia.ed with multisystem infla.ma.ory syndrome in children(MIS-C).Sa.S‑CoV-2 ha. undergone different *** publica.ions exist a.out specific va.ia.ts a.d their correla.ion with the severity of *** This wa. a.single-center,retrospective study including a.l pa.ients a.mitted with MIS-C a. Ra.y Children’s Hospita.-Sa. Diego between Ma. 2020 a.d Ma.ch *** epidemiologic da.a.including vira. genomic informa.ion,were obta.ned from public ***,clinica. presenta.ion,la.ora.ory va.ues,a.d outcomes were obta.ned from electronic medica. *** The a.a.ysis included 104 pedia.ric *** MIS-C wa.es were *** va.ia.ts in Sa. Diego during the first wa.e included cla.es 20a.to *** the second wa.e,there were va.ia.ts from cla.es 20a.to C,20G,21C(Epsilon),20I(a.pha.,a.d 20J(Ga.ma..The third wa.e ha. Delta.stra.ns(cla.es 21a.21I,a.d 21J),a.d the fourth ha. Omicron va.ia.ts(cla.es 21K,21L,a.d 22C).MIS-C presented with simila. symptoms a.d la.ora.ory findings a.ross a.l *** pa.ients were a.mitted to the pedia.ric intensive ca.e unit(PICU)(74%)a.d required inotropic support(63%)during the second *** of the pa.ients required mecha.ica. circula.ory support,a.d only two required inva.ive ventila.ory *** wa. no *** The va.ious stra.ns of Sa.S-CoV-2 triggered MIS-C with differing severities,with the second wa.e ha.ing a.more severe clinica. *** the differences in disea.e severity a.ross va.ia.ts were due to cha.ges in the virus or other fa.tors rema.ns unknown.

关键词： Complica.ions COVID-19 MIS-C Sa.S-CoV-2 va.ia.ts

Rea.ism, Norma.ivity a.d Professor Mea.sheimer

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Philosophy Study 2024年第2期14卷 63-65页

作者： Ja.-Erik lane Geneva.University GenevaSwitzerland

Interna.iona. rela.ions or politics a.e a.dyna.ic discipline within politics. It concentra.es upon the understa.ding or expla.a.ion of conflict a.d power between na.ions or countries. It is of course highly releva.t toda. with much wa.fa.e or threa.s thereof. One centra. theory is the so-ca.led rea.ism or neorea.ism. Its foremost representa.ive toda. is Professor Mea.sheimer. Professor John Mea.sheimer ha. put severa. of his well-known lectures on YouTube. In these he spells out how he looks upon interna.iona. politics toda. through a.neorea.ist a.proa.h. Very much worth listening to, we must though question consistency in his messa.e.

关键词： Wa. conflict between na.ions neorea.ism

Pulmona.y a.tery dia.eter ra.io a. a.prognostic indica.or of congenita. dia.hra.ma.ic hernia

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World Journa. of Pedia.ric Surgery 2024年第1期7卷 20-25页

作者： Yuichiro Miya.e Hiroyuki Koga.Shuko Nojiri Shunsuke Ya.a.a.Ta.a.ori Ochi Go Miya.o Geoffrey J lane a.suyuki Ya.a.a.a.Ta.a.a.u Oka.a.i Depa.tment of Pedia.ric Genera. a.d Urogenita. Surgery Juntendo University School of MedicineBunkyo-kuTokyoJapan Depa.tment of Medica. Technology Innova.ion Center Juntendo UniversityBunkyo-ku TokyoJapan Depa.tment of Pedia.ric Surgery Juntendo University Urayasu HospitalUrayasuChibaJapan

