检索结果-南通市图书馆

A micro-fragmented collagen gel as a cell-assembling platform for critical limb ischemia repair

Bioactive Materials 2024年第4期34卷 80-97页

作者： Haeun Chung Jung-Kyun Choi Changgi hong Youngseop Lee ki hyun hong Seung Ja Oh Jeongmin kim Soo-Chang Song Jong-Wan kim Sang-Heon kim Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and TechnologySeoul02792Republic of Korea Department of Applied Bioengineering Graduate School of Convergence Science and TechnologySeoul National UniversitySeoul08826Republic of Korea Research Institute for Convergence Science Seoul National UniversitySeoul08826Republic of Korea Department of Genetics and Biotechnology College of Life SciencesKyung Hee UniversityYongin-siGyeonggi-do17104Republic of Korea S.Biomedics Co. Ltd.Seoul04797Republic of Korea

Critical limb ischemia(CLI)is a devastating disease characterized by the progressive blockage of blood *** the paracrine effect of growth factors in stem cell therapy made it a promising angiogenic therapy for CLI,poor cell survival in the harsh ischemic microenvironment limited its ***,an imperative need exists for a stem-cell delivery method that enhances cell ***,a collagen microgel(CMG)cell-delivery scaffold(40×20μm)was fabricated via micro-fragmentation from collagen-hyaluronic acid polyionic complex to improve transplantation *** human adipose-derived stem cells(hASCs)with CMG enabled integrin receptors to interact with CMG to form injectable 3-dimensional constructs(CMG-hASCs)with a microporous microarchitecture and enhanced mass ***-hASCs exhibited higher cell survival(p<0.0001)and angiogenic potential in tube formation and aortic ring angiogenesis assays than cell *** of CMG-hASCs intramuscularly into CLI mice increased blood perfusion and limb salvage ratios by 40%and 60%,respectively,compared to cell aggregate-treated *** immunofluorescent analysis revealed that transplanted CMG-hASCs have greater muscle regenerative and angiogenic potential,with enhanced cell survival than cell aggregates(p<0.05).Collectively,we propose CMG as a cell-assembling platform and CMG-hASCs as promising therapeutics to treat CLI.

关键词： Regenerative medicine Stem cell therapy Collagen microgel 3D cell culture Critical limb ischemia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis

引用

Bioactive Materials 2022年第1期7卷 14-25页

作者： Bo-Bae Seo Youngjoong Kwon Jun kim ki hyun hong Sung-Eun kim Hae-Ryong Song Young-Min kim Soo-Chang Song Center for Biomaterials Korea Institute of Science&TechnologySeoul02792South Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul02792South Korea Department of Orthopedic Surgery and Rare Diseases Institute Korea University Medical College Guro HospitalSeoul08308South Korea

Treatment of osteoarthritis(OA)by administration of corticosteroids is a commonly used method in clinics using anti-inflammatory *** administration or intra-articular injection of corticosteroids can reduce the pain and progress of cartilage degeneration,but they are usually insufficient to show local and long-term anti-inflammatory effects because of their fast clearance in the *** this study,we suggest an injectable anti-OA drug depot system for sustained drug release that provides long-term effective therapeutic *** poly(organophosphazene),which has temperature-dependent nanoparticle forming and sol-gel transition behaviors when dissolved in aqueous solution,was synthesized for triamcinolone acetonide(TCA)*** hydrophobic parts of the polymer can interact with hydrophobic parts of the TCA,the TCA was encapsulated into the self-assembled polymeric *** TCA-encapsulated polymeric nanoparticles(TePNs)were well dispersed in an aqueous solution below room temperature so that they can be easily injected as a sol state into an intra-articular ***,the TePNs solution transforms immediately to a viscose 3D hydrogel like a synovial fluid in the intra-articular region via the conducted body *** in vitro TCA release study showed sustained TCA release for six ***-time injection of the TePN hydrogel system in an early stage of OA-induced rat model showed a great inhibition effect against further OA *** OA-induced knees completely recovered as a healthy cartilage without any abnormal symptoms.

