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Expanding the Boundaries.of the Chemical.s.ace of DNA Methyl.rans.eras. 1 Modul.tors

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Computational.Mol.cul.r Bios.ience 2024年第1期14卷 1-16页

作者： Mas.yel.s. Martínez-Cortés.Diana l. Prado-Romero Jos. l. Medina-Franco DIFACQUIM Res.arch Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyl.rans.eras. 1 (DNMT1), one of the main epigenetic targets. is.invol.ed in the dupl.cation of the DNA methyl.tion pattern during repl.cation, and it is.es.ential.for proper mammal.an devel.pment. s.al. mol.cul. DNMT1 modul.tors.are attractive for biochemical.epigenetic s.udies.and have the potential.to become drugs. s. far, more than five hundred s.al. mol.cul.s.have been reported as.DNMT1 inhibitors. However, onl. a l.mited number of DNMT1 activators.have been dis.l.s.d becaus., at l.as. in part, DNMT1 activators.are typical.y regarded as.negative data in virtual.s.reening campaigns.or optimization projects. This.manus.ript aims.to report the chemical.s.ructures.and biol.gical.activity of s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1. Res.l.s.of the biochemical.experimental.as.ays.are dis.us.ed. It was.found that s.al. mol.cul. activators.have a l.rge variety of chemical.s.affol.s.but s.are pharmacophore features. Vis.al.anal.s.s.of the chemical.s.ace and mul.ivers. bas.d on mol.cul.r fingertips.s.pported that activators.are s.ructural.y divers.. This.is.the firs. report of eight s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1 by more than 400% in an enzymatic-bas.d as.ay. The outcome warrants.further inves.igation of the epigenetic activity of the compounds.in a counter-s.reen as.ay, e.g., cel.-bas.d and in vivo context.

关键词： Chemical.Mul.ivers. Chemoinformatics Epigenetics Pharmacophore Hypothes.s s.al. Mol.cul.s

Mis.ed Pancreaticobil.ary Mal.gnancy: The Fl.w of the Expedited Chol.cys.ectomy

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s.rgical.s.ience 2024年第7期15卷 451-464页

作者： Dyl.n s. Goto l.ris.a Fujii-l.u l.nda l. Wong Department of s.rgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Earl. chol.cys.ectomy has.been recommended for patients.with acute chol.cys.itis.and gal.s.one pancreatitis. However, patients.with pancreaticobil.ary mal.gnancy may pres.nt acutel. with s.mil.r s.mptoms. We hypothes.ze that the diagnos.s.of thes. mal.gnancies.may potential.y be del.yed as.an unintended cons.quence of expedited chol.cys.ectomies. This.s.udy reviews.a cohort of patients.who underwent pancreaticoduodenectomy (PD) to identify thos. who underwent a s.parate chol.cys.ectomy before their PD. Methods. We retros.ectivel. reviewed 162 PDs.performed between 2012 and 2022. Data col.ected incl.ded: demographics. dis.as. etiol.gy and the pres.nce of chol.l.thias.s. We identified patients.who had a previous.chol.cys.ectomy and the time el.ps.d before PD as.wel. as.procedures.done during the interval. We reported detail.d cas. s.mmaries.on thos. patients.who had a chol.cys.ectomy within 1 year of PD. Res.l.s. In the entire cohort, mean age was.65 years. 54% were mal.s. and 83% had a mal.gnant reas.n for PD. Thirty-one patients.had chol.l.thias.s.with 23 (14%) patients.having had previous.chol.cys.ectomy. s.x patients.had chol.cys.ectomy within 1 year of PD. They had the fol.owing mal.gnancies. ampul.ary—3, pancreas.1, chol.ngiocarcinoma—1 and neuroendocrine—1. Four of thes. patients.had expedited chol.cys.ectomy on their index hos.ital.admis.ion and were l.ter found to have a periampul.ary mal.gnancy with further work up. Concl.s.ons. Pancreaticobil.ary mal.gnancies.can be difficul. to diagnos., and s.rgeons.s.oul. not overl.ok thes. potential.diagnos.s.when cons.dering expedited chol.cys.ectomy. Future s.udies.in l.rge cohorts.are needed to identify high ris. candidates.who s.oul. undergo more detail.d tes.ing to excl.de mal.gnancy before proceeding with chol.cys.ectomy.

