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Increased atherosclerotic lesion area in apoprotein E deficient mice superimposed by experimental renal hypertension

Increased atherosclerotic lesion area in apoprotein E defici...

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第十五届国际药理学大会

作者： Heo Hyejin Yun Miran Lee Jiyoung Park Jiyoung Lee Eunkyoung Yun Sungji kim Sunja Bae Sunsik kim chidae Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea Department of Pharmacology College of Medicine and MRC for Ischemic Tissue Regeneration Pusan National University Pusan 602-739 Korea

＜正＞ It is known that hypertension is associated with an increased risk for atherosclerosis, however, little is known about the mechanisms underlying the interaction of hypertension and atherosclerosis. Thus, we developed a mouse model to assess the hypothesis that hypertension accelerates atherosclerotic lesion formation. When apoprotein E （ApoE）-deficient mice （8 wks） were submitted to 2 kidney 1-clip （2K1C） operation, arterial pressure was elevated 1-2 wks after renal arterial clipping, and remained high until 16 wks. In the histopathological and immunohisto chemical analyses, animals with hypertension for 8 weeks showed a high incidence of foam cell accumulation in the intima of aortic sinus. The foam cells exhibited positive staining for antimonocyte/macrophage antibody and lipids. suggesting that the origin of these cells can be attributed to lipid-laden macrophages. This study shows that renal hypertension augments the development of atherosclerosis in apoE-deficient mice. The mechanisms could be direct effects of renal ischemia-derived humoral factors on cellular processes in the vessel wall or the result of hypertensive state.

关键词： Atherosclerosis Hypertension Hyperlipidemia Foam Cell

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