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Characteristics of nonvariceal upper gastrointestinal hemorrhage in patients with chronic kidney disease

World Journal of Gastroenterology 2013年第43期19卷 7719-7725页

作者： Chang Seok Bang Yong Seop Lee Yun Hyeong Lee Hotaik Sung Hong Jun Park Hyun Soo kim Jin Bong kim Gwang Ho Baik Yeon Soo kim Jai Hoon yoon Dong Joon kim ki tae Suk Department of Internal Medicine Hallym University College of MedicineChuncheon 200-704South Korea Department of Biology Stanford UniversityStanfordCA 94305United States Department of Internal Medicine Yonsei University Wonju College of MedicineWonju 220-786South Korea

AIM:To evaluate the clinical characteristics of nonvariceal upper gastrointestinal hemorrhage(NGIH)in patients with chronic kidney disease(CKD).METHODS:From 2003 to 2010,a total of 72 CKD patients(male n=52,72.2%;female n=20,27.8%)who had undergone endoscopic treatments for NGIH were retrospectively *** findings,endoscopic features,prognosis,rebleeding risk factors,and mortality-related factors were *** characteristics of the patients and rebleeding-related data were recorded for the following variables:gender,age,alcohol use and smoking history,past hemorrhage history,endoscopic findings(the cause,location,and size of the hemorrhage and the hemorrhagic state),therapeutic options for endoscopy,endoscopist experience,clinical outcomes,and ***:The average size of the hemorrhagic site was 13.7±10.2 mm,and the most common hemorrhagic site in the stomach was the antrum(n=21,43.8%).The most frequent method of hemostasis was combination therapy(n=32,44.4%).The incidence of rebleeding was 37.5%(n=27),and 16.7%(n=12)of patients expired due to *** a multivariate analysis of the risk factors for rebleeding,alcoholism(OR=11.19,P=0.02),the experience of endoscopists(OR=0.56,P=0.03),and combination endoscopic therapy(OR=0.06,P=0.01)compared with monotherapy were significantly related to rebleeding after endoscopic *** a risk analysis of mortality after endoscopic therapy,only rebleeding was related to mortality(OR=7.1,P=0.02).CONCLUSION:Intensive combined endoscopic treatments by experienced endoscopists are necessary for the treatment of NGIH in patients with CKD,especially when a patient is an alcoholic.

关键词： Chronic kidney diseases Gastrointestinal hemorrhage Endoscopy Peptic ulcer Alcoholics

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Trends in the eradication rates of Helicobacter pylori infection for eleven years

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World Journal of Gastroenterology 2012年第45期18卷 6628-6634页

作者： Jai Hoon yoon Gwang Ho Baik Kyoung Min Sohn Dae Yong kim Yeon Soo kim ki tae Suk Jin Bong kim Dong Joon kim Jin Bae kim Woon Geon Shin Hak Yang kim Il Hyun Baik Hyun Joo Jang Department of Internal Medicine Hallym University College of MedicineChuncheon Sacred Heart Hospital153Gyo-dongChuncheonGangwon-do 200-704South Korea Department of Internal Medicine Hallym University College of MedicineKangnam Sacred Heart HospitalSeoul 150-950South Korea Department of Internal Medicine Hallym University College of MedicineKangdong Sacred Heart HospitalSeoul 134-814South Korea Department of Internal Medicine Hallym University College of MedicineHallym University Sacred Heart HospitalAnyang 431-070South Korea Department of Internal Medicine Hallym University College of MedicineHangang Sacred Heart HospitalSeoul 150-719South Korea