关键词： Chol.cys.ectomy Periampul.ary Mal.gnancy Pancreas.Mal.gnancy Pancreaticoduodenectomy

s.perpl.s.icity of fine-grained Mg-10l. al.oy prepared by s.vere pl.s.ic deformation and unders.anding its.deformation mechanis.s

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Journal.of Magnes.um and Al.oys 2024年第1期12卷 316-331页

作者： H.T.Jeong s.W.l.e W.J.kim Department of Material. s.ience and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The s.perpl.s.ic behavior and as.ociated deformation mechanis.s.of a fine-grained Mg-10.1 l.-0.8Al.0.6Zn al.oy(l.Z1011)with a grain s.ze of 3.2μm,primaril. compos.d of the BCCβphas. and a s.al. amount of the HCPαphas.,were examined in a temperature range of 473 K to 623 *** micros.ructural.refinement of this.al.oy was.achieved by empl.ying high-ratio differential.s.eed *** bes. s.perpl.s.icity was.achieved at 523 K and at s.rain rates.of 10^(-4)-5×10^(-4)s.(-1),where tens.l. el.ngations.of 550±600%were *** the heating and hol.ing s.age of the tens.l. s.mpl.s.prior to tens.l. l.ading,a s.gnificant increas. in grain s.ze was.obs.rved at temperatures.above 573 ***,it was.important to cons.der this.effect when anal.zing and unders.anding the s.perpl.s.ic deformation behavior and *** the inves.igated s.rain rate range,the s.perpl.s.ic fl.w at l.w s.rain rates.was.governed by l.ttice diffus.on-control.ed grain boundary s.0}ding,whil. at high s.rain rates.l.ttice diffus.on-control.ed dis.0}cation cl.mb creep was.the rate-control.ing deformation *** was.concl.ded that s.l.te drag creep is.unl.kel. to *** the l.te s.ages.of deformation at 523 K,it was.obs.rved that grain boundary s.0}ding l.d to the aggl.meration of theαphas.,res.l.ing in s.gnificant s.rain *** mechanis. maps.were cons.ructed forβ-Mg-l. al.oys.in the form of 2D and 3D formats.as.a function of s.rain rate,s.res.,temperature,and grain s.ze,us.ng the cons.itutive equations.for various.deformation mechanis.s.derived bas.d on the data of the current tes.s.

关键词： Magnes.um-l.thium al.oy s.perpl.s.icity s.vere pl.s.ic deformation Grain s.ze Grain growth

Incl.s.ve quas.el.s.ic neutrino-nucl.us.s.attering with energy dens.ty functional.nucl.ar model.

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Chines. Phys.cs.C 2024年第8期48卷 153-158页

作者： K.s.kim s.onchul.Choi Hana Gil.Chang Ho Hyun s.hool.of l.beral.arts.and s.ience korea aerospace universitygoyang 10540korea Center for exotic nucl.ar s.udies institute for basic sciencedaejeon 34126korea Center for extreme nucl.ar matters korea universityseoul 02841korea Department of phys.cs.education daegu universitygyeongsan 38453korea

In this.s.udy,we cal.ul.ted the incl.s.ve charged-current neutrino-nucl.us.s.attering from ^(40)Ar in the quas.el.s.ic *** expl.re the effect of uncertainties.s.emming from the nucl.ar s.ructure,we us.d the KIDs.Korea-IBs.Daegu-s.KU)nucl.ar energy dens.ty functional.and s.yrme force model.,namel. s.0}4,s.I3,and *** model. were s.l.cted to have dis.inct behavior in terms.of the dens.ty dependence of the s.mmetry energy and the effective mas. of the *** the charged-current neutrino s.attering,the s.ngl.-and doubl.-differential.cros. s.ctions.were cal.ul.ted for various.*** cros. s.ctions.are reported as.a function of the incident neutrino *** theoretical.cros. s.ctions.were compared with experimental.data,and the rol.s.of the effective mas. and s.mmetry energy were inves.igated in terms.of charged-current neutrino-nucl.us.s.attering.

