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Electrochemical characteristics of HVOF spray coated layer with WC-27NiCr and WC-10Co4Cr for Al bronze

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中国有色金属学会会刊：英文版 2012年第S3期22卷 753-759页

作者： Min-su HAN Seung-jun LEE Min-sung kim Seok-ki JANG Seong-jong kim Division of Marine Engineering Mokpo Maritime University

Among the environmentally friendly marine energies,tidal current power plants require low cost because they do not need to construct a large *** power is particularly reliable energy source because the power generation capacity is predictable regardless of weather or *** materials or stainless steel have been used as materials of blades for current power ***,their strength and welding performance generated many problems in field *** alloys with excellent cavitation resistance and corrosion resistance were applied as blade materials to improve the durability of copper *** were coated with WC-27NiCr and WC-10Co4Cr using the high velocity oxy-fuel (HVOF) *** metal spray coating technology has the advantage in terms of the selection of materials for cost effectiveness and environmental effects of corrosion because the properties of the coat layer can be controlled *** with WC-27NiCr and WC-10Co4Cr by HVOF,WC-27NiCr shows better corrosion resistance *** reason for this seems to be that corrosion resistance improves and a stable passive film forms due to the effects of Ni and Cr.

关键词： tidal power copper alloys HVOF coating corrosion resistance

Inhibitory Effect of the Extract of Phellodendron amurense Ruprecht Root on Collagen-Induced Arthritis in Mice

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Chinese Journal of Integrative Medicine 2017年第10期23卷 755-762页

作者： Hyo Won Jung Kyung-Ho kim Yong-ki Park Department of Herbology College of Korean Medicine Dongguk University Gyeongju (740-814) Republic of Korea Korean Medicine Research and Development Center Dongguk University Gyeongju (740-814) Republic of Korea Department of Acupuncture College of Korean Medicine Dongguk University Gyeongju (740-814) Republic of Korea

Objective： To investigate whether the dried root of Phellodendron amurense Ruprecht（Phellodendri cortex; PC） extract improves arthritic symptoms through anti-inflammatory and immune-modulatory effects in collagen-induced arthritis in mice. Methods： Rheumatoid arthritis（RA） was induced in male DBA/1 mice by immunization with type Ⅱ collagen（ColⅡ）. CIA mice were divided into 5 groups（n=10 per a group） with normal, CIA control, PC extract（50 mg/kg and 100 mg/kg）-treated, and meloxicam（50 mg/kg）-treated as the reference drug. The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. Arthritic score, levels of anti-ColⅡ IgG2a antibody, prostaglandin E2（PGE2）, tumor necrosis factor（TNF）-α, and interleukin（IL）-17 in the sera of CIA mice were measured. Histopathological changes in the ankle joints of CIA mice were also analyzed by staining with hematoxylin and eosin（H and E）, safranin-O and immunohistochemistry using anti-TNF-α and anti-IL-17 antibodies. Results： The arthritic score was increased in CIA mice in a time-dependent manner, as were the serum levels of anti-ColⅡ IgG2a antibody, PGE2, TNF-α, and IL-17. However, the oral administration of PC extract at 50 and 100 mg/kg in CIA mice significantly decreased the arthritic scores, and the serum levels of anti-ColⅡ IgG2a, PGE2, TNF-α, and IL-17 compared with those in the CIA group（P〈0.05 or P〈0.01）. Furthermore, histopathological improvement of the joint architecture in CIA mice was observed after administration of PC extract. PC extract also significantly inhibited the expression of TNF-α and IL-17 in the joints of CIA mice by suppressing the expression of their m RNA and proteins. Conclusion： PC extract may improve the pathological progression of RA through the inhibition of joint destruction by synovial inflammation and immune-stimulation, therefore, it would be a potential anti-arthritic agent in RA.

关键词： Phellodendron amurense Phellodendri cortex collagen-induced arthritis anti-arthritic effect

Wind response of high-rise building in diversified inlets to construct wind turbine system on roof

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Journal of Central South University 2014年第11期21卷 4395-4403页

作者： YOU ki-pyo YOU Jang-youl kim Young-moon Department of Architecture Engineering Long-Span Steel Frame System Research Center Chonbuk National UniversityChonju 561-756 Korea KOCED Wind Tunnel Center Chonbuk National UniversityChonju 561-756 Korea

Many skyscrapers have installed wind turbine systems to use new renewable energy. In particular, building an integrated wind power generation system by installing a wind power generator inside a building is an attractive method to secure safe energy. However, most studies have dealt with the efficiency of wind turbines and the response effects of wind induced vibration; space preparation for wind turbine installations has not been sufficiently considered. This work reviewed the shapes of openings where wind turbines can be installed in skyscrapers, and the characteristics of wind induced vibration responses occurring in the building with changes in cross sectional area. Nine wind power models were constructed to carry out the experiment. According to the experimental results, wind speed varies with shape of opening in the order of C-type>S-type>R-type. Moreover, wind speed increases as the area is reduced.