Ba.kground Following on from a. ea.lier study published in 2008 a.out left pulmona.y a.tery(LPa.flow mea.ured on seria. echoca.diogra.hy being strongly prognostic in left-sided congenita. dia.hra.ma.ic hernia.CDH)a.d the ra.io of LPa.to right pulmona.y a.tery(RPa.dia.eters being a.simple a.d relia.le indica.or for commencing nitric oxide(NO)thera.y,the ra.io of LPa.RPa.dia.eters(Pa.ra.io orPa.)wa. hypothesized to possibly reflect ca.diopulmona.y stresses a.compa.ying CDH *** Subjects with isola.ed left-sided CDH trea.ed between 2007 a.d 2020 a. a.single pedia.ric surgica. center were recruited a.d cla.sified a.cording to *** obta.ned retrospectively for subject demogra.hics,clinica. course,LPa.RPa.dia.eters,a.d Pa. were compa.ed between survivors a.d *** va.ue of Pa. for optimizing the prognostic va.ue of Pa.dia.eter da.a.in CDH were a.a.yzed with receiver opera.ing cha.a.teristic(ROC)curve *** Of 65 subjects,there were 54 survivors(82.3%)a.d 11 non-survivors(17.7%);7 of 11 non-survivors died before surgica. repa.r could be *** Pa. for survivors(0.851±0.152)wa. significa.tly higher tha. for non-survivors(0.672±0.108)(p=0.0003).Mea. Pa. for non-survivors wa. not a.fected by surgica. *** of survivors were:LPa.2 mm(n=52 of 54;mea. Pa.=0.866±0.146)a.d RPa.3mm(n=46 of 54;mea. Pa.=0.857±0.152).Non-survivors with simila. LPa.a.d RPa.dia.eters to survivors ha. significa.tly lower mea. *** curve cut-off for Pa. wa. *** with high Pa.(≥0.762)required high-frequency oscilla.ory ventila.ion/NO less tha. subjects with low Pa.(a.d p=0.0485,respectively)a.d subjects with high Pa. sta.ilized significa.tly ea.lier tha. subjects with low Pa.(1.71±0.68 da.s vs 3.20±0.87 da.s)(pa. would a.pea. to be strongly correla.ed with clinica. outcome in CDH a.d be useful for pla.ning ma.a.ement of ca.diopulmona.y insta.ility in CDH.

关键词： hernia congenita. dia.eters

How completely a.e ra.domized controlled tria.s of non-pha.ma.ologica. interventions following concussion reported? a.systema.ic review

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Journa. of Sport a.d Hea.th Science 2024年第4期13卷 537-547页

作者： Ja.queline Josee va. Ierssel Olivia.Ga.ea.kirsten Holte Ca.oline Lusza.ski Eliza.eth Jenkins Jennifer O’Neil Ca.olyn a.Emery Rebeka. Ma.nix Ka.hryn Schneider Keith Owen Yea.es Roger Zemek Children’s Hospita. of Ea.tern Onta.io Resea.ch Institute OttawaON K1H 8L1Canada The Centre for Hea.th Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Resea.ch Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada a.berta.Children’s Hospita. Resea.ch Institute University of Ca.ga.y CalgaryAB T2N 1N4Canada Hotchkiss Bra.n Institute University of CalgaryCalgaryAB T2N 4N1Canada Depa.tment of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Reha.ilita.ion Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Resea.ch Institute OttawaON K1N 5C8Canada Depa.tments of Pedia.rics a.d Emergency Medicine Harvard Medical SchoolBostonMA 02115USA Depa.tments of Pedia.rics a.d Emergency Medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study a.med to exa.ine the reporting completeness of ra.domized controlled tria.s(RCTs)of non-pha.ma.ologica. interventions following ***:We sea.ched MEDLINE,Emba.e,PsycInfo,CINa.L,a.d Web of Science up to Ma. *** reviewers independently screened studies a.d a.sessed reporting completeness using the Templa.e for Intervention Description a.d Replica.ion(TIDieR),Consensus on Exercise Reporting Templa.e(CERT),a.d interna.iona. Consensus on Thera.eutic Exercise a.d Tra.ning(i-CONTENT)*** informa.ion wa. sought my study a.thors where reporting wa. *** of bia.(ROB)wa. a.sessed with the Cochra.e ROB-2 *** exa.ining non-pha.ma.ologica. interventions following ***:We included 89 RCTs(n=53 high ROB)exa.ining 11 different interventions for concussion:sub-symptom threshold a.robic exercise,cervicovestibula. thera.y,physica./cognitive rest,vision thera.y,educa.ion,psychothera.y,hyperba.ic oxygen thera.y,tra.scra.ia. ma.netic stimula.ion,blue light thera.y,osteopa.hic ma.ipula.ion,a.d hea./neck *** scores were:TIDieR 9/12(75%;interqua.tile ra.ge(IQR)=5;ra.ge:5-12),CERT 17/19(89%;IQR=2;ra.ge:10-19),a.d i-CONTENT 6/7(86%;IQR=1;ra.ge:5-7).Percenta.e of studies completely reporting a.l items wa. TIDieR 35%(31/89),CERT 24%(5/21),a.d i-CONTENT 10%(2/21).Studies were more completely reported a.ter publica.ion of TIDieR(t_(87)=2.08;p=0.04)a.d CERT(t_(19)=2.72;p=0.01).Reporting completeness wa. not strongly a.socia.ed with journa. impa.t fa.tor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pha.ma.ologica. interventions following concussion demonstra.e modera.e to good reporting completeness,but a.e often missing key components,pa.ticula.ly modifica.ions,motiva.iona. stra.egies,a.d qua.ified *** completeness improved a.ter TIDieR a.d CERT publica.ion,but p

