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Microfluidic systems for axonal growth and regeneration research

Neural Regeneration Research 2014年第19期9卷 1703-1705页

作者： sunja kim Jaewon Park Arum Han Jianrong Li Department of Veterinary Integrative Biosciences Texas A&M UniversityCollege Station Institution for Neuroscience Texas A&M UniversityCollege Station Department of Electrical and Computer Engineering Texas A&M UniversityCollege Station

Damage to the adult mammalian central nervous system （CNS） often results in persistent neurological deficits with limited recovery of functions. The past decade has seen in- creasing research efforts in neural regeneration research with the ultimate goal of achieving functional recovery. Many studies have focused on prevention of further neural damage and restoration of functional connections that are com- promised after iniurY or pathological damage.

关键词： Microfluidic systems for axonal growth and regeneration research CNS Figure

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Increased atherosclerotic lesion area in apoprotein E deficient mice superimposed by experimental renal hypertension

Increased atherosclerotic lesion area in apoprotein E defici...

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第十五届国际药理学大会

作者： Heo Hyejin Yun Miran Lee Jiyoung Park Jiyoung Lee Eunkyoung Yun Sungji kim sunja Bae Sunsik kim Chidae Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea

＜正＞ It is known that hypertension is associated with an increased risk for atherosclerosis, however, little is known about the mechanisms underlying the interaction of hypertension and atherosclerosis. Thus, we developed a mouse model to assess the hypothesis that hypertension accelerates atherosclerotic lesion formation. When apoprotein E （ApoE）-deficient mice （8 wks） were submitted to 2 kidney 1-clip （2K1C） operation, arterial pressure was elevated 1-2 wks after renal arterial clipping, and remained high until 16 wks. In the histopathological and immunohisto chemical analyses, animals with hypertension for 8 weeks showed a high incidence of foam cell accumulation in the intima of aortic sinus. The foam cells exhibited positive staining for antimonocyte/macrophage antibody and lipids. suggesting that the origin of these cells can be attributed to lipid-laden macrophages. This study shows that renal hypertension augments the development of atherosclerosis in apoE-deficient mice. The mechanisms could be direct effects of renal ischemia-derived humoral factors on cellular processes in the vessel wall or the result of hypertensive state.

关键词： Atherosclerosis Hypertension Hyperlipidemia Foam Cell

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