关键词： wind induced vibration tall building shapes of opening wind turbine

Analysis of prognostic factors and outcomes of gastric cancer in younger patients:A case control study using propensity score methods

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World Journal of Gastroenterology 2014年第12期20卷 3369-3375页

作者： ki-Han kim Yoo-Min kim Min-Chan kim Ghap-Joong Jung Department of Surgery Dong-A University College of Medicine

AIM:To understand the clinicopathological and prognostic features of gastric cancer in younger and older ***:Between January 2002 and December2008,1667 patients underwent curative gastric *** comparative purposes,the patients were divided into two groups:younger patients who were less than 40 years old(112 patients),and older patients who were 40 years old and older(1555 patients).In both groups,propensity scoring methods were used to select patients with similar disease statuses.A total of224 matched cases,with 112 patients in each group,were included in the final ***:Compared to the older group,the younger group with gastric cancer had a significantly higher percentage of females(P=0.007),poorly differentiated or signet ring cell carcinoma(P<0.001),advanced T stage gastric cancer(P=0.045),and advanced tumornode-metastasis stage cancer(P=0.036).The older group with gastric cancer had more comorbidities(P<0.001).With the exception of the number of lymph node dissection(P<0.001)and retrieved lymph node(P=0.010),there were no statistically significant differences between the postoperative outcomes of the two *** the follow-up period,there were19 recurrences in the younger group and 11 recurrences in the older *** overall five-year survival rates in the younger and older groups were 84.3%and89.6%,respectively(P=0.172).There were no significant differences(P=0.238)in the overall survival of patients with advanced T stage gastric cancer in the two groups,with five-year survival rates of 70.8%in the younger group and 79.5%in the older *** regard to the age-adjusted survival rate,there was significant difference between the two groups(P=0.225).CONCLUSION:In spite of aggressive cancer patterns in the younger group with gastric cancer,the younger group did not have a worse prognosis than the older group in our study.

关键词： Gastric cancer Younger patients Prognosis

Application of automated cone penetrometer for railway investigation using correlations with DCPI and deflection modulus

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Research in Cold and Arid Regions 2022年第4期14卷 235-238页

作者： Sang Yeob kim Won-taek Hong Jong-Sub Lee School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea Department of Civil&Environmental Engineering Gachon UniversitySeongnam-si 13120Republic of Korea

Portable in-situ devices have been used for characterizing low accessible field,such as the railway *** this study,the automated cone penetrometer(ACP)was designed for the application on the railway *** is composed of the cone tip,driving rod,and hydraulic hammer *** hydraulic motor lifts and drops the 294.3 N hammer from a height of 200 mm such that the potential energy of 58.9 N m impacts the driving *** N-value(NACP)from the ACP test was compared with the dynamic cone penetration index(DCPI)from the dynamic cone penetrometer(DCP)*** test results show that the NACP and DCPI profiles show opposite trend owing to the inverse concept of the *** the correlation of DCPI and NACP,the limitation of DCPI reveals owing the minimum manually measured value of 1 mm/***,the evaluation of the deflection modulus(EFWD)using NACP is more efficient than that using *** on the result of this study,we suggest that ACP can be used for strength and stiffness evaluation of railway subgrade rapidly and reliably.

关键词： Automated cone penetrometer DCPI E_(FWD )N_(ACP) Railway subgrade

Understanding cell-extracellular matrix interactions for topology-guided tissue regeneration

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BIOCELL 2023年第4期47卷 789-808页

作者： AAYUSHI RANDHAWA SAYAN DEB DUTTA KEYA GANGULY TEJAL V.PATIL RACHMI LUTHFIKASARI ki-taek LIM Department of Biosystems Engineering Kangwon National UniversityChuncheon24341Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Korea

Tissues are made up of cells and the extracellular matrix(ECM)which surrounds *** cells and tissues are actively adaptable to enduring significant stress that occurs in daily *** astonishing mechanical stress develops due to the interaction between the live cells and the non-living *** in the matrix microenvironment can sense the signals and forces produced and initiate a signaling cascade that plays a crucial role in the body’s normal functioning and influences various properties of the native cells,including growth,proliferation,and ***,the matrix’s characteristic features also impact the repair and regeneration of the damaged *** current study reviewed how the cell-ECM interaction regulates cellular behavior and physicochemical ***,we have described the response of cells to mechanical stresses,the importance of substrate stiffness and geometry in tissue regeneration,and the development of scaffolds to mimic the nature of native ECM in 3D for tissue engineering applications has also been ***,the study summarizes the conclusions and promising prospects based on the cell-ECM interplay.

