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The current status of hormone treatment for prostate cancer patients in Korean real-world practice:a multi-institutional observational study

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Asian Journal of Andrology 2019年第2期21卷 115-120页

作者： Jung Kwon kim Jung Jun kim taek Won Gang tae Kyun Kwon Hong Sup kim Seung Chui Park Jae-Shin Park Jong-Yeon Park Seok Joong yoon Youn-Soo Jeon Jin Seon Cho Kwan Joong Joo Sung-Hoo Hong Seok-Soo Byun the Korean Urological Oncology Society Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Hallym University Sacred Heart HospitalAnyang 14068Korea Department of Urology Kangbuk Samsung HospitalSeoul 03181Korea Department of Urology Seoul St.Mary HospitalSeoul 06591Korea 不详 Department of Urology Chonnam National University HospitalGwangju 61469Korea School of Medicine Kyungpook National University Medical CenterDaegu 41404Korea Department of Urology Konkuk University Medical CenterSeoul 05080Korea Department of Urology Wonkwang University HospitalIksan 54538Korea Department of Urology Daegu Catholic University Medical CenterDaegu 41911Korea Department of Urology Ulsan UniversityGangneung Asan HospitalGangneung 25440Korea Department of Urology Chungbuk National University HospitalCheongju 28644Korea Department of Urology Soonchunhyang University HospitalCheonan 31151Korea

We aimed to evaluate the current nationwide trend,efficacy,safety,and quality of life(QoL)profiles of hormone treatment in real-world practice settings for prostate cancer(PCa)patients in Korea.A total of 292 men with any biopsy-proven PCa(TanyNanyMany)from 12 institutions in Korea were included in this multi-institutional,observational study of prospectively collected *** luteinizing hormone-releasing hormone(LHRH)agonists were allowed to be investigational *** was defined as(1)the rate of castration(serum testosterone≤50 ng dl^-1)at 4-week visit and(2)breakthrough(serum testosterone>50 ng dl^-1 after castration).Safety assessments included routine examinations for potential adverse events,laboratory tests,blood pressure,body weight,and bone min era I density(BMD,at baseli ne and at the last follow-up visit).QoL was assessed using the Expa nded Prostate Cancer Index Composite-26(EPIC-26).The most comm on initial therapeutic regimen was LHRH agonist with an ti-androge n(78.0%),and the most commonly used LHRH agonist for combination and mono therapy was leuprolide(64.0%for combi natio n and 58.0%for monotherapy).The castration and breakthrough rates were 78.4%and 6.6%,*** laboratory results related to dyslipidemia worsened after 4 weeks of hormone *** addition,the mean BMD T-score was significantly lower at the last follow-up(mean:-1.950)compared to baseline(mean:-0.195).The mean total EPIC-26 score decreased from 84.8(standard deviation[s.d.]:12.2)to 78.3(s.d.:8.1),with significant deterioration only in the urinary domain(mean:23.5 at baseli ne and 21.9 at the 4-week visit).These findi ngs dem on strate the n ationwide trend of current practice setti ngs in hormone treatment for PCa in Korea.

关键词： efficacy hormonal treatment Korean population prostate cancer safety trend

Primary signet ring cell carcinoma of the appendix:A rare case report and our 18-year experience

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World Journal of Gastroenterology 2008年第37期14卷 5763-5768页

作者： yoon Ho Ko Chan-Kwon Jung Soon Nam Oh tae Hee kim Hye Sung Won Jin Hyoung Kang,Hyung Jin kim, Won Kyung Kang, Seong taek Oh, Young Seon Hong Jin Hyoung Kang Hyung Jin kim Won Kyung Kang Seong taek Oh Young Seon Hong Departmentof Internal Medicine Kangnam St. Mary's hospital CatholicUniversity Seoul 137-701 South Korea Department of Hospital Pathology Kangnam St. Mary's hospital Catholic University Seoul137-70 l South Korea Department of Radiology Kangnam St. Mary'shospital Catholic University Seoul 137-701 South Korea Department of General Surgery Kangnam St. Mary's hospitalCatholic University Seoul 137-701 South Korea

Primary adenocarcinoma of the appendix is a rare malignancy that constitutes 〈 0.5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carc noma of the appendix is an exceedingly rare entity. We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appen- dectomy over the past 18 years. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient. She underwent ap- pendectomy and bilateral salpingo-oophorectomy with a laparoscopy procedure. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-flurorouracil, and leucovorin （FOIFOX-4）. The patient currently is well without progression of disease 12 mo after beginning chemotherapy.

