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Calculus bovis in hepatocellular carcinoma:Tumor molecular basis,Wnt/β-catenin pathway role,and protective mechanism

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World Journal of Gastroenterology 2024年第35期30卷 3959-3964页

作者： khaled mohamed mohamed Koriem Department of Medical Physiology Medical Research and Clinical Studies InstituteNational Research CentreGiza 12622Egypt

In this editorial,we comment on the recent article by Huang et *** editorial focuses specifically on the molecular mechanisms of hepatocellular carcinoma(HCC),mechanism of Wnt/β-catenin pathway in HCC,and protective mechanism of Calculus bovis(CB)in *** cancer is the fourth most common cause of cancer-related deaths *** most prevalent kind of primary liver cancer,HCC,is typically brought on by long-term viral infections(hepatitis B and C),non-alcoholic steatohepatitis,excessive alcohol consumption,and other conditions that can cause the liver to become chronically inflamed and *** is a wellknown traditional remedy in China and Japan and has been used extensively to treat a variety of diseases,such as high fever,convulsions,and *** in lipid metabolism,cholesterol metabolism,bile acid metabolism,alcohol metabolism,and xenobiotic detoxification lead to fatty liver disease and liver ***,which is a tricarboxylic acid cycle intermediate,is vital to energy production and mitochondrial *** is also thought to be a signaling molecule in metabolism and in the development and spread of liver *** Wnt/β-catenin pathway is made up of a group of proteins that are essential for both adult tissue homeostasis and embryonic *** is frequently caused by the dysregulation of the Wnt/β-catenin signaling *** HCC liver carcinogenesis,Wnt/β-catenin signaling is activated by the expression of downstream target *** between the liver and the gut exists via the portal vein,biliary tract,and systemic ***"gutliver axis"controls intestinal *** of the main factors contributing to the development,progression,and treatment resistance of HCC is the abnormal activation of the Wnt/β-Catenin signaling ***,understanding this pathway is essential to treating *** ingredients of CB,particularly oleanolic acid,ergosterol,and ursolic acid,have anti-p

关键词： Hepatocellular carcinoma MicroRNAs Wnt/β-catenin pathway Calculus bovis Apoptosis

Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19:A review

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World Journal of Gastroenterology 2021年第1期27卷 37-54页

作者： khaled mohamed mohamed Koriem Medical Physiology Department Medical Research DivisionNational Research CentreDokki 12622CairoEgypt

The term lipidome is mentioned to the total amount of the lipids inside the biological *** lipid enters the human gastrointestinal tract through external source and internal *** absorption pathway of lipids in the gastrointestinal tract has many ways;the 1st way,the lipid molecules are digested in the lumen before go through the enterocytes,digested products are re-esterified into complex lipid *** 2nd way,the intracellular lipids are accumulated into lipoproteins(chylomicrons)which transport lipids throughout the whole *** lipids are re-synthesis again inside the human body where the gastrointestinal lipids are:(1)Transferred into the endoplasmic reticulum;(2)Collected as lipoproteins such as chylomicrons;or(3)Stored as lipid droplets in the *** lipids play an important role in many stages of the viral replication *** specific lipid change occurs during viral infection in advanced viral replication *** are 47 lipids within 11 lipid classes were significantly disturbed after viral *** virus connects with blood-borne lipoproteins and apolipoprotein E to change viral *** viral interest is cholesterol-and lipid raft-dependent *** conclusion,lipidome is important in gastrointestinal fat absorption and coronavirus disease 2019(COVID-19)infection so lipidome is basic in gut metabolism and in COVID-19 infection success.

