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Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2022年第15期28卷 1563-1573页

作者： Thaninee Prasoppokakorn Wah-Kheong Chan Vincent Wai-Sun Wong Panyavee Pitisuttithum Sanjiv Mahadeva Nik Raihan Nik Mustapha Grace lai-Hung Wong Howard Ho-Wai Leung Pimsiri Sripongpun Sombat Treeprasertsuk Department of Medicine Division of GastroenterologyFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand Department of Medicine Division of GastroenterologyDivision of Gastroenterology and Hepatology UnitFaculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Medicine Division of General Internal MedicineFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand Department of Pathology Hospital Sultanah BahiyahAlor SetarKedah 05460Malaysia Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong KongChina Department of Internal Medicine Prince of Songkla UniversityHat Yai 90110Thailand Department of Medicine Division of Gastroenterology and HepatologyStanford University School of MedicinePalo AltoCA 94305United States

BACKGROUND Identifying hepatic fibrosis is crucial for nonalcoholic fatty liver disease(NAFLD)*** fibrosis-8(FIB-8)score,recently developed by incorporating four additional variables into the fibrosis-4(FIB-4)score,showed better performance in predicting significant fibrosis in *** To validate the FIB-8 score in a biopsy-proven NAFLD cohort and compare the diagnostic performance of the FIB-8 and FIB-4 scores and NAFLD fibrosis score(NFS)for predicting significant *** We collected the data of biopsy-proven NAFLD patients from three Asian centers in three *** the patients with available variables for the FIB-4 score(age,platelet count,and aspartate and alanine aminotransferase levels)and FIB-8 score(the FIB-4 variables plus 4 additional parameters:The body mass index(BMI),albumin to globulin ratio,gamma-glutamyl transferase level,and presence of diabetes mellitus)were *** fibrosis stage was scored using nonalcoholic steatohepatitis CRN criteria,and significant fibrosis was defined as at least fibrosis stage *** A total of 511 patients with biopsy-proven NAFLD and complete data were included for *** these 511 patients,271(53.0%)were female,with a median age of 51(interquartile range:41,58)*** median BMI was 29(26.3,32.6)kg/m2,and 268(52.4%)had *** the 511 NAFLD patients,157(30.7%)had significant fibrosis(≥F2).The areas under the receiver operating characteristic curves of the FIB-8 and FIB-4 scores and NFS for predicting significant fibrosis were 0.774,0.743,and 0.680,*** FIB-8 score demonstrated significantly better performance for predicting significant fibrosis than the NFS(P=0.001)and was also clinically superior to FIB-4,although statistical significance was not reached(P=0.073).The low cutoff point of the FIB-8 score for predicting significant fibrosis of 0.88 showed 92.36%sensitivity,and the high cutoff point of the FIB-8 score for predicting significant fibrosis of 1.

关键词： Nonalcoholic fatty liver disease Fibrosis-8 score Fibrosis-4 score Nonalcoholic fatty liver disease fibrosis score

人才数据建设的跃升路径分析——从“数据为王”到“需求为王”

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技术经济与管理研究 2017年第11期 69-73页

作者：王修来全军博士后信息管理中心江苏南京210000

数据是基础,需求是导向,数据建设必须对接需求,才能发挥数据的基础支撑作用。从"数据为王"到"需求为王"体现了人类对数据建设的规律性认识,是数据建设的跃升阶段。在人才建设领域,企业只有挖掘到优秀人才,才能创造最大效益;人才只有找... 详细信息

数据是基础,需求是导向,数据建设必须对接需求,才能发挥数据的基础支撑作用。从"数据为王"到"需求为王"体现了人类对数据建设的规律性认识,是数据建设的跃升阶段。在人才建设领域,企业只有挖掘到优秀人才,才能创造最大效益;人才只有找到合适岗位,才能发挥最大潜能;人才数据只有与用人需求精准对接,才能岗位适配,人尽其才。"需求为王"回应了人才建设和人才数据建设的呼声,为直接抓住用人需求,缩短人才和用人单位之间的距离提供了方便,揭示了人才信息数据建设的目标,代表着人才数据信息技术集成应用的重要方向,也是促进人才优化配置和提升用人效益的有效途径。