关键词： ECM Stress Mechanical force Scaffold Mechanotransduction Tissue engineering

Mesenchymal stem cells,the secretome and biomaterials:Regenerative medicine application

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BIOCELL 2022年第10期46卷 2201-2208页

作者： ki-taek LIM TEJAL V.PATIL DINESH KPATEL SAYAN DEB DUTTA KEYA GANGULY AAYUSHI RANDHAWA Department of Biosystems Engineering Interdisciplinary Program in Smart AgricultureKangwon National UniversityChuncheon341Korea

Mesenchymal stem cells(MSCs)are multipotent cells usually isolated from bone marrow,endometrium,adipose tissues,skin,and dental *** played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material ***,MSCs have been widely explored for their application in regenerative medicine and COVID-19 *** approaches to evaluate the future of biomaterials and stem cell properties have been ***,misconceptions and ethical issues still exist,such as MSCs being non-angiogenic,anti-apoptotic,and immunoregulatory *** stem cells isolation primarily requires the consent of donors and can include the killing of fertilized *** issues generate questions related to ethical and moral ***,MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory *** are capable of secreting a broad range of biomolecules such as proteins,nucleic acids,exosomes,microRNAs,and membrane vesicles,collectively known as *** are released in response to the surrounding *** this article,we briefly address topics related to the therapeutic potential of MSCs as an advanced approach in the field of regenerative medicine and various perspectives.

关键词： Mesenchymal Stem Cells Secretome Biomaterials Regenerative Medicine

A Study of the Vortical Flow over a Delta Wing with a Leading Edge Extension

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Journal of Thermal Science 2003年第4期12卷 299-303页

作者： Heuy-Dong kim Young-ki Lee Tae-Ho kim Myoung-Hwan Sohn School of Mechanical Engineering Andong National University Andong 760-749 KoreaSchool of Mechanical Engineering Andong National University Andong 760-749 KoreaSchool of Mechanical Engineering Andong National University Andong 760-749 KoreaDepartment of Aerospace Engineering Korean Air Force Academy Chongwon-gun ChungBook-Do 363-849 Korea

The present paper describes computational and experimental work on the vortex flow characteristics of a sharp-edged delta wing with a leading edge extension (LEX). Experiment was carried out using a low-speed wind tunnel that has a test section of 3.5 m(W)×2.45 m(H)×8.7 m(L). The angle of attack of the delta wing ranges from 10° to 30°. The free stream velocity is fixed at 20 m/s, which corresponds to Reynolds number of 0.88×106. Computations using the mass-averaged implicit 3D Navier-Stokes equations were applied to predict the complicated vortical flow over the delta wing. The governing equations were discretized in space using a fully implicit finite volume differencing formation. The standard k-e turbulent model was employed to close the governing equations. The present computations predicted the experimented flow field with a good accuracy.

关键词： delta wing leading edge extension (LEX) vortex core vortex strength.

Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage

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Nano Research 2018年第7期11卷 3582-3592页

作者： Bong Geun Cha Han-Gil Jeong Dong-Wan Kang Myong-Joo Nam Chi Kyung kim Do Yeon kim In-Young Choi Seul ki ki Song I kim Ju hee Han Jaeyun kim Seung-Hoon Lee School of Chemical Engineering Sungkyunkwan University Suwon 16419 Republic of Korea Department of Laboratory of Innovative Nanobiotechnology Biomedical Research Institute Seoul National University Hospital 101 Daehak-ra Jongno-gu Seou103080 Republic of Korea Department of Neurology Seoul National University Hospital 101 Daehak-ro Jongno-gu Seou103080 Republic of Korea Department of Neurology Korea University Guro Hospital and Korea University College of Medicine Seoul 08308 Republic of Korea Department of Health Sdences and Technology Samsung Advanced Institute for Health Science & Technology (SAIHST) Sungkyunkwan University Suwon 16419 Republic of Korea Biomedical Institute for Convergence at SKKU (BICS) Sungkyunkwan University Suwon 16419 Republic of Korea

Intracerebral hemorrhage （ICH）, caused by the sudden rupture of an artery within the brain, is a devastating subtype of stroke, which currently has no effective treatment. Intense inflammatory reactions that occur in the peri-hematomal area after ICH are more deleterious than the hematoma itself, resulting in subsequent brain edema and neurologic deterioration. Thus, we developed lipid-coated magnetic mesoporous silica nanoparticles doped with ceria nanoparticles （CeNPs）, abbreviated as LMCs, which have both potent anti-inflammatory therapeutic effects via scavenging reactive oxygen species and help in increasing the efficacy of magnetic resonance imaging enhancement in the peri-hematomal area. LMCs consist of mesoporous silica nanopartide-supported lipid bilayers, which are loaded with large amounts of CeNPs for scavenging of reactive oxygen species, and iron oxide nanoparticles for magnetic resonance imaging contrast. LMCs loaded with CeNPs exhibited strong anti-oxidative and anti-inflammatory activities in vitro. In the rodent ICH model, intracerebraUy injected LMCs reached the peri-hematomal area and were engulfed by macrophages, which were clearly visualized by magnetic resonance imaging of the brain. Moreover, LMCs reduced inflammatory macrophage infiltration, and thus significantly reduced brain edema. Finally, LMC treatment markedly improved neurologic outcomes of the animals with ICH. Thus, LMC is the first nanobiomaterial that successfully showed theragnostic effects in ICH.

关键词： magnetic mesoporous silica nanoparticle ceria nanoparticles intracerebral hemorrhage reactive oxygen species therapeutics imaging