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Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways

World Journal of Gastroenterology 2020年第24期26卷 3365-3400页

作者： Aida Kamalian Masoud Sohrabi Asl Mahsa Dolatshahi khashayar afshari Shiva Shamshiri Nazanin Momeni Roudsari Saeideh Momtaz Roja Rahimi Mohammad Abdollahi Amir Hossein Abdolghaffari Department of Medicine Tehran University of Medical SciencesTehran ***Iran Students'Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Department of Traditional Pharmacy School of Persian MedicineTehran University of Medical SciencesTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehran ***Iran Medicinal Plants Research Center Institute of Medicinal PlantsACECRTehran ***Iran Toxicology and Diseases Group(TDG) Pharmaceutical Sciences Research Center(PSRC)The Institute of Pharmaceutical Sciences(TIPS)and Department of Toxicology and PharmacologySchool of PharmacyTehran University of Medical SciencesTehran ***Iran Gastrointestinal Pharmacology Interest Group Universal Scientific Education and Research NetworkTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran

Inflammatory bowel disease(IBD)refers to a group of disorders characterized by chronic inflammation of the gastrointestinal(GI)*** elevated levels of nitric oxide(NO)in serum and affected tissues;mainly synthesized by the inducible nitric oxide synthase(iNOS)enzyme;can exacerbate GI inflammation and is one of the major biomarkers of GI *** natural and synthetic agents are able to ameliorate GI inflammation and decrease iNOS expression to the extent comparable with some IBD ***,the purpose of this study was to gather a list of natural or synthetic mediators capable of modulating IBD through the NO *** databases including Google Scholar and PubMed were searched from 1980 to May *** found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factorκB(NF-κB)and JAK/STAT signaling *** and probiotics can also alter the GI microbiota and reduce NO expression in IBD models through a broad array of mechanisms.A number of synthetic molecules have been found to suppress NO expression either dependent on the NF-κB signaling pathway(i.e.,dexamethasone,pioglitazone,tropisetron)or independent from this pathway(i.e.,nicotine,prednisolone,celecoxib,β-adrenoceptor antagonists).Co-administration of natural and synthetic agents can affect the tissue level of NO and may improve IBD symptoms mainly by modulating the Toll like receptor-4 and NF-κB signaling pathways.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Nitric oxide Nuclear factor-κB Natural or synthetic mediators

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On Zero Dynamics and Controllable Cyber-Attacks in Cyber-Physical Systems and Dynamic Coding Schemes as Their Countermeasures

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IEEE/CAA Journal of Automatica Sinica 2024年第11期11卷 2191-2203页

作者： Mahdi Taheri khashayar Khorasani Nader Meskin the Department of Electrical and Computer Engineering Concordia University the Department of Electrical Engineering Qatar University

In this paper, we study stealthy cyber-attacks on actuators of cyber-physical systems(CPS), namely zero dynamics and controllable attacks. In particular, under certain assumptions, we investigate and propose conditions under which one can execute zero dynamics and controllable attacks in the CPS. The above conditions are derived based on the Markov parameters of the CPS and elements of the system observability matrix. Consequently, in addition to outlining the number of required actuators to be attacked, these conditions provide one with the minimum system knowledge needed to perform zero dynamics and controllable cyber-attacks. As a countermeasure against the above stealthy cyber-attacks, we develop a dynamic coding scheme that increases the minimum number of the CPS required actuators to carry out zero dynamics and controllable cyber-attacks to its maximum possible value. It is shown that if at least one secure input channel exists, the proposed dynamic coding scheme can prevent adversaries from executing the zero dynamics and controllable attacks even if they have complete knowledge of the coding system. Finally, two illustrative numerical case studies are provided to demonstrate the effectiveness and capabilities of our derived conditions and proposed methodologies.