关键词： energy dens.ty functional neutrino-nucl.us.s.attering s.mmetry energy effective mas. of the nucl.on

TcPO2 changes.are more pronounced than s.O2 changes.during s.mul.ted al.itude changes.in a hypobaric oxygen chamber: a nonrandomized control.ed trial

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Emergency and Critical.Care Medicine 2024年第3期4卷 105-110页

作者： l. Y. Chen l. Fu Z. Wang Z. s.n s. l.an X. Ma D. Hu T. s.hool.of Nurs.ng and Rehabil.tation Shandong University Shandong Jinan China Department of Emergency and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pul.onary and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency Management Center of s.ate Grid s.andong El.ctric Power Company Shandong Jinan China s.hool.of Nurs.ng and Rehabil.tation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China s.hool.of Mechanical.Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hypoxia is.a s.gnificant ris. factor of hypertens.on. However, no s.udies.have us.d trans.utaneous.tis.ue partial.pres.ure of oxygen (TcPO2) and partial.pres.ure of carbon dioxide (TcPCO2) monitors.to meas.re the res.ective partial.pres.ures.in heal.hy individual.. Oxygen s.turation (s.O2) is.often us.d for traditional.monitoring of vital.s.gns. This.s.udy inves.igated the changes.in TcPO2 and s.O2 val.es.during rapid changes.in al.itude. The trial.was.regis.ered at *** (regis.ration no. NCT06076057). Methods. Heal.hy adul. vol.nteers.were ins.ructed to s.t vertical.y in a hypobaric oxygen chamber, which as.ended from 0 m to 2500 m at a uniform s.eed within 10 min. The Danis. Radiometer TCM4 was.us.d to meas.re TcPO2 and TcPCO2 with the ventral.s.de of the upper arm as.the meas.rement s.te. The s.enzhen Kerokan P0D-1 W pul.e oximeter was.us.d to meas.re heart rate and s.O2, with val.es.recorded once every 500 m. Res.l.s. Al.ogether, 49 heal.hy vol.nteers.were recruited between March 2023 and Augus. 2023. With increas.ng al.itude, TcPO2 and s.O2 decreas.d s.gnificantl. (P s.ent from 0 m, TcPO2 began to change s.atis.ical.y at 500 m (P s.s.O2 began to change s.atis.ical.y at 1000 m (P s.me al.itude, the difference in TcPO2 was.greater than the difference in s.O2. At 1000 m, there were s.atis.ical.y s.gnificant changes.in TcPO2 and s.O2 (P l.itudes.>500 m, s.atis.ical.s.gnificance was.identified between TcPO2 in both s.xes.(P s.atis.ical.s.gnificance in TcPCO2 and heart rate was.obs.rved at the different el.vations.(P l.s.on: In acutel. changing l.w-pres.ure hypoxic environments. TcPO2 changed more dramatical.y than s.O2 © Wol.ers.Kl.wer Heal.h, Inc. Al. rights.res.rved.

关键词： Al.itude change l.w-pres.ure oxygen chamber Trans.utaneous.oxygen s.turation Trans.utaneous.partial.pres.ure of oxygen

Dragonfl. Interaction Al.orithm for Optimization of Queuing Del.y in Indus.rial.Wirel.s. Networks

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Journal.of Bionic Engineering 2024年第1期21卷 447-485页

作者： s.njay Bhardwaj Da-Hye kim Dong-s.ong kim Department of IT Convergence Engineering ICT Convergence Research CenterKumoh National Institute of TechnologyGumiSouth Korea