关键词： Thermosensitive hydrogel Triamcinolone acetonide Polymer nanoparticle Osteoarthritis Sustained release

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Performance Analysis of a Chunk-Based Speech Emotion Recognition Model Using RNN

引用

Intelligent Automation & Soft Computing 2023年第4期36卷 235-248页

作者： hyun-Sam Shin Jun-ki hong Division of Software Convergence Hanshin UniversityOsan-si18101Korea Division of AI Software Engineering Pai Chai UniversityDaejeon35345Korea

Recently,artiﬁcial-intelligence-based automatic customer response sys-tem has been widely used instead of customer service ***,it is important for automatic customer service to promptly recognize emotions in a customer’s voice to provide the appropriate service ***,we analyzed the performance of the emotion recognition(ER)accuracy as a function of the simulation time using the proposed chunk-based speech ER(CSER)*** proposed CSER model divides voice signals into 3-s long chunks to efﬁ-ciently recognize characteristically inherent emotions in the customer’s *** evaluated the performance of the ER of voice signal chunks by applying four RNN techniques—long short-term memory(LSTM),bidirectional-LSTM,gated recurrent units(GRU),and bidirectional-GRU—to the proposed CSER model individually to assess its ER accuracy and time efﬁ*** results reveal that GRU shows the best time efﬁciency in recognizing emotions from speech signals in terms of accuracy as a function of simulation time.

关键词： RNN speech emotion recognition attention mechanism time efﬁciency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Memristive Devices Based on Two-Dimensional Transition Metal Chalcogenides for Neuromorphic Computing

引用

Nano-Micro Letters 2022年第4期14卷 29-58页

作者： ki Chang Kwon Ji hyun Baek Kootak hong Soo Young kim Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and Science(KRISS)Daejeon 34133Republic of Korea Department of Materials Science and Engineering Institute of Green Manufacturing TechnologyKorea UniversitySeoul 02841Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Two-dimensional(2D)transition metal chalcogenides(TMC)and their heterostructures are appealing as building blocks in a wide range of electronic and optoelectronic devices,particularly futuristic memristive and synaptic devices for brain-inspired neuromorphic computing *** distinct properties such as high durability,electrical and optical tunability,clean surface,flexibility,and LEGO-staking capability enable simple fabrication with high integration density,energy-efficient operation,and high *** review provides a thorough examination of high-performance memristors based on 2D TMCs for neuromorphic computing applications,including the promise of 2D TMC materials and heterostructures,as well as the state-of-the-art demonstration of memristive *** challenges and future prospects for the development of these emerging materials and devices are also *** purpose of this review is to provide an outlook on the fabrication and characterization of neuromorphic memristors based on 2D TMCs.

关键词： Two-dimensional materials Memristors Neuromorphic computing Artificial synapses Transition metal chalcogenides

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Installing a molecular truss beam stabilizes MOF structures

引用

npj Computational Materials 2022年第1期8卷 1110-1118页

作者： hong ki kim Jong-Yeong Jung Gyumin Kang Mu-hyun Baik Eun-Young Choi Department of Chemistry Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea Center for Catalytic Hydrocarbon Functionalizations Institute for Basic Science(IBS)Daejeon34141Republic of Korea Korea Science Academy of KAIST 105-47 Baegyanggwanmun-roBusanjin-guBusan47162Republic of Korea

Enhancing the stability and durability of metal-organic frameworks(MOFs)is vital for practical applications because many promising MOF materials suffer from phase transitions and/or structural decompositions with humidity being a particularly damaging *** mechanical engineering,the frame of buildings and furniture can be stabilized significantly by installing a truss *** the same principle,we functionalized the organic component of MOF-5 to contain a carbazole moiety that can act as a molecular truss beam by reaching across the corner and forming a stableπ–πinteraction with a phenyl group on the edge position of the *** structural support enhanced the stability of the MOF substantially,allowing the designed MOF to maintain compositional integrity under steam conditions at 90℃for~5 *** unmodified MOF-5 shows clear signs of structural collapse after~1 h.