关键词： Controllable attacks cyber-physical systems (CPS) dynamic coding zero dynamics attacks stealthy cyber-attacks

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Effect of ultrasonic and mechanical vibration treatments on evolution of Mn-rich phases and mechanical properties of Al−12Si−4Cu−1Ni−1Mg−2Mn piston alloys

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2393-2414页

作者： Bo LIN Xiang-xiang HE Song-chao XIA Hua-qiang XIAO Yu-liang ZHAO khashayar KHANLARI School of Mechanical Engineering Guizhou UniversityGuiyang 550025China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China Centro Nacional de Investigaciones Metalúrgicas(CENIM) C.S.I.C.Avda.de Gregorio del Amo 8Madrid 28040Spain Department of Chemical&Biotechnological Engineering Universitéde SherbrookeQuébecQC J1K 2R1Canada

Effects of ultrasonic vibration(UV)and mechanical vibration(MV)on the Mn-rich phase modification and mechanical properties of Al−12Si−4Cu−1Ni−1Mg−2Mn piston alloys were *** results show that the UV and UV+MV treatments can significantly refine and fragmentize the *** addition,UV treatment can significantly passivate the primary Mn-rich Al15Mn3Si2 *** formation mechanisms of refinement and passivation of the grains and non-dendrite particles were *** with the gravity die-cast alloys,the UV and UV+MV treated alloys exhibit improved tensile and creep resistance at room and elevated *** results can be attributed to the refinement of theα(Al)grains and the secondary intermetallics,the increased proportion of refined heat-resistant precipitates,and the formation of nano-sized Si *** ultimate tensile strength of the UV treated alloys at 350℃ exceeds that of commercial piston *** indicates the high application potential of the developed piston alloys in density diesel engines.

关键词： Al−Si piston alloys Mn-rich phases mechanical properties ultrasonic vibration mechanical vibration

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Experimental investigation on freeze-thaw durability of polymer concrete

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Frontiers of Structural and Civil Engineering 2021年第4期15卷 1038-1046页

作者： khashayar JAFARI Fatemeh HEIDARNEZHAD Omid MOAMMER Majid JARRAH Department of Civil and Environmental Engineering Pennsylvania State UniversityUniversity ParkPA16802USA Department of Civil Engineering Sharif University of TechnologyTehranIran Department of Civil and Environmental Engineering Washington State UniversityPullmanWA99164USA

Assessing the durability of concrete is of prime importance to provide an adequate service life and reduce the repairing cost of ***-thaw is one such test that indicates the ability of concrete to last a long time without a significant loss in its *** this study,the freeze-thaw resistance of polymer concrete containing different polymer contents was explored and compared to various conventional cement ***’fresh and hardened properties were assessed for their workability,air content,and compressive *** mass loss,length change,dynamic modulus of elasticity,and residual compressive strength were determined for all types of concretes subjected to freeze-thaw cycles according to ASTM C666-procedure *** showed that polymer concrete(PC)specimens prepared with higher dosages of polymer contents possessed better freeze-thaw durability compared to other *** high durability performance of PCs is mainly due to their impermeable microstructures,absence of water in their structure,and the high bond strength between aggregates and a polymer *** is also indicated that the performance of high-strength concrete containing air-entraining admixture is comparable with PC having optimum polymer content in terms of residual compressive strength,dynamic modulus of elasticity,mass loss,and length change.

关键词： durability test freeze-thaw resistance polymer concrete residual compressive strength ASTM C666-15

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Effects of the number of particles and coordination number on viscous-flow agglomerate sintering

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Particuology 2019年第2期17卷 76-83页

作者： Mohammadmahdi Kamyabi khashayar Saleh Rahmat Sotudeh-Gharebagh Reza Zarghami Multiphase Systems Research Laboratory School of Chemical Engineering College of Engineering University of Tehran Tehran 11155/4563 Iran Sorbonne University/Compiegne University of Technology EA 4297 Transformations Integrees de la Matiere renouvelable France

The process of sinteri ng of several particles in con tact via a viscous flow mecha nism was studied numerically using computational fluid dynamics. The volume of fluid technique within a finite volume method was used to simulate bridge formation between particles, as well as densification at different configurational states of the particles. The method was validated by comparing results for two-particle coalescence with the *** effect of the numberof particles on agglomerati on kin etics was studied by comparing bridge growth rate for systems having different numbers of particles in a chain. Although increasing the number of particles led to a decrease in the local bridge growth rate and to slower equilibration, there were no marked differences, when the overall volume of the system was considered. The effect of coordination number on the densification rate was directly studied by changing the number of particles in contact with a central *** the coordination nurnbec caused the overall rate of densificatio n to in crease, but delayed equilibration, analogous to steric effects. These findi ngs describe the con figurational state of agglomerates, typical of mesoscale caking. In a multi-scale study, they can be used to characterize caking at a bulk scale to partly address the lack of experimental data in this field.

