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Assessment of post-myocardial infarction lipid levels and management:Results from a tertiary care hospital of Pakistan

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World Journal of Cardiology 2024年第5期16卷 282-292页

作者： Rubina Rauf Muhammad Ismail Soomro Muhamman Nauman Khan Mukesh Kumar Najia Aslam Soomro khawar abbas Kazmi Department of Preventive Cardiology National Institute of Cardiovascular DiseasesKarachi 75510Pakistan Department of Adult Cardiology National Institute of Cardiovascular DiseasesKarachi 75510Pakistan Department of Cardiology Liaquat National HospitalKarachi 74800Pakistan

BACKGROUND Lipid treatment practices and levels in post-acute myocardial infarction(AMI)patients,which are crucial for secondary *** To evaluate the lipid treatment practices and lipid levels in post-myocardial infarction(MI)patients at a tertiary care hospital in *** In this cross-sectional study,we analyzed patients who had experienced their first AMI event in the past 3 *** assessed fasting and non-fasting lipid profiles,reviewed statin therapy prescriptions,and examined patient *** recommended dose was defined as rosuvastatin≥20 mg or atorvastatin≥40 mg,with target total cholesterol levels set at<160 mg/dL and target low-density lipoprotein cholesterol(LDL-C)at<55 mg/*** Among 195 patients,71.3%were male,and the mean age was 57.1±10.2 *** median duration since AMI was 36(interquartile range:10-48)months and 60% were diagnosed with ST-segment elevation *** 13.8% of patients were advised to undergo lipid profile testing after AMI,88.7% of patients were on the recommended statin therapy,and 91.8% of patients were compliant with statin *** 11.5% had LDL-C within the target range and 71.7% had total cholesterol within the target *** admission in the past 12 months was reported by 14.4%,and the readmission rate was significantly higher among non-compliant patients(37.5%vs 5.6%).Subsequent AMI event rate was also significantly higher among non-compliant patients(43.8%vs 11.7%).CONCLUSION Our study highlights that while most post-AMI patients received the recommended minimum statin therapy dose,the inadequate practice of lipid assessment may compromise therapy optimization and raise the risk of subsequent events.

关键词： Lipid profile Dyslipidemia Acute myocardial infarction Secondary prevention Lipid lowering therapy

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Nano-Patterning of Diffraction Gratings on Human Hair for Cosmetic Purposes

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第3期4卷 173-178页

作者： khawar abbas Drew F. Goettler Bruce C. Lamartine Zayd C. Leseman Los Alamos National Laboratory Los Alamos USA Mechanical Engineering Department University of New Mexico Albuquerque USA

A method is presented for nano-patterning a diffraction grating on human hair with a focused ion beam. Strands of brown hair are patterned with hyperbolas and Archimedean spirals whose pitches range from 540 nm to 1040 nm. Exposure of the hair strands to white light at various incident angles demonstrates that light of varying wavelengths is diffracted by the diffraction gratings. The diffraction causes the brown strands of hair to reflect light from the entire range of visible light.

关键词： Diffraction Hair Nanopatterning Focused Ion Beam Milling

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Vasculitis with renal involvement in essential mixed cryoglobulinemia:Case report and mini-review

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World Journal of Clinical Cases 2014年第5期2卷 160-166页

作者： Sabiha Anis khawar abbas Mohammad Mubarak Ejaz Ahmed Sajid Bhatti Rana Muzaffar Department of Immunology and Molecular Biology Dewan Farooq Medical ComplexSindh Institute of Urology and TransplantationKarachi 74200Pakistan Department of Histopathology Sindh Institute of Urology and TransplantationKarachi 74200Pakistan Department of Nephrology Sindh Institute of Urology and TransplantationKarachi 74200Pakistan