关键词： Concussion Intervention Ra.domized controlled tria. Systema.ic review

Muscle strength deficits a.e a.socia.ed with low bone minera. density in young pedia.ric ca.cer survivors:The iBoneFIT project

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Journa. of Sport a.d Hea.th Science 2024年第3期13卷 419-427页

作者： a.dres Ma.mol-Perez Jose J.Gil-Cosa.o Esther Uba.o-Guisa.o Fra.cisco J.Llorente-Ca.ta.ero Jua. Fra.cisco Pa.cua.-Gázquez kirsten K.Ness Vicente Ma.tinez-Vizca.no Jona.a. R.Ruiz Luis Gra.ia.Ma.co Depa.tment of Physica. Educa.ion a.d Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Depa.tment of Epidemiology a.d Ca.cer Control St.Jude Children's Research HospitalMemphisTN 38105USA Depa.tment of Communica.ion a.d Educa.ion Loyola University AndalusiaSeville 41704Spain Biosa.ita.y Resea.ch Institute ibs.GranadaGranada 18012Spain Ma.monides Biomedica. Resea.ch Institute of Cordoba.IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Depa.tment of Specific Dida.tics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pedia.ric a.d a.olescent hema.ology a.d oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Hea.th a.d Socia. Resea.ch Center Universidad de Castilla-La ManchaCuenca 13001Spain

Ba.kground Pedia.ric ca.cer survivors a.e a. increa.ed risk of muscle wea.ness a.d low a.ea. bone minera. density(a.MD).However,the preva.ence of muscle strength deficits is not well documented,a.d the a.socia.ions of muscle strength with a.MD a.e unknown in this ***,this study a.med to investiga.e the preva.ence of upper-a.d lower-body muscle strength deficits a.d to exa.ine the a.socia.ions of upper-a.d lower-body muscle strength with a.e-,sex,a.d ra.e-specific a.MD Z-scores a. the tota. body,tota. hip,femora. neck,a.d lumba. *** This cross-sectiona. study included 116 pedia.ric ca.cer survivors(12.1±3.3 yea.s old,mea.±SD;42.2%fema.e).Upper-a.d lower-body muscle strength were a.sessed by ha.dgrip a.d sta.ding long jump test,***‑energy X‑ra. a.sorptiometry wa. used to mea.ure a.MD(g/cm2).a.socia.ions between muscle strength a.d a.MD were eva.ua.ed in multiva.ia.le linea. regression *** regression wa. used to eva.ua.e the contribution of muscle strength(1-decile lower)to the odds of ha.ing low a.MD(Z-score≤1.0).a.l a.a.yses were a.justed for time from trea.ment completion,ra.iothera.y exposure,a.d body ma.s *** More tha. one-ha.f of survivors were within the 2 lowest deciles for upper-(56.9%)a.d lower-body muscle strength(60.0%)in compa.ison to a.e-a.d sex-specific reference *** strength deficits were a.socia.ed with lower a.MD Z-scores a. a.l sites(B=0.133–0.258,p=0.001–0.032).Ea.h 1-decile lower in upper-body muscle strength wa. a.socia.ed with 30%–95%higher odds of ha.ing low a.MD Z-scores a. a.l *** 1-decile lower in lower-body muscle strength wa. a.socia.ed with 35%–70%higher odds of ha.ing low a.MD Z-scores a. tota. body,tota. hip,a.d femora. *** Muscle strength deficits a.e preva.ent in young pedia.ric ca.cer survivors,a.d such deficits a.e a.socia.ed with lower a.MD Z-scores a. a.l *** results suggest tha. interventions designed to improve muscle strength in t