AIM:To evaluate the trends in the eradication rate of Helicobacter pylori(***) over the past 11 years in a single ***:This retrospective study covered the period from January 2000 to December *** evaluated 5746 patients diagnosed with gastric ulcers(GU),duodenal ulcers(DU),GU + DU,or nonpeptic ulcers associated with an *** *** treated them annually with the 2 wk standard first-line triple regimen,proton pump inhibitor(PPI) + amoxicilin + clarithromycin(PAC;PPI,clarithromycin 500 mg,and amoxicillin 1 g,all twice a day).The follow-up test was performed at least 4 wk after the completion of the 2 wk standard *** eradication using the PAC *** also assessed the eradication rates of 1 wk second-line therapy with a quadruple standard regimen(PPI b.i.d.,tripotassium dicitrate bismuthate 300 mg q.i.d.,metronidazole 500 mg t.i.d.,and tetracycline 500 mg q.i.d.) after the failure of the first-line *** analysis was performed with 95%CI for the differences in the annual eradication ***:A total of 5746 patients [2333 males(58.8%),1636 females(41.2%);mean age of males vs females 51.31 ± 13.1 years vs 52.76 ± 13.6 years,P < 0.05,total mean age 51.9 ± 13.3 years(mean ± SD)] were *** these patients,1674 patients were excluded:35 patients refused treatment;18 patients ceased *** eradication due to side effects;1211 patients had inappropriate indications for *** eradication,having undergone stomach cancer operation or chemotherapy;and 410 patients did not undergo the *** also excluded 103 patients who wanted to stop eradication treatment after only 1 wk due to poor compliance or the side effects mentioned ***,we evaluated the annual eradication success rates in a total of 3969 patients who received 2 wk first-line PAC *** endoscopic and clinical findings in patients who received the 2 wk PAC were as follows:gastric ulcer in 855(21.5%);duodenal ulcer in 878(22.1%);

关键词： Helicobacter pylori Eradication Protonpump inhibitor Therapy Clarithromycin

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Comparison of postoperative corneal changes between dry eye and non-dry eye in a murine cataract surgery model

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 218-224页

作者： Jin Woo Kwon Yeon Woong Chung Jin A Choi tae yoon La Dong Hyun Jee Yang Kyung Cho Department of Ophthalmology St.Vincent's HospitalCollege of Medicine The Catholic University of Korea

AIM： To compare the effects of the surgical insult of cataract surgery on corneal inflammatory infiltration, neovascularization （NV） and lymphangiogenesis （LY） between the dry eye and non-dry eye in murine cataract surgery models.METHODS： We established two groups of animals, one with normal eyes （non-dry eye） and the second with induced dry eyes. In both groups, we used surgical insults to mimic human cataract surgery, which consisted of lens extraction, corneal incision and suture. After harvesting of corneas on the 9th postoperative day and immunohistochemical staining, we compared NV, LY and CD11b＋ cell infiltration in the corneas.RESULTS： Dry eye group had significantly more inflammatory infiltration （21.75%±7.17% r/s 3.65%±1.49%; P=0.049）. The dry eye group showed significantly more NV （48.21% ±4.02% ys 26.24% ±6.01% ; P =0.016） and greater levels of LY （9.27%±0.48% ys 4.84%±1.15%; P= 0.007）. In corneas on which no surgery was performed, there was no induction of NV in both the dry and non- dry group, but dry eye group demonstrated more CD11b＋ cells infiltration than the non-dry eye group （0.360%± 0.160% vs 0.023%±0.006%; P=0.068）. Dry eye group showed more NV than non-dry eye group in both topical PBS application and subconjunctival PBS injection （P= 0.020 and 0.000, respectively）.

关键词： angiogenesis cataract surgery dry eyedisease inflammation

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Current status of intragastric balloon for obesity treatment

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World Journal of Gastroenterology 2016年第24期22卷 5495-5504页

作者： Seung Han kim Hoon Jai Chun Hyuk Soon Choi Eun Sun kim Bora Keum yoon tae Jeen Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Gastrointestinal Medical Instrument Research Korea University College of Medicine