关键词： Lipidome Gastrointestinal tract Fat metabolism COVID-19 Viral infection Future therapy

Multiple sclerosis: New insights and trends

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 429-440页

作者： khaled mohamed mohamed Koriem Department of Medical Physiology Medical Research DivisionNational Research Centre

Multiple sclerosis(MS) is the most famous autoimmune disease attacking the central nervous system. It attacks people from age 20–50 years old and the females' attacks double than males' attacks. MS is an autoimmune disease affecting principally the central nervous system that cause nerve sheath demyelination followed by axon damage and paralysis. MS symptoms include muscle weakness, weak reflexes, muscle spasm, difficult in move, miss-coordination and unbalance with others. There are many factors may be responsible for MS: microbial, viral, smoking, stress, environmental toxins, contaminated diet, and gout. MS is wide spread in the populations in North Europe and this related to lack of vitamin D due to decrease of sunlight exposure. MS biomarkers include nitric oxide, interleukin-6, nitric oxide synthase, fetuin-A and osteopontin. MS is not a genetic disease where MS occurs when human leukocyte antigen system related genes are changed in chromosome 6. The physiology of MS is monitored by activation of immuneinflammatory, oxidative, and nitrosative stress pathways. MS is including two main steps:(1) myelin sheath destruction and formation of lesions and,(2) inflammation. Four types of MS can be distinguished: relapsing-remitting, primary progressive, secondary progressive and progressive relapsing. Nine treatments have been accepted for relapsingremitting MS type: interferon b-1a, interferon b-1b, mitoxantrone, natalizumab, glatiramer acetate, fingolimod, dimethyl fumarate, teriflunomide, and alemtuzumab, however,the only treatment used is mitoxantrone for progressive MS but many of MS treatments side effects are recorded. Complementary treatments also used in MS treatments such as:vitamin D, Yoga, medicinal plants, oxygen therapy, acupuncture and reflexology.

关键词： Multiple sclerosis Diagnosis Genetics Physiology Treatments

A lipidomic concept in infectious diseases

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 265-274页

作者： khaled mohamed mohamed Koriem Department of Medical Physiology Medical Research Division National Research CentreDokki Cairo Egypt

Infectious diseases resemble a great threat to the human health according to World Health Organization where about 17% of all deaths(z9.2 million deaths) in 2013 recorded are related to infectious diseases. The pathogenic microorganisms such as bacteria, viruses,fungi and parasites are the principle causes of infectious diseases. Ebola, AIDS, dengue,hepatitis, malaria, tuberculosis and schistosomiasis are among 216 infectious diseases found where the immunity represents the first line defense in infection. Lipidomic includes examination of different biological lipids in the biological cell. The lipidomic research covers all aspects of individual lipid molecule including its structure, function,connection with other cell constituents such as protein, lipid, and metabolite in both health and disease conditions. Details of cell biology obtained from different pathogens(viruses, bacteria, and parasites) provide a great data on molecular structure of hostpathogen relation and consequently on infection process. The lipids here play a very important role in many processes involved in host-pathogen relations. The role of lipid in host-pathogen link includes many processes in(1) structural host constituents,(2) host recognition,(3) intracellular transferring, and(4) energy and resource homeostasis during pathogen duplication. There are many lipid phosphatases, kinases, and lipases molecules that greatly involved in these processes and controlling pathogen expression and infection progress. The cell lipid metabolism depends on an adequate energy stores that push the infection to be accelerated and disease symptoms to be appeared. Consequently, future lipidomics studies are the basic for detecting the lipid role in host-pathogen relations which help in therapy advances and biomarkers development.

关键词： Lipidomics Virus Bacteria Parasite Membrane trigger

Protective effect of natural products and hormones in colon cancer using metabolome:A physiological overview

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 957-966页

作者： khaled mohamed mohamed Koriem Department of Medical Physiology Medical Research DivisionNational Research CentreDokkiCairoEgypt