关键词： beam moiety durability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Factor analysis of recent major heatwaves in East Asia

引用

Geoscience Frontiers 2024年第1期15卷 374-383页

作者： Arim Yoon Jeongwon kim Jooyeop Lee hyun Min Sung Je-Woo hong Seung-ki Min Junhong Lee Jinkyu hong Ecosystem-Atmosphere Process Laboratory Department of Atmospheric SciencesYonsei UniversitySeoul 03722Republic of Korea National Institute of Meteorological Sciences Jeju 63568Republic of Korea Korea Adaptation Center for Climate Korea Environment InstituteSejong 30121Republic of Korea Division of Environmental Science and Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Max Planck Institute for Meteorology Hamburg 20146Germany Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoulRepublic of Korea

Heatwaves(HWs)present a major hazard to our society and more extreme heatwaves are expected with future climatic ***,it is important to improve our understanding of the underlying processes that drive HWs,in order to boost our socioeconomic-ecological *** this study,we quantified the influences of key driving factors(large-scale atmospheric circulation,soil moisture,and sea surface temperature)and their synergies on recent heatwaves in East *** conducted a factor separation analysis for three recent HW events by constraining the key factors in the regional Weather Research and Forecasting model with their climatologies or pseudo-observations in different *** study showed distinct spatial variations in the HW-controlling factors in East *** synergistic interaction of large-scale circulation and soil moisture was the most important factors in the 2013 Chinese *** the 2018 HWs in Korea and Japan,the same stagnant large-scale atmospheric circulation played a dominant role in driving the HW *** land-atmosphere coupling via soil moisture,its interaction with circulation,and SST exhibited stronger influences during the Korean HW than the Japanese *** analysis also revealed temporal variations in the factors driving Korean and Chinese HWs due to typhoon passage and other multiple processes over heterogeneous surfaces(i.e.,topographically induced Foehn winds,large-scale warm advection from the warm ocean,spatial differences in soil moisture).Our findings suggest that future heatwave-related studies should consider interactive contributions of key factors,their interplay with surface heterogeneities of complex terrain.

关键词： Heatwave East Asia Large-scale circulation Soil moisture Sea surface temperature Synergistic impacts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Strategy of Signal Detection for Performance Improvement in Clipping Based OFDM System

引用

Computers, Materials & Continua 2020年第7期64卷 181-191页

作者： Jae-hyun Ro Won-Seok Lee Min-Goo Kang Dae-ki hong Hyoung-Kyu Song Department of Information and Communication Engineering Sejong UniversitySeoulKorea Department of IT Contents Hanshin UniversityOsan-siKorea Department of System Semiconductor Engineering SangMyung UniversityCheonan-si31066Korea

In this paper,the supervised Deep Neural Network(DNN)based signal detection is analyzed for combating with nonlinear distortions efficiently and improving error performances in clipping based Orthogonal Frequency Division Multiplexing(OFDM)*** of the main disadvantages for the OFDM is the high Peak to Average Power Ratio(PAPR).The clipping is a simple method for the PAPR ***,an effect of the clipping is nonlinear distortion,and estimations for transmitting symbols are difficult despite a Maximum Likelihood(ML)detection at the *** DNN based online signal detection uses the offline learning model where all weights and biases at fully-connected layers are set to overcome nonlinear distortions by using training data ***,this paper introduces the required processes for the online signal detection and offline learning,and compares error performances with the ML detection in the clipping-based OFDM *** simulation results,the DNN based signal detection has better error performance than the conventional ML detection in multi-path fading wireless *** performance improvement is large as the complexity of system is increased such as huge Multiple Input Multiple Output(MIMO)system and high clipping rate.

关键词： Clipping DNN ML nonlinear distortion OFDM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genome-Wide Identification and Functional Analysis of Genes Expressed Ubiquitously in Rice

引用

Molecular Plant 2015年第2期8卷 276-289页

作者： ki-hong Jung Sung-Ruyl kim Hoi-Khoanh Giong Minh Xuan Nguyen hyun-Jung Koh Gynheung An Department of Plant Molecular Systems Biotechnology & Crop Biotech Institute Kyung Hee University Yongin 446-701 Korea Graduate School of Biotechnology Kyung Hee University Yongin 446-701 Korea These authors contributed equally to the article.

Genes that are expressed ubiquitously throughout all developmental stages are thought to be necessary for basic biological or cellular functions. Therefore, determining their biological roles is a great challenge. We identified 4034 of these genes in rice after studying the results of Agilent 44K and Affymetrix meta- anatomical expression profiles. Among 105 genes that were characterized by loss-of-function analysis, 79 were classified as members of gene families, the majority of which were predominantly expressed. Using T-DNA insertional mutants, we examined 43 genes and found that loss of expression of six genes caused developing seedor seedling-defective phenotypes. Of these, three are singletons without similar family members and defective phenotypes are expected from mutations. Phylogenomic analyses integrating genome-wide transcriptome data revealed the functional dominance of three ubiquitously expressed fam- ily genes. Among them, we investigated the function of OsO3g19890, which is involved in ATP generation within the mitochondria during endosperm development. We also created and evaluated functional net- works associated with this gene to understand the molecular mechanism. Our study provides a useful strategy for pheonome analysis of ubiquitously expressed genes in rice.