关键词： Caking Agglomeration Sintering Viscous flow mechanism Volume of fluid Coordination number

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A creative method to tune Fe–O interaction in ferrites

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先进陶瓷(英文) 2023年第8期12卷 1612-1624页

作者： Farshad Farshidfar Arash Fattahi Ralf Brüning Dominic H.Ryan khashayar Ghandi Department of Chemistry University of GuelphGuelph N1G 2W1Canada Physics Department Mount Allison UniversitySackville E4L 1E6Canada Physics Department McGill UniversityMontreal H3A 2T8Canada

To be able to regulate the anionic oxygen position in ferrites,an original compositing method is developed by introducing a porous p-type phase in the n-type matrix of ferrite spinel semiconductors.A result of this method is the synergetic effect of the enhanced mass and charge transport that impacted the morphology and anionic oxygen position within the MgFe_(2)O_(4) *** hypothesis is that fine tuning of the anionic oxygen position in ferrites allows us to regulate their physicochemical properties significantly,with the implications for diverse *** electron exchange interaction(J)between O-centered and octahedral-occupying iron(Fe)-centered orbitals affected both the electrical and magnetic properties of the matrix significantly,supporting our *** three-dimensional variable range electron hopping is one such effect.

关键词： Fe_(2)O_(4) spinel structural distortion electron hopping

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Minimizing torque ripple in a brushless DC motor with fuzzy logic: applied to control rod driving mechanism of MNSR

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Nuclear Science and Techniques 2015年第1期26卷 50-56页

作者： Mohammad Divandari Mehdi Hashemi-Tilehnoee Bahram Asgari-Ziarati Mohammadreza Hosseinkhah khashayar Sabagh Department of Electrical Engineering Aliabad Katoul branchIslamic Azad University Department of Mechanical Engineering Babol Noshirvani University of Technology

A permanent magnet BLDC(brushless direct current) motor is used to move the control rod of a miniature neutron source reactor(MNSR). The BLDC motor drive is modeled using MATLAB/SIMULINK. Two main parts of the modeling are the inverter switching and the current control. Current control with chopping used to minimize the torque ripple of the MNSR control rod drive. Fuzzy logic current control together with soft chopping control shows the best response of all the three strategies. The prototype drive mechanism has an ATmega32 controller and power MOSFET switches. The simulation results are compared with experimental drive mechanism.

关键词：永磁无刷直流电机控制棒驱动机构微型反应堆模糊逻辑最小化转矩波动机用 Simulink模型

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Additive manufacturing of a Co-Cr-W alloy by selective laser melting:In-situ oxidation,precipitation and the corresponding strengthening effects

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Journal of Materials Science & Technology 2022年第30期125卷 171-181页

作者： Kefeng Li Zhi Wang Kaikai Song khashayar Khanlari Xu-Sheng Yang Qi Shi Xin Liu Xinhua Mao Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China National Engineering Research Center of Powder Metallurgy of Titanium and Rare Metals Guangzhou 510650China Guangdong Key Laboratory for Advanced Metallic Materials Processing South China University of TechnologyGuangzhou 510641China School of Mechanical Electrical and Information EngineeringShandong UniversityWeihai 264209China Advanced Manufacturing Technology Research Center Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000China

