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metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： mohammad m khan Zaw Ali khan mohsin Ali khan Laboratory of Translational Neurology and molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term.u.e has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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Symmetries,optimal system,exact and soliton solutions of(3+1)-dimensional Gardner-KP equation

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Journal of Ocean Engineering and Science 2024年第2期9卷 178-190页

作者： Amjad Hussain Ashreen Anjum m.Junaid-u-Rehman Ilyas khan mariam A.Sameh Amnah S.Al-Johani Department of mathematics Quaid-I-Azam University 45320Islamabad 44000Pakistan Department of mathematics College of Science Al-ZulfiMajmaah UniversityAl-MajmaahP.O Box 66Majmaah 11952Saudi Arabia Electrical Engineering Department Faculty of Engineering and TechnologyFuture University in EgyptNew Cairo 11845Egypt mathematics Department Faculty of ScienceUniversity of TabukTabukSaudi Arabia

In this research article,the(3+1)-dimensional nonlinear Gardner-Kadomtsov-Petviashvili(Gardner-KP)equation which depicts the nonlinear modulation of periodic waves,is analyzed through the Lie group-theoretic *** the Lie invariance condition,we find the symmetry *** pro-posed model yields eight-dimensional Lie ***,an optimal system of sub-algebras is com-puted,and similarity reductions are *** considered nonlinear partial differential equation is re-duced into ordinary differential equations(ODEs)by utilizing the similarity transformation method(STm),which has the benefit of yielding a large number of accurate traveling wave *** ODEs are further solved to get closed-form solutions of the Gardner-KP equation in some cases,while in other cases,we use the new auxiliary equation method to get its soliton *** evolution profiles of the obtained solutions are examined graphically under the appropriate selection of arbitrary parameters.

关键词： Gardner-KP equation Lie symmetry analysis Optimal system New auxiliary equation method Solitary wave solutions

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Cervical Cancer Prediction Empowered with Federated machine Learning

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Com.u.ers, materials & Continua 2024年第4期79卷 963-981页

作者： muhammad umar Nasir Omar Kassem Khalil Karamath Ateeq Bassam SaleemAllah Almogadwy m.A.khan khan muhammad Adnan Department of Com.u.er Sciences Bahria University Lahore CampusLahore54000Pakistan Faculty of Information Technology Liwa CollegeAbu Dhabi20009UAE Department of Com.u.ing Skyline University CollegeSharjah999041UAE Department of Com.u.er Science Taibah UniversityMedina42315Saudi Arabia Riphah School of Com.u.ing and Innovation Faculty of ComputingRiphah International UniversityLahore54000Pakistan Department of Software Faculty of Artificial Intelligence and SoftwareGachon UniversitySeongnam13120Korea

Cervical cancer is an intrusive cancer that imitates various women around the world. Cervical cancer ranks in thefourth position because of the leading death cause in its premature stages. The cervix which is the lower end of thevagina that connects the uterus and vagina forms a cancerous tumor very slowly. This pre-mature cancerous tumorin the cervix is deadly if it cannot be detected in the early stages. So, in this delineated study, the proposed approachuses federated machine learning with numerous machine learning solvers for the prediction of cervical cancer totrain the weights with varying neurons empowered fuzzed techniques to align the neurons, Internet of medicalThings (IomT) to fetch data and blockchain technology for data privacy and models protection from hazardousattacks. The proposed approach achieves the highest cervical cancer prediction accuracy of 99.26% and a 0.74%misprediction rate. So, the proposed approach shows the best prediction results of cervical cancer in its early stageswith the help of patient clinical records, and all medical professionals will get beneficial diagnosing approachesfrom this study and detect cervical cancer in its early stages which reduce the overall death ratio of women due tocervical cancer.

关键词： Cervical cancer federated machine learning neurons blockchain technology

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Acceleration of solar wind particles due to inertial Alfvén waves

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Com.u.ications in Theoretical Physics 2024年第6期76卷 137-141页

作者： Kiran Batool Imran A khan m Shamir Abdul Kabir S Ayaz Theoretical Physics Department National Centre for PhysicsIslamabad 44000Pakistan Department of Space Sciences Institute of Space TechnologyIslamabad 44000Pakistan Space and Astrophysics Research Lab(SARL) National Center of GIS and Space Applications(NCGSA)Islamabad 44000Pakistan Salam Chair Department of PhysicsGC University LahoreKatchery RoadLahorePunjab 54000Pakistan Department of Space Science and CSPAR University of Alabama in HuntsvilleHuntsvilleAL 35899United States of America

Gaining an understanding of the effects and dynamics of the solar wind is crucial for the study of space weather,Earth's magnetosphere,spacecraft protection,the dynamics of the Solar System,and various other *** show that Alfvén waves effectively transfer energy to resonant *** study demonstrates how inertial Alfvén waves deliver their energy to resonant plasma particles in different solar environments under certain *** analysis shows that inertial Alfvén waves experience more rapid damping with increasing parallel wavenumber,ambient magnetic field strength,and particle number density,coupled with a decrease in *** rate of energy transfer to resonant particles intensifies with higher temperatures and reduced parallel wavenumber and particle number *** with higher initial velocities actively participate in Landau damping,especially in regions with a stronger ambient magnetic field.

