Fertaric acid amends bisphenol A-induced toxicity,DNA breakdown,and histopathological changes in the liver,kidney,and testis
作者机构：Department of Medical PhysiologyNational Research CentreGiza 12622Egypt
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2022年第14卷第3期
页 面：535-550页
学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学]
主 题：Bisphenol A Fertaric acid Liver Kidney Testis Toxicity DNA
摘 要：BACKGROUND Bisphenol A(BPA)is present in many plastic products and food *** the other hand,fertaric acid(FA)is a hydroxycinnamic *** To investigate the effect of FA on BPA-related liver,kidney,and testis toxicity,DNA breakdown,and histopathology in male *** Thirty male albino rats were divided into five equal groups(6 rats/group):Control,paraffin oil,FA-,BPA-,and FA+BPA-treated *** control and paraffin oil groups were administered orally with 1 mL distilled water and 1 mL paraffin oil,*** FA-,BPA-,and FA+BPA-treated groups were administered orally with FA(45 mg/kg,bw)dissolved in 1 mL distilled water,BPA(4 mg/kg,bw)dissolved in 1 mL paraffin oil,and FA(45 mg/kg,bw)followed by BPA(4 mg/kg,bw),*** these treatments were given once a day for 6 *** BPA induced a significant decrease in serum alkaline phosphatase,acid phosphatase,sodium,potassium and chloride,testosterone,dehydroepiandrosterone sulfate,glucose-6-phosphate dehydrogenase,3β-hydroxysteroid dehydrogenase,and testis protein levels but a highly significant increase in serum aspartate aminotransferase,alanine aminotransferase,γ-glutamyl transpeptidase,lactate dehydrogenase,bilirubin,urea,creatinine,uric acid,luteinizing hormone,follicle stimulating hormone,sex hormone binding globulin,blood urea nitrogen,and testis cholesterol ***,FA inhibited the degradation of liver,kidney,and testis DNA *** administration of FA to BPA-treated rats restored all the above parameters to normal *** FA ameliorates BPA-induced liver,kidney,and testis toxicity,DNA breakdown,and histopathological changes.
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