关键词：大数据人力资源数据建设管理创新

Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains

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Asian Journal of Andrology 2021年第2期23卷 178-187页

作者： Junaid Kashir Bhavesh V Mistry Maha Adel Gumssani Muhammad Rajab Reema Abu-Dawas Falah AlMohanna Michail Nomikos Celine Jones Raed Abu-Dawud Nadya Al-Yacoub Kevin Coward F Anthony lai Abdullah M Assiri College of Medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Comparative Medicine King Faisal Specialist Hospital and Research CentreRiyadh 11211Saudi Arabia College of Medicine QU HealthQatar UniversityDoha PO Box 2713Qatar Nuffield Department of Women’s and Reproductive Health University of OxfordLevel 3Women’s CentreJohn Radcliffe HospitalOxford OX39DUUnited Kingdom Biomedical Research Centre Qatar UniversityDoha PO Box 2713Qatar

Sperm-specific phospholipase C zeta(PLCζ)initiates intracellular calcium(Ca2+)transients which drive a series of concurrent events collectively termed oocyte *** investigations have linked abrogation and absence/reduction of PLCζwith forms of male infertility in humans where oocyte activation ***,very few studies have examined potential relationships between PLCζand advancing male age,both of which are increasingly considered to be major effectors of male *** efforts in humans may be hindered by inherent PLCζvariability within the human population,alongside a lack of sufficient controllable ***,utilizing immunoblotting,immunofluorescence,and quantitative reverse transcription PCR(qRT-PCR)we examined for the first time PLCζprotein levels and localization patterns in sperm,and PLCζmRNA levels within testes,from mice at 8 weeks,12 weeks,24 weeks,and 36 weeks of age,from two separate strains of mice,C57BL/6(B6;inbred)and CD1(outbred).Collectively,advancing male age generally diminished levels and variability of PLCζprotein and mRNA in sperm and testes,respectively,when both strains were ***,advancing male age altered the predominant pattern of PLCζlocalization in mouse sperm,with younger mice exhibiting predominantly post-acrosomal,and older mice exhibiting both post-acrosomal and acrosomal populations of PLCζ.However,the specific pattern of such decline in levels of protein and mRNA was ***,our results demonstrate a negative relationship between advancing male age and PLCζlevels and localization patterns,indicating that aging male mice from different strains may serve as useful models to investigate PLCζin cases of male infertility and subfertility in humans.

关键词： ageing fertilization male infertility oocyte activation phospholipase C zeta sperm

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小学教师眼中的分布式课程领导

教师教育学报 2021年第3期8卷 107-115页

作者：李臣之罗厚辉赖允珏深圳大学师范学院广东深圳518060

分布式领导强调领导的实现是领导者与其他因素交互作用的结果。教师对分布式课程领导的看法决定其参与课程领导的程度与取得的成效。为了解教师对分布式课程领导的看法,选取深圳市20所小学中的929名教师为调查研究样本,确定了学校组织-... 详细信息

分布式领导强调领导的实现是领导者与其他因素交互作用的结果。教师对分布式课程领导的看法决定其参与课程领导的程度与取得的成效。为了解教师对分布式课程领导的看法,选取深圳市20所小学中的929名教师为调查研究样本,确定了学校组织-基础设施、学校组织-时间管理、学校愿景、学校文化、教学设计、学与教的进步、教师领导、校长领导、科组表现、质量效益、改变效益、组织与计划效益、人际效益、价值效益等14个调查维度,并对各维度及总体效益数据进行探索性因素分析。研究发现,小学教师对分布式课程领导的看法在不同发展水平的学校和区域上存在显著性差异。深圳和香港特别行政区两地的小学教师对分布式课程领导的看法存在一定的共性和差异。价值观念在某种程度上决定了教师的课程领导力度。目前,有必要进一步唤醒教师课程共生意识、加强课程领导共同体的构建、强化课程社群建设,从而促进教师专业化的发展。