关键词： solar wind inertial Alfven waves resonant particles

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Enhancement of coercivity,permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory and high frequency devices

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Journal of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.Sardar m.D.Hossain m.S.Sikder m.N.I.khan m.R.Rahman Physics Discipline Khulna UniversityKhulna9208Bangladesh Department of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh Department ofCom.u.er Science and Engineering Northern University of Business&Technology KhulnaKhulna9100Bangladesh material Science Division Atomic Energy CentreDhaka1000Bangladesh

Spinel cubic ferrites have huge applications in me mory and high frequency *** the improvement of these modern devices,the magnetic coercivity,permeability,and dielectric properties of a ferrite are the important *** article focuses on improving the magnetic coercivity,magnetic permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,and *** X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FESEm),energy dispersive X-ray(EDX),vibrating sample magnetometer(VSm),and an impedance analyzer were used to characterize the structural,magnetic,and dielectric properties of the *** XRD patterns indicate the formation of spinel cubic structure of the samples with a secondary peak(EuFeO_(3))for Eu doped *** densities and porosities of the samples follow an inverse trend,where the doped samples’lattice parameters are increased with the increment of rare earth Eu *** FTIR analysis also proves the spinel cubic phase of the *** average grain size of the ferrites is obtained via FESEm images,and it is increased from 121 to 198 *** analysis confirms that doping of the Eu content also changes other hysteresis loop properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped samples is greater than that of the mother alloy(x=0.00).The EDX study shows that there is no im.u.ity contamination in the *** permeability and dielectric measurements show an improved quality factor of the Eu-doped samples with low magnetic and dielectric *** dependent resistivity and impedance analysis also show the improved *** the observed properties of the samples,all the investigated ferrites might be strong candidates for potential applications in memory devices,magnetic sensors,and high frequency applications.

关键词： Ferrites Raree arths Coercivity Permeability EDX Resistivity

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Dust particle surface potential in an argonhelium plasma using the(r,q)-distribution function

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Com.u.ications in Theoretical Physics 2024年第9期76卷 143-150页

作者： Bahaaudin m Raffah A A Abid Abdullah khan Amin Esmaeili Yas Al-Hadeethi m N S Qureshi Department of Physics Faculty of Sciences King Abdulaziz University Lithography in Devices Fabrication and Development Research Group Deanship of Scientific ResearchKing Abdulaziz University Joint Laboratory of Plasma Application Technology Institute of Advanced Technology University of Science and Technology of China CAS Key Laboratory of Geospace Environment University of Science and Technology of China Department of Physics Zhejiang Normal University Department of Physics Graduate School of Science Tokyo Metropolitan University Department of Physics GC University

In this paper, the dust particle surface potential for argon-helium plasma is evaluated analytically and numerically in the context of negatively charged dust particles by employing a power-law(r, q)-distribution function. Recent studies have reported the argon-helium plasma and conducted a brief theoretical and experimental survey. To deepen our understanding further, this study aims to analyze the argon-helium plasma comprehensively using the same pattern but with the(r, q)-distribution function. For this purpose, the current balance equations are derived for electron, helium and argon ions, when these charge species attain the quasineutrality *** numerically examined the currents of plasma species for a broad range of effective distribution function parameters r and q. It is revealed that the surface potential of dust particles is significantly affected by the parameters r and q, helium ion-to-electron temperature ratio,argon ion-to-electron temperature ratio, and helium ion to argon ion number density ratio. By incorporating the multi-ion(argon-helium) species, the significance of low-temperature nonmaxwellian dusty(complex) plasma is briefly examined.

关键词： dust charge potential dusty plasma helium argon plasma non-maxwellian distribution plasma physics q distribution function r

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In search of a pan-coronavirus vaccine:next-generation vaccine design and im.u.e mechanisms

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Cellular & molecular Im.u.ology 2024年第2期21卷 103-118页

作者： S.Cankat m.u.Demael L.Swadling Division of Infection and Im.u.ity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2,mERS-CoV and the four seasonal coronaviruses(HCoV-OC43,NL63,HKu1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation SARS-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral im.u.ity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of im.u.ity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive im.u.ity Cross-protection universal

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Base Pressure Control with Semi-Circular Ribs at Critical mach Number

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Fluid Dynamics & materials Processing 2024年第9期20卷 2007-2028页

作者： Ambareen khan Sher Afghan khan mohammed Nishat Akhtar Abdul Aabid muneer Baig School of Aerospace Engineering Universiti Sains MalaysiaPenang11600Malaysia Department of mechanical and Aerospace Engineering Faculty of EngineeringInternational Islamic University MalaysiaKuala Lumpur59000Malaysia Department of Engineering management College of EngineeringPrince Sultan UniversityP.O.Box 66833Riyadh11586Saudi Arabia

