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A Chiral Phosphorous Derivatizing Agent for the Determination of the Enantiomeric Excess of Chiral Alcohols, Amines by ^(31)P NMR

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Chinese Chemical Letters 2001年第10期12卷 907-908页

作者： Kang Ying LI Zheng Hong ZHOU Chi Hung yeung Chu Chi TANG State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071 Laboratory of Chiral Technology and Department of Applied Biology and Chemical Technology The Hong Kong Polytcchnic UniversityHong Kong

A chiral phosphorous derivatizing agent prepared from PCl3 and (S)-BINOL was described. It is used to determine the enantiomeric excess of chiral alcohols and amines by 31P NMR.

关键词： Chiral phosphorous derivation chiral alcohols chiral amines enantiomeric excess asymmetric induction.

Nanograins on Ti-25Nb-3Mo-2Sn-3Zr alloy facilitate fabricating biological surface through dual-ion implantation to concurrently modulate the osteogenic functions of mesenchymal stem cells and kill bacteria

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Journal of Materials Science & Technology 2021年第14期73卷 31-44页

作者： Run Huang Lei Liu Bo Li Liang Qin Lei Huang Kelvin W.K.yeung Yong Han School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan232001China Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina State-key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi'an710049China Department of Gastrointestinal Surgery Hubei Cancer HospitalWuhan430060China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053China

Surface mechanical attrition treatment(SMAT)method is an effective way to generate nanograined(NG)surface on Ti-25 Nb-3 Mo-2 Sn-3 Zr(wt.%)(named as TLM),a kind ofβ-type titanium alloy,and the achieved nanocrystalline surface was proved to promote positive functions of osteoblastic *** this work,to further endow the NG TLM alloy with both good osteogenic and antibacterial properties,magnesium(Mg),silver(Ag)ion or both were introduced onto the NG TLM surface by ion implantation process,as a comparison,the Mg and Ag ions were also co-implanted onto coarsegrained(CG)TLM *** obtained results show that subsequent ion implantation does not remarkably induce the surface roughness and topography alteration of the SMAT-treated layers,and it also has little impact on the microstructure of the SMAT-derivedβ-Ti *** addition,the implanted Mg and Ag ions are observed to exist as MgO and metallic Ag na noparticles(NPs)embedding tightly in theβ-Ti matrix with grain size of about 15 and 7 nm,*** cell adhesion and functions(including proliferation,osteo-differentiation and extracellular matrix mineralization)of rabbit bone marrow mesenchymal stem cells(rBMMSCs)and the bacterial colonization of Staphylococcus aureus(***)on the different surfaces were *** in-vitro experimental results reveal that the Mg and Ag single-ion implanted NG surface either significantly promotes the rBMMSCs response or inhibits the growth ***,whereas the Mg/Ag coimplanted NG surface could concurrently enhance the rBMMSCs functions as well as inhibit the bacterial growth compared to the NG surface,and this efficacy is more pronounced as compared to the Mg/Ag co-implantation in the CG *** SMAT-achieved nanograins in the TLM surface layer are identified to not only play a leading role in determining the fate of rBMMSCs but also facilitate fabricating dualfunctio nal surface with both good osteogenic and antibacterial activities through co-imp

关键词： β-Type titanium Nanograined surface Ion implantation Stem cells Antibacterial property

Quality and readability of online information resources on insomnia

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Frontiers of Medicine 2017年第3期11卷 423-431页

作者： Yan Ma Albert C. Yang Ying Duan Ming Dong Albert S. yeung Division of Interdisciplinary Medicine and Biotechnology Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA Sleep Medicine Center Airforee General Hospital Beijing 100142 China IBM Software Development Lab Littleton MA 01460 USA Depression Clinical and Research Program Massachusetts General Hospital Harvard Medical School Boston MA 02114 USA

The internet is a major source for health information. An increasing number of people, including patients with insomnia, search for remedies online; however, little is known about the quality of such information. This study aimed to evaluate the quality and readability of insomnia-related online information. Google was used as the search engine, and the top websites on insomnia that met the inclusion criteria were evaluated for quality and readability. The analyzed websites belonged to nonprofit, commercial, or academic organizations and institutions such as hospitals and universities. Insomnia-related websites typically included definitions （85%）, causes and risk factors （100%）, symptoms （95%）, and treatment options （90%）. Cognitive behavioral therapy for insomnia （CBT-I） was the most commonly recommended approach for insomnia treatment, and sleep drugs are frequently mentioned. The overall quality of the websites on insomnia is moderate, but all the content exceeded the recommended reading ease levels. Concerns that must be addressed to increase the quality and trustworthiness of online health information include sharing metadata, such as authorship, time of creation and last update, and conflicts of interest; providing evidence for reliability; and increasing the readability for a layman audience.