The discovery of a strong association between hepatitis C virus(HCV) infection and mixed cryoglobulinemia(MC) has led to an increasingly rare diagnosis of idiopathic essential MC(EMC).The incidence of EMC is high in regions where there is a comparatively low HCV infection burden and low in areas of high infection prevalence,including *** diagnosis of EMC requires an extensive laboratory investigation to exclude all possible causes of cryoglobulin *** addition,although cryoglobulin testing is simple,improper testing conditions will result in false negative ***,we present a 46-year-old female patient with a case of EMC with dermatological and renal manifestations,highlighting the importance of extensive investigation to reacha proper *** review the need for appropriate laboratory testing,which is often neglected in clinical practice and which can result in false negative *** review also emphasizes the significance of an extended testing repertoire necessary for better patient *** a strong association of MC with HCV infection and other causes that lead to cryoglobulin formation,EMC remains a separate *** diagnosis requires proper temperature regulation during sample handling,as well as characterization and quantification of the *** of rheumatoid factor activity and complement levels in the cryoglobulin test-panel promotes better patient management and *** guidelines should be developed and implemented for cryoglobulin detection and the diagnosis of cryoglobulinemic syndrome,which will reduce variability in inter-laboratory reporting.

关键词： Cryoglobulin characterization Cryoglobulin detection Essential mixed cryoglobulinemia Cryoglobulinemic glomerulonephritis Hepatitis C virus Renal manifestations

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Clinical applications of stem cell-derived exosomes

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Signal Transduction and Targeted Therapy 2024年第2期9卷 621-651页

作者： Fei Tan Xuran Li Zhao Wang Jiaojiao Li khawar Shahzad Jialin Zheng Department of ORL-HNS Shanghai Fourth People’s Hospitaland School of MedicineTongji UniversityShanghaiChina Plasma Medicine and Surgical Implants Center Tongji UniversityShanghaiChina The Royal College of Surgeons in Ireland DublinIreland The Royal College of Surgeons of England LondonUK Center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital affiliated to Tongji University School of MedicineShanghaiChina Shanghai Frontiers Science Center of Nanocatalytic Medicine Tongji UniversityShanghaiChina

Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery,it nevertheless comes with inescapable drawbacks that might limit its clinical *** to stem cells,stem cell-derived exosomes possess numerous advantages,such as non-immunogenicity,non-infusion toxicity,easy access,effortless preservation,and freedom from tumorigenic potential and ethical *** can inherit similar therapeutic effects from their parental cells such as embryonic stem cells and adult stem cells through vertical delivery of their pluripotency or *** a thorough search and meticulous dissection of relevant literature from the last five years,we present this comprehensive,up-to-date,specialty-specific and disease-oriented review to highlight the surgical application and potential of stem cell-derived *** derived from stem cells(e.g.,embryonic,induced pluripotent,hematopoietic,mesenchymal,neural,and endothelial stem cells)are capable of treating numerous diseases encountered in orthopedic surgery,neurosurgery,plastic surgery,general surgery,cardiothoracic surgery,urology,head and neck surgery,ophthalmology,and obstetrics and *** diverse therapeutic effects of stem cells-derived exosomes are a hierarchical translation through tissue-specific responses,and cell-specific molecular signaling *** this review,we highlight stem cell-derived exosomes as a viable and potent alternative to stem cell-based therapy in managing various surgical *** recommend that future research combines wisdoms from surgeons,nanomedicine practitioners,and stem cell researchers in this relevant and intriguing research area.

关键词： viable stem capable

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Unlocking epigenetics for precision treatment of Ewing’s sarcoma

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Chinese Journal of Cancer Research 2024年第3期36卷 322-340页

作者： Zhehao Fan Shuangshuang Dong Ning Wang Muhammad Babar khawar Jingcheng Wang Haibo Sun Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225001China Jiangsu Key Laboratory of Experimental&Translational Non-Coding RNA Research Yangzhou 225001China Department of Pathology Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical CollegeYangzhou UniversityYangzhou 225001China Department of Orthopedics Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhou 225001China

Ewing’s sarcoma(EWS)is a highly aggressive malignant bone tumor primarily affecting adolescents and young *** the efficacy of chemoradiotherapy in some cases,the cure rate for patients with metastatic and recurrent disease remains ***,there is an urgent need for innovative therapeutic approaches to address the challenges associated with EWS *** regulation,a crucial factor in physiological processes,plays a significant role in controlling cell proliferation,maintaining gene integrity,and regulating *** studies highlight the importance of abnormal epigenetic regulation in the initiation and progression of EWS.A comprehensive understanding of the intricate interactions between EWS and aberrant epigenetic regulation is essential for advancing clinical drug *** review aims to provide a comprehensive overview of both epigenetic targets implicated in EWS,integrating various therapeutic modalities to offer innovative perspectives for the clinical diagnosis and treatment of EWS.