When better fuel-air mixing in the com.u.tion chamber or a reduction in base drag are required in vehicles,rockets,and aeroplanes,the base pressure control is *** the base pressure and drag is necessary in both *** this work,semi-circular ribs with varying diameters(2,4,and 6 mm)positioned at six distinct positions(0.5D,1D,1.5D,2D,3D,and 4D)inside a square duct with a side of 15 mm are proposed as an efficient way to apply the passive control ***-depth research is done on optimising rib size for various rib *** to this study,the base pressure rises as rib height ***,the optimal location for the semi-circular ribs with a diameter of 2 mm is at *** 1D location appears to be optimal for the 4 mm size as *** the 6 mm size,however,the 4D position fills this function.

关键词： Base pressure nozzle pressure ratio base drag sonic mach number passive control

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Smart Energy management System.u.ing machine Learning

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Com.u.ers, materials & Continua 2024年第1期78卷 959-973页

作者： Ali Sheraz Akram Sagheer Abbas muhammad Adnan khan Atifa Athar Taher m.Ghazal Hussam Al Hamadi School of Com.u.er Science National College of Business Administration&EconomicsLahore54000Pakistan Riphah School of Com.u.ing&Innovation Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Pattern Recognition and machine Learning Lab Department of SoftwareGachon UniversitySeongnamGyeonggido13120Korea Department of Com.u.er Science COMSATS University IslamabadLahore CampusLahore54000Pakistan School of Information Technology Skyline University CollegeSharjah1797United Arab Emirates Network and Com.u.ication Technology Lab Center for Cyber SecurityFaculty of Information Science and TechnologyUniversiti Kebangsaan MalaysiaBangiSelangor43600Malaysia College of Engineering and IT University of DubaiDubaiUnited Arab Emirates

Energy management is an inspiring domain in developing of renewable energy ***,the growth of decentralized energy production is revealing an increased complexity for power grid managers,inferring more quality and reliability to regulate electricity flows and less imbalance between electricity production and *** major objective of an energy management system is to achieve optimum energy procurement and utilization throughout the organization,minimize energy costs without affecting production,and minimize environmental *** energy management is an essential and complex subject because of the excessive consumption in residential buildings,which necessitates energy optimization and increased user *** address the issue of energy management,many researchers have developed various frameworks;while the objective of each framework was to sustain a balance between user comfort and energy consumption,this problem hasn’t been fully solved because of how difficult it is to solve *** inclusive and Intelligent Energy management System(IEmS)aims to provide overall energy efficiency regarding increased power generation,increase flexibility,increase renewable generation systems,improve energy consumption,reduce carbon dioxide emissions,improve stability,and reduce energy *** Learning(mL)is an emerging approach that may be beneficial to predict energy efficiency in a better way with the assistance of the Internet of Energy(IoE)*** IoE network is playing a vital role in the energy sector for collecting effective data and usage,resulting in smart resource *** this research work,an IEmS is proposed for Smart Cities(SC)using the mL technique to better resolve the energy management *** proposed system minimized the energy consumption with its intelligent nature and provided better outcomes than the previous approaches in terms of 92.11% accuracy,and 7.89% miss-rate.

关键词： Intelligent energy management system smart cities machine learning

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Twinning aspects and their efficient roles in wrought mg alloys:A comprehensive review

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Journal of magnesium and Alloys 2024年第6期12卷 2201-2230页

作者： S.S.A.Shah manping Liu Azim khan Farooq Ahmad m.R.Abdullah Xingquan Zhang Shiwei Xu Zhen Peng School of materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of mechanical Engineering Anhui University of TechnologyMáanshan 243002China College of mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China

Twinning is widely recognized as an effective and cost-efficient method for controlling the microstructure and properties of wrought magnesium(mg)***,twins play a crucial role in initiating dynamic recrystallization(DRX),while twin regions experience rapid recrystallization during static recrystallization(SRX).The activation of twinning can lead to changes in lattice orientation,significantly impacting the final texture in mg *** active roles of twinning are influenced by various factors during the activation process,and the mobility of twin boundaries(TB)can be amplified by stress effects,dislocation interactions,and thermal ***,annealing treatments that involve proper segregation or precipitation on TBs serve to stabilize them,restraining their *** such as segregation may also alter the twinning propensity in magnesium-rare earth(mg-RE)***{10-11}contraction twins(CT)and{10-11}-{10-12}double twins(DT)can promote dynamic recrystallization(DRX),they also pose a risk as potential sources of voids and ***,understanding the nucleation and growth mechanisms of twinning is crucial,and these aspects are briefly reviewed in this *** the factors mentioned above,this article summarizes the recent research progress in this field,shedding light on advancements in recent eras.©2024 Chongqing *** services provided by Elsevier *** behalf of KeAi Com.u.ications ***.

关键词： mg alloys Twinning Recrystallization Texture mechanical properties

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