Endoscopic bariatric therapy may be a useful alternative to pharmacological treatment for obesity, and it provides greater efficacy with lower risks than do conventional surgical procedures. Among the various endoscopic treatments for obesity, the intragastric balloon is associated with significant efficacy in body weight reduction and relief of comorbid disease symptoms. Anatomically, this treatment is based on gastric space-occupying effects that increase the feeling of satiety and may also affect gut neuroendocrine signaling. The simplicity of the intragastric balloon procedure may account for its widespread role in obesity treatment and its applicability to various degrees of obesity. However, advances in device properties and procedural techniques are still needed in order to improve its safety and cost-effectiveness. Furthermore, verification of the physiological outcomes of intragastric balloon treatment and the clinical predictive factors for treatment responses should be considered. In this article, we discuss the types, efficacy, safety, and future directions of intragastric balloon treatment.

关键词： Intragastric balloon Obesity Bariatric Metabolic Endoscopy

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Thermal energy harvesting circuit with maximum power point tracking control for self-powered sensor node applications

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Frontiers of Information Technology & Electronic Engineering 2018年第2期19卷 285-296页

作者： Eun-Jung yoon Jong-tae PARK Chong-Gun YU Department of Electronics Engineering Incheon National University

We present a simple implementation of a thermal energy harvesting circuit with the maximum power point tracking（MPPT） control for self-powered miniature-sized sensor nodes. Complex start-up circuitry and direct current to direct current（DC-DC） boost converters are not required, because the output voltage of targeted thermoelectric generator（TEG） devices is high enough to drive the load applications directly. The circuit operates in the active/asleep mode to overcome the power mismatch between TEG devices and load applications. The proposed circuit was implemented using a 0.35-μm complementary metal-oxide semiconductor（CMOS） process. Experimental results confirmed correct circuit operation and demonstrated the performance of the MPPT scheme. The circuit achieved a peak power efficiency of 95.5% and an MPPT accuracy of higher than 99%.

关键词： Thermoelectric energy Energy harvesting Maximum power point tracking (MPPT) control Self-powered system Sensor node

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Impact of statin intensity on adverse cardiac and cerebrovascular events in older adult patients with myocardial infarction

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Journal of Geriatric Cardiology 2021年第8期18卷 609-622页

作者： In tae Moon Si-Hyuck Kang Wonjae Lee Youngjin Cho Jin Joo Park Yeonyee Eyoon Il-Young Oh Chang-Hwan yoon Jung-Won Suh tae-Jin Youn In-Ho Chae Dong-Ju Choi Young-Seok Cho Uijeongbu Eulji Medical Center Eulji University School of MedicineUijeongbuSouth Korea Seoul National University Bundang Hospital SeongnamSouth Korea Department of Cardiology Incheon Sejong HospitalIncheonSouth Korea

BACKGROUND There is insufficient evidence regarding the effect of high-intensity statin therapy in older *** study aimed to investigate the effects of high-intensity statin treatment on the clinical outcomes in older adults with myocardial infarc-tion(MI).METHODS Consecutive patients with MI aged at least 75 years were analyzed *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE),defined as a composite of all-cause death,MI,rehospitalization due to un-stable angina,repeat revascularization,and ischemic *** high-intensity group was compared to the low-to-moderate in-tensity group in the propensity score-matched *** Average age of total 546 patients was 81 *** them,84%of patients underwent percutaneous coronary *** unadjusted seven-year MACCE rate differed by statin intensity(high-intensity statin group:38%,moderate-intensity statin group:42%,low-intensity statin group:56%,and no-statin group:61%,P=0.004).However,among these groups,many baseline characteristics were significantly *** the 74 propensity score-matched pairs,which lacked any significant differences in all baseline characteristics,the high-intensity group had a significantly lower rate of MACCE than the low-to-moderate intensity group(37%vs.53%,P=0.047).Follow-up low-density lipoprotein cholesterol levels were significantly lower in the high-intensity group than that in the low-to-moderate intensity group(69.4±16.0 mg/dL vs.77.9±25.9 mg/dL,P=0.026).CONCLUSIONS In older adult patients with MI,the use of high-intensity statin caused significantly less occurrence of MACCE in comparison to that in low-to-moderate intensity for up to seven years of follow-up.