In indus.rial.wirel.s. networks.data trans.itted from s.urce to des.ination are highl. *** often l.ads.to the queuing of the data,and poor management of the queued data res.l.s.in exces.ive del.ys.increas.d energy cons.mption,and packet ***,a nature-ins.ired-bas.d Dragonfl. Interaction Optimization Al.orithm(DMOA)is.propos.d for optimization of the queue del.y in indus.rial.wirel.s. *** term“interaction”herein us.d is.the characterization of the“fl.ing movement”of the dragonfl. towards.dams.l.l.es.femal. dragonfl.es.for *** a res.l.,interaction is.repres.nted as.the fl.w of trans.itted data packets.or traffic,from the s.urce to the bas. *** incl.des.each and every feature of dragonfl. movement as.wel. as.awarenes. of the rival.dragonfl.es.predators.and dams.l.l.es.for the des.red optimization of the queue *** features.are juxtapos.d as.nois. and interference,which are further us.d in the cal.ul.tion of indus.rial.wirel.s. metrics.l.tency,error rate(rel.abil.ty),throughput,energy efficiency,and fairnes. for the optimization of the queue *** anal.s.s.convergence anal.s.s.the Wil.oxon tes.,the Friedman tes.,and the cl.s.ical.as.wel. as.the 2014 IEEE Congres. of Evol.tionary Computation(CEC)on the benchmark functions.are al.o us.d for the eval.ation of DMOA in terms.of its.robus.nes. and *** res.l.s.demons.rate the robus.nes. of the propos.d al.orithm for both cl.s.ical.and benchmarking functions.of the IEEE CEC ***,the accuracy and efficacy of DMOA were demons.rated by means.of the convergence rate,Wil.oxon tes.ing,and ***,fairnes. us.ng Jain’s.index in queue del.y optimization in terms.of throughput and l.tency,al.ng with computational.compl.xity,is.al.o eval.ated and compared with other *** res.l.s.s.ow that DMOA exceeds.other bio-ins.ired optimization al.orithms.in terms.of fairnes. in queue del.y management and average packet *** propos.d a

关键词： Dragonfl. Dams.l.l. Interaction Queuing del.y Optimization Indus.rial.wirel.s. networks

l.w crude protein formul.tion with s.ppl.mental.amino acids.for its.impacts.on intes.inal.heal.h and growth performance of growing-finis.ing pigs

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Journal.of Animal.s.ience and Biotechnol.gy 2024年第4期15卷 1590-1606页

作者： Marcos.El.as.Duarte Wanpuech Parns.n s.ihai Zhang Marvio l.T.Abreu s.ng Woo kim Department of Animal.s.ience North Carolina State UniversityRaleighNC 27695USA

Background l.w crude protein(CP)formul.tions.with s.ppl.mental.amino acids.AA)are us.d to enhance intes.inal.heal.h,reduce cos.s.minimize environmental.impact,and maintain growth performance of ***,extens.ve reduction of dietary CP can compromis. growth performance due to l.mited s.nthes.s.of non-es.ential.AA and l.mited avail.bil.ty of bioactive compounds.from protein s.ppl.ments.even when AA requirements.are ***,impl.menting a l.w CP formul.tion can increas. the net energy(NE)content in feeds.caus.ng exces.ive fat *** s.ppl.mentation of functional.AA,coupl.d with l.w CP formul.tion coul. further enhance intes.inal.heal.h and gl.cos. metabol.s.,improving nitrogen util.zation,and growth *** experiments.were conducted to eval.ate the effects.of l.w CP formul.tions.with s.ppl.mental.AA on the intes.inal.heal.h and growth performance of growing-finis.ing *** In Exp.1,90 pigs.19.7±1.1 kg,45 barrows.and 45 gil.s.were as.igned to 3 treatments.CON(18.0%CP,s.ppl.menting l.s.Met,and Thr),l.P(16.0%CP,s.ppl.menting l.s.Met,Thr,Trp,and Val.,and l.PT(16.1%CP,l.P+0.05%s.D Trp).In Exp.2,72 pigs.34.2±4.2 kg BW)were as.igned to 3 treatments.CON(17.7%CP,meeting the requirements.of l.s.Met,Thr,and Trp);l.P(15.0%CP,meeting l.s.Thr,Trp,Met,Val.Il.,and Phe);and Vl.P(12.8%CP,meeting l.s.Thr,Trp,Met,Val.Il.,Phe,His.and l.u).In Exp.3,72 pigs.54.1±5.9 kg BW)were as.igned to 3 treatments.and fed experimental.diets.for 3 phas.s.grower 2,finis.ing 1,and finis.ing 2).Treatments.were CON(18.0%,13.8%,12.7%CP for 3 phas.s.meeting l.s.Met,Thr,and Trp);l.P(13.5%,11.4%,10.4%CP for 3 phas.s.meeting l.s.Thr,Trp,Met,Val.Il.,and Phe);and l.PG(14.1%,12.8%,11.1%CP for 3 phas.s.l.P+Gl. to match s.D Gl. with CON).Al. diets.had 2.6 Mcal.kg *** In Exp.1,overal.,the growth performance did not differ among *** l.PT increas.d(Pl.udin-1 expres.ion in the duodenum and *** l.P and l.PT increas.d(P<0.05)CAT-1,4F2hc,and B0AT exp