Globally, the third cause of males cancer and the fourth cause of females cancer is colon cancer(CC). In Egypt, high CC percentage occurs in children and in individuals below 40 years of age. The complete loss of biological enzyme function is the main cause of CC and consequently CC increased in smoking and pollution exposure. The aim of this review is to focus on the application of metabolome as a physiological tool that can play an important role in preventing CC incidence by natural products and hormones. The dietary factors, intestinal micro-flora and endogenously produced metabolites are the main three causes that produce free radicals in the colon. A correlation occurs between the enzyme activity and CC polymorphisms or property. Nowadays metabolome is applied with the progress of different analytical methods, data bases and tools for cancer predication and stimulation especially in CC cases. Metabolism is defined as intracellular chemical reactions that produce chemical substances and energies sustaining life. Metabolic pathway networks are also composed of links that are defined as transformation of chemical structures between two metabolites and an enzyme reaction. The most important advantage of metabolome is its ability to analyze metabolites from any source, regardless of origin, where the application of liquid chromatography combined with mass spectra in metabolome analysis to a series of cancer cell lines that were progressively more tumorigenic due to the induction of 1,2,3 or 4 oncogenes to cell lines could be a metabolome example application. In conclusion, natural products and hormones are very important in preventing CC in humans and animal models where both natural products and hormones play a significant and important effect in regulating physiological process especially in CC cases. In this situation, metabolome must increase in its application in the future for the diagnosis of CC cases.

关键词： Colon cancer Metabolome Physiology Natural products Hormones

Loading characteristics of mechanical rib bolts determined through testing and numerical modeling

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International Journal of Mining Science and Technology 2020年第1期30卷 17-24页

作者： khaled mohamed Gamal Rashed Zorica Radakovic-Guzina Centers for Disease Control National Institute for Occupational Safety and HealthPittsburghPA 15236USA ITASCA Consulting Group MinneapolisMN 55401USA

Underground coal mines use mechanical bolts in addition to other types of bolts to control the rib deformation and to stabilize the yielded coal *** research has been conducted to understand the performance of the mechanical bolts in coal *** from the National Institute for Occupational Safety and Health(NIOSH)conducted this work to understand the loading characteristics of mechanical bolts(stiffness and capacity)installed in coal ribs at five underground coal *** pull-out tests were performed in this study to define the loading characteristics of mechanical rib *** installation torques were applied to the tested bolts based on the strength of the coal seam.A typical tri-linear load-deformation response for mechanical bolts was obtained from these *** was found that the anchorage capacity depended mainly on the coal *** for modeling mechanical bolts have been developed using the tri-linear load-deformation *** outcome of this research provides essential data for rib support design.

关键词： Coal rib Mechanical bolt Conventional bolt Tension bolt Point-anchored bolt Rib support Pull-out test Numerical modeling FLAC3D

A practical application of photogrammetry to performing rib characterization measurements in an underground coal mine using a DSLR camera

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International Journal of Mining Science and Technology 2017年第1期27卷 83-90页

作者： Brent A.Slaker khaled M.mohamed Mining Engineer Ground Control Branch NIOSH Office of Mine Safety and Health ResearchPittsburghPAUSA

Understanding coal mine rib behavior is important for inferring pillar loading conditions as well as ensuring the safety of miners who are regularly exposed to ribs. Due to the variability in the geometry of underground openings and ground behavior, point measurements often fail to capture the true movement of mine workings. Photogrammetry is a potentially fast, cheap, and precise supplemental measurement tool in comparison to extensometers, tape measures, or laser range meters, but its application in underground coal has been limited. The practical use of photogrammetry was tested at the Safety Research Coal Mine, National Institute for Occupational Safety and Health(NIOSH). A commercially available, digital single-lens reflex(DSLR) camera was used to perform the photogrammetric surveys for the experiment. Several experiments were performed using different lighting conditions, distances to subject,camera settings, and photograph overlaps, with results summarized as follows: the lighting method was found to be insignificant if the scene was appropriately illuminated. It was found that the distance to the subject has a minimal impact on result accuracy, and that camera settings have a significant impact on the photogrammetric quality of images. An increasing photograph resolution was preferable when measuring plane orientations; otherwise a high point cloud density would likely be excessive. Focal ratio(F-stop) changes affect the depth of field and image quality in situations where multiple angles are necessary to survey cleat orientations. Photograph overlap is very important to proper three-dimensional reconstruction, and at least 60% overlap between photograph pairs is ideal to avoid unnecessary post-processing. The suggestions and guidelines proposed are designed to increase the quality of photogrammetry inputs and outputs as well as minimize processing time, and serve as a starting point for an underground coal photogrammetry study.