关键词： Ewing’s sarcoma epigenetic targets drug resistance drug development

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Unraveling the complex landscape of endocrine resistance in breast cancer: Emerging role of long noncoding RNA AGPG and beyond

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中华医学杂志(英文版) 2024年第16期137卷 2024 Jul 19页

作者： khawar Muhammad Babar Yu Shiyi Afzal Ali Sun Haibo Institute of Translational Medicine Medical College Yangzhou University Yangzhou Jiangsu China Jiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research Yangzhou University Yangzhou Jiangsu China Applied Molecular Biology and Biomedicine Lab Department of Zoology University of Narowal Narowal Pakistan Molecular Medicine and Cancer Therapeutics Lab Department of Zoology Faculty of Sciences Technology University of Central Punjab Lahore Pakistan

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Circulating tumor DNA and its role in detection, prognosis and therapeutics of hepatocellular carcinoma

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Chinese Journal of Cancer Research 2024年第2期36卷 195-214页

作者： Sana Rashid Yingchuan Sun Umair Ali Khan Saddozai Sikandar Hayyat Muhammad Usman Munir Muhammad Usman Akbar Muhammad Babar khawar Zhiguang Ren Xinying Ji Malik Ihsan Ullah Khan Institute of Molecular Biology and Biotechnology University of LahoreLahore 54590Pakistan Department of Internal Oncology(Section Ⅰ) Xuchang Municipal Central HospitalXuchang 461000China Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225001China Australian Institute for Bioengineering&Nanotechnology the University of QueenslandBrisbane 4072Australia Gomal Center of Biochemistry and Biotechnology Gomal UniversityDera Ismail Khan 29111Pakistan Applied Molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowal Punjab 51600Pakistan Kaifeng Municipal Key Laboratory for Infection and Biosafety Henan International Joint Laboratory of Nuclear Protein RegulationSchool of Basic Medical SciencesHenan UniversityKaifeng 475004China Faculty of Basic Medical Subjects Shu-Qing Medical College of ZhengzhouZhengzhou 450064China Department of Medicine Huaxian County People's HospitalHuaxian 456400China

Hepatocellular carcinoma(HCC) is considered the fifth most prevalent cancer among all types of cancers and has the third most morbidity value. It has the most frequent duplication time and a high recurrence rate. Recently, the most unique technique used is liquid biopsies, which carry many markers;the most prominent is circulating tumor DNA(ctDNA). Varied methods are used to investigate ctDNA, including various forms of polymerase chain reaction(PCR) [emulsion PCR(ePCR), digital PCR(dPCR), and bead, emulsion, amplification, magnetic(BEAMing) PCR]. Hence ctDNA is being recognized as a potential biomarker that permits early cancer detection,treatment monitoring, and predictive data on tumor burden are subjective to therapy or surgery. Numerous ctDNA biomarkers have been investigated based on their alterations such as 1) single nucleotide variations(either insertion or deletion of a nucleotide) markers including TP53, KRAS, and CCND1;2) copy number variations which include markers such as CDK6, EFGR, MYC and BRAF;3) DNA methylation(RASSF1A, SEPT9, KMT2C and CCNA2);4) homozygous mutation includes ctDNA markers as CDKN2A, AXIN1;and 5) gain or loss of function of the genes, particularly for HCC. Various researchers have conducted many studies and gotten fruitful ***, there are some drawbacks to ctDNA namely low quantity, fragment heterogeneity, less stability, limited mutant copies and standards, and differential sensitivity. However, plenty of investigations demonstrate ctDNA's significance as a polyvalent biomarker for cancer and can be viewed as a future diagnostic, prognostic and therapeutic agent. This article overviews many conditions in genetic changes linked to the onset and development of HCC, such as dysregulated signaling pathways, somatic mutations, single-nucleotide polymorphisms, and genomic instability. Additionally, efforts are also made to develop treatments for HCC that are molecularly targeted and to unravel some of the genetic pathways that f