关键词： Bone hea.th Childhood ca.cer DXA Lea. ma.s Resista.ce tra.ning

The computerized La.SI-BC Test versus the Sta.da.d La.SI-L Pa.er-a.d-Pencil Version in Community-Ba.ed-Sa.ples

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a.va.ces in a.zheimer's Disea.e 2024年第1期13卷 11-25页

作者： Rosie E. Curiel Cid a.exa.dra.Ortega.Ubbo Visser Ma.cela.Kita.gorodsky D. Dia.e Zheng Dia.a.Hinca.ie kirsten Horne Crensha. a.hleigh Bea.lieu Brooke Bosworth Liz Ga.la.do Emory Neer Sofia.Ra.irez Eliza.eth a. Crocco Mike Georgiou Efrosyni Sfa.ia.a.i Da.id a. Loewenstein Center for Cognitive Neuroscience a.d a.ing a.d Depa.tment of Psychia.ry a.d Beha.iora. Sciences Miller School of Medicine University of Miami Miami FL USA Depa.tment of Computer Sciences University of Miami Coral Gables FL USA Nova.Southea.tern University Fort Lauderdale FL USA Depa.tment of Ra.iology a.d Nuclea. Medicine Miller School of Medicine University of Miami Miami FL USA

Proa.tive Sema.tic Interference (PSI) a.d fa.lure to recover from PSI (frPSI), a.e novel constructs a.sessed by the La.SI-L. These mea.ures a.e sensitive to cognitive cha.ges in ea.ly Mild Cognitive Impa.rment (MCI) a.d preclinica. a. determined by a. loa. using PET. The goa. of this study wa. to compa.e a.new computerized version of the La.SI-L (La.SI-Brief Computerized) to the sta.da.d pa.er-a.d-pencil version of the test. In this study, we exa.ined 110 cognitively unimpa.red (CU) older a.ults a.d 79 with a.nestic MCI (a.CI) who were a.ministered the pa.er-a.d-pencil form of the La.SI-L. Their performa.ce wa. compa.ed with 62 CU older a.ults a.d 52 a.CI pa.ticipa.ts exa.ined using the La.SI-BC. a.ter a.justment for cova.ia.es (degree of initia. lea.ning, sex, educa.ion, a.d la.gua.e of eva.ua.ion) both the sta.da.d a.d computerized versions distinguished between a.CI a.d CU pa.ticipa.ts. The performa.ce of CU a.d a.CI groups using either form wa. rela.ively commensura.e. Importa.tly, a. optima. combina.ion of Cued B2 reca.l a.d Cued B1 intrusions on the La.SI-BC yielded a. a.ea.under the ROC curve of .927, a.sensitivity of 92.3% a.d specificity of 88.1%, rela.ive to a. a.ea.under the ROC curve of .815, a.sensitivity of 72.5%, a.d a.specificity of 79.1% obta.ned for the pa.er-a.d-pencil La.SI-L. Overa.l, the La.SI-BC wa. compa.a.le, a.d in some wa.s, superior to the pa.er-a.d-pencil La.SI-L. a.va.ta.es of the La.SI-BC include a.more sta.da.dized a.ministra.ion, suita.ility for remote a.sessment, a.d a. a.toma.ed scoring mecha.ism tha. ca. be verified by a.built-in a.dio recording of responses.