关键词： Photogrammetry Coal mining Underground Rib characterization

Fertaric acid amends bisphenol A-induced toxicity,DNA breakdown,and histopathological changes in the liver,kidney,and testis

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World Journal of Hepatology 2022年第3期14卷 535-550页

作者： khaled mohamed mohamed Koriem Department of Medical Physiology National Research CentreGiza 12622Egypt

BACKGROUND Bisphenol A(BPA)is present in many plastic products and food *** the other hand,fertaric acid(FA)is a hydroxycinnamic *** To investigate the effect of FA on BPA-related liver,kidney,and testis toxicity,DNA breakdown,and histopathology in male *** Thirty male albino rats were divided into five equal groups(6 rats/group):Control,paraffin oil,FA-,BPA-,and FA+BPA-treated *** control and paraffin oil groups were administered orally with 1 mL distilled water and 1 mL paraffin oil,*** FA-,BPA-,and FA+BPA-treated groups were administered orally with FA(45 mg/kg,bw)dissolved in 1 mL distilled water,BPA(4 mg/kg,bw)dissolved in 1 mL paraffin oil,and FA(45 mg/kg,bw)followed by BPA(4 mg/kg,bw),*** these treatments were given once a day for 6 *** BPA induced a significant decrease in serum alkaline phosphatase,acid phosphatase,sodium,potassium and chloride,testosterone,dehydroepiandrosterone sulfate,glucose-6-phosphate dehydrogenase,3β-hydroxysteroid dehydrogenase,and testis protein levels but a highly significant increase in serum aspartate aminotransferase,alanine aminotransferase,γ-glutamyl transpeptidase,lactate dehydrogenase,bilirubin,urea,creatinine,uric acid,luteinizing hormone,follicle stimulating hormone,sex hormone binding globulin,blood urea nitrogen,and testis cholesterol ***,FA inhibited the degradation of liver,kidney,and testis DNA *** administration of FA to BPA-treated rats restored all the above parameters to normal *** FA ameliorates BPA-induced liver,kidney,and testis toxicity,DNA breakdown,and histopathological changes.

关键词： Bisphenol A Fertaric acid Liver Kidney Testis Toxicity DNA

Approach to pharmacological and clinical applications of Anisi aetheroleum

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Asian Pacific Journal of Tropical Biomedicine 2015年第1期5卷 60-67页

作者： khaled mohamed mohamed Koriem Medical Physiology Department Medical Research DivisionNational Research Centre

Anisi aetheroleum is the oil obtained from Pimpinella anisuin L.(***) by steam *** seeds were air-dried,and then the dry seeds were crushed,pulverized,and weighed in sequence for anise oil *** is one of the oldest medicinal plants that belong to family *** fruit of *** is harvested in August and *** is widespread in Asia,Africa and *** names of *** include anise,anisoon,roomy,saunf,sweet cumin and *** anise oil odour is aromatic while the oil tastes *** average daily dose of Anisi aetheroleum is 0.3 *** is the major ingredient of the anise *** aetheroleum also displays a protective action against *** *** aetheroleum increases glucose absorption and reduces urine output in the *** plant oil have pharmacological(antimicrobial,***,anti-inflammatory,antispasmodic,***,expectorant and insecticidal) effects and clinical effects on nausea,constipation,menopausal period,virus,diabetes,obesity and sedative *** to the wide application of Anisi aetheroleum in pharmacological and clinical fields,it is recommended for more clinical trails to discover a new medication from the active constituents of the plant oil in the future to treat human diseases especially chronic ones.

关键词： Anisi aetheroleum Pimpinella anisum Apiaceae Pharmacology Clinical effect