关键词： Hepatocellular carcinoma circulating tumor DNA biomarkers single nucleotide variations diagnosis prognosis

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老年肠上皮持续性内质网应激损伤肠黏膜屏障的机制研究

老年肠上皮持续性内质网应激损伤肠黏膜屏障的机制研究

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中国解剖学会2019年年会

作者：陈虹刘晓卉马健 Muhammad.khawar.abbas 刘强杨姝周德山首都医科大学基础医学院人体解剖与组织胚胎学学系

＜正＞随年龄的增加,肠黏膜屏障功能逐渐减退,是导致细菌移位、慢性肠道感染甚至肿瘤等的重要原因;因此维持肠黏膜屏障的功能是"健康老龄化"的关键环节。本研究前期发现:肠上皮受体酪氨酸激酶KIT信号在维持肠黏膜屏障结构上发挥重要作用...

＜正＞随年龄的增加,肠黏膜屏障功能逐渐减退,是导致细菌移位、慢性肠道感染甚至肿瘤等的重要原因;因此维持肠黏膜屏障的功能是"健康老龄化"的关键环节。本研究前期发现:肠上皮受体酪氨酸激酶KIT信号在维持肠黏膜屏障结构上发挥重要作用,并随年龄增加KIT的表达明显减少,但其具体调控机制尚不完全清楚。衰老作为一种持续性的应激原,极有可能诱发慢性内质网应激（ERS）和未折叠蛋白反应（UPR）,被

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Reducing Dataset Specificity for Deepfakes Using Ensemble Learning

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Computers, Materials & Continua 2023年第2期74卷 4261-4276页

作者： Qaiser abbas Turki Alghamdi Yazed Alsaawy Tahir Alyas Ali Alzahrani khawar Iqbal Malik Saira Bibi Faculty of Computer and Information Systems Islamic University Madinah Madinah42351Saudi Arabia Department of Computer Science Lahore Garrison UniversityLahore54000Pakistan The University of Lahore Sargodha40100Pakistan University of Sargodha Department of Computer Science&ITSargodha40100Pakistan

The emergence of deep fake videos in recent years has made image falsification a real danger.A person’s face and emotions are deep-faked in a video or speech and are substituted with a different face or voice employing deep learning to analyze speech or emotional *** of how clever these videos are frequently,Manipulation is challenging to *** media are the most frequent and dangerous targets since they are weak outlets that are open to extortion or slander a *** earlier times,it was not so easy to alter the videos,which required expertise in the domain and ***,the generation of fake videos has become easier and with a high level of realism in the *** are forgeries and altered visual data that appear in still photos or video *** automatic identification systems have been developed to solve this issue,however they are constrained to certain datasets and performpoorly when applied to different *** study aims to develop an ensemble learning model utilizing a convolutional neural network(CNN)to handle deepfakes or *** employed ensemble learning,a technique combining many classifiers to achieve higher prediction performance than a single classifier,boosting themodel’s *** performance of the generated model is evaluated on Face *** work is about building a new powerful model for automatically identifying deep fake videos with the DeepFake-Detection-Challenges(DFDC)*** test our model using the DFDC,one of the most difficult datasets and get an accuracy of 96%.

关键词： Deep machine learning deep fake CNN DFDC ensemble learning

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Rare earth elements in tropical surface water,soil and sediments of the Terengganu River Basin,Malaysia

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Journal of Rare Earths 2009年第6期27卷 1072-1078页

作者： khawar Sultan Noor Azhar Shazili Institute of Oceanography University Malaysia TerengganuMengabang Telipot21030 Kuala TerengganuTerengganuMalaysia

The 14 stable rare earth element(REE) concentrations and distribution patterns were investigated for surface waters(n=51),soils(n=52) and sediments(n=42) from the tropical Terengganu River basin,*** chondrite normalized REE patterns of soils developed on four geological units showed enrichment of LREE,a pronounced negative Eu,and depletion of HREE with an enrichment order granite>>metasedimentary>alluvium>*** REE patterns in sediments reflected the soil REE patterns with an ove...

关键词： rare earth elements river/lake water soil sediment Malaysia

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