关键词： Appendiceal neoplasms Carcinoma Signet ring cell Chemotherapy

Erratum to:Tyrosine-mediated analog resistive switching for artificial neural networks

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Nano Research 2023年第8期16卷 11543-11543页

作者： Min-Kyu Song Seok Daniel Namgung Hojung Lee Jeong Hyun yoon Young-Woong Song Kang Hee Cho yoon-Sik Lee Jong-Seok Lee ki tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

Turbulent-Induced Noise around a Circular Cylinder Using Permeable FW-H Method

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Journal of Applied Mathematics and Physics 2015年第2期3卷 161-165页

作者： Woen-Sug Choi Suk-yoon Hong Jee-Hun Song Hyun-Wung Kwon Chul-Min Jung tae-Gyoung kim Departmentof Naval Architecture and Ocean Engineering Seoul National University Seoul Republic of Korea Department of Naval Architecture and Ocean Engineering Chonnam National University Yeosu Republic of Korea Department of Naval Architecture and Ocean Engineering Koje College Koje Republic of Korea Advanced Naval Technology Center NSRDI Agency for Defense Development Chinhae Republic of Korea

Varieties of research on turbulent-induced noise are conducted with combinations of acoustic analogy methods and computational fluid dynamic methods to analyse efficiently and accurately. Application of FW-H acoustic analogy without turbulent noise is the most popular method due to its calculation cost. In this paper, turbulent-induced noise is predicted using RANS turbulence model and permeable FW-H method. For simplicity, noise from 2D cylinder is examined using three different methods: direct method of RANS, FW-H method without turbulent noise and permeable FW-H method which can take into account of turbulent-induced noise. Turbulent noise was well predicted using permeable FW-H method with same computational cost of original FW-H method. Also, ability of permeable FW-H method to predict highly accurate turbulent-induced noise by applying adequate permeable surface is presented. The procedure to predict turbulent- induced noise using permeable FW-H is established and its usability is shown.

关键词： Turbulent-Induced Noise Circular Cylinder Acoustic Analogy FW-H Method Permeable FW-H Method

Nobiletin Prevents Body Weight Gain and Bone Loss in Ovariectomized C57BL/6J Mice

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Pharmacology & Pharmacy 2014年第10期5卷 959-965页

作者： Young-Sil Lee Midori Asai Sun-Sil Choi Takayuki Yonezawa Toshiaki Teruya Kazuo Nagai Je-tae Woo Byung-yoon Cha Research Institute for Biological Functions Chubu University Kasugai Japan Faculty of Education University of the Ryukyus Nishihara Japan Department of Biological Chemistry Chubu University Kasugai Japan Department of Research and Development Erina Co. Inc. Tokyo Japan

Obesity and osteoporosis are associated with estrogen deficiency following menopause. Therefore, it is important to prevent and treat both disorders to maintain a healthy life in postmenopausal women. Nobiletin, a polymethoxylated flavone, exhibits various pharmacologic effects, including anti-tumor and anti-inflammatory activities. Therefore, in this study, we examined the effects of nobiletin on obesity, obesity-related metabolic disorders, and bone mass in ovariectomized (OVX) mice. Mice were divided into four groups and underwent sham operation or OVX. OVX mice were treated with 50 or 100 mg/kg nobiletin, or received vehicle alone (0.3% carboxyl methyl cellulose/0.5% dimethyl sulfoxide). Nobiletin decreased body weight gain and white adipose tissue weight in OVX mice. Nobiletin also decreased triglyceride levels, and tended to reduce plasma total cholesterol and glucose levels. Additionally, nobiletin prevented the reduction in bone mineral density of the trabecular region of the femur in OVX mice. Taken together, our results suggest that nobiletin improves adiposity, dyslipidemia, hyperglycemia, and prevents bone loss in OVX mice. Therefore, nobiletin is expected to have beneficial effects for the prevention and improvement of metabolic disorders and osteoporosis in postmenopausal women.

关键词： Nobiletin Ovariectomy Obesity Lipid and Glucose Metabolism Bone Mineral Density

Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis

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World Journal of Gastroenterology 2013年第16期19卷 2543-2549页

作者： Sang Jung Park Jin Dong kim Yeon Seok Seo Beom Jin Park Min Ju kim Soon Ho Um Chang Ha kim Hyung Joon Yim Soon Koo Baik Jin Yong Jung Bora Keum yoon tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck kim Ho Sang Ryu Department of Internal Medicine College of Medicine Korea University Department of Internal Medicine Cheju Halla General Hospital Department of Radiology College of Medicine Korea University Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Christian Hospital

AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95%CI: 1.024-1.342,P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis.

关键词： Acute hepatitis Cholestasis Computed tomography Prognosis Gallbladder

Effects of edible insect extracts on the antioxidant, physiochemical, and microbial properties of Tteokgalbi during refrigerated storage

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Food Bioscience 2023年第2期52卷 326-333页

作者： Hae In Yong tae-Kyung kim Ji yoon Cha Jae Hoon Lee Min-Cheol Kang Samooel Jung Yun-Sang Choi Research Group of Food Processing Korea Food Research InstituteWanju55365Republic of Korea Division of Animal and Dairy Science Chungnam National UniversityDaejeon34134Republic of Korea

In this study,Tteokgalbi,a meat product,was prepared with edible insect larvae extracts and its antioxidant,physiochemical,and microbial properties were evaluated during refrigerated *** prepared with 2%*** and 2%*** showed the highest radical-scavenging activity and metal-chelating activity,but the lowest thiobarbituric acid reactive substance(TBARS)value,among the treatments(Pking yield,but the lowest shear force value(P<0.05).During all storage days,the total aerobic bacteria level did not differ significantly among the *** conclusion,*** extracts(2%)were effective as antioxidants,inhibiting lipid oxidation,and improving the quality properties of Tteokgalbi,without negatively affecting microbial *** results confirmed that the edible insect extracts have industrial value as a food additive.