关键词： patients cardiac intensity

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Ectopic peritoneal paragonimiasis mimicking tuberculous peritonitis:A care report

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World Journal of Clinical Cases 2022年第16期10卷 5359-5364页

作者： Jung Woo Choi Chang Min Lee Seong Je kim Se In Hah Ji yoon Kwak Hyun Chin Cho Chang yoon Ha Woon tae Jung Ok Jae Lee Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University HospitalJinju 52727South Korea Institute of Health Sciences Gyeongsang National UniversityJinju 52828South Korea

BACKGROUND The most common site of paragonimiasis is in the *** migratory route passes through the duodenal wall,peritoneum,and diaphragm to the lungs;thus,the thoracic cavity and central nervous system,as well as the liver,intestine,and abdominal cavity may be ***,we present a case of intraperitoneal paragonimiasis without other organ involvement,mimicking tuberculous *** SUMMARY A 57-year-old man presented with recurrent abdominal pain for 4 *** examination revealed tenderness in the right lower *** findings showed complete blood counts within the normal range without *** reactive lymph nodes and diffuse peritoneal infiltration were noted on abdominal computed tomography(CT).There were no abnormalities on chest CT or *** findings of diagnostic laparoscopy for the differential diagnosis of tuberculous peritonitis and peritoneal carcinomatosis included multiple small whitish nodules and an abscess in the *** reports confirmed the presence of numerous eggs of Paragonimus westermani(***).A postoperative serum enzyme-linked immunosorbent assay revealed *** *** and repetitive history-taking led him to retrospectively recall the consumption of freshwater *** 3 d of treatment with praziquantel(1800 mg;25 mg/kg),he recovered from all *** In patients who require diagnostic laparoscopy for the differential diagnosis of tuberculous peritonitis and peritoneal carcinomatosis,repetitive history-taking and preoperative serologic antibody tests against Paragonimus may be helpful in diagnosing intraperitoneal paragonimiasis without other organ involvement.

关键词： Differential diagnoses Intraperitoneal abscess Paragonimiasis Paragonimus westermani Peritonitis Tuberculosis Case report

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Carbon and nitrogen dynamics in a Pinus densiflora forest with low and high stand densities

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Journal of Plant Ecology 2013年第5期6卷 368-379页

作者： Nam Jin Noh Choonsig kim Sang Won Bae Woo Kyun Lee tae Kyung yoon Hiroyuki Muraoka Yowhan Son Division of Environmental Science and Ecological Engineering Korea UniversitySeoul 136-713Republic of Korea River Basin Research Center Gifu UniversityGifu 501-1193Japan Department of Forest Resources Gyeongnam National University of Science and TechnologyJinju 660-758Republic of Korea Department of Forest Conservation Korea Forest Research InstituteSeoul 130-712Republic of Korea

Aims Understanding carbon(C)and nitrogen(N)dynamics and their dependence on the stand density of an even-aged,mature forest provides knowledge that is important for forest *** study investigated the differences in ecosystem total C and N storage and flux between a low-density stand(LD)and a high-density stand(HD)and examined the effects of stand density on aboveground net primary productivity(ANPP),total belowground C allocation(TBCA)and net ecosystem production(NEP)in a naturally regenerated,65-to 75-year-old Pinus densiflora *** *** LD(450 trees ha^(−1))and HD(842 trees ha^(−1))were established in an even-aged,mature *** forest in September *** forest had been naturally regenerated following harvesting,and the stand density was naturally maintained without any artificial management such as *** diameter at breast height(DBH≥5.0cm)of all live stems within the stands was measured yearly from 2007 to *** compare C and N storage and fluxes in LD and HD,C and N pools in aboveground and belowground biomass,the forest floor,coarse woody debris(CWD)and soil;soil CO_(2) efflux(R_(S));autotrophic respiration(R_(A));litter production;and soil N availability were ***,ANPP,TBCA and NEP were estimated from plot-based measurement *** Findings Ecosystem C(Mg C ha^(−1))and N(Mg N ha^(−1))storage was,respectively,173.0±7.3(mean±SE)and 4.69±0.30 for LD and 162±11.8 and 4.08±0.18 for *** were no significant differences in C and N storage in the ecosystem components,except for soils,between the two *** contrast,there were significant differences in aboveground ANPP and TBCA between the two stands(P<0.05).Litterfall,biomass increment and R_(S) were major C flux components with values of,respectively,3.89,3.74 and 9.07 Mg C ha^(−1) year^(−1) in LD and 3.15,2.94 and 7.06 Mg C ha^(−1) year^(−1) in ***-based NEP(Mg C ha^(−1) year^(−1))was 4.18 in LD and 5.50 in *** the even-aged,mature P

