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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Shin Jung Tae-Young Jung In-Young kim Kyung-Sub moon Sam-Suk Kang Brain Tumor Research Laboratory Department of NeurosurgeryBrain Tumor ＆ Gamma Knife CenterChonnam National University Hwasun Hospital ＆ Medical School

OBJECT:The dural tail was first described as a thin,tapering rim of dural enhancement,in continuity with meningiomas on enhanced T1-weighted magnetic resonance（MR） *** the exact nature of the tail pathology is still *** we would like to investigate the immunohistochemical characteristics of dural tail in intracranial *** and METHODS:Twenty-two patients with meningioma undergoing MRI imaging showed dural *** immunohistochemical（IHC） staining,expression of EMA,Vimentin,ki-67,CD34 and vascular endothelial growth factor（VEGF） were evaluated between tumor mass and dural tail of meningioma.H＆E and Masson’s Trichrome staining were also ***:Sixteen of 22 cases（72.7%） show dural tail involved by tumor *** staining showed Vimentin and EMA intensively expressed in tumour mass,ki-67 expression nearly negative in both tumour mass and dural tail,CD34 overexpressed in duarl tail,VEGF overexpressed in tumour cells which invade to dural ***’s Trichrome staining clearly showed components of tumor,tail and dural ***:Our study showed most of dural tail involved by tumor cells（72.7%）,different immunohistochemical staining of CD34,and VEGF profiles obtained between tumour mass and dural tail.

关键词： Dural tail sign Meningioma Immunohistochemisty(IHC) CD34 Vascular endothelial growth factor(VEGF) ki-67 EMA Vimentin

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Pathologic Analysis of Glioblastoma Via Stereotactic Biopsies Combined with Enhanced MR Images and ~11C-methionine PET

Pathologic Analysis of Glioblastoma Via Stereotactic Biopsie...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Tae-Young Jung Shin Jung In-Young kim Kyung-Sub moon Woo-Youl Jang Seung-Jin Park Young-Hee kim Hyung-Seok kim Jung-Joon Min Jahae kim Departments of Neurosurgery Chonnam National University Research Institute of Medical Sciences Chonnam National University Hwasun Hospital & Medical School GwangjuSouth Korea Departments of Brain Tumor Research Laboratory Chonnam National University Research Institute of Medical Sciences Departments of Biomedical Engineering Chonnam National University Research Institute of Medical Sciences Departments of Pathology Chonnam National University Research Institute of Medical Sciences Departments of Nuclear Medicine Chonnam National University Research Institute of Medical Sciences

Objective:To obtain more representative biopsy specimens in glioblastoma,we combined MR stereotactic planning with 11C-methionine PET and analyzed the pathologic ***:From December 2009 to October 2010,we performed stereotactic biopsies in 12 patients with radiologically heterogeneous,ring-enhanced *** biopsied the MR enhanced lesions having higher 11C-methionine uptake and the MR non-enhanced lesions having lower uptake and analyzed differences in pathologic diagnoses between *** pathologic findings,including cell density,ki-67 LI,microvessel density,and number of endothelial proliferations,were analyzed as correlating factors of the degree of 11C-methionine uptake（T/N ratio）.We performed immunohistochemical staining for L-amino acid transporter 1（LAT1） to demonstrate the correlation with T/N ratio and the pattern of ***:The final diagnosis of each specimen was *** T/N ratio correlated statistically with enhancement（p = 0.000）.The diagnostic failure rate was 33.3%（4/12 patients） when we selected only one MR enhanced,high 11C-methionine uptake lesion,and 40%（4/10 patients） when we selected one MR non-enhanced,low 11C-methionine uptake *** T/N ratio showed a statistical correlation with cell density depending on the degree of necrosis,LAT1 immunopositivity,microvessel density,number of endothelial proliferations,and ki-67 LI（p = 0.002,0.032,0.057,0.24 and 0.741,respectively）.LAT1 was localized in the tumor cells,vascular endothelium,and the vicinity of endothelial ***:Multiple stereotactic biopsies combined with enhanced MR images and 11Cmethionine PET could provide the diagnostic yield in glioblastoma,which mostly differing cell densities depending on the degree of necrosis.

关键词： biopsy 11C-methionine PET enhanced MRI glioblastoma LAT1 stereotaxic

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三阴性乳腺癌的PET/CT检查时18F-FDG摄取和预后因素之间的相关性

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国际医学放射学杂志 2016年第1期 89-89页

作者： H.R.Koo J.S.Park K.W.Kang W.Han I.A.Park W.K.moon 程琳 Department of Radiology Seoul National University College of Medicine

摘要目的本研究旨在观察F-氟代脱氧葡萄糖(F-FDG)的摄取和三阴性乳腺癌(TNBC)的预后因素之间是否存在相关性。方法 2009年1月—2013年12月间,103例三阴性乳腺癌病人(平均年龄,50.6岁;病灶平均直径2.6 cm,最小1.0 cm,最大6.5 cm)为了明... 详细信息

摘要目的本研究旨在观察F-氟代脱氧葡萄糖(F-FDG)的摄取和三阴性乳腺癌(TNBC)的预后因素之间是否存在相关性。方法 2009年1月—2013年12月间,103例三阴性乳腺癌病人(平均年龄,50.6岁;病灶平均直径2.6 cm,最小1.0 cm,最大6.5 cm)为了明确分期情况进行了F-FDG PET/CT检查。评估PET/CT检查的最大标准化吸收值(SUV)、肿瘤大小、淋巴结转移情况、病理分级、增殖指数ki-67、肿瘤抑制因子p53以及"基底样细胞"制造者(表皮生长因子受体和K5/6)这些预后因素之间的关系。结果 103例

关键词：三阴性乳腺癌 F-FDG PET/CT 预后因素相关性 CT

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