关键词：分布式课程领导小学教师粤港澳大湾区课程共生课程社群

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原發孤立性腸系膜上動脈夾層動脈瘤1例

镜湖医学 2018年第1期18卷 83-83,17页

作者：石漢輝黎啟盛何澄邦澳鬥鏡湖醫院急診科中國

原發性孤立性腸系膜上動脈夾層動脈瘤(spontaneous isolated superior mesenteric artery dissection,SISMAD),臨床上較少見,容易出現誤診或漏診。本院急診科於2017年8月21日收治1例SISMAD,現報導如下。患者男性,48歲,旅客。因“持續性... 详细信息

原發性孤立性腸系膜上動脈夾層動脈瘤(spontaneous isolated superior mesenteric artery dissection,SISMAD),臨床上較少見,容易出現誤診或漏診。本院急診科於2017年8月21日收治1例SISMAD,現報導如下。患者男性,48歲,旅客。因“持續性劍突下絞痛,向背部放射伴囈心、出冷汗3小時”來急診。既往無高血壓病、糖尿病.冠心病史。

关键词：背部放射冠心病史 artery 系膜孤立性糖尿病

乳腺黏液囊腫樣病變——組織病理學及針吸細胞學改變

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镜湖医学 1998年第1期 1-5页

作者：王念黎溫淑瓊鏡湖医院病理科中國澳門香港伊利沙伯醫院病理科中国

目的:分析乳腺黏液囊腫樣病變(Mucocele-like lesion,MLL)的組織病理學及細針吸取(FNA)細胞學特點,尋求在手術前根據FNA細胞學鑑別MLL與乳腺黏液癌。方法:重祈評估7例MLL(良性5例,惡性2例)的組織病理學及FNA細胞學材料,並以同期14例黏... 详细信息

目的:分析乳腺黏液囊腫樣病變(Mucocele-like lesion,MLL)的組織病理學及細針吸取(FNA)細胞學特點,尋求在手術前根據FNA細胞學鑑別MLL與乳腺黏液癌。方法:重祈評估7例MLL(良性5例,惡性2例)的組織病理學及FNA細胞學材料,並以同期14例黏液癌作對照,比較兩病在組織學及FNA細胞學上的差異。結果:所有MLL均有乳腺結節,病人年輕(平均年齡34.8),組織學上良性MLL的特徴是形成黏液性囊腫,應腫壁由良性的上皮披覆(惡性MLL囊壁上皮部分呈導管内癌改變);漏出間質的黏液内通常無腫瘤細胞,黏液癌不形成黏液性囊腫,間質的黏液池中有較多的腫瘤細胞。在FNA細胞學上,所有MLL病例針吸時均可吸出黏稠的黏液樣物質,塗片背景均可見豐富的黏液。MLL與典型的黏液癌的最大區別是吸出物中腫瘤細胞稀少,細胞黏合性好,基本上無游離的上皮細胞,細胞呈單層排列而無異型性,結論:可按FNA細胞學改體將MLL與黏液癌區別。黏液癌可直接手術治療,但MLL應行切除活檢,從組織病理學進一步區別良性與惡性MLL。

关键词：乳腺黏液奏腫檢病變(MLL) 乳腺黏液癌細針吸取細胞學(FNAC)

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產程後期硬膜外鎮痛對初產婦分娩結局的影響

镜湖医学 2020年第1期20卷 15-17页

作者：李濤黃鍇亮錢曉暉曹麗勤澳門鏡湖醫院麻醉科中國

目的探討在第一產程後期(宮口大於或等於5cm)時施行硬膜外分娩鎮痛對初產婦分娩結局的影響。方法回顧分析2017~2018年兩年間本院接受硬膜外分娩鎮痛的初產婦分娩記錄資料,按鎮痛時產婦宮口的擴張程度分為三組:宮口大於或等於5cm(第一產... 详细信息