Additive manufacturing exhibits great potentials for the fabrication of novel materials due to its unique non-equilibrium solidification and heating *** this work,a novel nano-oxides dispersion strengthened Co28 Cr9 W1.5 Si(wt.%)alloy,fabricated by laser powder bed fusion(LPBF),was comprehensively *** the layer-by-layer featured process,in-situ formation of Si rich,amorphous,nano-oxide inclusions was observed,whose formation is ascribed to the high affinity of Si to ***,distinctive body-centered cubic(BCC)Co5 Cr3 Si2 nano-precipitates with an 8-fold symmetry were also confirmed to *** precipitates,rarely reported in previous studied Co-Cr alloys,were found to tightly bond with the in-situ ***,the morphologies,the size distributions as well as the microstructure of the interface between the matrix and the inclusions were investigated in detail and their influence on the tensile deformation was also *** existence of transition boundaries between these inclusions and the matrix strongly blocked the movement of dislocations,thereby increasing the strength of the *** was understood that when the plastic deformation proceeds,the fracture occurs in the vicinity of the oxide inclusions where dislocations accumulate.A quantitative analysis of the strengthening mechanism was also established,in which an additional important contribution to strength(~169 MPa)caused by the effects of in-situ formed oxide inclusions was calculated.

关键词： Co-Cr-W-Si alloy Selective laser melting Oxide inclusion Precipitation Strengthening mechanisms

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Efficient keyword search over graph-structured data based on minimal covered r-cliques

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Frontiers of Information Technology & Electronic Engineering 2020年第3期21卷 448-465页

作者： Asieh GHANBARPOUR khashayar NIKNAFS Hassan NADERI School of Computer Engineering Iran University of Science and TechnologyTehran 13114-16846Iran Department of Computer Engineering University of Sistan and BaluchestanZahedan 98167-45845Iran

Keyword search is an alternative for structured languages in querying graph-structured data.A result to a keyword query is a connected structure covering all or part of the queried *** textual coverage and structural compactness have been known as the two main properties of a relevant result to a keyword *** previous works examined these properties after retrieving all of the candidate results using a ranking function in a comparative ***,this needs a time-consuming search process,which is not appropriate for an interactive system in which the user expects results in the least possible *** problem has been addressed in recent works by confining the shape of results to examine their coverage and compactness during the ***,these methods still suffer from the existence of redundant nodes in the retrieved *** this paper,we introduce the semantic of minimal covered r-clique(MCCr)for the results of a keyword query as an extended model of existing *** propose some efficient algorithms to detect the MCCrs of a given *** algorithms can retrieve a comprehensive set of non-duplicate MCCrs in response to a keyword *** addition,these algorithms can be executed in a distributive manner,which makes them outstanding in the field of keyword *** also propose the approximate versions of these algorithms to retrieve the top-k approximate MCCrs in a polynomial *** is proved that the approximate algorithms can retrieve results in *** experiments on two real-world datasets confirm the efficiency and effectiveness of the proposed algorithms.

关键词： Keyword search Graph mining Information retrieval Database Clique

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DNA methylome study of human cerebellar tissues identified genes and pathways possibly involved in essential tremor

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Precision Clinical Medicine 2019年第4期2卷 221-234页

作者： Jennifer L.Paul khashayar Dashtipour Zhong Chen Charles Wang Center for Genomics School of MedicineLoma Linda UniversityLoma LindaCA 92350USA Division of Movement Disorders Department of NeurologyLoma Linda University Medical CenterLoma LindaCA 92350USA Department of Basic Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92350USA

Background:Essential tremor(ET)is a neurological syndrome of unknown origin with poorly understood etiology and *** is suggested that the cerebellum and its tracts may be involved in the pathophysiology of *** methylome interrogation of cerebellar tissue may help shine some light on the understanding of the mechanism of the development of *** study used postmortem human cerebellum tissue samples collected from 12 ET patients and 11 matched non-ET controls for DNA methylome study to identify differentially methylated genes in ***:Using Nugen’s Ovation reduced representation bisulfite sequencing(RRBS),we identified 753 genes encompassing 938 CpG sites with significant differences in DNA methylation between the ET and the control *** genes were further analyzed with Ingenuity Pathway Analysis(IPA)by which we identified certain significant pathways,upstream regulators,diseases and functions,and networks associated with ***:Our study provides evidence that there are significant differences in DNA methylation patterns between the ET and control samples,suggesting that the methylation alteration of certain genes in the cerebellum may be associated with ET *** identified genes allude to the GABAergic hypothesis which supports the notation that ET is a neurodegenerative disease,particularly involving the cerebellum.

关键词： DNA methylome reduced representation bisulfite sequencing essential tremor cerebellum epigenetics CpGs

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