关键词： Mild Cognitive Impa.rment Proa.tive Sema.tic Interference La.SI-L Computerized Cognitive a.sessment

Ma.sive Dira. pa.ticles ba.ed on ga.ped gra.hene with Rosen-Morse potentia. in a.uniform ma.netic field

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Chinese Physics B 2024年第8期33卷 170-178页

作者： a.Ka.a.i a.ireza.a.a.i M.a.Ra.za.pour Depa.tment of Physics Ayatollah Amoli BranchIslamic Azad UniversityAmolIran

We explore the ga.ped gra.hene structure in the two-dimensiona. plane in the presence of the Rosen-Morse potentia. a.d a. externa. uniform ma.netic *** order to describe the corresponding structure,we consider the propa.a.ion of electrons in gra.hene a. rela.ivistic fermion qua.i-pa.ticles,a.d a.a.yze it by the wa.e functions of two-component spinors with pseudo-spin symmetry using the Dira. ***,to solve a.d a.a.yze the Dira. equa.ion,we obta.n the eigenva.ues a.d eigenvectors using the Legendre differentia. *** tha.,we obta.n the bounded sta.es of energy depending on the coefficients of Rosen-Morse a.d ma.netic potentia.s in terms of qua.tum numbers of principa. n a.d spin-orbit ***,the va.ues of the energy spectrum for the ground sta.e a.d the first excited sta.e a.e ca.cula.ed,a.d the wa.e functions a.d the corresponding proba.ilities a.e plotted in terms of coordina.es *** wha. follows,we explore the ba.d structure of ga.ped gra.hene by the modified dispersion rela.ion a.d write it in terms of the two-dimensiona. wa.e vectors K_(x) a.d K_(y).Fina.ly,the energy ba.ds a.e plotted in terms of the wa.e vectors K_(x) a.d K_(y) with a.d without the ma.netic term.

关键词： ma.sive Dira. equa.ion Rosen–Morse potentia. Legendre polynomia. ga.ped gra.hene pseudospin symmetry

Photometric Studies of EV Cnc a.d a. Cnc in the Open Cluster M67

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Resea.ch in a.tronomy a.d a.trophysics 2024年第8期24卷 198-213页

作者： Ma.a.ha.Ra.i G. K.Srira. Deblina.La.iri Vija.a.a. Depa.tment of a.tronomy Osmania University

Conta.t bina.ies a. va.ious sta.es of evolution unveil va.ious opera.ing mecha.isms tha. drive *** report the photometric a.d period va.ia.ion a.a.ysis of two conta.t bina.ies EV Cnc a.d a. Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope a.d utilized TESS a.d Kepler *** photometric solutions of EV Cnc a.d a. Cnc revea.ed a.ma.s ra.io of q～0.41 a.d～0.15 with a. inclina.ion of i=42°a.d87°*** solutions suggest tha. EV Cnc is proba.ly a.semi-deta.hed a.d a. Cnc is a.deep low-ma.s ra.io conta.t *** study of O-C va.ia.ion a.a.ysis indica.es tha. for both systems,the period is increa.ing which suggests the ma.s tra.sfer is occurring from seconda.y to *** the ca.e of a. Cnc a.d ba.ed on simula.ions by ra.domly va.ying the time of minima.to fit the LITE solution,we noted the third body orbita. period to be a.ound P3=26.82±2.54 yr,which is different from ea.lier reported va.ues a.d conclude tha. future observa.ions a.e required to confirm this *** compa.e these two systems with other simila. conta.t bina.ies to get a. estima.e of the fina. configura.ion of the respective systems.

关键词： (sta.s:) bina.ies (including multiple): close (sta.s:) bina.ies: eclipsing sta.s: a.tivity