目的探討在第一產程後期(宮口大於或等於5cm)時施行硬膜外分娩鎮痛對初產婦分娩結局的影響。方法回顧分析2017~2018年兩年間本院接受硬膜外分娩鎮痛的初產婦分娩記錄資料,按鎮痛時產婦宮口的擴張程度分為三組:宮口大於或等於5cm(第一產程後期)時施行鎮痛的60例初產婦為Ⅰ組;宮口小於3cm時施行鎮痛的60例初產婦為Ⅱ組;宮口大於或等於3cm並小於5cm時施行鎮痛的60例初產婦為Ⅲ組。所有產婦自願接受分娩鎮痛,記錄所有產婦的分娩方式、第一產程時間、第二產程時間、出血量、新生兒1、5min的Apgar評分和產婦從施行硬膜外分娩鎮痛到第一產程結束的時間。結果三組產婦的順產率相若(P>0.05);三組產婦第一產程時間、第二產程時間、出血量和新生兒1、5min的Apgar評分差異無統計學意義(P>0.05);三組產婦施行分娩鎮痛後宮口擴張的速度相若,差異無統計學意義(P>0.05)。結論在第一產程後期(宮口大於或等於5cm)時施行硬膜外分娩鎮痛安全可行,但會影響產婦宮口的擴張速度。

关键词：產程分娩鎮痛順產率

Personal Exposure to Fine Particulates and Polycyclic Aromatic Hydrocarbons in an Office Environment in Xi＇an, China

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环境科学前沿（中英文版） 2013年第4期2卷 33-45页

作者： Hongmei Xu Junji Cao Meiling Gao Kin fai Ho Xinyi Niu Teresa L. Coons Steven Sai Hang H0 Gehui Wang Zhuzi Zhao Key Lab of Aerosol Science & Technology SKLLQG Institute of Earth Environment Chinese Academy of Sciences Xi'an710075 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Global Environmental Change Xi'an Jiaotong University Xi'an 710054 China University of California Berkeley USA School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China Washington State University USA Hong Kong Premium Services and Research Laboratory Lai Chi Kok Kowloon Hong Kong China

In-Home Drug Storage by Older Adults

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Journal of Geriatric Medicine 2020年第3期2卷 22-31页

作者： Lori Suet Hang Lo Linda Yin king Lee Irene Yuen Fung Wong Yuen Yan lai Hoi Tong Au Tsz Ying Wong Chui Ping Chueng Wai Lam Shek Choi Yi Wong Hoi Lam Chan Hon Sze Cheuk Nga Hing Mark Shu Ching Wong Wing Yan Cheung The Open University of Hong Kong Hong KongChina

Globally,in-home drug-storage compliance is often unsatisfactory,especially among older adults,and can lead to negative health *** study used a cross-sectional and descriptive design to examine inhome drug-storage compliance among older *** sampling was used to recruit 117 older adults in Hong *** in-home drugstorage checklist was used to assess the in-home drug-storage environments(light,temperature,and humidity)and drug-storage methods(drug safety,packaging,information,and expiration)of each older *** findings showed that Hong Kong older adults’overall compliance rate in drug storage was 87.25%,and their compliance rate for drug-storage methods(84.59%)was lower than that for drug-storage environments(97.02%).Older adults who were of advanced age,who were less educated or who lived alone demonstrated lower in-home drug-storage *** indicates the need to revise existing health-education strategies to encourage in-home drug-storage *** professionals should assess older adults’drug-storage compliance to identify less compliant subgroups and deliver specific drug-storage support as *** members should also be involved in this process.

关键词： Drug storage Compliance Older adults Home