Increased atherosclerotic lesion area in apoprotein E deficient mice superimposed by experimental renal hypertension
作者单位：Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea
会议名称：《第十五届国际药理学大会》
会议日期：2006年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：Atherosclerosis Hypertension Hyperlipidemia Foam Cell
摘 要：正 It is known that hypertension is associated with an increased risk for atherosclerosis, however, little is known about the mechanisms underlying the interaction of hypertension and atherosclerosis. Thus, we developed a mouse model to assess the hypothesis that hypertension accelerates atherosclerotic lesion formation. When apoprotein E （ApoE）-deficient mice （8 wks） were submitted to 2 kidney 1-clip （2K1C） operation, arterial pressure was elevated 1-2 wks after renal arterial clipping, and remained high until 16 wks. In the histopathological and immunohisto chemical analyses, animals with hypertension for 8 weeks showed a high incidence of foam cell accumulation in the intima of aortic sinus. The foam cells exhibited positive staining for antimonocyte/macrophage antibody and lipids. suggesting that the origin of these cells can be attributed to lipid-laden macrophages. This study shows that renal hypertension augments the development of atherosclerosis in apoE-deficient mice. The mechanisms could be direct effects of renal ischemia-derived humoral factors on cellular processes in the vessel wall or the result of hypertensive state.