关键词： Edible insect Lipid oxidation Natural antioxidant Refrigerated storage Tteokgalbi

Developing Stable Cultivar through Microspore Mutagenesis in ×Brassicoraphanus koranhort, Inter-Generic Allopolyploid between Brassica rapaand Raphanus sativus

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American Journal of Plant Sciences 2017年第6期8卷 1345-1356页

作者： Soo-Seong Lee Byoung Ho Hwang tae yoon kim Jeongmin Yang Na Rae Han Jongkee kim Hyun Hee kim Hadassah Roa Belandres BioBreeding Institute Sillyeong-Ro 153 Daeduk Ansung Gyeonggi Korea Dept. of Integrative Plant Science Chung-Ang University Ansung Korea Plant Biotechnology Institute Department of Life Science Sahmyook University Seoul Korea

A stable progeny was developed through induced mutation, using microspore culture, of the hybrid (F1F1) produced by crossing a newly synthesized, unstable allopolyploid (F1) and a stable cultivar, BB#1(F1) in xBrassicoraphanus. An F1F1 plant was subjected to the induced mutation system established during production of BB#1. Morphological characteristics of the progeny such as color, and leaf number and length, differed from those of BB#1. The bolting time of the progeny in spring cropping was very late compared to BB#1, allowing it to be grown to an adult plant in spring. Genomic in situ hybridization analysis of pollen mother cells at prophase I identified 19 bivalents, 10 from Brassica rapa and 9 from Raphanus sativus. The glucoraphenin content was almost identical to that of BB#1. Two cultivars are available in the baemoochae crop now. These results indicate that induced mutation using microspore culture is a viable method of stabilizing intergeneric allopolyploids between B. rapa and R. sativus.

关键词： xBrassicoraphanus Intergeneric Hybrid Baemoochae Brassica rapa Raphanus sativus

Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy

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Bioactive Materials 2022年第12期7卷 433-445页

作者： Hyo-Jin yoon Songhyun Lee tae Young kim Seung Eun Yu Hye-Seon kim Young Shin Chung Seyong Chung Suji Park Yong Cheol Shin Eun Kyung Wang Jihye Noh Hyun Jung kim Cheol Ryong Ku Hong Koh Chang-Soo kim Joon-Sang Park Young Min Shin Hak-Joon Sung Department of Medical Engineering Yonsei University College of MedicineSeoul03722Republic of Korea School of Electrical and Electronic Engineering Yonsei UniversitySeoul03722Republic of Korea Department of Obstetrics and Gynecology Institution of Women’s Life Medical ScienceSeverance HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Biomedical Engineering The University of Texas at AustinAustinTX78712USA Department of Internal Medicine EndocrinologyInstitute of Endocrine ResearchYonsei University College of MedicineSeoul03722Republic of Korea Department of Pediatrics GastroenterologySeverance HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Computer Engineering Hongik UniversitySeoul04066Republic of Korea Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Numais Co. Ltd.Korea Seoul 04799Republic of Korea

All-in-one treatments represent a paradigm shift in future *** example,inflammatory bowel disease(IBD)is mainly diagnosed by endoscopy,which could be applied for not only on-site monitoring but also the intestinal lesion-targeted spray of injectable ***,molecular conjugation to the hydrogels would program both lesion-specific adhesion and drug-free *** study validated this concept of all-in-one treatment by first utilizing a well-known injectable hydrogel that underwent efficient solution-to-gel transition and nanomicelle formation as a translatable *** properties enabled spraying of the hydrogel onto the intestinal walls during ***,peptide conjugation to the hydrogel guided endoscopic monitoring of IBD progress upon adhesive gelation with subsequent moisturization of inflammatory lesions,specifically by *** peptide was designed to mimic the major component that mediates intestinal interaction with Bacillus subtilis flagellin during IBD ***,the peptide-guided efficient adhesion of the hydrogel nanomicelles onto Toll-like receptor 5(TLR5)as the main target of flagellin binding and *** peptide binding potently suppressed inflammatory signaling without drug loading,where TLR5 and Notch-1 operated collaboratively through downstream actions of tumor necrosis *** results were produced using a human colorectal cell line,clinical IBD patient cells,gut-on-a-chip,a mouse IBD model,and pig experiments to validate the translational utility.

关键词： Nanomicelle Injectable hydrogel Peptide display Theranostic All-in-one treatment Inflammatory bowel disease