关键词： aboveground net primary productivity net ecosystem production Japanese red pine stand density total belowground carbon allocation

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Customizable design ofmultiple-biomolecule delivery platform for enhanced osteogenic responses via‘tailored assembly system’

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Bio-Design and Manufacturing 2022年第3期5卷 451-464页

作者： Hyun Lee Min-Kyu Lee Ginam Han Hyoun-Ee kim Juha Song Yuhyeon Na Chang-Bun yoon SeKwon Oh tae-Sik Jang Hyun-Do Jung Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon 14662Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon 14662Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Biomedical Implant Convergence Research Center Advanced Institutes of Convergence TechnologySuwon 443-270Republic of Korea School of Chemical and Biomedical Engineering Nanyang Technological University70 Nanyang DriveSingapore 637457Singapore Department of Advanced Materials Engineering Korea Polytechnic UniversitySiheung-siGyeonggi-do 15073Republic of Korea Surface R&D Group Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical ***,naturally formed TiO2 on the surface limits fast *** biomolecules have been widely utilized to overcome this issue;however,homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release *** this study,functionally graded porous Ti scaffolds(FGPTs)with dense inner and porous outer parts were fabricated using a two-body combination and densification *** with growth factor(BMP-2)and antibiotics(TCH)exhibited suitable mechanical properties as bone substituting material and presented good structural *** release of BMP-2 was considerably prolonged,whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds(control group).The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of *** antimicrobial properties of these scaffolds were verified using *** in terms of prior release *** addition,various candidates for graded porous Ti scaffolds with altered pore characteristics were presented.

关键词： Functionally graded porous titanium scaffold Tailored assembly system Mechanical tunability Multiplebiomolecule delivery Bone tissue engineering

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Congenital ovarian anomaly manifesting as extra tissue connection between the two ovaries:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9318-9322页

作者： Myeong Gyun Choi Jong Woon kim yoon Ha kim A Mi kim tae Young kim Hyun Kyung Ryu Department of Obstetrics and Gynecology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Ovarian anomalies except for uni-or bilateral streak gonads are *** present a rare case of an ovarian anomaly in which both ovaries were connected by extra *** SUMMARY A 32-year-old,primipara with a twin pregnancy at 36 weeks of gestation was admitted to the hospital with severe *** underwent emergency cesarean section owing to persistent headache,blurred vision,and general *** a peritoneal incision,a thin rectangular-shaped tissue was seen in front of the *** delivery,the extra tissue was removed;no other anomalies were reported in either the ovaries or *** results of the removed tissue disclosed a well-vascularized loose stromal tissue with few follicles and scattered luteinized *** this case,to prevent pelvic adhesion or intestinal obstruction resulting from volvulus,strangulation,and torsion,the extra tissue was *** We report a case of a rare ovarian anomaly where both ovaries were connected by extra *** the extra tissue extends to the abdominal cavity,it should be removed to prevent pelvic adhesion or abdominal complications including intestinal volvulus,strangulation,and torsion.

关键词： Connected ovaries Extra tissue Ovarian anomaly Case report

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