关键词： insomnia intemet readability information quality health literacy cognitive behavioral therapy treatment

The association between weight stability and parenteral nutrition characteristics and survival in patients with colorectal cancer

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Gastroenterology Report 2019年第6期7卷 419-425,I0002页

作者： Wenli Liu Aiham Qdaisat Eric Lee Jason yeung Khanh Vu Jun-Zhong Lin Todd Canada Shouhao Zhou Lorenzo Cohen Eduardo Bruera Sai-Ching J.yeung Department of Palliative Rehabilitation and Integrative MedicineThe University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Emergency Medicine The University of Texas MD Anderson Cancer CenterHoustonTXUSA McGovern Medical School HoustonTXUSA Biomedical Science Texas A&M UniversityCollege StationTXUSA Department of General Internal Medicine The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Colorectal Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdongP.R.China Division of Pharmacy The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Public Health Sciences Pennsylvania State University School of MedicineHersheyPAUSA Department of Endocrine Neoplasia and Hormonal Disorders The University of Texas MD Anderson Cancer CenterHoustonTXUSA

Objective:Knowledge about the impact of metabolic disturbances and parenteral nutrition(PN)characteristics on the survival of cancer patients receiving PN is *** aimed to assess the association between clinical and PN characteristics and survival in colorectal-cancer patients receiving PN ***:Our study included 572 consecutive colorectal-cancer patients who had received PN support between 2008 and *** characteristics,body mass index,weight,medical/surgical history,indication for PN,PN data and survival were *** between clinical and PN characteristics and survival were analysed with important confounding ***:The final cohort included 437 evaluable patients,with a mean age of 57 ***-one percent of the study population had advanced stage of colorectal *** weight(weight change≥2.5%)prior to PN initiation[hazard ratio(HR)=1.41,P=0.023]was adversely associated with survival after adjusting for multiple factors including cancer *** obstruction(HR=1.75,P=0.017)as a PN indication was associated with worse survival when compared with without bowel *** PN amino acid by ideal body weight(g•kg^(-1))(HR=0.59,P=0.029)was associated with longer survival,whereas a higher percentage of non-PN intravenous calories(HR=1.04,P=0.011)was associated with shorter survival independently of confounding ***:Body mass index and weight stability can be useful nutritional indices for survival prediction in cancer patients receiving *** planning should take into account of non-PN calories to achieve optimal energy support and *** research is needed to define optimal PN amino-acid requirement and energy balance.

关键词： BMI weight loss non-parenteral calorie energy balance parenteral nutrition

Binary Image Steganalysis Based on Distortion Level Co-Occurrence Matrix

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Computers, Materials & Continua 2018年第5期55卷 201-211页

作者： Junjia Chen Wei Lu Yuileong yeung Yingjie Xue Xianjin Liu Cong Lin Yue Zhang School of Data and Computer Science Guangdong Key Laboratory of Information Security TechnologySun Yat-sen UniversityGuangzhou 510006China State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of SciencesBeijing 100093China Center for Faculty Development and Educational Technology Guangdong University of Finance and EconomicsGuangzhou 510320China Department of Computer Science College of Engineering and Computer ScienceEastern Lake AvenueOrlandoFLUSA.

In recent years,binary image steganography has developed so rapidly that the research of binary image steganalysis becomes more important for information *** most state-of-the-art binary image steganographic schemes,they always find out the flippable pixels to minimize the embedding *** this reason,the stego images generated by the previous schemes maintain visual quality and it is hard for steganalyzer to capture the embedding trace in spacial ***,the distortion maps can be calculated for cover and stego images and the difference between them is *** this paper,a novel binary image steganalytic scheme is proposed,which is based on distortion level co-occurrence *** proposed scheme first generates the corresponding distortion maps for cover and stego *** the co-occurrence matrix is constructed on the distortion level maps to represent the features of cover and stego ***,support vector machine,based on the gaussian kernel,is used to classify the *** with the prior steganalytic methods,experimental results demonstrate that the proposed scheme can effectively detect stego images.