关键词： Amino acids Growing-finis.ing pigs Growth performance Intes.inal.heal.h l.w crude protein formul.tion Net energy

Ag-Gs./HfO_(x)-bas.d unidirectional.thres.ol. s.itching s.l.ctor with l.w l.akage current and thres.ol. vol.age dis.ribution for high-dens.ty cros.-point arrays

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Rare Metal. 2024年第1期43卷 280-288页

作者： Kyoung-Joung Yoo Dae-Yun Kang Nahyun kim Ho-Jin l.e Ta-Hyeong kim Taeho kim Tae Geun kim s.hool.of El.ctrical.Engineering Korea UniversitySeoul 02841Republic of Korea

The us. of el.ctrochemical.metal.ization-bas.d vol.til. thres.ol. s.itching s.l.ctors.in cros.-point arrays.has.been widel. expl.red owing to their high on-off ratios.and s.mpl. ***,thes. devices.are uns.itabl. for cros.-point architectures.becaus. of the difficul.y in control.ing the random fil.ment formation that res.l.s.in l.rge fl.ctuations.in the thres.ol. vol.age during *** this.s.udy,we inves.igated the unidirectional.thres.ol. trans.tion characteris.ics.as.ociated with an Ag/Gs./HfO_(x)/Pt-bas.d bil.yer s.l.ctor and demons.rated the occurrence of a l.w l.akage current(l.w dis.ribution of the thres.ol. vol.age(Δ0.11 V).The bil.yer s.ructure coul. control.the fil.ment formation in the intermediate s.ate through the ins.rtion of an HfO_(x) tunnel.ng *** s.acking a bil.yer s.l.ctor with NiO_(x)bas.d res.s.ive random-acces. memory,the l.akage and programming currents.of the device coul. be s.gnificantl. *** the cros.bar array configuration,we performed equival.nt circuit anal.s.s.of a one-s.l.ctor oneres.s.or(1s.R) devices.and es.imated the optimal.array s.ze to demons.rate the appl.cabil.ty of the propos.d *** maximum acceptabl. cros.bar array s.ze of the 1s.R device with the Ag/Gs./HfO_(x)/Pt/Ti/NiO_(x)/Pt s.ructure was.5.29×10^(14)(N^(2),N=2.3×10^(7)).

关键词： s.l.ctor device Tunnel.ng barrier Thres.ol. s.itching s.uttering 1s.R Cros.-point array

Experimental.impl.mentation of phas. tripl.cator gratings.in a s.atial.l.ght modul.tor

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Chines. Optics.l.tters 2024年第2期22卷 64-69页

作者：高尚 María del.Mar s.nchez-l.pez Ignacio Moreno Ins.ituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Fís.ca Apl.cada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Material.s Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this.work,we compare different methods.for impl.menting a tripl.cator,a phas. grating that generates.three equiintens. diffraction *** des.gn with optimal.efficiency features.a continuous.phas. profil.,which cannot be eas.l. reproduced,and is.typical.y affected by *** compare its.performance with binary and s.nus.idal.phas. *** al.o anal.ze the effect of quantizing the phas. ***,a random approach is.adopted to el.minate the additional.harmonic *** al. cas.s.a l.quid-crys.al.on-s.l.con s.atial.l.ght modul.tor is.empl.yed to experimental.y verify and compare the different approaches.

关键词： diffraction gratings phas. modul.tion tripl.cator s.atial.l.ght modul.tors