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A fully inkjet-printed disposable glucose sensor on paper

npj Flexible Electronics 2018年第1期2卷 263-270页

作者： Eloïse Bihar Shofarul Wustoni Anna Maria Pappa khaled n.salama Derya Baran Sahika Inal Division of Biological and Environmental Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955Saudi Arabia Division of Physical Science and Engineering KAUST Solar CenterKAUSTThuwal 23955Saudi Arabia Department of Chemical Engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCambridge CB30ASUK Division of Computer Electrical and Mathematical Sciences and EngineeringAdvanced Membranes and Porous Materials CenterKAUSTThuwal 23955Saudi Arabia

Inexpensive and easy-to-use diagnostic tools for fast health screening are imperative,especially in the developing world,where portability and affordability are a *** monitoring of metabolite levels can provide useful information regarding key metabolic activities of the body and detect the concomitant irregularities such as in the case of diabetes,a worldwide chronic ***,the majority of daily glucose monitoring tools rely on piercing the skin to draw *** pain and discomfort associated with finger pricking have created a global need to develop non-invasive,portable glucose *** this work,we develop a disposable analytical device which can measure physiologically relevant glucose concentrations in human saliva based on enzymatic electrochemical *** use inkjet-printing technology for the rapid and low-cost deposition of all the components of this glucose sensor,from the electronics to the biorecognition elements,on commercially available paper *** only electronic component of the sensor is the conducting polymer poly(3,4 ethylenedioxythiophene)doped with polystyrene sulfonate(PEDOT:PSS),while the biorecognition element comprises of the enzyme glucose oxidase coupled with an electron *** demonstrate that one month after its fabrication and storage in air-free environment,the sensor maintains its function with only minor performance *** fully printed,all-polymer biosensor with its ease of fabrication,accuracy,sensitivity and compatibility with easy-to-obtain biofluids such as saliva aids in the development of next generation low-cost,noninvasive,eco-friendly,and disposable diagnostic tools.

关键词： maintain sensor printing

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A flexible capacitive photoreceptor for the biomimetic retina

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Light(Science & Applications) 2022年第1期11卷 38-49页

作者： Mani Teja Vijjapu Mohammed E.Fouda Agamyrat Agambayev Chun Hong Kang Chun-Ho Lin Boon S.Ooi Jr-Hau He Ahmed M.Eltawil khaled n.salama Sensors lab Advanced Membranes and Porous Materials CenterComputerElectrical and Mathematical Science and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Communication and Computing Systems Lab ComputerElectrical and Mathematical Science and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Department of Electrical Engineering and Computer Science University of California-IrvineIrvineCA 92612USA Department of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZUSA Computer Electrical and Mathematical Science and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Department of Materials Science and Engineering City University of Hong KongHong Kong SARChina

neuromorphic vision sensors have been extremely beneficial in developing energy-efficient intelligent systems for robotics and privacy-preserving security *** is a dire need for devices to mimic the retina's photoreceptors that encode the light illumination into a sequence of spikes to develop such ***,we develop a hybrid perovskite-based flexible photoreceptor whose capacitance changes proportionally to the light intensity mimicking the retina's rod cells,paving the way for developing an efficient artificial retina *** proposed device constitutes a hybrid nanocomposite of perovskites(methyl-ammonium lead bromide)and the ferroelectric terpolymer(polyvinylidene fluoride trifluoroethylene-chlorofluoroethylene).A metal-insulator-metal type capacitor with the prepared composite exhibits the unique and photosensitive capacitive behavior at various light intensities in the visible light *** proposed photoreceptor mimics the spectral sensitivity curve of human photopic *** hybrid nanocomposite is stable in ambient air for 129 weeks,with no observable degradation of the composite due to the encapsulation of hybrid perovskites in the hydrophobic *** functionality of the proposed photoreceptor to recognize handwritten digits(MnIST)dataset using an unsupervised trained spiking neural network with 72.05%recognition accuracy is *** demonstration proves the potential of the proposed sensor for neuromorphic vision applications.