关键词： Binary image steganalysis informational security embedding distortion distortion level map co-occurrence matrix support vector machine.

Three-dimensional stability of landslides based on local safety factor

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Journal of Mountain Science 2016年第9期13卷 1515-1526页

作者： YANG Tao Man-chu Ronald yeung YANG Bing LIU Yong-jiang YANG Yan-xin School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China MOE Key Laboratory of Transportation Tunnel Engineering Chengdu 610031China Department of Civil Engineering California State Polytechnic UniversityPomonaCA 91768USA Transportation Research Institute of Chongqing Chongqing 400072China

Unlike the limit equilibrium method(LEM), with which only the global safety factor of the landslide can be calculated, a local safety factor(LSF) method is proposed to evaluate the stability of different sections of a landslide in this paper. Based on three-dimensional(3D) numerical simulation results, the local safety factor is defined as the ratio of the shear strength of the soil at an element on the slip zone to the shear stress parallel to the sliding direction at that element. The global safety factor of the landslide is defined as the weighted average of all local safety factors based on the area of the slip surface. Some example analyses show that the results computed by the LSF method agree well with those calculated by the General Limit Equilibrium(GLE) method in two-dimensional(2D) models and the distribution of the LSF in the 3D slip zone is consistent with that indicated by the observed deformation pattern of an actual landslide in China.

关键词： Landslide stability Local safety factor Stability analysis method Slip mechanism

Investigation in Longitudinal Compression of Wool Based Suiting Fabrics

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Journal of China Textile University(English Edition) 1999年第4期16卷 95-100页

作者： LeungMei-yi LoT.Y. DhingraR.C. yeung K.W.

This paper describes an investigation in the fabric longi-tudinal compressibility of thirty-one suiting and trouse-ring materials using a newly developed device attached to the advanced Instron extensometer *** at-tachment was designed mainly to ensure a correct align-meat of fabric plane at the start of *** newly developed testing method,fabric longitudinalcompression curve was obtained and the results of longi-tudinal compressibility measured by two different com-pression load ranges(from 0 to 0.5 N/m width and 0 to1 N/m width)were *** addition,their rela-tionships with the fabric low-stress mechanical proper-ties measured by the KES-F system were investigatedusing statistical *** results clearly indicatedthat significant differences existed when substituting fab-ric longitudinal compressibility with fabric extensibilitymeasured using the KES-F system under a *** infiuence of yarn rotational movement in fab-ric on the longitudinal

关键词： longitudinal compressibility extensibility shear rigidity formability and bending rigidity

Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies

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Cancer Biology & Medicine 2014年第1期11卷 1-19页

作者： Liem Minh Phan Sai-Ching Jim yeung Mong-Hong Lee Department of Molecular and Cellular Oncology Department of General Internal Medicine Ambulatory Treatment and Emergency Care Department of Endocrine Neoplasia and Hormonal Disorders The University of Texas MD Anderson Cancer Center

Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warhurg＇s discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.

关键词： Cell cycle energy metabolism glycolysis glutaminolysis mitochondria biogenesis

Seeking Convergence to advance Biomaterials Science and Translation by Chinese Association for Biomaterials

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Bioactive Materials 2017年第4期2卷 281-286页

作者： Guigen Zhang Jian Yang Bingyun Li Kelvin yeung Yi Hong Department of Bioengineering Clemson UniversityClemsonSC 29634USA Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Orthopaedics School of MedicineWest Virginia UniversityMorgantownWV 26506USA Department of Orthopaedics and Traumatoloy The University of Hong KongHong Kong Special Administrative Region Department of Bioengineering University of Texas at ArlingtonArlingtonTX 76019USA

In the afternoon of April 5,2017,the Chinese Association for Biomaterials(CAB)organized a CAB Day Symposium with a theme of“Seeking Convergence to Advance Biomaterials Science and Translation.”This symposium,sponsored by the KeAi Publisher and the Advanced Medical Technology,brought together distinguished Chinese scholars and entrepreneurs from the *** China in biomaterials to share their advanced research and translational work,explore collaborations and promote the mission of CAB on the campus of University of Minnesota(Photo 1).

关键词： king biomaterials translational