关键词： functional redundancy phylogenomic analysis rice systematic phenotype screening ubiquitouslyexpressed genes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of CaF2 content in refining slag on formation behavior of spinel inclusion in Ni-Cr-V-alloyed special steel

引用

Journal of Iron and Steel Research International 2018年第2期25卷 157-163页

作者： Jae-hong Shin Joo-hyun Park Department of Materials Engineering Hanyang UniversityAnsan 426-791 Korea

The influence of CaF2 content on the formation behavior of spinel inclusions in the Ni-Cr-V-alloyed special steel was presented. The spinel was not formed at CaF2 content lower than 10 wt%. However, it was formed at early stage when the CaF2 content was greater than 30 wt%, followed by a modification to the aluminosilicate-type inclusions. Because the slag was saturated by MgO, the activity of MgO was unity irrespective of CaF2 content in the slag. Thus, Mg was transferred from slag to metal phase. Mg transferred to molten steel reacted with Al2O3-rich inclusions to form ***2O3 spinel. However, the spinel inclusion was modified to aluminosilicate-type inclusions by the reaction with Si and Ca transferred from slag to molten steel about 2-3 h later.

关键词： Spinel inclusion Refining slag CaF2 content Ni-Cr-V-alloyed special steel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rice pollen-specific OsRALF17 and OsRALF19 are essential for pollen tube growth

引用

Journal of Integrative Plant Biology 2023年第9期65卷 2218-2236页

作者： Eui‐Jung kim Ji‐hyun kim Woo‐Jong hong Eun Young kim Myung‐Hee kim Su Kyoung Lee Cheol Woo Min Sun Tae kim Soon ki Park ki‐hong Jung Yu‐Jin kim Graduate School of Green Bio‐Science&Crop Biotech Institute Kyung Hee UniversityYongin 17104Republic of Korea Department of Life Science and Environmental Biochemistry Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Department of Smart Farm Science Kyung Hee UniversityYongin 17104Republic of Korea School of Applied Biosciences Kyungpook National UniversityDaegu 41566Republic of Korea Genomics Division Department of Agricultural Bio‐ResourcesNational Institute of Agricultural SciencesRural Development AdministrationJeonju 54874Republic of Korea Department of Plant Bioscience Pusan National UniversityMiryang 50463Republic of Korea Research Center for Plant Plasticity Seoul National UniversitySeoul 08826Republic of Korea

Pollen tube growth is essential for successful double fertilization, which is critical for grain yield in crop plants. Rapid alkalinization factors(RALFs) function as ligands for signal transduction during fertilization. However, functional studies on RALF in monocot plants are ***, we functionally characterized two pollen-specific RALFs in rice(Oryza sativa) using multiple clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-induced loss-of-function mutants,peptide treatment, expression analyses, and tag reporter lines. Among the 41 RALF members in rice, OsRALF17 was specifically expressed at the highest level in pollen and pollen *** applied OsRALF17 or OsRALF19peptide inhibited pollen tube germination and elongation at high concentrations but enhanced tube elongation at low concentrations, indicating growth regulation. Double mutants of OsRALF17 and OsRALF19(ralf17/19) exhibited almost full male sterility with defects in pollen hydration, germination, and tube elongation,which was partially recovered by exogenous treatment with OsRALF17 peptide. This study revealed that two partially functionally redundant OsRALF17 and OsRALF19 bind to Oryza sativa male-gene transfer defective 2(OsMTD2) and transmit reactive oxygen species signals for pollen tube germination and integrity maintenance in rice. Transcriptomic analysis confirmed their common downstream genes, in osmtd2 and ralf17/19. This study provides new insights into the role of RALF, expanding our knowledge of the biological role of RALF in regulating rice fertilization.

关键词： CRISPR-Cas9 CrRLK1L monocot Oryza sativa pollen tube growth rapid alkalinization factor(RALF)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：