关键词： perovskite illumination preserving

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Robust Fractional-Order Proportional-Integral Observer for Synchronization of Chaotic Fractional-Order Systems

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IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 268-277页

作者： Ibrahima n’Doye khaled nabil salama Taous-Meriem Laleg-Kirati IEEE Computer Electrical and Mathematical Sciences and Engineering Division (CEMSE)King Abdullah University of Science and Technology (KAUST)

In this paper, we propose a robust fractional-order proportional-integral(FOPI) observer for the synchronization of nonlinear fractional-order chaotic systems. The convergence of the observer is proved, and sufficient conditions are derived in terms of linear matrix inequalities(LMIs) approach by using an indirect Lyapunov method. The proposed FOPI observer is robust against Lipschitz additive nonlinear uncertainty. It is also compared to the fractional-order proportional(FOP) observer and its performance is illustrated through simulations done on the fractional-order chaotic Lorenz system.

关键词： Chaos synchronization fractional-order chaotic systems indirect Lyapunov approach linear matrix inequality(LMI) robust proportional-integral observer design

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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Taxonomic description of a new marine ciliate,Euplotes qingdaoensis n. sp.(Ciliophora:Euplotida)

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Chinese Journal of Oceanology and Limnology 2014年第2期32卷 426-432页

作者：陈相瑞马洪钢 khaled A.S.AL-RASHEID School of Marine Science Ningbo University Laboratory of Protozoology Institute of Evolution & Marine BiodiversityOcean University of China Zoology Department College of ScienceKing Saud University

The characteristics and infraciliature of a new euplotid ciliate, Euplotes qingdaoensis n. sp., discovered from the coastal waters of Jiaozhou Bay, northern China, were studied using live observation and silver impregnation. The new marine species is characterized by a slightly flattened body （90-110 um×70- 80 um, in vivo）, an adoral zone of 26-29 membranelles, 10 strong frontoventral and five transverse cirri, two caudal cirri, a single left marginal cirrus, seven dorsal kineties, a middle kinety with about 15 pairs of basal bodies, a silverline system of the double-eurystomus type, and a C-shaped macronucleus.

关键词： Euplotes infraciliature morphology new species taxonomy

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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Ab initio study of structural,electronic,thermo-elastic and optical properties of Pt3Zr intermetallic compound

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Chinese Physics B 2020年第4期29卷 405-414页

作者： Wahiba Metiri khaled Cheikh Departement de Physique Facultedes SciencesUniversite 20 aout 1955-Skikda BP 26Route El-Hadaiek21000 SkikdaAlgeria Departement de Technologie Facultede TechnologieUniversite 20 aout 1955-Skikda BP 26Route El-Hadaiek21000 SkikdaAlgeria

Structural,elastic,electronic and optical properties of the Pt3Zr intermetallic compound are investigated using first principles calculations based on the density functional theory(DFT)within the generalized gradient approximation(GGA)and the local density approximation(LDA).The Pt3Zr compound is predicted to be of cubic L12 and hexagonal D024 *** calculated equilibrium ground-state properties(lattice parameters a and c,bulk modulus B and its pressure derivative B',formation enthalpy ΔH)of the Pt3Zr compound,for both cubic and hexagonal phases,show good agreement with the experimental results and other theoretical *** constants(C11,C12,C13,C33,C44,and C55)are *** predicted elastic properties such as Young's modulus E and shear modulus GH,Poisson ratioν,anisotropic ratio A,Kleinman parameter ξ,Cauchy pressure(C12-C44),ratios B/C44 and B/G,and Vickers hardness Hv indicate the stiffness,hardness and ductility of the *** characteristic parameters such as Debye temperature θD and melting temperature Tm are *** properties such as density of states(DOS)and electronic specific heat γ are also *** calculated results reveal that the Fermi level is on the psedogap for the D024 structure and on the antibonding side for the L12 *** optical property functions(real partε1(ω)and imaginary part ε2(ω)of dielectric function),optical conductivity σ(ω),refraction index n(ω),reflectivity R(ω),absorption α(ω)and extinction coefficients k(ω)and loss function L(ω)are also investigated for the first time for Pt3Zr in a large gamme of energy from 0 to 70 eV.

关键词： density functional theory intermetallic density of states L12 D024 optical properties

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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